Article
Neurosciences
Marissa DiPiero, Hassan Cordash, Molly B. Prigge, Carolyn K. King, Jubel Morgan, Jose Guerrero-Gonzalez, Nagesh Adluru, Jace B. King, Nicholas Lange, Erin D. Bigler, Brandon A. Zielinski, Andrew L. Alexander, Janet E. Lainhart, Douglas C. Dean
Summary: All diffusion MRI measures showed significant associations with age across white matter and gray matter. Significant group differences were observed in both white matter and gray matter. There were no significant age-by-group interactions detected. Within the ASD group, positive relationships were found between white matter microstructure and ADOS-2 Calibrated Severity Scores. The findings provide new insights into group differences of white matter and gray matter microstructure in autistic males from adolescence into adulthood, contributing to a better understanding of brain-behavior relationships of ASD.
FRONTIERS IN NEUROSCIENCE
(2023)
Review
Pathology
Katharina Eikermann-Haerter, Susie Y. Huang
Summary: Migraine is a well-known risk factor for subclinical focal deep white matter lesions, with ischemic and inflammatory mechanisms proposed as underlying causes, negatively impacting both physical and cognitive functions.
AMERICAN JOURNAL OF PATHOLOGY
(2021)
Review
Geriatrics & Gerontology
Xiaoqin Wu, Jingyuan Ya, Da Zhou, Yuchuan Ding, Xunming Ji, Ran Meng
Summary: The article focuses on the pathogenesis and neuroimaging features of white matter lesions (WMLs), revealing a series of pathophysiological findings and discussions about WMLs and providing robust references for clinicians to further understand and customize treatment strategies for different WML patterns caused by vascular etiologies.
Article
Clinical Neurology
Mariya Malova, Elena Morelli, Valentina Cardiello, Domenico Tortora, Mariasavina Severino, Maria Grazia Calevo, Alessandro Parodi, Laura Costanza De Angelis, Diego Minghetti, Andrea Rossi, Luca Antonio Ramenghi
Summary: This study compared the neuroradiological and clinical characteristics of SWI+ and SWI- PWMLs, revealing that SWI+ lesions were closer to the ventricle wall, more frequently organized in linear pattern, and associated with certain clinical factors. Other prospective studies are needed to confirm these findings.
FRONTIERS IN NEUROLOGY
(2021)
Article
Behavioral Sciences
Justine Daoust, Joelle Schaffer, Yashar Zeighami, Alain Dagher, Isabel Garcia-Garcia, Andreanne Michaud
Summary: Research has shown that individuals with obesity tend to have lower white matter integrity, particularly in the genu of the corpus callosum, a tract linking areas involved in executive function. Further studies are needed to explore the mechanisms linking obesity with loss of white matter integrity.
NEUROSCIENCE AND BIOBEHAVIORAL REVIEWS
(2021)
Article
Neurosciences
Mahsa Dadar, Olivier Potvin, Richard Camicioli, Simon Duchesne
Summary: The study investigated the impact of white matter hyperintensities (WMHs) on FreeSurfer gray matter (GM) structure volumes, finding higher overlaps of WMHs with GM volumes in several brain structures for participants with higher WMH volumes. Uncorrected caudate volumes increased with age, with no difference between cognitively healthy individuals and probable Alzheimer's disease patients. However, after correcting for WMHs, caudate volumes decreased with age and Alzheimer's disease patients had lower caudate volumes than cognitively healthy individuals. The presence of WMHs can lead to systematic inaccuracies in GM segmentations and change clinical associations, affecting cognitive performance assessments.
HUMAN BRAIN MAPPING
(2021)
Article
Clinical Neurology
Sara Pietracupa, Daniele Belvisi, Claudia Piervincenzi, Silvia Tommasin, Gabriele Pasqua, Nikolaos Petsas, Maria Ilenia De Bartolo, Andrea Fabbrini, Matteo Costanzo, Nicoletta Manzo, Alfredo Berardelli, Patrizia Pantano
Summary: This study aimed to identify white matter (WM) and gray matter (GM) abnormalities in early PD patients and their correlations with motor and non-motor symptom severity. Results showed that PD patients exhibited lower WM fractional anisotropy and higher mean, axial, and radial diffusivity. There were also correlations between cognitive performance and WM fractional anisotropy values. Smaller cerebellar volumes in early PD patients were also found. No GM changes were observed in subcortical or cortical regions.
