Article
Neurosciences
Farnaz Sharif, Behnam Tayebi, Gyorgy Buzsaki, Sebastien Royer, Antonio Fernandez-Ruiz
Summary: Hippocampal neurons exhibit different spatial coding characteristics in different environments, with superficial place cells more active in cue-poor environments and deep place cells more active in cue-rich environments. These differences are driven by intra-hippocampal and entorhinal inputs, supported by the interaction between excitatory gamma inputs and local inhibition.
Article
Biology
Davide Cavalieri, Alexandra Angelova, Anas Islah, Catherine Lopez, Marco Bocchio, Yannick Bollmann, Agnes Baude, Rosa Cossart
Summary: Cellular diversity in the CA1 output node of the murine hippocampus is increasingly recognized as heterogeneous, with principal neurons segregating along the hippocampal axes by birthdate. A subpopulation of pioneer neurons with unique features is found to be recruited in familiar environments, highlighting the importance of early steps of development in determining hippocampal circuit diversity.
Article
Neurosciences
Liqin Gu, Minglong Ren, Longnian Lin, Jiamin Xu
Summary: This study reveals the heterogeneity of hippocampal pyramidal neurons and suggests that CB+ neurons encode spatial information more efficiently, possibly due to stronger inputs from the lateral entorhinal cortex to CB+ neurons.
Article
Pharmacology & Pharmacy
Ying Zhang, Hai-Yan Yin, Patrizia Rubini, Peter Illes, Yong Tang
Summary: There is a dispute about whether CNS neurons possess ATP-sensitive P2X7 receptors. By genetically deleting P2X7 receptors in astrocytes and oligodendrocytes, it was found that these receptors indirectly modulate the neuronal input to neighboring neurons.
FRONTIERS IN PHARMACOLOGY
(2022)
Article
Biology
Lingjun Ding, Giuseppe Balsamo, Hongbiao Chen, Eduardo Blanco-Hernandez, Ioannis S. Zouridis, Robert Naumann, Patricia Preston-Ferrer, Andrea Burgalossi
Summary: Neural circuits are composed of diverse neuronal cell types, and this diversity plays a crucial role in brain function during natural behavior. In this study, the combination of juxtacellular recording, labeling, and optogenetics enabled the investigation of molecularly defined cell classes in freely moving mice, revealing the weaker spatial modulation and information transmission of Calbindin-positive CA1 pyramidal cells.
Article
Neurosciences
Hadas E. Sloin, Amir Levi, Shirly Someck, Lidor Spivak, Eran Stark
Summary: Single hippocampal cells can encode the spatial position of an animal through phase rolling, a faster and distinct form of phase change compared to phase precession. Place fields exhibiting phase rolling are larger in size than nonrolling fields.
JOURNAL OF NEUROSCIENCE
(2022)
Article
Neurosciences
Tobias Bock, Adrian Negrean, Steven A. Siegelbaum
Summary: Synaptic inputs targeting distal dendrites can amplify local dendritic spikes, but these spikes are often weak due to dendritic cable properties. Despite this, they are implicated in memory storage, sensory perception, and place field formation. Somatic depolarization can enhance dendritic spike propagation, leading to enhanced memory specificity and long-term synaptic plasticity in hippocampal-dependent spatial representations and learning.
JOURNAL OF NEUROSCIENCE
(2022)
Article
Neurosciences
Sachin S. Deshmukh
Summary: The study shows that the inputs from different regions in the proximal and distal CA1 areas cause differential representation responses. While pCA1 representation splits when faced with conflicting inputs, dCA1 is more influenced by global cues. Overall spatial selectivity is not significantly different, possibly due to the richer sensory information available in the behavioral environment.
JOURNAL OF NEUROSCIENCE
(2021)
Article
Anatomy & Morphology
Denise Riquelme, Oscar Cerda, Elias Leiva-Salcedo
Summary: In this study, the localization and expression of TRPM4 in CA1 pyramidal neurons during postnatal development were examined using immunofluorescence and patch-clamp techniques in C57BL/6J mice. The results show that TRPM4 is expressed in the soma and apical dendrites of CA1 pyramidal neurons, associated with a TRPM4-like current that depolarizes the neurons. These findings suggest that TRPM4 may play a role in controlling membrane potential and action potential firing during critical periods of neuronal development, particularly in circuit establishment.
