Article
Medicine, General & Internal
Chao Wang, Cheng Zhou, Tao Guo, Yeerfan Jiaerken, Siyu Yang, Xiaopei Xu, Ling Hu, Peiyu Huang, Xiaojun Xu, Minming Zhang
Summary: This study found that current coffee consumption is associated with decreased striatal dopamine transporter availability in the caudate. However, the effects of caffeine on dopamine transporter may fade and disappear after quitting coffee consumption.
Review
Clinical Neurology
Paolo Calabresi, Giulia Di Lazzaro, Gioia Marino, Federica Campanelli, Veronica Ghiglieri
Summary: The critical role of alpha-synuclein in Parkinson's disease has been discovered, but current treatments still face challenges. Developing cellular and animal models helps understand the physiological and pathological functions of alpha-synuclein, as well as the pathogenesis of Parkinson's disease.
Article
Clinical Neurology
Andreas-Antonios Roussakis, Zhou Zeng, Nicholas P. Lao-Kaim, Antonio Martin-Bastida, Paola Piccini
Summary: The study found that in moderate-stage Parkinson's disease, asymmetry in striatal dopaminergic degeneration becomes less prominent over time, while the asymmetry of motor symptoms remains consistent between the clinically most and least affected body sides.
JOURNAL OF NEUROLOGY
(2021)
Review
Biochemistry & Molecular Biology
Kathryn Lanza, Christopher Bishop
Summary: Parkinson's Disease (PD) and long-term L-DOPA treatment induce plasticity that contributes to L-DOPA-induced dyskinesia (LID), with the dopamine D3 receptor (D3R) emerging as a promising target in LID management due to its upregulation in LID. D3R undergoes dynamic changes in both PD and LID, and recent genetic and pharmacologic tools have helped clarify its role in LID.
Article
Neurosciences
Leah G. Mann, Kaitlyn R. Hay, Alexander K. Song, Steven P. Errington, Paula Trujillo, David H. Zald, Yan Yan, Hakmook Kang, Gordon D. Logan, Daniel O. Claassen
Summary: The stop-signal task is a well-established assessment of response inhibition, where PD patients showed changes in efficiency related to dorsal striatum D-2 receptor availability. Faster response inhibition was associated with greater D-2 receptor availability in the amygdala and hippocampus, suggesting a potential interaction between limbic and motor loops in action-control networks.
JOURNAL OF NEUROSCIENCE
(2021)
Article
Clinical Neurology
Yayoi Shigemune, Iori Kawasaki, Akira Midorikawa, Toru Baba, Atsushi Takeda, Nobuhito Abe
Summary: The study found that while PD patients showed less interest in viewing negative pictures compared to healthy controls, their motivation to resolve uncertainty remained relatively intact.
NEUROLOGICAL SCIENCES
(2021)
Article
Neurosciences
Vignayanandam Ravindernath-Jayashree Muddapu, Karthik Vijayakumar, Keerthiga Ramakrishnan, V. Srinivasa Chakravarthy
Summary: Parkinson's disease is caused by the progressive loss of dopaminergic cells in the substantia nigra pars compacta, possibly linked to metabolic deficiency. L-DOPA treatment for PD may have toxic effects on neurons. A proposed computational model aims to investigate the mechanism behind neurodegeneration and offer insights for therapeutic development.
FRONTIERS IN NEUROSCIENCE
(2022)
Article
Behavioral Sciences
Yayoi Shigemune, Iori Kawasaki, Toru Baba, Atsushi Takeda, Nobuhito Abe
Summary: The study found that patients with Parkinson's disease are less sensitive to the loss of options compared to healthy controls, possibly due to a decline in dopaminergic neurotransmission.
Article
Neurosciences
Ashley C. Parr, Heidi C. Riek, Brian C. Coe, Giovanna Pari, Mario Masellis, Connie Marras, Douglas P. Munoz
Summary: Genetic variation in dopamine function may affect mixed-strategy decision-making in Parkinson's disease patients. Patients with higher dopamine transmission scores showed better performance, and genetic variation modulated cognitive aspects of performance beyond motor function.
EUROPEAN JOURNAL OF NEUROSCIENCE
(2022)
Article
Neurosciences
Kelsey Barcomb, Christopher P. Ford
Summary: This review summarizes the previous work on the changes in neurotransmitter co-release and circuit dysfunction associated with the degeneration of midbrain dopamine neurons in Parkinson's disease.
