Article
Behavioral Sciences
Juan M. J. Ramos, Ignacio Moron
Summary: The study found that there are different roles between the dorsal hippocampus (DHip) and ventral hippocampus (VHip) in spatial learning and memory. Specifically, DHip-lesioned rats showed an acquisition deficit, while VHip-lesioned rats only exhibited deficits under specific training protocols.
BEHAVIOURAL BRAIN RESEARCH
(2022)
Article
Neurosciences
Caroline Zeitouny, Martin Korte, Kristin Michaelsen-Preusse
Summary: Fragile X syndrome (FXS) is a genetic disorder that causes cognitive impairment and autism. Both FXS patients and a mouse model of FXS (Fmr1 KO) show excess immature dendritic spines in the brain, particularly in the CA3 subregion of the hippocampus. This spine pathology is associated with memory deficits and can be alleviated by specific spatial training during development, suggesting a potential therapeutic strategy.
NEUROBIOLOGY OF DISEASE
(2023)
Article
Behavioral Sciences
Juan M. J. Ramos
Summary: This study compares the effects of dorsal and ventral hippocampus lesions on long-term spatial memory retention and finds that both lesioned groups show significant impairment in spatial memory 24 days after learning.
BEHAVIOURAL BRAIN RESEARCH
(2022)
Article
Psychology, Biological
Adnan M. Massadeh, Karem H. Alzoubi, Amal M. Milhem, Abeer M. Rababa'h, Omar F. Khabour
Summary: Chronic sleep deprivation impairs both short-term and long-term memory, while chronic selenium administration can prevent this impairment by normalizing antioxidant enzyme activities in the hippocampus.
PHYSIOLOGY & BEHAVIOR
(2022)
Article
Behavioral Sciences
Soniya Assudani Patel, Karyn M. Frick, Paul A. Newhouse, Robert S. Astur
Summary: The study examined the role of estradiol in hippocampal-dependent spatial memory in women. Results showed that the high estradiol group demonstrated superior spatial reference memory, while the low estradiol group exhibited the poorest probe trial performance. There were no group differences in performance on the virtual memory tasks.
BEHAVIOURAL BRAIN RESEARCH
(2022)
Article
Multidisciplinary Sciences
Fumiya Sawatani, Yuta Tamatsu, Kaoru Ide, Hirotsugu Azechi, Susumu Takahashi
Summary: This article introduces a reconfigurable maze for spatial navigation behavior assessment, addressing the limitations of traditional mazes in scalability and reproducibility. The reconfigurable maze consists of multiple components that allow flexible configurations of maze pathways to evaluate various aspects of spatial navigation behavior.
JOVE-JOURNAL OF VISUALIZED EXPERIMENTS
(2022)
Review
Biochemistry & Molecular Biology
Ewa Baczynska, Katarzyna Karolina Pels, Subhadip Basu, Jakub Wlodarczyk, Blazej Ruszczycki
Summary: This article reviews experimental approaches designed to assess quantitative features of dendritic spines under physiological stimuli and in pathological conditions. By comparing various methodological pipelines and systematically summarizing the methodology and results of relevant experiments, the focus is on quantitative data regarding the number of animals, cells, dendritic spines, types of studied parameters, size of observed changes, and their statistical significance.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Biochemistry & Molecular Biology
Jing Dong, Hui Fu, Yuanyuan Fu, Mingdan You, Xudong Li, Chaonan Wang, Kunkun Leng, Yuan Wang, Jie Chen
Summary: Exposure to DEHP during pregnancy can impair hippocampal synaptic plasticity in male offspring, affecting synaptic structure and dendritic spine development, possibly through the downregulation of the Rac1/PAK/LIMK1/cofilin signaling pathway. Female offspring did not show these alterations in hippocampal structure.
ACS CHEMICAL NEUROSCIENCE
(2021)
Article
Biochemistry & Molecular Biology
Jiyeon Seo, Hongik Hwang, Heesung Sohn, Eunsil Cho, Sunmin Jung, Soohyun Kim, Seung Min Um, Ji Yeon Kim, Muwon Kang, Yuri Choi, Jong-Hwan Kim, Mirang Kim, Seon-Young Kim, Sun-Kyung Lee, Joohong Ahnn, Hyewhon Rhim, Dong-Gyu Jo, Eunjoon Kim, Mikyoung Park
Summary: Spatial learning and memory flexibility are regulated by long-term potentiation (LTP) and long-term depression (LTD) at the cellular level. This study demonstrates that Ccny knockout (KO) mice exhibit enhanced LTP, weak LTD, and improved spatial learning and memory. CCNY modulates memory flexibility by modulating the cofilin-actin signaling pathway in the hippocampus.