JOURNAL OF NEUROLOGY
(2023)
Article
Neurosciences
David K. Wright, Georgia F. Symons, William T. O'Brien, Stuart J. McDonald, Akram Zamani, Brendan Major, Zhibin Chen, Daniel Costello, Rhys D. Brady, Mujun Sun, Meng Law, Terence J. O'Brien, Richelle Mychasiuk, Sandy R. Shultz
Summary: The preliminary study showed that male athletes with SRC reported more severe symptoms compared to female athletes. dMRI revealed white matter differences between SRC athletes and non-concussed athletes at 48 hours post-injury, which persisted at 2 weeks post-injury. Furthermore, male SRC athletes exhibited significantly greater white matter disruption than female SRC athletes. These findings have implications for concussion management, including return-to-play decisions, and enhance our understanding of the role of sex in SRC outcomes.
Article
Geriatrics & Gerontology
Wen-Xin Li, Jing Yuan, Fei Han, Li-Xin Zhou, Jun Ni, Ming Yao, Shu-Yang Zhang, Zheng-Yu Jin, Li-Ying Cui, Fei-Fei Zhai, Yi-Cheng Zhu
Summary: This study aimed to investigate the global and topographic changes of white matter integrity and cortical structure related to cognitive impairments in a community-based population. The results showed that disrupted white matter integrity is associated with visuomotor processing speed, semantic memory, and executive function, while cortical surface area is related to cognitive scores. These findings contribute to a better understanding of the pathological process underlying cognitive impairments.
FRONTIERS IN AGING NEUROSCIENCE
(2023)
Article
Cell Biology
Nira Cedres, Patricia Diaz-Galvan, Lucio Diaz-Flores, J-Sebastian Muehlboeck, Yaiza Molina, Jose Barroso, Eric Westman, Daniel Ferreira
Summary: The study found that subjective cognitive decline (SCD) is associated with neurodegeneration in both gray matter and white matter, involving brain areas beyond those typically targeted by Alzheimer's disease. This suggests that SCD may be a sensitive behavioral marker of heterogeneous brain pathologies in individuals recruited from the community.
Review
Biochemistry & Molecular Biology
Marta Valenza, Roberta Facchinetti, Luca Steardo, Caterina Scuderi
Summary: Palmitoylethanolamide (PEA) is a naturally occurring amide compound with analgesic, neuroprotective, immune-modulating, and anti-inflammatory effects. Recent studies have shown that PEA promotes oligodendrocyte differentiation, which is crucial for myelin formation. PEA has therapeutic potential in restoring white matter defects.
Article
Neurosciences
Hanjing Liu, Yayun Xiang, Junhang Liu, Jinzhou Feng, Silin Du, Tianyou Luo, Yongmei Li, Chun Zeng
Summary: This study compared parameters of DTI and DKI to evaluate the microstructural changes in anti-NMDAR encephalitis patients. The results showed that DKI parameters were better at describing the changes and correlated with cognitive impairment and neurofunctional recovery severity. The gray matter damage was more extensive than white matter damage in these patients.
FRONTIERS IN NEUROSCIENCE
(2022)
Article
Geriatrics & Gerontology
Yahui Ouyang, Dong Cui, Zilong Yuan, Zhipeng Liu, Qing Jiao, Tao Yin, Jianfeng Qiu
Summary: Population aging has led to a focus on changes in elderly brains, particularly in white matter fibers. This study used various parameters to analyze age-related changes in white matter fibers, finding significant differences in FA, MD, AD, and RD between young and middle-age groups. Deterministic fiber tracking showed a correlation between fiber length and age, with specific fibers identified as potential image markers for age-related white matter changes.
