Article
Neurosciences
Laura Bonanni, Davide Moretti, Alberto Benussi, Laura Ferri, Mirella Russo, Claudia Carrarini, Filomena Barbone, Dario Arnaldi, Nicola Walter Falasca, Giacomo Koch, Annachiara Cagnin, Flavio Nobili, Claudio Babiloni, Barbara Borroni, Alessandro Padovani, Marco Onofrj, Raffaella Franciotti
Summary: The study found significant changes in functional cortical connectivity in patients with frontotemporal dementia (FTD) and Alzheimer's disease (AD) during the course of the diseases, with hyperconnectivity in the early stages disappearing during follow-up.
Article
Radiology, Nuclear Medicine & Medical Imaging
Hugh G. Pemberton, Olivia Goodkin, Ferran Prados, Ravi K. Das, Sjoerd B. Vos, James Moggridge, William Coath, Elizabeth Gordon, Ryan Barrett, Anne Schmitt, Hefina Whiteley-Jones, Christian Burd, Mike P. Wattjes, Sven Haller, Meike W. Vernooij, Lorna Harper, Nick C. Fox, Ross W. Paterson, Jonathan M. Schott, Sotirios Bisdas, Mark White, Sebastien Ourselin, John S. Thornton, Tarek A. Yousry, M. Jorge Cardoso, Frederik Barkhof
Summary: The study found that providing a quantitative report of regional brain volumes can significantly improve sensitivity for detecting volume loss and AD across all raters, with the consultant group showing the most improvement in accuracy. Agreement with the 'gold standard' was not significantly affected by the QReport overall, but the consultant group did show a significant improvement. In conclusion, referencing single-subject results to normative data alongside visual assessment can improve sensitivity, accuracy, and interrater agreement for detecting volume loss.
EUROPEAN RADIOLOGY
(2021)
Article
Health Care Sciences & Services
Vincenzo Alfano, Mariachiara Longarzo, Giulia Mele, Marcello Esposito, Marco Aiello, Marco Salvatore, Dario Grossi, Carlo Cavaliere
Summary: This study examined the large-scale brain networks involved in apathy syndrome in patients with FTD and PD compared to healthy controls, revealing significant hypoconnectivity between apathetic patients and HC. The alterations detected in apathetic patients may indicate specific reduction of information processing and motor outcome involved in neural pathways. Additionally, the underlying neurodegenerative pathology did not fully explain these neural alterations.
JOURNAL OF PERSONALIZED MEDICINE
(2021)
Article
Clinical Neurology
Jeremy C. S. Johnson, Charles R. Marshall, Rimona S. Weil, Doris-Eva Bamiou, Chris J. D. Hardy, Jason D. Warren
Summary: The relationship between hearing impairment and dementia highlights the crucial role of the auditory brain in cognitive function, suggesting potential opportunities for early diagnosis and management strategies. Research emphasizes the importance of auditory cognitive function in neurodegenerative dementias, calling for the development of novel auditory testing methods and early diagnosis strategies.
Article
Clinical Neurology
Jeremy C. S. Johnson, Charles R. Marshall, Rimona S. Weil, Doris-Eva Bamiou, Chris J. D. Hardy, Jason D. Warren
Summary: The association between hearing impairment and dementia poses a significant public health challenge, with potential for earlier diagnosis and prevention. Neurodegenerative pathologies are predicted to target the auditory brain and damage hearing function early. It is important to reconsider the role of auditory cognitive function in dementia and develop new auditory tests for early diagnosis.
Review
Neurosciences
Stefano Lasaponara, Fabio Marson, Fabrizio Doricchi, Marco Cavallo
Summary: Neurodegenerative diseases, such as Alzheimer's disease and Parkinson's disease, lack viable pharmacological options for cognitive symptoms and are being targeted with Computerized Cognitive Training (CCT) and Virtual Reality (VR) tools. This paper aims to report the state-of-the-art of CCT and VR studies targeting cognitive impairment in common neurodegenerative conditions, in order to support healthcare professionals in considering these promising therapeutic tools for rehabilitation.
