Review
Psychiatry
Maryline Couette, Stephane Mouchabac, Vladimir Adrien, Vanessa Cagnone, Alexis Bourla, Florian Ferreri
Summary: Brain dysfunctions can be observed in patients with post-traumatic stress disorder, even without overt behavioral defects.
PSYCHIATRY RESEARCH
(2022)
Review
Psychology, Clinical
Renato Polimanti, Frank R. Wendt
Summary: Posttraumatic stress disorder (PTSD) is a complex mental disorder affecting approximately 7% of the population. Research has shown that the diverse number of traumatic events and symptom combinations leading to PTSD diagnosis pose challenges for studies. Studies have revealed the heritable risk for PTSD and the significant differences in PTSD risk between sexes have important implications. Future research should focus on detecting PTSD risk, expanding ancestral diversity among study cohorts, and remaining cognizant of the influence of social stigma on certain traumatic events.
PSYCHOLOGICAL MEDICINE
(2021)
Article
Clinical Neurology
Angela Nickerson, Yulisha Byrow, Meaghan O'Donnell, Richard A. Bryant, Vicki Mau, Tadgh McMahon, Greg Benson, Belinda J. Liddell
Summary: This study investigated the associations between self-efficacy, beliefs about others, and psychological and social outcomes in refugees. The results showed that exposure to potentially traumatic events was associated with lower self-efficacy and positive beliefs about others. Self-efficacy was negatively associated with depression and anger, while positive beliefs about others were positively associated with social engagement and depression symptoms.
JOURNAL OF AFFECTIVE DISORDERS
(2022)
Article
Psychology, Clinical
Sara A. Heyn, Sophie Bailowitz, Justin D. Russell, Ryan J. Herringa
Summary: Female youth are more likely to develop pPTSD after trauma exposure compared to males. However, little is known about the underlying biomarkers of these sex-based variations. This study found sex-based differences in clinical and brain structure characteristics of youth with PTSD.
DEPRESSION AND ANXIETY
(2022)
Article
Clinical Neurology
Yuanhui Li, Nan Li, Liqun Zhang, Yanru Liu, Tianjiao Zhang, Dai Li, Dexiang Bai, Xiang Liu, Lingjiang Li
Summary: This study develops a fear-potentiated startle paradigm and a machine learning approach to accurately predict PTSD symptoms in Chinese firefighters. The machine learning model can identify firefighters with a PCL-C score of 38 or above with sensitivity and specificity both above 0.85 when 5-fold cross validated on a 1107-person sample.
JOURNAL OF AFFECTIVE DISORDERS
(2022)
Article
Psychiatry
Nicholas Barr, Hazel Atuel, Shaddy Saba, Carl A. Castro
Summary: Moral injury has gained significant research and clinical attention, but there is still much work to be done in comprehensively defining it and understanding its associations with traumatic illness. A novel dual process model is introduced that provides a flexible analytical framework for evaluating symptoms and has important implications for treatment.
FRONTIERS IN PSYCHIATRY
(2022)
Article
Psychiatry
Thormod Idsoe, Tracy Vaillancourt, Atle Dyregrov, Kristine Amlund Hagen, Terje Ogden, Ane Naerde
Summary: Research suggests that bullying victimization and trauma are connected, and a developmental perspective is needed to understand the consequences of childhood bullying. Developmental trauma disorder and complex post-traumatic stress disorder may be more suitable for considering the consequences of bullying victimization, capturing the complexity of symptoms better than PTSD.
FRONTIERS IN PSYCHIATRY
(2021)
Article
Psychology, Clinical
Nithya Ramakrishnan, Marijn Lijffijt, Charles E. Green, Nicholas L. Balderston, Nicholas Murphy, Christian Grillon, Tabish Iqbal, Brittany Vo-Le, Brittany O'Brien, James W. Murrough, Alan C. Swann, Sanjay J. Mathew
Summary: The study demonstrated successful occupancy of lanicemine on NMDAR and effects on arousal symptoms. While lanicemine strongly attenuated APS following a single infusion, differential changes from placebo after three infusions may have been obscured by habituation effects. This research supports selective NMDAR antagonism as a viable pharmacological strategy for treating salient aspects of PTSD.
DEPRESSION AND ANXIETY
(2021)
Article
Obstetrics & Gynecology
Avelina C. Padin, Natalie R. Stevens, Mandy L. Che, Ihuoma N. Erondu, Marisa J. Perera, Madeleine U. Shalowitz
Summary: Over 10% of pregnant patients in this study screened positive for PTSD alone, highlighting a critical mental health need that is left unaddressed by current obstetric standards of care.