EXPERIMENTAL NEUROLOGY
(2023)
Article
Clinical Neurology
Chao Wang, Cheng Zhou, Tao Guo, Peiyu Huang, Xiaojun Xu, Minming Zhang
Summary: This study explored the neural mechanisms of the association between cigarette smoking and Parkinson's disease (PD). The findings suggest that the degeneration of dopaminergic neurons in PD leads to a reduction in dopamine levels, while smoking inhibits the action of striatal DAT, resulting in increased dopamine levels. Additionally, smoking and PD showed an interaction effect in the left medial prefrontal cortex, and PD patients with a smoking history exhibited reduced gray matter volume in this region, which may be associated with cognitive impairment.
THERAPEUTIC ADVANCES IN NEUROLOGICAL DISORDERS
(2022)
Article
Biochemistry & Molecular Biology
Siamak K. Sorooshyari, Nicholas Ouassil, Sarah J. Yang, Markita P. Landry
Summary: The emergence of new imaging tools has revolutionized our understanding of neurochemistry in brain development and cognition. In this study, near-infrared catecholamine nanosensors were used to image dopamine modulation in brain tissue slices. Machine learning techniques were applied to identify unique features of dopamine modulation related to stimulation strength and specific neuroanatomical regions. The results showed that machine learning could accurately distinguish dopamine release in different regions of the brain, which was not achievable with conventional statistical analysis. The study highlights the potential of machine learning as a powerful tool in differentiating neuroanatomical regions and detecting features not detectable by conventional statistical analysis.
ACS CHEMICAL NEUROSCIENCE
(2023)
Review
Biochemistry & Molecular Biology
Allen P. F. Chen, Lu Chen, Thomas A. Kim, Qiaojie Xiong
Summary: Dopamine plays a crucial role in controlling CNS function and its dysregulation can lead to various cognitive symptoms associated with neuropsychiatric diseases. Different brain areas have varying functions and roles for dopamine, suggesting potential differential dysregulation in different disease states.
Article
Neurosciences
Yong Wang, Lu Yao, Shasha Gao, Gejuan Zhang, Qiongchi Zhang, Wanyuan Liu, Yingqiong Zhou, Yina Sun, Jie Feng, Jian Liu
Summary: The study found that the striatal dopamine D-5 receptor plays an important role in the pathophysiology of levodopa-induced dyskinesia in patients with Parkinson's disease, by regulating the activity of sensorimotor striatum neurons to affect the development of dyskinetic symptoms.
Review
Clinical Neurology
Kaitlyn M. L. Cramb, Dayne Beccano-Kelly, Stephanie J. Cragg, Richard Wade-Martins
Summary: Cramb et al. provide a review of evidence suggesting dopamine release deficits occur prior to neurodegeneration in Parkinson's disease. They also highlight the need for further investigation in understanding the mechanisms behind these deficits.
Article
Psychology, Clinical
Blair Uniacke, Reile Slattery, B. Timothy Walsh, Daphna Shohamy, Karin Foerde, Joanna Steinglass
INTERNATIONAL JOURNAL OF EATING DISORDERS
(2020)
Article
Multidisciplinary Sciences
Celia Durkin, Eileen Hartnett, Daphna Shohamy, Eric R. Kandel
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
(2020)
Review
Behavioral Sciences
Natalie Biderman, Akram Bakkour, Daphna Shohamy
TRENDS IN COGNITIVE SCIENCES
(2020)
Article
Clinical Neurology
Madeleine E. Sharp, Katherine Duncan, Karin Foerde, Daphna Shohamy
Article
Psychology, Clinical
Karin Foerde, Janet E. Schebendach, Lauren Davis, Nathaniel Daw, B. Timothy Walsh, Daphna Shohamy, Joanna E. Steinglass
Summary: Restrictive eating is a central feature of anorexia nervosa (AN) and other eating disorders. This study examined the behavioral and neural mechanisms of restrictive eating among individuals with and without eating disorders. The findings showed that healthy individuals tended to choose high-fat foods, while patients with AN focused more on the healthiness of the food. Dorsal striatal activation associated with food choice was most pronounced among individuals with AN, and it was significantly associated with selecting fewer high-fat choices and lower caloric intake.