MOLECULAR PSYCHIATRY
(2023)
Article
Behavioral Sciences
Daisuke Ishii, Hironobu Osaki, Arito Yozu, Kiyoshige Ishibashi, Kenta Kawamura, Satoshi Yamamoto, Mariko Miyata, Yutaka Kohno
Summary: Unilateral spatial neglect is a disorder of higher brain function that occurs after a brain injury and leads to a failure to attend to stimuli on one side. A mouse model was used to study the relationship between lesion size and severity of spatial bias, finding that mice with anterior AGm lesions had lower recovery rates. This model could be useful in developing treatments for unilateral spatial neglect in humans.
BEHAVIOURAL BRAIN RESEARCH
(2021)
Article
Biochemistry & Molecular Biology
Juan Li, Yue Wu, Tao Xue, Jing He, Lei Zhang, Yutong Liu, Jinlan Zhao, Zhenzhong Chen, Minjuan Xie, Bin Xiao, Yingshan Ye, Sifei Qin, Qingqiu Tang, Mengfan Huang, Hangfei Zhu, N. Liu, Fukun Guo, Lin Zhang, Lu Zhang
Summary: The study found that the regulation of Cdc42 signaling in the hippocampus plays an important role in the morphological and behavioral adaptations to cocaine addiction. Knockout or mutation of Cdc42 blocked the increase in synaptic plasticity in hippocampal neurons, leading to a decrease in conditioned place preference memory and spatial learning and memory. The Cdc42 signaling pathway correlates specific brain regions with cocaine-induced CPP behavior.
BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE
(2023)
Article
Neurosciences
Megane Missaire, Nicolas Fraize, Jean-Christophe Comte, Bruno Truchet, Regis Parmentier, Paul-Antoine Salin, Gael Malleret
Summary: Long-term storage of information in memory relies on long-term synaptic plasticity processes. Studies have shown synaptic changes after training in long-term/reference memory and working memory tasks. Consolidation of long-term information leads to delayed synaptic potentiation, while optimal information processing into working memory triggers synaptic depression.
Article
Neurosciences
Hiroko Sugiura, Tadayuki Shimada, Keiko Moriya-Ito, Jun-Ichi Goto, Hiroki Fujiwara, Rie Ishii, Hiroshi Shitara, Choji Taya, Satoshi Fujii, Toshiyuki Kobayashi, Okio Hino, Paul F. Worley, Kanato Yamagata
Summary: This study discovered a new signaling pathway involving Rheb1 activation, rather than mTORC1 activation, in synapse formation. Treatment with lonafarnib, a farnesyltransferase inhibitor, restored synaptic abnormalities and memory impairments in TSC patients by increasing unfarnesylated Rheb1 levels. These findings provide new insights into potential treatment options for TSC-associated neuropsychiatric disorders.
JOURNAL OF NEUROSCIENCE
(2022)
Article
Biology
Maximilian Lenz, Amelie Eichler, Pia Kruse, Julia Muellerleile, Thomas Deller, Peter Jedlicka, Andreas Vlachos
Summary: The study demonstrates that the vitamin A metabolite all-trans retinoic acid (atRA) induces synaptic plasticity in mouse dentate granule cells, particularly in the dorsal hippocampus, leading to an increase in excitatory postsynaptic current frequencies and synapse numbers. AtRA treatment improved the ability of dentate granule cells to express LTP, with this plasticity-promoting effect being dependent on synaptopodin. These findings highlight the role of atRA in mediating synaptopodin-dependent metaplasticity in mouse dentate granule cells.
Review
Behavioral Sciences
Marta Mendez-Couz, Denise Manahan-Vaughan, Ana Paula Silva, Hector Gonzalez-Pardo, Jorge Luis Arias, Nelida Maria Conejo
Summary: The neuropeptide Y2 receptors play a significant role in hippocampus-dependent spatial memory, with receptor expression dynamically regulated by learning experiences. Antagonism of the receptors in the dorsal intrahippocampal area improves spatial reference memory.
BEHAVIOURAL BRAIN RESEARCH
(2021)
Article
Endocrinology & Metabolism
Jose Ramon Munoz-Rodriguez, Teresa Rodriguez-Cano, Filomena Polo, Luis Saenz-Mateos, Andrea Agarrado, Esperanza Segura, Gloria Casas, Jesus Martin-Fernandez, Luis Beato-Fernandez, Elisabet Salas, Carmen Gonzalez-Martin, Luis F. Alguacil
NEUROENDOCRINOLOGY
(2020)
Article
Food Science & Technology
Jose M. Perez-Ortiz, Luis F. Alguacil, Elisabet Salas, Isidro Hermosin-Gutierrez, Sergio Gomez-Alonso, Carmen Gonzalez-Martin
FOOD SCIENCE & NUTRITION
(2019)
Article
Neurosciences
Victor Naranjo, Ana Contreras, Beatriz Merino, Adrian Plaza, Maria P. Lorenzo, Cristina Garcia-Caceres, Antonia Garcia, Julie A. Chowen, Mariano Ruiz-Gayo, Nuria Del Olmo, Victoria Cano
Article
Chemistry, Medicinal
Ana Contreras, Lidia Morales, Nuria Del Olmo, Carmen Perez-Garcia
CHEMICAL RESEARCH IN TOXICOLOGY
(2020)
Review
Pharmacology & Pharmacy
Mariano Ruiz-Gayo, Nuria D. Olmo
CURRENT PHARMACEUTICAL DESIGN
(2020)
Article
Neurosciences
Carmen Rodriguez-Rivera, Rocio Giron, Eva Sanchez-Robles, Carmen Gonzalez-Martin, Carlos Goicoechea, Luis F. Alguacil
Article
Clinical Neurology
Inigo Pallardo-Fernandez, Jose Ramon Munoz-Rodriguez, Carmen Gonzalez-Martin, Luis F. Alguacil
JOURNAL OF PSYCHOPHARMACOLOGY
(2020)
Article
Neurosciences
Carmen Rodriguez-Rivera, Carmen Gonzalez-Martin, Elisa Fernandez-Millan, Carmen Alvarez, Fernando Escriva, Luis F. Alguacil
Summary: Perinatal malnutrition induces significant changes in brain neurochemistry that are not fully reversed by rehabilitation of normal feeding, potentially contributing to behavioral disturbances in adulthood.