Article
Clinical Neurology
Patrick Oeckl, Sarah Anderl-Straub, Christine A. F. Von Arnim, Ines Baldeiras, Janine Diehl-Schmid, Timo Grimmer, Steffen Halbgebauer, Anna M. Kort, Marisa Lima, Taina M. Marques, Marion Ortner, Isabel Santana, Petra Steinacker, Marcel M. Verbeek, Alexander E. Volk, Albert C. Ludolph, Markus Otto
Summary: This study reveals differences in serum levels of GFAP in AD and bvFTD, showing an early increase in MCI-AD and superior diagnostic performance for AD compared to NfL.
JOURNAL OF NEUROLOGY NEUROSURGERY AND PSYCHIATRY
(2022)
Article
Behavioral Sciences
Megan S. Barker, Masood Manoochehri, Sandra J. Rizer, Brian S. Appleby, Danielle Brushaber, Sheena Dev, Katrina L. Devick, Bradford C. Dickerson, Julie A. Fields, Tatiana M. Foroud, Leah K. Forsberg, Douglas R. Galasko, Nupur Ghoshal, Neill R. Graff-Radford, Murray Grossman, Hilary W. Heuer, Ging-Yuek Hsiung, John Kornak, Irene Litvan, Ian R. Mackenzie, Mario F. Mendez, Belen Pascual, Katherine P. Rankin, Katya Rascovsky, Adam M. Staffaroni, Maria Carmela Tartaglia, Sandra Weintraub, Bonnie Wong, Bradley F. Boeve, Adam L. Boxer, Howard J. Rosen, Jill Goldman, Edward D. Huey, Stephanie Cosentino
Summary: This study aimed to investigate the performance patterns on an abbreviated list learning task in mutation carriers with mild behavioral and/or cognitive symptoms consistent with prodromal bvFTD, with a focus on recognition memory. Results showed that MAPT mutation carriers performed worse in list recall and had difficulty discriminating targets from distractors on the recognition memory task. Identification of the earliest cognitive indicators of bvFTD is of critical importance, and distinct cognitive profiles may be evident in carriers of the three disease causing genes during the prodromal stage.
Article
Medicine, General & Internal
Vincenzo Alfano, Giovanni Federico, Giulia Mele, Federica Garramone, Marcello Esposito, Marco Aiello, Marco Salvatore, Carlo Cavaliere
Summary: This study investigated the brain networks involved in depression in patients with frontotemporal dementia (FTD) and Parkinson's disease (PD), compared to healthy controls. The findings suggest the presence of specific connectivity patterns in depressed patients that may be related to neurocognitive disorders.
Article
Geriatrics & Gerontology
Monica M. De Icaza Valenzuela, Thomas H. Bak, Harriet E. Thompson, Shuna Colville, Suvankar Pal, Sharon Abrahams
Summary: The ECAS is a valid and sensitive assessment tool for bvFTD and AD, especially suitable for detecting behavioral abnormalities related to frontal lobe disorders.
INTERNATIONAL JOURNAL OF GERIATRIC PSYCHIATRY
(2021)
Article
Clinical Neurology
Shreyasee Das, Julie Goossens, Dirk Jacobs, Nele Dewit, Yolande A. L. Pijnenburg, Sjors G. J. G. In't Veld, Charlotte E. Teunissen, Eugeen Vanmechelen
Summary: The relationship between fluid biomarkers of neurodegeneration and synaptic dysfunction was studied in patients with AD, FTD, and SCD. The levels of synaptic proteins SNAP25, VAMP2, and Ng were found to be elevated in AD and FTD patients compared to SCD, suggesting that they may not be specific biomarkers for AD. The correlations between synaptic proteins were weaker in AD and FTD groups compared to SCD.
ALZHEIMERS RESEARCH & THERAPY
(2023)
Article
Neurosciences
Nan Lin, Jing Gao, Chenhui Mao, Heyang Sun, Qiang Lu, Liying Cui
Summary: This study found that early-onset Alzheimer's disease (EOAD) and frontotemporal dementia (FTD) have different EEG changes, which are correlated with clinical severity and CSF biomarkers. EEG microstate may be more sensitive than visual EEG in distinguishing between AD and FTD, and could potentially serve as a biomarker for the diagnosis and assessment of early-onset dementias.
