Article
Immunology
Heba A. Farid, Rabab H. Sayed, Marwa El-Sayed El-Shamarka, Omar M. E. Abdel-Salam, Nesrine S. El Sayed
Summary: The study aimed to investigate the neuroprotective role of roflumilast in a rotenone-induced rat model of Parkinson's disease. The results showed that roflumilast improved motor activity and coordination, preserved dopaminergic neurons in the striatum, and activated the PI3K/AKT pathway through the stimulation of multiple signaling cascades. These findings indicate that PDE4 inhibition may be a promising therapeutic approach for Parkinson's disease by activating the PI3K/AKT signaling pathway.
INFLAMMOPHARMACOLOGY
(2023)
Article
Integrative & Complementary Medicine
Wen-Ya Su, Ying Li, Xuan Chen, Xin Li, Heng Wei, Zhi Liu, Qiong Shen, Chen Chen, Ying-Ping Wang, Wei Li
Summary: This study evaluates the ameliorative effects of ginsenoside Rh1 on obesity-linked diabetic nephropathy induced by high fat diet and streptozotocin. The results suggest that G-Rh1 shows potential in improving treatment of DN.
AMERICAN JOURNAL OF CHINESE MEDICINE
(2021)
Article
Chemistry, Medicinal
Yue Xu, Weiyin Chen, Zeran Chen, Mengyuan Huang, Fang Yang, Yang Zhang
Summary: This study explored the material basis and molecular mechanism of the traditional Chinese medicine formulation Xiaoyao San (XYS) in the treatment of ischemic stroke (IS) using network pharmacology, in vitro experiments, and molecular docking. XYS was found to target 175 proteins through 136 chemical components, with its main signaling pathways involving apoptosis and the phosphoinositide 3-kinase/protein kinase B (PI3K-Akt) pathway. In vitro experiments demonstrated that XYS could improve PC12-cell activity and inhibit apoptosis by regulating oxidative stress and apoptosis-related gene expression.
DRUG DESIGN DEVELOPMENT AND THERAPY
(2021)
Article
Medicine, Research & Experimental
Shanshan Qiao, Dexin Yang, Xiaofeng Li, Weiping Li, Yuan Zhang, Wenlan Liu
Summary: The study reveals the crucial role of PAQR3 in ischemia/reperfusion injury, showing that silencing PAQR3 protects neuronal cells and improves cell survival by inhibiting the apoptosis pathway. Knockdown of PAQR3 significantly attenuates apoptosis and increases cell viability, offering a novel therapeutic target for preventing cerebral ischemia/reperfusion injury.
Editorial Material
Neurosciences
Mohammad Rafi Khezri, Morteza Ghasemnejad-Berenji, Donya Moloodsouri
Summary: One of the main players in apoptosis during Alzheimer's disease progression are different members of caspase family of proteases, with caspase-3 being the most well-known. The PI3K/AKT signaling pathway is the most important intracellular factor involved in regulating caspase-3 activity. This commentary aims to highlight the possible relations between the PI3K/AKT signaling pathway and caspase-3 in Alzheimer's disease.
JOURNAL OF ALZHEIMERS DISEASE
(2023)
Article
Cell Biology
Jiayue Song, Fuqiang Zhang, Yu Wang, Yuxiang Wang, Jingtian Zhang, Zixuan Xiao, Xueqi Fu, Xuemin Xu, Linlin Zeng
Summary: This study elucidated the association between Bak and the MAPK and PI3K/AKT kinases in TNF alpha/CHX-induced apoptosis, and revealed the regulatory effect of Bak on AKT activity.
MOLECULAR AND CELLULAR BIOCHEMISTRY
(2022)
Article
Biology
Fat-Moon Suk, Chi-Ching Chang, Pei-Chi Sun, Wei-Ting Ke, Chia-Chen Chung, Kun-Lin Lee, Tze-Sian Chan, Yu-Chih Liang
Summary: MCPIP1 is rapidly produced under proinflammatory stimuli to downregulate excessive inflammation. In this study, the expression of WT MCPIP1 increased apoptosis and caspase activation in TNF-alpha-treated cells. MCPIP1 also suppressed NF-kappa B activation and cFLIP expression, further enhancing the apoptotic pathway induced by TNF-alpha.
Article
Chemistry, Medicinal
Ramona Meanti, Laura Rizzi, Elena Bresciani, Laura Molteni, Vittorio Locatelli, Silvia Coco, Robert John Omeljaniuk, Antonio Torsello
Summary: Hexarelin displays inhibitory effects on H2O2-induced apoptosis in Neuro-2A cells, improving cell viability, reducing NO2- release, restoring cell morphology, and modulating apoptotic gene expression and protein kinase phosphorylation levels.