FRONTIERS IN AGING NEUROSCIENCE
(2021)
Article
Neuroimaging
Qihui Niu, Jianyu Li, Lei Yang, Zitong Huang, Mingmin Niu, Xueqin Song, Yuanchao Zhang, Youhui Li
Summary: In this study, the researchers investigated alterations in intracortical myelin and white matter microstructure in patients with obsessive-compulsive disorder (OCD). They found that OCD patients exhibited abnormal intracortical myelination and reduced white matter microstructure. These abnormalities may contribute to the disrupted brain connectivity and inhibitory control in OCD.
NEUROIMAGE-CLINICAL
(2022)
Article
Multidisciplinary Sciences
Junyan Huo, Gan Zhang, Wenjing Wang, Wen Cao, Mengxia Wan, Tao Huang, Dongsheng Fan, Yu Fu
Summary: In this study, the bidirectional causal relationship between migraine and white matter lesions was explored using a two-sample mendelian randomization method. The analysis of a recent large-scale genome-wide association study data did not provide evidence for causality between white matter lesions and migraine.
SCIENTIFIC REPORTS
(2023)
Review
Cardiac & Cardiovascular Systems
Swarna Vishwanath, Vazhma Qaderi, Claire J. Steves, Christopher M. Reid, Ingrid Hopper, Joanne Ryan
Summary: There is an association between heart failure (HF) and cognitive change and dementia. HF is not significantly associated with dementia, but increases the risk of cognitive impairment. Patients with HF perform worse on cognitive tests.
JOURNAL OF CARDIAC FAILURE
(2022)
Article
Geriatrics & Gerontology
Sara E. Espinoza, Robyn L. Woods, A. R. M. Saifuddin Ekram, Michael E. Ernst, Galina Polekhina, Rory Wolfe, Raj C. Shah, Stephanie A. Ward, Elsdon Storey, Mark R. Nelson, Christopher M. Reid, Jessica E. Lockery, Suzanne G. Orchard, Ruth Trevaks, Sharyn M. Fitzgerald, Nigel P. Stocks, Andy Chan, John J. McNeil, Anne M. Murray, Anne B. Newman, Joanne Ryan
Summary: Low-dose aspirin use in healthy older adults does not reduce the risk of incident frailty or alter the trajectory of frailty.
JOURNALS OF GERONTOLOGY SERIES A-BIOLOGICAL SCIENCES AND MEDICAL SCIENCES
(2022)
Article
Surgery
Eloi Debourdeau, Gabriel Gardes, David Nocca, Isabelle Carriere, Christophe Chiquet, Max Villain, Camille Roubille, Guilhem Du Cailar, Mathieu Sardinoux, Vincent Daien, Pierre Fesler
Summary: This study demonstrates that retinal microvascular phenotype improves during the first year after bariatric surgery, with decreased central retinal vein equivalent and increased arteriole-to-venule ratio. Factors associated with retinal microvascular plasticity include male sex, high baseline weight, and absence of diabetes.
Article
Ophthalmology
Chloe Chamard, Jerome J. Maller, Nicolas Menjot, Eloi Debourdeau, Virginie Nael, Karen Ritchie, Isabelle Carriere, Vincent Daien
Summary: This study investigated the association between visual function and cortical thickness in older adults, finding that vision loss was associated with thinning of the right insula cortex. The reduced insula thickness may lead to increased cognitive burden in the ageing brain.
Article
Geriatrics & Gerontology
A. R. M. Saifuddin Ekram, Joanne Ryan, Sara E. Espinoza, Anne B. B. Newman, Anne M. M. Murray, Suzanne G. Orchard, Sharyn M. Fitzgerald, John J. J. McNeil, Michael E. Ernst, Robyn L. Woods
Summary: This study examined the relationship between physical frailty and healthy community-dwelling older adults and explored the impact of frailty on disability-free survival. The results showed that frailty is common among older adults and is associated with factors such as age, waist circumference, education, and ethnicity. Frailty significantly reduces disability-free survival and addressing modifiable correlates such as depression and polypharmacy may help mitigate its adverse effects.
