Article
Orthopedics
Chen Yang, Julie N. Cote
Summary: The study found that sex differences may affect variations in shoulder, elbow, and spinal joint angles and angular variability. Women's fatigue responses are more focused on the trunk and spine.
BMC MUSCULOSKELETAL DISORDERS
(2022)
Article
Geriatrics & Gerontology
Momoko Yamagata, Hiroshige Tateuchi, Itsuroh Shimizu, Junya Saeki, Noriaki Ichihashi
Summary: This study found that a high variance in segmental configurations destabilizing the CoM in the vertical direction was related to future falls, suggesting that UCM analysis variables can be useful for evaluating fall risk.
Article
Biophysics
Haruki Toda, Yuki Hashimoto, Takuya Ibara, Mitsunori Tada
Summary: This study investigates the effect of vibrotactile stimulation of the hallux nail on segmental coordination to control center of mass (CoM) movement in the mediolateral direction during walking. The results show that vibrotactile stimulation is more effective for young individuals with larger motor noise and smaller synergy index during the single-stance phase.
JOURNAL OF BIOMECHANICS
(2022)
Article
Multidisciplinary Sciences
E. Kaminski, M. Engelhardt, M. Hoff, C. Steele, A. Villringer, P. Ragert
Summary: This study investigated the effects of tDCS on explicit and implicit learning parameters, showing that tDCS has an impact on explicit skill acquisition but limited effects on implicit learning parameters.
SCIENTIFIC REPORTS
(2021)
Article
Orthopedics
Peter Altenburger, Satyajit S. Ambike, Jeffrey M. Haddad
Summary: Traditional therapeutic assessments in rehabilitation often overlook the complexity of motor behavior and variability in real-world environments. This Perspective argues for the inclusion of motor variability measures in clinical assessment to better evaluate a patient's progress in real-world mobility. Leveraging technology can advance understanding of motor variability and improve rehabilitative approaches.
Review
Neurosciences
Mingyu Hu, Toshiki Kobayashi, Jin Zhou, Wing-Kai Lam
Summary: This systematic review summarized the current applications, methodology, parameters of interest, and interpretations of CRP variables in running and jumping. The results suggest that CRP tools are effective to assess the coordination and performances in running and jumping, providing meaningful interpretation of movement behavior. In the future, studying higher-order analysis of movement patterns using CRP tools can further enhance understanding of coordination patterns.
Article
Engineering, Industrial
J. Savin, C. Gaudez, M. A. Gilles, V Padois, P. Bidaud
Summary: The variability of human movement is crucial for performance and adaptability, as well as for preventing musculoskeletal damage. Research has shown that individuals adopt successive coordination patterns at an intra-individual level during repetitive pointing tasks, with inter-individual variability characterized by the number and type of these patterns.
APPLIED ERGONOMICS
(2021)
Article
Neurosciences
Charlend K. Howard, Arend W. A. Van Gemmert, Nikita A. Kuznetsov
Summary: Adopting an external focus of attention has been found beneficial for performing motor skills compared to an internal focus. This study used uncontrolled manifold analysis to investigate the effects of focus of attention instructions on joint coordination in a reaching task. The results showed that internal focus led to higher radial error and goal-relevant variance among the joints, indicating disrupted coordination. However, goal-irrelevant variance and coordination stability were not affected by focus of attention.
HUMAN MOVEMENT SCIENCE
(2023)
Article
Sport Sciences
Devon H. Frayne, Valerie T. Norman-Gerum, Samuel J. Howarth, Stephen H. M. Brown
Summary: This study compared experienced and inexperienced Nordic skiers and found differences in the stabilization of hand and trunk center of mass (COM) velocity, suggesting the potential utility of these performance variables as indicators of motor skill development.
JOURNAL OF SPORTS SCIENCES
(2023)
Article
Anesthesiology
Charlotte Verfaille, Lieve Filbrich, Yves Rossetti, Anne Berquin, Dominique Mouraux, Olivier Barbier, Xavier Libouton, Virginie Fraselle, Valery Legrain
Summary: This study evaluated the spatial cognitive abilities of CRPS patients by varying sensory inputs through visual and proprioceptive tasks. The results indicate that CRPS patients are more likely to make deviation errors during visually guided movements of the limb, suggesting difficulties in integrating somatic information during these tasks.
Article
Neurosciences
Jocelyn F. Hafer, Ronald F. Zernicke
Summary: The study found that older adults with knee osteoarthritis and young adults exhibit different lower extremity segment coordination patterns in response to changes in walking speed, especially during terminal swing and early stance. Coordination patterns vary in different gait cycle phases and strategies, potentially aiding in the design of fall prevention interventions targeting specific gait cycle phases.