BMC PREGNANCY AND CHILDBIRTH
(2022)
Review
Psychology, Clinical
Elizabeth Alpert, Chelsea Shotwell Tabke, Travis A. Cole, Daniel J. Lee, Denise M. Sloan
Summary: Despite the presence of empirically supported treatments for PTSD, little is known about their mechanisms of change. This systematic review summarizes the findings and methodological quality of studies that investigated mediators/mechanisms of change in PTSD treatments. Sixty-two eligible studies were analyzed, and the most consistent mediator/mechanism identified was reduction in negative posttraumatic cognitions, followed by between-session extinction and decreased depression. The study highlights the need for improved methodology in researching treatment mediators and mechanisms. Implications for clinical care and research are discussed. PROSPERO ID: 248088.
CLINICAL PSYCHOLOGY REVIEW
(2023)
Review
Psychology, Multidisciplinary
Laura J. Long
Summary: This paper reviews the relationship between hope and PTSD, as well as broader functioning after a trauma, including potential mechanisms and factors impacting these relationships, and the role of hope as a mechanism of change in PTSD interventions.
CURRENT OPINION IN PSYCHOLOGY
(2022)
Article
Behavioral Sciences
Dayan Knox, Stephanie A. Stout-Oswald, Melissa Tan, Sophie A. George, Israel Liberzon
Summary: The study suggests that the combined maternal separation and single prolonged stress models can be used to explore how changes in maternal care during infancy lead to sex differences in sensitivity to the effects of traumatic stress as adolescents and adults.
FRONTIERS IN BEHAVIORAL NEUROSCIENCE
(2021)
Review
Physiology
Emily C. Reed, Adam J. Case
Summary: Post-traumatic stress disorder (PTSD) is a mental health disorder that lacks definitive biological signatures for diagnosis. The field of redox biology, a potential area for biomarker research, has been overlooked and undervalued.
FRONTIERS IN PHYSIOLOGY
(2023)
Article
Psychology, Clinical
Krystal Morrison, Shiyang Su, Michelle Keck, Deborah C. Beidel
Summary: This study investigated the psychometric properties of the PTSD Checklist for DSM-5 (PCL-5) in first responders seeking treatment for PTSD. The results showed that PCL-5 scores had strong internal consistency and validity, with a recommended cutoff score of 41 for detecting PTSD. Confirmatory factor analyses suggested that the anhedonia model of PTSD best fit the data, supporting the use of PCL-5 as a reliable measure of PTSD in high-risk individuals.
JOURNAL OF ANXIETY DISORDERS
(2021)
Review
Behavioral Sciences
Reihaneh Ahmadi, Sama Rahimi-Jafari, Mahnaz Olfati, Nooshin Javaheripour, Farnoosh Emamian, Mohammad Rasoul Ghadami, Habibolah Khazaie, David C. Knight, Masoud Tahmasian, Amir A. Sepehry
Summary: Posttraumatic stress disorder (PTSD) is strongly associated with insomnia, and the prevalence of insomnia in PTSD patients is high. Screening and managing insomnia in PTSD patients are of great importance.
NEUROSCIENCE AND BIOBEHAVIORAL REVIEWS
(2022)
Article
Psychiatry
Dmitri A. Young, Linda L. Chao, Huaiyu Zhang, Thomas Metzler, Jessica Ross, Anne Richards, Aoife O'Donovan, Sabra S. Inslicht, Thomas C. Neylan
Summary: The study reveals an interaction between BDNF Val66Met polymorphism and brain area volumes in predicting fear-enhanced physiological responses, particularly significantly associated with vmPFC and IC volumes. Val66Met polymorphism may increase susceptibility to PTSD and anxiety disorders through an interaction with reduced volume of vmPFC and IC.
JOURNAL OF PSYCHIATRIC RESEARCH
(2021)
Article
Psychiatry
A. J. Khan, K. Nishimi, P. Tripp, D. Maven, A. Jiha, E. Woodward, S. Inslicht, A. Richards, T. C. Neylan, S. Maguen, A. O'Donovan
Summary: The study revealed that COVID-19 related moral injury primarily includes betrayal, transgression by others, and self-transgression. Perceived future threat to health is associated with betrayal and transgression by others, while risky behaviors are linked to self-transgression.
JOURNAL OF PSYCHIATRIC RESEARCH
(2021)
Article
Neurosciences
Sabra S. Inslicht, Andrea N. Niles, Thomas J. Metzler, Sa'ar L. Lipshitz, Christian Otte, Mohammed R. Milad, Scott P. Orr, Charles R. Marmar, Thomas C. Neylan
Summary: This study found that a single dose of hydrocortisone and D-Cycloserine can facilitate fear extinction learning in individuals with PTSD symptoms, with reduced skin conductance response during extinction learning, especially in the DCS and HC groups compared to placebo. These findings suggest that glucocorticoids and NMDA agonists hold promise for enhancing extinction learning in PTSD.