Article
Biochemistry & Molecular Biology
Abeer Mostafa, Dina Sabry, Nesreen Aboraia, Ahmed Fawzy, Amany A. Abou-Elalla
Summary: This study aims to clarify the unprecedented role of NEAT in psoriasis pathogenesis. The results showed that psoriasis patients have dyslipidemia, increased expression of NEAT, TNF-a, VEGF genes, and elevated levels of ROS and caspase-3. NEAT can be considered as a good diagnostic biomarker for psoriasis.
MOLECULAR BIOLOGY REPORTS
(2023)
Review
Pharmacology & Pharmacy
Bingyao Xu, Lan Bai, Lu Chen, Rongsheng Tong, Yibin Feng, Jianyou Shi
Summary: This review provides an overview of recent research on a range of terpenoid natural products associated with the PI3K/Akt pathway. It discusses their chemical structures, mechanisms of action, associated diseases, and experimental methods. The review highlights 16 natural terpenoids and their structure-activity relationships (SAR), suggesting their potential as natural neuroprotective agents.
FRONTIERS IN PHARMACOLOGY
(2022)
Article
Biochemistry & Molecular Biology
Ahmed M. Fathi, Shaimaa Waz, Eman Alaaeldin, Nisreen D. M. Toni, Azza A. K. El-Sheikh, Ahmed M. Sayed, Usama Ramadan Abdelmohsen, Maiiada H. Nazmy
Summary: Blackberry leaves have anti-inflammatory and antioxidant activities. In this study, site-specific delivery of blackberry leaves extract loaded AgNPs to hepatocytes in ischemia-reperfusion injury (IRI) was achieved, and the possible molecular mechanisms were verified. The results showed that pre-treatment with BBE protected against liver damage caused by I/R by reducing oxidative stress and promoting the activation of the anti-apoptotic signaling pathway.
Article
Pharmacology & Pharmacy
Jia-Yi Sun, Yi-Tong Liu, Sheng-Nan Jiang, Peng-Mei Guo, Xin-Yu Wu, Jia Yu
Summary: This study systematically investigated the antidepressant effect of essential oil from Paeonia lactiflora Pall (PLP), demonstrating its ability to alleviate symptoms of corticosterone-induced depression and protect hippocampal neurons from injury. The study also revealed that the PI3K/Akt/Nrf2 signaling pathway may contribute to the antidepressant effect of the essential oil.
FRONTIERS IN PHARMACOLOGY
(2022)
Article
Neurosciences
Manish Kumar, Nitin Bansal
Summary: Alzheimer's disease is a prevalent type of dementia in the elderly population, with complex pathophysiological processes involving cell apoptosis, tauopathy, beta-amyloidopathy, etc. Despite significant advancements in understanding the pathogenesis, treatment remains a challenge. The PI3K-Akt pathway may serve as a crucial therapeutic target in AD.
MOLECULAR NEUROBIOLOGY
(2022)
Article
Pharmacology & Pharmacy
Matteo Brindisi, Luca Frattaruolo, Raffaella Mancuso, Antonio Palumbo Piccionello, Ida Ziccarelli, Marco Catto, Orazio Nicolotti, Cosimo D. Altomare, Bartolo Gabriele, Anna Rita Cappello
Summary: Six newly synthesized alkyl (Z)-2-(2-oxopyrrolidin-3-ylidene)acetates were evaluated for their potential cytotoxic and anticancer effects, with the most lipophilic derivatives showing cytotoxicity against various breast cancer cell lines. In-depth mechanistic studies suggested that these derivatives may interfere with key enzymes in the PI3K/AKT signaling pathway, which could be a potential target for cancer treatment.