PSYCHOLOGICAL MEDICINE
(2022)
Article
Behavioral Sciences
Caroline B. Marvin, Ellen Tedeschi, Daphna Shohamy
CURRENT OPINION IN BEHAVIORAL SCIENCES
(2020)
Article
Neurosciences
Karin Foerde, Nathaniel D. Daw, Teresa Rufin, B. Timothy Walsh, Daphna Shohamy, Joanna E. Steinglass
Summary: Research in computational psychiatry has found that individuals with anorexia nervosa show impairments in model-based learning, indicating a persistent contribution of habitual over goal-directed control. This pattern remains consistent across different contexts and time points, suggesting that achieving weight restoration may not remediate the preference for habitual behavior over goal-directed behavior in individuals with AN.
JOURNAL OF COGNITIVE NEUROSCIENCE
(2021)
Article
Psychology, Clinical
Karin Foerde, B. Timothy Walsh, Maya Dalack, Nathaniel Daw, Daphna Shohamy, Joanna E. Steinglass
Summary: The study found that there was a stronger association between caudate activity and food choices among individuals with anorexia nervosa compared to healthy controls before treatment, and decreases in caudate engagement among individuals with anorexia nervosa undergoing treatment were associated with increases in high-fat food choices.
JOURNAL OF EATING DISORDERS
(2021)
Article
Psychology, Clinical
Alexandra F. Muratore, Mariya Bershad, Joanna E. Steinglass, Karin E. Foerde, Loren Gianini, Allegra Broft, Evelyn Attia
Summary: The study found that HF-rTMS to the right DLPFC was associated with a reduction of fat avoidance among inpatients with anorexia nervosa in a food choice task. This suggests that this region and related neural circuits may be involved in restrictive food choice.
INTERNATIONAL JOURNAL OF EATING DISORDERS
(2021)
Article
Neurosciences
Alice M. Xue, Karin Foerde, B. Timothy Walsh, Joanna E. Steinglass, Daphna Shohamy, Akram Bakkour
Summary: Decisions about what to eat involve the OFC and the evaluation of taste and health attributes. By using fMRI and behavioral tasks, this study found that activity patterns in the OFC can decode subjective ratings of tastiness and healthiness. However, the OFC activity related to health attributes is more related to choice preferences in patients with AN compared to healthy individuals.
JOURNAL OF NEUROSCIENCE
(2022)
Article
Neurosciences
E. Caitlin Lloyd, Karin E. Foerde, Alexandra F. Muratore, Natalie Aw, David Semanek, Joanna E. Steinglass, Jonathan Posner
Summary: Diffusion-weighted magnetic resonance imaging and tractography were used to investigate the structural connectivity in patients with anorexia nervosa. Reduced subcortical connectivity and increased frontal cortical connectivity were found in individuals with AN compared to healthy controls. These findings suggest alterations in feeding, emotion, and executive control circuits in AN.
BIOLOGICAL PSYCHIATRY-COGNITIVE NEUROSCIENCE AND NEUROIMAGING
(2023)
Article
Psychology, Clinical
Joanna E. Steinglass, Wenbo Fei, Karin Foerde, Caroline Touzeau, Julia Ruggiero, Caitlin Lloyd, Evelyn Attia, Yuanjia Wang, B. Timothy Walsh
Summary: This study examined the relationship between changes in food choices during inpatient treatment and longer-term clinical course in individuals with anorexia nervosa (AN). Short-term treatment led to improvements in body mass index (BMI), but did not result in significant changes in the food choices made in a task known to predict actual eating. However, the extent to which patients increased high-fat food choices and decreased the use of self-control in food choices during treatment were associated with less weight loss over the following three years.
PSYCHOLOGICAL MEDICINE
(2023)
Article
Neurosciences
Rotem Botvinik-Nezer, Akram Bakkour, Tom Salomon, Daphna Shohamy, Tom Schonberg
Summary: This study explores the role of memory in preference change, finding that enhanced memory for trained items influences individual choices, suggesting that memory plays a significant role in value-based decision-making.
Article
Psychology, Multidisciplinary
E. Caitlin Lloyd, Zarrar Shehzad, Janet Schebendach, Akram Bakkour, Alice M. Xue, Naomi Folasade Assaf, Rayman Jilani, B. Timothy Walsh, Joanna Steinglass, Karin Foerde
FRONTIERS IN PSYCHOLOGY
(2020)