NEUROPSYCHOPHARMACOLOGY
(2022)
Article
Clinical Neurology
Anne Richards, Sabra S. Inslicht, Leslie M. Yack, Thomas J. Metzler, J. Russell Huie, Laura D. Straus, Cassandra Dukes, Samantha Q. Hubachek, Kim L. Felmingham, Daniel H. Mathalon, Steven H. Woodward, Thomas C. Neylan
Summary: This study examines the relationship between emotional learning and REM sleep in trauma-exposed participants using fear-potentiated startle (FPS) and nap sleep protocol. The results show that safety learning is positively correlated with REM sleep and REM sleep is related to rapid extinction learning. Moreover, the study reveals unexpected effects of PTSD symptoms and biological sex on the learning-sleep relationship.
Article
Obstetrics & Gynecology
Anna Blanken, Carolyn J. Gibson, Yongmei Li, Alison J. Huang, Amy L. Byers, Shira Maguen, Sabra Inslicht, Karen Seal
Summary: Despite the unique racial/ethnic diversity of women veterans served by the Veteran's Health Administration, this study finds racial/ethnic disparities in menopause symptoms and hormone therapy management. Non-Hispanic/Latinx Black and Hispanic/Latinx women veterans have lower odds of systemic hormone therapy prescription and yet higher odds of vaginal estrogen prescription compared to non-Hispanic/Latinx White women veterans.
MENOPAUSE-THE JOURNAL OF THE NORTH AMERICAN MENOPAUSE SOCIETY
(2022)
Article
Psychology, Clinical
Alexandra H. Cowden Hindash, Allison Diamond Altman, Julia Levitan, Sabra S. Inslicht
Summary: The study aims to explore treatment response of patients with posttraumatic stress disorder during prolonged exposure therapy through analyzing continuously collected physiological data. Three potential therapeutic mechanisms were proposed and preliminary results were obtained through analyzing heart rate data.
AMERICAN JOURNAL OF PSYCHOTHERAPY
(2022)
Article
Obstetrics & Gynecology
Lizabeth A. Goldstein, Karen P. Jakubowski, Alison J. Huang, Karen H. Seal, Shira Maguen, Sabra S. Inslicht, Amy L. Byers, Carolyn J. Gibson
Summary: More than a third of women in the United States have reported a history of intimate partner violence. While previous studies have found a link between intimate partner violence and poor subjective sleep, these studies mostly focused on reproductive-aged women and used suboptimal measures of violence and/or insomnia. This study examined the relationship between lifetime intimate partner violence and current clinical insomnia in midlife women veterans.
MENOPAUSE-THE JOURNAL OF THE NORTH AMERICAN MENOPAUSE SOCIETY
(2023)
Meeting Abstract
Neurosciences
Morgan Bartholomew, Thomas Metzler, Thomas Neylan, Sabra Inslicht
NEUROPSYCHOPHARMACOLOGY
(2022)
Meeting Abstract
Neurosciences
Sabra Inslicht, Morgan Bartholomew, Connie Fee, Thomas Metzler, Thomas Neylan
NEUROPSYCHOPHARMACOLOGY
(2022)
Article
Neurosciences
Morgan E. Bartholomew, Vincent Rozalski, Anne Richards, Joyce Gurdock, Mary Thornton, Connie Fee, Sa'ar L. Lipshitz, Thomas J. Metzler, Thomas C. Neylan, Sabra S. Inslicht
Summary: Sex differences in fear conditioning and extinction, as well as the effects of hormones, may contribute to the development of PTSD. Hormonal contraceptives may enhance fear conditioning and extinction. Understanding the impact of sex and hormones on fear processes can provide insights into the pathophysiology of PTSD and potentially lead to sex-specific advancements in treatment.
Meeting Abstract
Psychiatry
Carolyn Gibson, Alison Huang, Shira Maguen, Sabra Inslicht, Amy Byers, Anita Hargrave, Karen Seal
PSYCHOSOMATIC MEDICINE
(2022)
Meeting Abstract
Neurosciences
Dmitri Young, Linda Chao, Huaiyu Zhang, Thomas Metzler, Jessica Ross, Anne Richards, Aoife O'Donovan, Sabra Inslicht, Thomas Neylan
NEUROPSYCHOPHARMACOLOGY
(2021)
Meeting Abstract
Clinical Neurology
Anne Richards, Sabra Inslicht, J. Russell Huie, Leslie Yack, Laura Straus, Kim Felmingham, Steve Woodward, Thomas Neylan
Meeting Abstract
Health Care Sciences & Services
Anita S. Hargrave, Shira Maguen, Sabra Inslicht, Amy Byers, Karen H. Seal, Alison Huang, Carolyn Gibson
JOURNAL OF GENERAL INTERNAL MEDICINE
(2021)
Meeting Abstract
Neurosciences
Aoife O'Donovan, Amy Byers, Eleanor Woodward, Daniel Bertenthal, Sabra Inslicht, Karen Seal, Thomas Neylan
BIOLOGICAL PSYCHIATRY
(2021)