BIOCHEMICAL PHARMACOLOGY
(2021)
Article
Biochemistry & Molecular Biology
Celine Baron-Menguy, Arnaud Bocquet, Alexis Richard, Anne-Laure Guihot, Bertrand Toutain, Pierre Pacaud, Celine Fassot, Gervaise Loirand, Daniel Henrion, Laurent Loufrani
Summary: The study found that sildenafil can enhance revascularization after ischemia, improve tissue blood flow and promote arteriogenesis. These effects are associated with the activation of PI3K, Akt, and eNOS, but not with VEGF.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Clinical Neurology
Haifa Kassis, Amjad Shehadah, Michael Chopp, Cynthia Roberts, Zheng Gang Zhang
Article
Biochemistry & Molecular Biology
Haifa Kassis, Amjad Shehadah, Chao Li, Yi Zhang, Yisheng Cui, Cynthia Roberts, Neema Sadry, Xianshuang Liu, Michael Chopp, Zheng Gang Zhang
NEUROCHEMISTRY INTERNATIONAL
(2016)
Review
Genetics & Heredity
Haifa Kassis, Amjad Shehadah, Michael Chopp, Zheng Gang Zhang
Article
Cell & Tissue Engineering
Xu Cui, Michael Chopp, Amjad Shehadah, Alex Zacharek, Nicole Kuzmin-Nichols, Cyndy Davis Sanberg, Junhao Dai, Chunling Zhang, Yuji Ueno, Cynthia Roberts, Jieli Chen
CELL TRANSPLANTATION
(2012)
Article
Cell & Tissue Engineering
Jieli Chen, Amjad Shehadah, Ajai Pal, Alex Zacharek, Xu Cui, Yisheng Cui, Cynthia Roberts, Mei Lu, Andrew Zeitlin, Robert Hariri, Michael Chopp
CELL TRANSPLANTATION
(2013)
Article
Neurosciences
Xinchun Ye, Michael Chopp, Xu Cui, Alex Zacharek, Yisheng Cui, Tao Yan, Amjad Shehadah, Cynthia Roberts, Xinfeng Liu, Mel Lu, Jieli Chen
EXPERIMENTAL NEUROLOGY
(2011)
Article
Endocrinology & Metabolism
Jieli Chen, Alex Zacharek, Xu Cui, Amjad Shehadah, Hao Jiang, Cynthia Roberts, Mei Lu, Michael Chopp
JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM
(2010)
Article
Clinical Neurology
Amjad Shehadah, Jieli Chen, Xu Cui, Cynthia Roberts, Mei Lu, Michael Chopp
JOURNAL OF THE NEUROLOGICAL SCIENCES
(2010)
Article
Clinical Neurology
Amjad Shehadah, Jieli Chen, Yisheng Cui, Li Zhang, Cynthia Roberts, Mei Lu, Michael Chopp
JOURNAL OF THE NEUROLOGICAL SCIENCES
(2011)
Article
Biochemistry & Molecular Biology
Haifa Kassis, Michael Chopp, Xian Shuang Liu, Amjad Shehadah, Cynthia Roberts, Zheng Gang Zhang
NEUROCHEMISTRY INTERNATIONAL
(2014)
Article
Neurosciences
X. Cui, M. Chopp, A. Zacharek, J. Dai, C. Zhang, T. Yan, R. Ning, C. Roberts, A. Shehadah, N. Kuzmin-Nichols, C. D. Sanberg, J. Chen
Article
Multidisciplinary Sciences
Amjad Shehadah, Jieli Chen, Brian Kramer, Alex Zacharek, Yisheng Cui, Cynthia Roberts, Mei Lu, Michael Chopp
Article
Multidisciplinary Sciences
Amjad Shehadah, Jieli Chen, Ajai Pal, Shuyang He, Andrew Zeitlin, Xu Cui, Alex Zacharek, Yisheng Cui, Cynthia Roberts, Mei Lu, Robert Hariri, Michael Chopp
Article
Clinical Neurology
Alex Zacharek, Amjad Shehadah, Jieli Chen, Xu Cui, Cynthia Roberts, Mei Lu, Michael Chopp
Article
Neurosciences
Nihal A. Salem, Lawrence Manzano, Michael W. Keist, Olga Ponomareva, Amanda J. Roberts, Marisa Roberto, R. Dayne Mayfield
Summary: This study identified cell-type specific gene expression changes associated with alcohol dependence in the medial prefrontal cortex of mice. The results revealed dysregulated gene co-expression networks and differentially expressed genes in multiple cell types, highlighting the involvement of inhibitory neurons and astrocytes in alcohol dependence. Novel targets for studying molecular mechanisms contributing to alcohol dependence were also identified.
NEUROBIOLOGY OF DISEASE
(2024)
Article
Neurosciences
Laura E. Hawley, Megan Stringer, Abigail J. Deal, Andrew Folz, Charles R. Goodlett, Randall J. Roper
Summary: This study found that the overexpression of DYRK1A protein in Down syndrome mice varies with age, sex, and brain region, and reducing the copy number of Dyrk1a can decrease the expression of DYRK1A. These sex-specific patterns of DYRK1A overexpression may provide mechanistic targets for therapeutic intervention in Down syndrome.
NEUROBIOLOGY OF DISEASE
(2024)