NUTRITIONAL NEUROSCIENCE
(2022)
Article
Food Science & Technology
Carmen Rodriguez-Rivera, Jose Manuel Perez-Ortiz, Elizabeth Pook, Nina Conjaerts, Luis F. Alguacil, Carmen Gonzalez-Martin
Summary: The study showed that high-fat diets have short-term reinforcement and long-term reduction effects on sucrose reward, which spontaneously disappear after a period of high-fat diet. High-fat diets also increase the expression of clusterin in the nucleus accumbens.
FOOD AND CHEMICAL TOXICOLOGY
(2021)
Article
Nutrition & Dietetics
Jose Ramon Munoz-Rodriguez, Javier Luna-Castro, Inmaculada Ballesteros-Yanez, Jose Manuel Perez-Ortiz, Francisco Javier Gomez-Romero, Francisco Javier Redondo-Calvo, Luis F. Alguacil, Carlos A. Castillo
Summary: The study aimed to explore the impact of an enrolled degree course on health and eating habits in Spanish university students aged 17-26. Results showed that biomedical students demonstrated healthier lifestyle factors in areas such as body image perception, health consciousness, dietary habits, and physical activity compared to non-biomedical students. The data highlighted the importance of developing health promotion strategies specifically targeting university students.
Article
Anatomy & Morphology
Carmen Rodriguez-Rivera, Laura Santin Moreda, Luis F. Alguacil, Fernando Escriva, Carmen Alvarez, Carmen Gonzalez-Martin
Summary: There is a relationship between the distribution of fat mass, metabolic disorders, and increased risk of morbidity and mortality. In obese animals, there is a significant increase in white fat deposits, while undernourished animals show possible transformations between types of adipose tissues. The discovery of beige adipose tissue has led to thoughts on the adaptability of different cells in adipose tissue under pathological conditions.
Article
Surgery
Laura Pajares Arribas, Luis Fernando Alguacil Merino, Juan Segui Montesinos
Summary: This study aimed to investigate the impact of various physical, medical, and psychopathological variables on the outcomes of sleeve gastrectomy in patients with class II-IV obesity. The results revealed that factors such as advanced age, high body mass index, diabetes, and respiratory problems were associated with poor surgical response, while a history of adjustment disorder predicted a better response.
SURGERY FOR OBESITY AND RELATED DISEASES
(2022)
Article
Substance Abuse
Inigo Pallardo-Fernandez, Nuria Garcia-Marchena, Carmen Rodriguez-Rivera, Francisco Javier Pavon, Carmen Gonzalez-Martin, Fernando Rodriguez De Fonseca, Luis E. Alguacil
Summary: This study compared plasma midkine levels between patients with cocaine use disorder and control subjects, and found that early-abstinent patients had higher midkine concentrations, which tended to normalize with prolonged abstinence. These results suggest a close relationship between midkine levels and cocaine use, and support the idea that midkine may play a protective role by limiting the biological activity of psychostimulants.
Article
Food Science & Technology
Carmen Rodriguez-Rivera, Maria Dolores Perez-Carrion, Lucia Casariego Olavarria, Luis F. Alguacil, Maria Jose Polanco Mora, Carmen Gonzalez-Martin
Summary: Food-related disorders are on the rise in developed societies, with a growing focus on the psychological component of these disorders. Research has shown that overnourishment with high-fat diets and perinatal undernourishment in mice are associated with increased motivation toward food intake. The protein clusterin (CLU) is overexpressed in the nucleus accumbens of over-fed rats and those suffering from chronic undernutrition, and its increase has been observed in obese patients with food addiction, suggesting its implication in this eating disorder.
FOOD & NUTRITION RESEARCH
(2021)
Article
Substance Abuse
Inigo Pallardo-Fernandez, Victoria Iglesias, Carmen Rodriguez-Rivera, Carmen Gonzalez-Martin, Luis F. Alguacil
JOURNAL OF SMOKING CESSATION
(2020)