Article
Computer Science, Cybernetics
Xianliang Ge, Jie Xu, Wanwan Zheng, Hao Ni, Liezhong Ge, Huagen Wan
Summary: This study investigated the impact of initial and terminal positions (ITPs) on pointing task performance, revealing that ITPs influence task performance, possibly due to different movements associated with human biomechanical characteristics.
INTERNATIONAL JOURNAL OF HUMAN-COMPUTER INTERACTION
(2021)
Article
Biophysics
Christopher A. Bailey, Fariba Hasanbarani, Matthew Slopecki, Chen Yang, Julie N. Cote
Summary: The size of motor variability increases with fatigue in repetitive upper limb tasks, and the structure of variability differs with old age. However, the combined influences of old age and fatigue on the size and structure of movement-to-movement variability are unclear.
JOURNAL OF BIOMECHANICS
(2023)
Article
Radiology, Nuclear Medicine & Medical Imaging
Wenjin Liu, Xiaoqin Huang, Xuebing Liu, Dakota Ortega, Li Chen, Zhensen Chen, Jie Sun, Lulu Wang, Thomas S. Hatsukami, Chun Yuan, Haige Li, Junwei Yang
Summary: The study found that uncontrolled hypertension is associated with subclinical cerebrovascular injury, affecting both small and medium-to-large arteries. The presence of intracranial plaque, vascular rarefaction, reduced cerebral blood flow, and increased white matter hyperintensity were all correlated with uncontrolled hypertension, particularly with uncontrolled diastolic blood pressure.
EUROPEAN RADIOLOGY
(2021)
Article
Computer Science, Information Systems
Mohammad Ridwan Kabir, Mohammad Ishrak Abedin, Rizvi Ahmed, Hasan Mahmud, Md Kamrul Hasan
Summary: Shannon's Index of Difficulty is used for quantifying the perceived difficulty of pointing tasks, but it may not accurately quantify the true difficulty in real-life scenarios. This study proposes a new formulation, ANTASID, with a temporal adjustment factor to compensate for contextual differences and minimize non-linearity. The performance analysis shows that ANTASID has significantly superior fitness values and throughput compared to classical formulations.
Article
Neurosciences
Stefan Hess, Petroula Mousikou, Julius Verrel, Sascha Schroeder
HUMAN MOVEMENT SCIENCE
(2019)
Article
Neurosciences
Patricio Donnelly-Kehoe, Victor M. Saenger, Nina Lisofsky, Simone Kuehn, Morten L. Kringelbach, Jens Schwarzbach, Ulman Lindenberger, Gustavo Deco
HUMAN BRAIN MAPPING
(2019)
Article
Biology
Niels A. Kloosterman, Jan Willem de Gee, Markus Werkle-Bergner, Ulman Lindenberger, Douglas D. Garrett, Johannes Jacobus Fahrenfort
Article
Psychology, Biological
Martin J. Dahl, Mara Mather, Sandra Duezel, Nils C. Bodammer, Ulman Lindenberger, Simone Kuhn, Markus Werkle-Bergner
NATURE HUMAN BEHAVIOUR
(2019)
Article
Biology
Niels A. Kloosterman, Julian Q. Kosciessa, Ulman Lindenberger, Johannes Jacobus Fahrenfort, Douglas D. Garrett
Article
Multidisciplinary Sciences
James M. Roe, Didac Vidal-Pineiro, Oystein Sorensen, Andreas M. Brandmaier, Sandra Duzel, Hector A. Gonzalez, Rogier A. Kievit, Ethan Knights, Simone Kuhn, Ulman Lindenberger, Athanasia M. Mowinckel, Lars Nyberg, Denise C. Park, Sara Pudas, Melissa M. Rundle, Kristine B. Walhovd, Anders M. Fjell, Rene Westerhausen
Summary: Aging and Alzheimer's disease lead to progressive disorganization of the brain, causing a loss of cortical asymmetry that becomes accelerated with age. This study shows that the adaptive asymmetric organization of the heteromodal cortex is dedifferentiated in aging and AD, emphasizing a system-wide impact on brain structure.
NATURE COMMUNICATIONS
(2021)
Article
Geriatrics & Gerontology
Shelby L. Bachman, Martin J. Dahl, Markus Werkle-Bergner, Sandra Duezel, Caroline Garcia Forlim, Ulman Lindenberger, Simone Kuehn, Mara Mather
Summary: The study found a positive relationship between LC contrast and cortical thickness in older adults, particularly in the parietal, frontal, and occipital regions. This suggests a link between LC structure and cortical brain structure in later adulthood.
NEUROBIOLOGY OF AGING
(2021)
Article
Multidisciplinary Sciences
Julian Q. Kosciessa, Ulman Lindenberger, Douglas D. Garrett
Summary: The study shows that heightened uncertainty shifts cortical networks from a rhythmic to an asynchronous (excited) state when people experience uncertainty about the relevance of a stimulus feature, with the thalamus playing a central role in this uncertainty-related adjustment.
NATURE COMMUNICATIONS
(2021)
Article
Neurosciences
Anna E. Karlsson, Ulman Lindenberger, Myriam C. Sander
Summary: Episodic memory declines with advancing age, especially when forming associations between items and their contexts. This decline is associated with compromised theta-gamma coupling, which is more pronounced in older adults. Theta-gamma coupling closer to the peak of the theta rhythm is beneficial for associative memory formation.
JOURNAL OF NEUROSCIENCE
(2022)
Correction
Multidisciplinary Sciences
James M. Roe, Didac Vidal-Pineiro, Oystein Sorensen, Andreas M. Brandmaier, Sandra Duzel, Hector A. Gonzalez, Rogier A. Kievit, Ethan Knights, Simone Kuhn, Ulman Lindenberger, Athanasia M. Mowinckel, Lars Nyberg, Denise C. Park, Sara Pudas, Melissa M. Rundle, Kristine B. Walhovd, Anders M. Fjell, Rene Westerhausen
NATURE COMMUNICATIONS
(2022)
Article
Multidisciplinary Sciences
Elliot M. Tucker-Drob, Javier de la Fuente, Ylva Koehncke, Andreas M. Brandmaier, Lars Nyberg, Ulman Lindenberger
Summary: Theories of adult cognitive development distinguish between fluid abilities, which decline with age, and crystallized abilities, which show gains into old age. In this study, data from two large longitudinal studies showed that rates of change are strongly correlated across these two abilities. Individuals who experience greater declines in fluid abilities tend to show smaller gains or losses in crystallized abilities. These findings suggest a common mechanism driving cognitive decline and maintenance in adulthood.
Article
Gerontology
Hans-Werner Wahl, Johanna Drewelies, Sandra Duezel, Margie E. Lachman, Jacqui Smith, Peter Eibich, Elisabeth Steinhagen-Thiessen, Ilja Demuth, Ulman Lindenberger, Gert G. Wagner, Nilam Ram, Denis Gerstorf
Summary: Comparing two independent studies of older adults, it was found that there is no evidence to suggest that today's older adults have more positive views on aging than older adults did two decades ago. The subjective views on aging have not improved over time, and there is a possibility that individual age views have become increasingly decoupled from societal age views.
PSYCHOLOGY AND AGING
(2022)
Article
Neurosciences
Elisabeth Wenger, Sarah E. Polk, Maike M. Kleemeyer, Nikolaus Weiskopf, Nils C. Bodammer, Ulman Lindenberger, Andreas M. Brandmaier
Summary: This study investigates the reliability of individual differences in four quantities measured by magnetic resonance imaging. The results show that these four parameters have high reproducibility and reliability in the whole brain. However, there are significant differences in the reliability of these parameters across different brain regions.
HUMAN BRAIN MAPPING
(2022)
Article
Automation & Control Systems
Armin W. Thomas, Ulman Lindenberger, Wojciech Samek, Klaus-Robert Mueller
Summary: Research has shown that transfer learning improves the performance of deep learning models in datasets with small sample sizes. In this study, the application of transfer learning to cognitive decoding analysis using functional neuroimaging data is systematically evaluated. Pre-trained deep learning models consistently achieve higher decoding accuracies and require less training time and data compared to models trained from scratch. The benefits of pre-training come from the ability to reuse learned features when training with new data. However, challenges arise when interpreting the decoding decisions of pre-trained models, as they may utilize fMRI data in unforeseen and counterintuitive ways.
JOURNAL OF THE FRANKLIN INSTITUTE-ENGINEERING AND APPLIED MATHEMATICS
(2023)
Article
Neurosciences
Ylva Koehncke, Sandra Duezel, Myriam C. Sander, Ulman Lindenberger, Simone Kuehn, Andreas M. Brandmaier
Summary: The study examined the impact of structural integrity of hippocampal and cortical gray matter on episodic memory in older adults, revealing significant associations between the integrity of hippocampus and parahippocampus with episodic memory, especially in men. Multimodal factors of structural brain integrity may enhance our understanding of human memory aging.
Article
Geriatrics & Gerontology
Sarah N. Kraeutner, Cristina Rubino, Jennifer K. Ferris, Shie Rinat, Lauren Penko, Larissa Chiu, Brian Greeley, Christina B. Jones, