Article
Biochemistry & Molecular Biology
Maria Consiglia Trotta, Sami Gharbia, Hildegard Herman, Bianca Mladin, Andrei Hermenean, Cornel Balta, Coralia Cotoraci, Victor Eduard Peteu, Carlo Gesualdo, Francesco Petrillo, Marilena Galdiero, Roberto Alfano, Mihaela Gherghiceanu, Michele D'Amico, Settimio Rossi, Anca Hermenean
Summary: The study found that aged mice had decreased endogenous levels of RvD1 in the retina, as well as sex-related differences in neuroinflammation and apoptosis.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Chemistry, Multidisciplinary
Mohammad Shamsul Ola, Ahmed Z. Alanazi, Ajmaluddin Malik, Abdul Malik, Mohammed Ahmed, Salim S. Al-Rejaie, Abdullah S. Alhomida
Summary: Diabetic retinopathy is a major cause of blindness and its prevalence is increasing with the diabetes pandemic. Early neurodegeneration caused by oxidative stress has been identified as a key factor in microvascular damage in the diabetic retina. Phytochemicals with high antioxidant properties have shown promise in preventing and treating diabetes-induced retinal damage.
APPLIED SCIENCES-BASEL
(2022)
Review
Medicine, Research & Experimental
Victoria Maneu, Pedro Lax, Antonio Miguel G. De Diego, Nicolas Cuenca, Antonio G. Garcia
Summary: This article discusses the multi-target therapy approach for treating retina degenerative diseases, with a focus on common signaling pathways leading to cell death. It suggests the use of combined medicines acting on complementary pathogenic mechanisms and highlights the potential efficacy of this approach compared to single-drug treatments.
BIOMEDICINE & PHARMACOTHERAPY
(2022)
Article
Biochemistry & Molecular Biology
Maria Cristina Barbalace, Lorenzo Zallocco, Daniela Beghelli, Maurizio Ronci, Serena Scortichini, Maria Digiacomo, Marco Macchia, Maria Rosa Mazzoni, Dennis Fiorini, Antonio Lucacchini, Silvana Hrelia, Laura Giusti, Cristina Angeloni
Summary: Phenols in extra-virgin olive oil have neuroprotective effects, with specific outcomes related to geographical origin and phenol composition.
Article
Biochemistry & Molecular Biology
Juan David Olivares-Hernandez, Martha Carranza, Jerusa Elienai Balderas-Marquez, David Epardo, Rosario Baltazar-Lara, Jose Avila-Mendoza, Carlos G. Martinez-Moreno, Maricela Luna, Carlos Aramburo
Summary: This study investigates the neuroprotective and regenerative effects of growth hormone (GH) in prenatal hypoxic-ischemic (HI) injury using chicken embryo models. The results demonstrate that GH has an anti-apoptotic effect and promotes cell survival and proliferation in HI-injured pallial neurons through the activation of ERK1/2 and Bcl-2 signaling pathways.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Chemistry, Medicinal
Alejandra Daruich, Emilie Picard, Justine Guegan, Thara Jaworski, Lea Parenti, Kimberley Delaunay, Marie-Christine Naud, Marianne Berdugo, Jeffrey H. Boatright, Francine Behar-Cohen
Summary: This study evaluated the neuroprotective effects of UDCA versus TUDCA in a neuroretinal degeneration model and compared the transcriptionally regulated pathways. The results showed that TUDCA regulated more neuroprotective genes than UDCA.
Article
Environmental Sciences
Xueying Ma, Yizhe Dai, Tiantong Qiu, Xin Chen, Peng Xiao, Wenhua Li
Summary: The purpose of this study was to evaluate the adverse effects of amisulbrom on retinal development in zebrafish. Zebrafish embryos were treated with different concentrations of amisulbrom and showed phenotypic abnormalities, dysregulation of gene transcription levels related to retinal cell layer differentiation, increased retinal apoptosis, and changes in glutathione and malondialdehyde content. These findings demonstrate the toxicity of amisulbrom to eye development and its potential ecotoxicological impacts on aquatic species.
ENVIRONMENTAL SCIENCE AND POLLUTION RESEARCH
(2023)
Article
Neurosciences
Acharya Balkrishna, Kunal Bhattacharya, Sunil Shukla, Anurag Varshney
Summary: This study demonstrates that Divya-Medha-Vati, an Ayurvedic polyherbal medicine, can promote neuronal health and inhibit Alzheimer-like cognitive dysfunction through enhanced antioxidant activities and modulation of neuronal activities.
MOLECULAR NEUROBIOLOGY
(2023)
Article
Ophthalmology
Annette Zwanzig, Jie Meng, Heidi Mueller, Susanne Buerger, Manuela Schmidt, Maik Pankonin, Peter Wiedemann, Jan Darius Unterlauft, Wolfram Eichler
Summary: Secreted neuroprotective factors produced by Muller cells can promote RGC survival, and R28 cells are more resistant to apoptosis when co-cultured with Muller cells. Under hypoxia, IL-6 and VEGF are upregulated in Muller cells, and these factors can also alter the expression of Bcl-2 family members, which regulate apoptosis.
EXPERIMENTAL EYE RESEARCH
(2021)
Article
Biochemistry & Molecular Biology
Tamas Kovacs-Oller, Renata Zempleni, Boglarka Balogh, Gergely Szarka, Balint Fazekas, Adam J. Tengolics, Krisztina Amrein, Endre Czeiter, Istvan Hernadi, Andras Buki, Bela Volgyi
Summary: Traumatic brain injury (TBI) is a major cause of sudden death after head trauma. The retina, as part of the brain, can also be affected by TBI, both in severe and mild-repetitive cases. Our study found that the level of inflammation and cell death in the retina differs between sTBI and rmTBI, indicating different response mechanisms. Therefore, the retina may serve as a model for studying head injuries and developing new diagnostic procedures.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Biochemistry & Molecular Biology
Cassie L. L. Rayner, Steven E. E. Bottle, Alexander P. P. Martyn, Nigel L. L. Barnett
Summary: Oxidative stress plays a major role in progressive neurodegenerative diseases and could be a key target for novel preventative and therapeutic strategies. The antioxidant DCTEIO has shown efficacy in protecting retinal neurocells and reducing inflammation and oxidative stress. These findings suggest that DCTEIO has potential as a neuroprotectant for degenerative diseases of the central nervous system.
NEUROCHEMICAL RESEARCH
(2023)
Article
Neurosciences
Qiang Ye, Jiaqi Wang, Xiangwen Liu, Zihua Liu, LuoSong BaZong, Jinhai Ma, Rong Shen, Weichun Ye, Wenfang Zhang, Degui Wang
Summary: RAD6B and PEDF play important roles in the health of the retina, and the absence of RAD6B accelerates retinal degeneration.
Article
Biochemistry & Molecular Biology
Vasiliy I. Vladimirov, Margarita P. Shchannikova, Alexey V. Baldin, Alexey S. Kazakov, Marina P. Shevelyova, Aliya A. Nazipova, Viktoriia E. Baksheeva, Ekaterina L. Nemashkalova, Anastasia S. Frolova, Natalia K. Tikhomirova, Pavel P. Philippov, Andrey A. Zamyatnin, Sergei E. Permyakov, Dmitry V. Zinchenko, Evgeni Yu. Zernii
Summary: The formation of the complex between Caveolin-1 and recoverin is regulated by redox state. The high affinity interaction of thiol-oxidized recoverin with Caveolin-1 may affect the translocation and desensitization of visual proteins.
Article
Biochemistry & Molecular Biology
Ioannis Tsialtas, Achilleas Georgantopoulos, Maria E. Karipidou, Foteini D. Kalousi, Aikaterini G. Karra, Demetrios D. Leonidas, Anna-Maria G. Psarra
Summary: Estrogens play a crucial role in regulating both reproductive and non-reproductive system physiology, with a particular impact on the nervous system. The presence of mitochondrial estrogen receptor beta (mtER beta) has been shown to directly participate in neuronal physiology maintenance. Overexpression of mtER beta in N2A cells enhances resistance to apoptotic stimuli, suggesting its potential as a therapeutic target for degenerative diseases associated with mitochondrial dysfunction.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Nutrition & Dietetics
Reny Pratiwi, Chanin Nantasenamat, Waralee Ruankham, Wilasinee Suwanjang, Virapong Prachayasittikul, Supaluk Prachayasittikul, Kamonrat Phopin
Summary: The study revealed that the plant sterol stigmasterol has the potential to protect neuronal cells from oxidative stress damage, maintaining intracellular reactive oxygen species levels and preventing oxidative stress-induced cell death.
FRONTIERS IN NUTRITION
(2021)
Article
Neurosciences
Nihal A. Salem, Lawrence Manzano, Michael W. Keist, Olga Ponomareva, Amanda J. Roberts, Marisa Roberto, R. Dayne Mayfield
Summary: This study identified cell-type specific gene expression changes associated with alcohol dependence in the medial prefrontal cortex of mice. The results revealed dysregulated gene co-expression networks and differentially expressed genes in multiple cell types, highlighting the involvement of inhibitory neurons and astrocytes in alcohol dependence. Novel targets for studying molecular mechanisms contributing to alcohol dependence were also identified.
NEUROBIOLOGY OF DISEASE
(2024)
Article
Neurosciences
Laura E. Hawley, Megan Stringer, Abigail J. Deal, Andrew Folz, Charles R. Goodlett, Randall J. Roper
Summary: This study found that the overexpression of DYRK1A protein in Down syndrome mice varies with age, sex, and brain region, and reducing the copy number of Dyrk1a can decrease the expression of DYRK1A. These sex-specific patterns of DYRK1A overexpression may provide mechanistic targets for therapeutic intervention in Down syndrome.
NEUROBIOLOGY OF DISEASE
(2024)