FRONTIERS IN NEUROSCIENCE
(2021)
Article
Medicine, General & Internal
Andreas Miltiadous, Katerina D. Tzimourta, Nikolaos Giannakeas, Markos G. Tsipouras, Theodora Afrantou, Panagiotis Ioannidis, Alexandros T. Tzallas
Summary: Dementia is characterized by progressive loss of cognitive and emotional abilities. Alzheimer's disease (AD) and frontotemporal dementia (FTD) are two common types. Analysis of EEG signals can provide an accurate biomarker for detecting changes in neuronal and cognitive dynamics associated with dementia. Different machine-learning techniques were compared for classifying processed EEG signals of AD and FTD, with decision trees achieving 78.5% accuracy for AD detection and random forests achieving 86.3% accuracy for FTD detection. Cross-validation methods were also evaluated for performance in this classification problem.
Article
Clinical Neurology
Lize C. C. Jiskoot, Esther van den Berg, Sascha A. A. M. Laenen, Jackie M. M. Poos, Lucia A. A. Giannini, Djaina D. D. Satoer, Judy van Hemmen, Yolande A. L. Pijnenburg, Jet M. J. Vonk, Harro Seelaar
Summary: Research suggests that qualitative measures of semantic fluency can provide valuable insights into the progression of different genetic mutations associated with Frontotemporal Dementia (FTD). Specifically, GRN mutation carriers show a decrease in clustering and an increase in cluster size, which is associated with decline in executive function. On the other hand, MAPT mutation carriers display an increase in lexical frequency and a decline in age of acquisition, which is associated with decline in semantic processing. These qualitative measures have the potential to serve as sensitive cognitive biomarkers for the diagnosis and monitoring of FTD.
JOURNAL OF NEUROLOGY
(2023)
Article
Clinical Neurology
M. -Marsel Mesulam, Christina A. Coventry, Eileen H. Bigio, Jaiashre Sridhar, Nathan Gill, Angela J. Fought, Hui Zhang, Cynthia K. Thompson, Changiz Geula, Tamar Gefen, Margaret Flanagan, Qinwen Mao, Sandra Weintraub, Emily J. Rogalski
Summary: Primary progressive aphasia is a neurodegenerative disease that selectively impairs language function. Autopsies and longitudinal studies have shown that primary progressive aphasia has various neuropathological changes, with Alzheimer's disease being the most common. Different variants of primary progressive aphasia have distinct neuropathological correlates, and word comprehension impairments are strong predictors of underlying neuropathology. Different types of primary progressive aphasia have different patterns of cortical atrophy, but all show severe damage to the left hemisphere language network. This study is important for understanding the neuropathological and clinical differences in primary progressive aphasia.
Article
Clinical Neurology
Giacomo Tondo, Giulia Carli, Roberto Santangelo, Maria Vittoria Mattoli, Luca Presotto, Massimo Filippi, Giuseppe Magnani, Sandro Iannaccone, Chiara Cerami, Daniela Perani
Summary: In a large cohort of aMCI subjects, using in vivo biomarkers such as cerebrospinal fluid measures and [F-18]fluorodeoxyglucose (FDG)-positron emission tomography (PET) imaging can accurately predict the prognosis of patients. The specific [F-18]FDG-PET limbic-predominant hypometabolism pattern is associated with clinical stability and low likelihood of progression to Alzheimer's disease, providing important implications for prognosis and clinical trial planning.
EUROPEAN JOURNAL OF NEUROLOGY
(2021)
Review
Clinical Neurology
Axel Petzold, Philipp Albrecht, Laura Balcer, Erik Bekkers, Alexander U. Brandt, Peter A. Calabresi, Orla Galvin Deborah, Jennifer S. Graves, Ari Green, Pearse A. Keane, Jenny A. Nij Bijvank, Josemir W. Sander, Friedemann Paul, Shiv Saidha, Pablo Villoslada, Siegfried K. Wagner, E. Ann Yeh
Summary: Artificial intelligence-based diagnostic algorithms have made ambitious achievements in the field of neurological disorders, particularly in utilizing scalable imaging technology like optical coherence tomography (OCT). By embedding quality control criteria into OCT reporting guidelines, machine learning in this area is advanced, showing significant progress in the diagnosis of neurological conditions.