FRONTIERS IN NEUROANATOMY
(2021)
Article
Clinical Neurology
Omowumi Moromoke Femi-Akinlosotu, Funmilayo Eniola Olopade, Jane Obiako, James Olukayode Olopade, Matthew Temitayo Shokunbi
Summary: This study investigates the effects of vanadium on the morphology of hippocampal pyramidal neurons and neurobehavior in juvenile hydrocephalic mice. The results suggest that vanadium has a dose-dependent protective effect on the pyramidal cells of the hippocampus and improves memory and spatial learning functions in hydrocephalic mice.
FRONTIERS IN NEUROLOGY
(2023)
Article
Neurosciences
Elena Spoleti, Paraskevi Krashia, Livia La Barbera, Annalisa Nobili, Carmen Alina Lupascu, Elisabetta Giacalone, Flavio Keller, Michele Migliore, Massimiliano Renzi, Marcello D'Amelio
Summary: This study reveals that impaired cell excitability and firing in ventral CA1 pyramidal neurons is an early feature in Tg2576 AD mice.
EXPERIMENTAL NEUROLOGY
(2022)
Article
Neurosciences
Paola Vitale, Fabio Librizzi, Andrea C. Vaiana, Elisa Capuana, Maurizio Pezzoli, Ying Shi, Armando Romani, Michele Migliore, Rosanna Migliore
Summary: The fundamental role of neurons in a network is to transform complex input patterns into output spikes, and understanding species-specific differences in this process is important. This study compared the morphological and electrophysiological properties of mouse and rat neurons to determine the parameters underlying their differences and created computational models to further investigate these distinctions.
FRONTIERS IN CELLULAR NEUROSCIENCE
(2023)
Article
Multidisciplinary Sciences
Yuichiro Hayashi, Ko Kobayakawa, Reiko Kobayakawa
Summary: Recent long-term optical imaging studies have shown that the activity levels of hippocampal neurons in familiar environments fluctuate on a daily to weekly basis. However, it is unclear whether there are any time-invariant properties in the neural representations of these cells. In this study, using miniature fluorescence microscopy, the neural activity of mouse hippocampus was measured in four different environments every 3 days. The results suggest that each cell has an inherent activity level and plays a characteristic role in the coding of space.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
(2023)
Review
Physiology
Giriraj Sahu, Ray W. Turner
Summary: Neuronal signal transmission is influenced by the frequency, pattern, and timing of spike output, all of which are controlled by spike afterhyperpolarizations (AHPs). Different types of AHPs, including fast, medium, and slow AHPs, have been found to be shaped by various potassium channels, with recent discoveries revealing the involvement of a calcium-gated intermediate conductance potassium channel in the slow AHP process.
FRONTIERS IN PHYSIOLOGY
(2021)
Article
Cell Biology
Matteo Guardamagna, Federico Stella, Francesco P. Battaglia
Summary: Theta sequences and phase precession shape hippocampal activity and memory formation. Heterogeneity exists in CA1, with some cells expressing theta sequences without phase precession and others showing phase precession only with certain gamma waves dominant. Additionally, sequences occur independently in different cell groups. These findings challenge the notion that phase precession is the mechanism underlying the emergence of theta sequences, suggesting a role for CA1 cells in multiplexing diverse computational processes.
Article
Neurosciences
Nihal A. Salem, Lawrence Manzano, Michael W. Keist, Olga Ponomareva, Amanda J. Roberts, Marisa Roberto, R. Dayne Mayfield
Summary: This study identified cell-type specific gene expression changes associated with alcohol dependence in the medial prefrontal cortex of mice. The results revealed dysregulated gene co-expression networks and differentially expressed genes in multiple cell types, highlighting the involvement of inhibitory neurons and astrocytes in alcohol dependence. Novel targets for studying molecular mechanisms contributing to alcohol dependence were also identified.
NEUROBIOLOGY OF DISEASE
(2024)
Article
Neurosciences
Laura E. Hawley, Megan Stringer, Abigail J. Deal, Andrew Folz, Charles R. Goodlett, Randall J. Roper
Summary: This study found that the overexpression of DYRK1A protein in Down syndrome mice varies with age, sex, and brain region, and reducing the copy number of Dyrk1a can decrease the expression of DYRK1A. These sex-specific patterns of DYRK1A overexpression may provide mechanistic targets for therapeutic intervention in Down syndrome.
NEUROBIOLOGY OF DISEASE
(2024)