Journal
NEUROBIOLOGY OF AGING
Volume 34, Issue 11, Pages 2548-2550Publisher
ELSEVIER SCIENCE INC
DOI: 10.1016/j.neurobiolaging.2013.04.019
Keywords
Progranulin; Frontotemporal lobar degeneration; Frontotemporal dementia; Progranulin knockout mouse; Neurotoxin; 3-Nitropropionic acid; Kainic acid; Quinolinic acid; Pilocarpine
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Funding
- Alzheimer Society of Canada
- Canadian Institute for Health Research [97857]
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Loss-of-function mutations in the progranulin (GRN) gene are a common cause of autosomal dominant frontotemporal lobar degeneration, a fatal and progressive neurodegenerative disorder common in people less than 65 years of age. In the brain, progranulin is expressed in multiple regions at varying levels, and has been hypothesized to play a neuroprotective or neurotrophic role. Four neurotoxic agents were injected in vivo into constitutive progranulin knockout (Grn(-/-)) mice and their wild-type (Grn(+/+)) counterparts to assess neuronal sensitivity to toxic stress. Administration of 3-nitropropionic acid, quinolinic acid, kainic acid, and pilocarpine induced robust and measurable neuronal cell death in affected brain regions, but no differential cell death was observed between Grn(+/+) and Grn(-/-) mice. Thus, constitutive progranulin knockout mice do not have increased sensitivity to neuronal cell death induced by the acute chemical models of neuronal injury used in this study. (C) 2013 Published by Elsevier Inc.
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