ANNALS OF CLINICAL AND TRANSLATIONAL NEUROLOGY
(2021)
Letter
Clinical Neurology
Paride Schito, Francesca Caso, Giuseppe Magnani, Lina Raffaella Barzaghi, Alessandra Barbieri, Maria Antonietta Volonte, Vittorio Martinelli, Luigia Brugliera, Sandro Iannaccone, Massimo Filippi
JOURNAL OF NEUROLOGY
(2022)
Article
Clinical Neurology
Marina Cattaneo, Pierre Jesus, Andrea Lizio, Philippe Fayemendy, Nicoletta Guanziroli, Ettore Corradi, Valeria Sansone, Letizia Leocani, Massimo Filippi, Nilo Riva, Philippe Corcia, Philippe Couratier, Christian Lunetta
Summary: The study revealed that 10% of ALS patients have hypometabolic state, while 40% have hypermetabolic state. Hypometabolism is associated with later need for gastrostomy, non-invasive ventilation and tracheostomy, and hypometabolic patients with ALS have significantly longer survival compared to normometabolic and hypermetabolic patients.
JOURNAL OF NEUROLOGY NEUROSURGERY AND PSYCHIATRY
(2022)
Article
Neurosciences
Arianna Sala, Maura Malpetti, Mohsen Farsad, Francesca Lubian, Giuseppe Magnani, Giulia Frasca Polara, Jean-Benoit Epiney, Jubin Abutalebi, Frederic Assal, Valentina Garibotto, Daniela Perani
Summary: Research suggests that lifelong bilingualism has a protective effect on the brain, delaying the onset of dementia. Bilingual individuals with Alzheimer's disease show more severe cerebral hypometabolism but also stronger connectivity in certain cognitive networks compared to monolinguals, particularly in the left hemisphere.
HUMAN BRAIN MAPPING
(2022)
Article
Biochemical Research Methods
Valerio Castoldi, Elena Rossi, Silvia Marenna, Giancarlo Comi, Letizia Leocani
Summary: This study compared the repeatability and stability of Motor Evoked Potentials (MEPs) induced by different stimulation methods in mice. The results showed that surface stimulation with a surface electrode had reduced inter-session variability and improved measurement stability.
JOURNAL OF NEUROSCIENCE METHODS
(2022)
Article
Neurosciences
Valerio Castoldi, Silvia Marenna, Su-Chun Huang, Raffaele d'Isa, Linda Chaabane, Giancarlo Comi, Letizia Leocani
Summary: In this study, female Dark Agouti rats were immunized with increasing doses of myelin oligodendrocyte glycoprotein (MOG) to develop experimental autoimmune encephalomyelitis (EAE), a preclinical model of multiple sclerosis. The results showed that increasing MOG dosage augmented visual function impairment in EAE, which could be monitored with noninvasive visual evoked potentials (VEPs) to assess demyelination and axonal loss along optic nerves (ONs).
JOURNAL OF NEUROSCIENCE RESEARCH
(2022)
Letter
Clinical Neurology
Davide Gusmeo Curti, Francesca Caso, Antonio Malvaso, Rosalinda Cardamone, Vittorio Martinelli, Giuseppe Magnani, Massimo Filippi
NEUROLOGICAL SCIENCES
(2022)
Article
Computer Science, Artificial Intelligence
Shuo Liu, Jing Han, Estela Laporta Puyal, Spyridon Kontaxis, Shaoxiong Sun, Patrick Locatelli, Judith Dineley, Florian B. Pokorny, Gloria Dalla Costa, Letizia Leocani, Ana Isabel Guerrero, Carlos Nos, Ana Zabalza, Per Soelberg Sorensen, Mathias Buron, Melinda Magyari, Yatharth Ranjan, Zulqarnain Rashid, Pauline Conde, Callum Stewart, Amos A. Folarin, Richard J. B. Dobson, Raquel Bailon, Srinivasan Vairavan, Nicholas Cummins, Vaibhav A. Narayan, Matthew Hotopf, Giancarlo Comi, Bjoern Schuller
Summary: This study introduces a contrastive convolutional auto-encoder (contrastive CAE) to identify potential COVID-19 infection in participants with multiple sclerosis (MS) based on heart-rate data, achieving high classification performance with effective symptom detection and low false alarm rate.