Article
Clinical Neurology
Marie-Laure Ancelin, Isabelle Jaussent, Karen Ritchie, Alain Besset, Joanne Ryan, Yves Dauvilliers
Summary: This study examines the association between BDNF variants and promoter I methylation with sleep disturbances in older adults. The results show that wake time after sleep onset (WASO) is associated with four SNPs in participants not taking psychotropic drugs, while the associations are either not significant or in the reverse direction in participants taking drugs. Higher BDNF methylation levels are found in participants with long WASO, and this varies depending on psychotropic drug use.
JOURNAL OF SLEEP RESEARCH
(2023)
Article
Clinical Neurology
Jessica Gong, Katie Harris, Darren M. Lipnicki, Erico Castro-Costa, Maria Fernanda Lima-Costa, Breno S. Diniz, Shifu Xiao, Richard B. Lipton, Mindy J. Katz, Cuiling Wang, Pierre-Marie Preux, Maelenn Guerchet, Antoine Gbessemehlan, Karen Ritchie, Marie-Laure Ancelin, Ingmar Skoog, Jenna Najar, Therese Rydberg Sterner, Nikolaos Scarmeas, Mary Yannakoulia, Mary H. Kosmidis, Antonio Guaita, Elena Rolandi, Annalisa Davin, Oye Gureje, Stella Trompet, Jacobijn Gussekloo, Steffi Riedel-Heller, Alexander Pabst, Susanne Rohr, Suzana Shahar, Devinder Kaur Ajit Singh, Nurul Fatin Malek Rivan, Martin van Boxtel, Sebastian Kohler, Mary Ganguli, Chung-Chou Chang, Erin Jacobsen, Mary Haan, Ding Ding, Qianhua Zhao, Zhenxu Xiao, Kenji Narazaki, Tao Chen, Sanmei Chen, Tze Pin Ng, Xinyi Gwee, Katya Numbers, Karen A. Mather, Marcia Scazufca, Antonio Lobo, Concepcion De-la-Camara, Elena Lobo, Perminder S. Sachdev, Henry Brodaty, Maree L. Hackett, Sanne A. E. Peters, Mark Woodward
Summary: This meta-analysis of data from 21 cohorts across six continents found that women have a higher risk of developing dementia than men, especially in low- and lower-middle-income economies. Longer education and former alcohol use are stronger risk factors for dementia in men than in women, while other risk factors have similar effects in both genders.
ALZHEIMERS & DEMENTIA
(2023)
Review
Public, Environmental & Occupational Health
Htet Lin Htun, Achamyeleh Birhanu Teshale, Miranda S. Cumpston, Lisa Demos, Joanne Ryan, Alice Owen, Rosanne Freak-Poli
Summary: Social prescribing (SP) links patients with non-medical interventions in the community to address socioeconomic and behavioral determinants. A systematic review of randomized controlled trials found that SP exercise interventions were associated with a slight increase in physical activity, but no significant improvement in metabolic factors. Further rigorous studies are needed to determine the effectiveness of SP in modifying the determinants of chronic disease and promoting sustainable healthy behaviors.
JOURNAL OF EPIDEMIOLOGY AND COMMUNITY HEALTH
(2023)
Review
Cardiac & Cardiovascular Systems
Achamyeleh Birhanu Teshale, Htet Lin Htun, Alice Owen, Danijela Gasevic, Aung Zaw Zaw Phyo, Daisy Fancourt, Joanne Ryan, Andrew Steptoe, Rosanne Freak-Poli
Summary: Cardiovascular disease is the leading cause of death worldwide, and addressing social determinants of health may be crucial in reducing its burden. This umbrella review aims to provide a comprehensive overview of the role of social determinants of health in cardiovascular disease.
