Journal
NEUROBIOLOGY OF AGING
Volume 34, Issue 2, Pages 634-U293Publisher
ELSEVIER SCIENCE INC
DOI: 10.1016/j.neurobiolaging.2012.02.030
Keywords
Dementia; Alzheimer's disease; Oxidized LDL; Inflammation; Oxidative stress
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Funding
- National Institute of Aging [K24 AG 031155, R01 AG 026720]
- Alzheimer's Association [IIRG-08-88872]
- National Institutes of Health
- National Institute on Aging (NIA) [R01 AG005407, R01 AR35582, R01 AR35583, R01 AR35584, R01 AG005394, R01 AG027574, R01 AG027576]
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We investigated the association between serum level of oxidized low-density lipoprotein (oxLDL) and risk of cognitive impairment (dementia or mild cognitive impairment) among 572 nondemented community-dwelling women from a prospective cohort study of aging. After 5 years of follow-up, 228 (39.9%) developed cognitive impairment; and this did not differ by tertile of baseline oxLDL level (highest compared with lowest tertile 38.2% vs. 39.5%; odds ratio, 0.90; 95% confidence interval, 0.63-1.43). Multivariate adjustment produced similar results (odds ratio, 0.91; 95% confidence interval, 0.60-1.39). These findings suggest that increased levels of serum oxLDL are not associated with a greater risk of incident cognitive impairment in older women. (C) 2013 Elsevier Inc. All rights reserved.
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