PATTERN RECOGNITION
(2022)
Article
Clinical Neurology
Valentina Pieri, Davide Gusmeo Curti, Rosina Paterra, Matteo Azzimonti, Giacomo Sferruzza, Giulia Berzero, Rosalinda Cardamone, Nicoletta Anzalone, Federica Agosta, Francesca Caso, Giuseppe Magnani, Gaetano Finocchiaro, Massimo Filippi
Summary: In this study, liquid biopsy diagnostic method successfully detected somatic mutations associated with gliomas in the patient's cerebrospinal fluid, providing therapeutically targetable mutations. This method can assist in the differential diagnosis of neurological diseases when imaging is not informative enough and surgical biopsy is not feasible.
NEUROLOGICAL SCIENCES
(2023)
Article
Clinical Neurology
Giancarlo Comi, Letizia Leocani, Luigi Ferini-Strambi, Marta Radaelli, Gloria D. Costa, Roberta Lanzillo, Giacomo Lus, Valentina Bianchi, Sebastiano Traccis, Fioravante Capone, Luigi M. E. Grimaldi, Giuseppe Salemi, Alessandra Cardillo, Valentina Zipoli
Summary: This multicentre observational study evaluated the effects of treatment with oral dimethyl fumarate on the quality of sleep in patients with relapsing-remitting multiple sclerosis. The results showed significant improvement in the quality of sleep and depression symptoms in patients treated with dimethyl fumarate. However, further randomised clinical trials are needed to confirm the long-term treatment benefits.
MULTIPLE SCLEROSIS JOURNAL-EXPERIMENTAL TRANSLATIONAL AND CLINICAL
(2023)
Article
Health Care Sciences & Services
Andrea Tacchino, Michela Ponzio, Paolo Confalonieri, Letizia Leocani, Matilde Inglese, Diego Centonze, Eleonora Cocco, Paolo Gallo, Damiano Paolicelli, Marco Rovaris, Loredana Sabattini, Gioacchino Tedeschi, Luca Prosperini, Francesco Patti, Placido Bramanti, Elisabetta Pedrazzoli, Mario Alberto Battaglia, Giampaolo Brichetto
Summary: This paper describes the design, development, and usability testing of MS Fitness Intervention Training (MS-FIT), a Kinect-based tool implementing customized Pilates exercises for people with MS. The user-centered design approach was used to create an accessible and challenging tool for balance training. The usability testing showed that MS-FIT is a promising system for enhancing the motivation and engagement of people with MS in performing exercises.
JMIR SERIOUS GAMES
(2023)
Article
Ophthalmology
Valerio Castoldi, Gianpaolo Zerbini, Silvia Maestroni, Ilaria Vigano, Paolo Rama, Letizia Leocani
Summary: This study investigates the effects of topical NGF on neuroretina function and shows that NGF can improve retinal functionality and restore retinal structure in Akita mice.
EXPERIMENTAL EYE RESEARCH
(2023)
Article
Medicine, Research & Experimental
Cristina Rivellini, Emanuela Porrello, Giorgia Dina, Simona Mrakic-Sposta, Alessandra Vezzoli, Marco Bacigaluppi, Giorgia Serena Gullotta, Linda Chaabane, Letizia Leocani, Silvia Marenna, Emanuela Colombo, Cinthia Farina, Jia Newcombe, Klaus-Armin Nave, Ruggero Pardi, Angelo Quattrini, Stefano C. Previtali
Summary: Oligodendrocytes are the primary target of demyelinating disorders. Lack of CSN5 (JAB1) expression leads to cellular senescence, chronic inflammation, and oxidative stress, resulting in CNS demyelination, neuroinflammation, and neurodegeneration.
JOURNAL OF CLINICAL INVESTIGATION
(2022)
Meeting Abstract
Clinical Neurology
E. Spinelli, S. Basaia, C. Cividini, N. Riva, G. Magnani, F. Caso, P. Caroppo, S. Prioni, T. Lucio, I. Appollonio, V. Silani, P. Carrera, M. Filippi, F. Agosta
EUROPEAN JOURNAL OF NEUROLOGY
(2021)
Article
Geriatrics & Gerontology
Sarah N. Kraeutner, Cristina Rubino, Jennifer K. Ferris, Shie Rinat, Lauren Penko, Larissa Chiu, Brian Greeley, Christina B. Jones, Beverley C. Larssen, Lara A. Boyd
Summary: This study examined the age-related changes in brain function and baseline brain structure that support motor skill acquisition. The findings showed that older adults experienced decreases in functional connectivity during motor skill acquisition, while younger adults experienced increases. Additionally, regardless of age group, lower baseline microstructure in a frontoparietal tract was associated with slower motor skill acquisition.
NEUROBIOLOGY OF AGING
(2024)
Article
Geriatrics & Gerontology
Karen Nuytemans, Farid Rajabli, Melissa Jean-Francois, Jiji Thulaseedhara Kurup, Larry D. Adams, Takiyah D. Starks, Patrice L. Whitehead, Brian W. Kunkle, Allison Caban-Holt, Jonathan L. Haines, Michael L. Cuccaro, Jeffery M. Vance, Goldie S. Byrd, Gary W. Beecham, Christiane Reitz, Margaret A. Pericak-Vance
Summary: This study conducted genetic research on African American AD families and identified a significant linkage signal associated with AD, highlighting the importance of diverse population-level genetic data in understanding the genetic determinants of AD.
NEUROBIOLOGY OF AGING
(2024)
Article
Geriatrics & Gerontology
Kazuya Suwabe, Ryuta Kuwamizu, Kazuki Hyodo, Toru Yoshikawa, Takeshi Otsuki, Asako Zempo-Miyaki, Michael A. Yassa, Hideaki Soya
Summary: Physical exercise has a positive impact on hippocampal memory decline with aging. Recent studies have shown that even light exercise can improve memory and this improvement is mediated by the ascending arousal system. This study aimed to investigate the effects of light-intensity exercise on hippocampal memory function in healthy older adults and found that pupil dilation during exercise played a role in the memory improvement.
NEUROBIOLOGY OF AGING
(2024)
Article
Geriatrics & Gerontology
Ajay Sood, Ana Werneck Capuano, Robert Smith Wilson, Lisa Laverne Barnes, Alifiya Kapasi, David Alan Bennett, Zoe Arvanitakis
Summary: The objective of this study was to explore the impact of metformin on cognition and brain pathology. The results showed that metformin users had slower decline in global cognition, episodic memory, and semantic memory compared to non-users. However, the relationship between metformin use and certain brain pathology remains uncertain.
NEUROBIOLOGY OF AGING
(2024)
Article
Geriatrics & Gerontology
Brian N. Lee, Junwen Wang, Molly A. Hall, Dokyoon Kim, Shana D. Stites, Li Shen
Summary: Alzheimer's disease (AD) is a neurodegenerative disorder characterized by memory and functional impairments. This study analyzed participants from the Alzheimer's Disease Neuroimaging Initiative and found differential associations between cerebral spinal fluid (CSF)/neuroimaging biomarkers and cognitive/functional outcomes, as well as variations between sexes. These findings suggest that sex differences may play a role in the development of AD.
NEUROBIOLOGY OF AGING
(2024)
Article
Geriatrics & Gerontology
Madeline R. Hale, Rebecca Langhough, Lianlian Du, Bruce P. Hermann, Carol A. Van Hulle, Margherita Carboni, Gwendlyn Kollmorgenj, Kristin E. Basche, Davide Bruno, Leah Sanson-Miles, Erin M. Jonaitis, Nathaniel A. Chin, Ozioma C. Okonkwo, Barbara B. Bendlin, Cynthia M. Carlsson, Henrik Zetterberg, Kaj Blennow, Tobey J. Betthauser, Sterling C. Johnson, Kimberly D. Mueller
Summary: This study demonstrates a relationship between cerebrospinal fluid biomarkers and the ability to recall proper names in the preclinical phase of Alzheimer's disease.
NEUROBIOLOGY OF AGING
(2024)
Article
Geriatrics & Gerontology
Thomas T. Austin, Christian L. Thomas, Ben Warren
Summary: This study investigated the effects of age on the robustness and resilience of auditory system using the desert locust. The researchers found that gene expression changes were mainly influenced by age rather than noise exposure. Both young and aged locusts were able to recover their auditory nerve function within 48 hours of noise exposure, but the recovery of transduction current magnitude was impaired in aged locusts. Key genes responsible for robustness to noise exposure in young locusts and potential candidates for compensatory mechanisms in auditory neurons of aged locusts were identified.
NEUROBIOLOGY OF AGING
(2024)