JOURNAL OF THE AMERICAN HEART ASSOCIATION
(2023)
Article
Psychiatry
Aoshuang Zhou, Marie-Laure Ancelin, Karen Ritchie, Joanne Ryan
Summary: Studies have investigated the potential role of DNA methylation in the enduring effects of early-life stress and trauma on health. This study aimed to explore the association between childhood adversity and BDNF promoter methylation in older adults. Results showed no strong evidence of a long-term association between childhood abuse/maltreatment or financial difficulties/poverty and BDNF methylation in older individuals. Differential methylation at some CpG sites was observed for war/natural disaster, but these findings were not significant after correction for multiple testing. Further large prospective studies are needed to examine DNA methylation across the genome.
FRONTIERS IN PSYCHIATRY
(2023)
Review
Geriatrics & Gerontology
Achamyeleh Birhanu Teshale, Htet Lin Htun, Jessie Hu, Lachlan L. Dalli, Michelle H. Lim, Barbara Barbosa Neves, J. R. Baker, Aung Zaw Zaw Phyo, Christopher M. Reid, Joanne Ryan, Alice J. Owen, Sharyn M. Fitzgerald, Rosanne Freak-Poli
Summary: Social health is closely related to cardiovascular disease, potentially mediated through its shared risk factors. However, the mechanisms underlying the relationship between social health and cardiovascular disease are poorly understood. Further research is needed to determine whether targeting certain social health constructs may directly improve cardiovascular disease risk factors.
ARCHIVES OF GERONTOLOGY AND GERIATRICS
(2023)
Article
Geriatrics & Gerontology
Tagrid A. Alharbi, Alice J. Owen, Joanne Ryan, Danijela Gasevic, John J. Mcneil, Robyn L. Woods, Mark R. Nelson, Rosanne Freak-Poli
Summary: The study identified associations between socio-demographic, lifestyle, and clinical characteristics with self-reported weight status in early and late adulthood. Obesity in late adulthood was linked to hypertension, diabetes, and dyslipidaemia, while obesity in early adulthood was associated with lower cognitive scores in later adulthood.
Article
Genetics & Heredity
Peter D. Fransquet, Jacqui A. Macdonald, Joanne Ryan, Christopher J. Greenwood, Craig A. Olsson
Summary: This study examined the impact of maternal health during pregnancy on epigenetic age in children. The results showed that maternal anxiety and stress, BMI, and parent-parent relationship quality were associated with pediatric epigenetic age. High blood pressure during pregnancy was associated with age acceleration based on the Horvath clock. Smoking during the third trimester and pre-pregnancy weight were also related to acceleration and deceleration, respectively. These findings suggest that maternal health during pregnancy may influence epigenetic age in children.
Review
Genetics & Heredity
Aoshuang Zhou, Joanne Ryan
Summary: Severe or chronic stress and trauma can have long-lasting effects on health, possibly even persisting across generations. Epigenetics is a mechanism that has been implicated in these effects. This article provides an overview of studies demonstrating the role of DNA methylation, a widely studied epigenetic mechanism, in the effects of early-life stress, as well as the transmission of stress across generations.
Article
Endocrinology & Metabolism
Dinuli Nilaweera, Caroline Gurvich, Rosanne Freak-Poli, Robyn L. Woods, Alice Owen, John Mcneil, Mark Nelson, Nigel Stocks, Joanne Ryan
Summary: Common adverse events in older individuals, especially the death of a spouse/partner, are associated with an increased risk of mortality, with a stronger impact on men than women.
COMPREHENSIVE PSYCHONEUROENDOCRINOLOGY
(2023)
Article
Geriatrics & Gerontology
Sarah N. Kraeutner, Cristina Rubino, Jennifer K. Ferris, Shie Rinat, Lauren Penko, Larissa Chiu, Brian Greeley, Christina B. Jones, Beverley C. Larssen, Lara A. Boyd
Summary: This study examined the age-related changes in brain function and baseline brain structure that support motor skill acquisition. The findings showed that older adults experienced decreases in functional connectivity during motor skill acquisition, while younger adults experienced increases. Additionally, regardless of age group, lower baseline microstructure in a frontoparietal tract was associated with slower motor skill acquisition.
NEUROBIOLOGY OF AGING
(2024)
Article
Geriatrics & Gerontology
Karen Nuytemans, Farid Rajabli, Melissa Jean-Francois, Jiji Thulaseedhara Kurup, Larry D. Adams, Takiyah D. Starks, Patrice L. Whitehead, Brian W. Kunkle, Allison Caban-Holt, Jonathan L. Haines, Michael L. Cuccaro, Jeffery M. Vance, Goldie S. Byrd, Gary W. Beecham, Christiane Reitz, Margaret A. Pericak-Vance
Summary: This study conducted genetic research on African American AD families and identified a significant linkage signal associated with AD, highlighting the importance of diverse population-level genetic data in understanding the genetic determinants of AD.
NEUROBIOLOGY OF AGING
(2024)
Article
Geriatrics & Gerontology
Kazuya Suwabe, Ryuta Kuwamizu, Kazuki Hyodo, Toru Yoshikawa, Takeshi Otsuki, Asako Zempo-Miyaki, Michael A. Yassa, Hideaki Soya
Summary: Physical exercise has a positive impact on hippocampal memory decline with aging. Recent studies have shown that even light exercise can improve memory and this improvement is mediated by the ascending arousal system. This study aimed to investigate the effects of light-intensity exercise on hippocampal memory function in healthy older adults and found that pupil dilation during exercise played a role in the memory improvement.
NEUROBIOLOGY OF AGING
(2024)
Article
Geriatrics & Gerontology
Ajay Sood, Ana Werneck Capuano, Robert Smith Wilson, Lisa Laverne Barnes, Alifiya Kapasi, David Alan Bennett, Zoe Arvanitakis
Summary: The objective of this study was to explore the impact of metformin on cognition and brain pathology. The results showed that metformin users had slower decline in global cognition, episodic memory, and semantic memory compared to non-users. However, the relationship between metformin use and certain brain pathology remains uncertain.
NEUROBIOLOGY OF AGING
(2024)
Article
Geriatrics & Gerontology
Brian N. Lee, Junwen Wang, Molly A. Hall, Dokyoon Kim, Shana D. Stites, Li Shen
Summary: Alzheimer's disease (AD) is a neurodegenerative disorder characterized by memory and functional impairments. This study analyzed participants from the Alzheimer's Disease Neuroimaging Initiative and found differential associations between cerebral spinal fluid (CSF)/neuroimaging biomarkers and cognitive/functional outcomes, as well as variations between sexes. These findings suggest that sex differences may play a role in the development of AD.
NEUROBIOLOGY OF AGING
(2024)
Article
Geriatrics & Gerontology
Madeline R. Hale, Rebecca Langhough, Lianlian Du, Bruce P. Hermann, Carol A. Van Hulle, Margherita Carboni, Gwendlyn Kollmorgenj, Kristin E. Basche, Davide Bruno, Leah Sanson-Miles, Erin M. Jonaitis, Nathaniel A. Chin, Ozioma C. Okonkwo, Barbara B. Bendlin, Cynthia M. Carlsson, Henrik Zetterberg, Kaj Blennow, Tobey J. Betthauser, Sterling C. Johnson, Kimberly D. Mueller
Summary: This study demonstrates a relationship between cerebrospinal fluid biomarkers and the ability to recall proper names in the preclinical phase of Alzheimer's disease.
NEUROBIOLOGY OF AGING
(2024)
Article
Geriatrics & Gerontology
Thomas T. Austin, Christian L. Thomas, Ben Warren
Summary: This study investigated the effects of age on the robustness and resilience of auditory system using the desert locust. The researchers found that gene expression changes were mainly influenced by age rather than noise exposure. Both young and aged locusts were able to recover their auditory nerve function within 48 hours of noise exposure, but the recovery of transduction current magnitude was impaired in aged locusts. Key genes responsible for robustness to noise exposure in young locusts and potential candidates for compensatory mechanisms in auditory neurons of aged locusts were identified.
NEUROBIOLOGY OF AGING
(2024)
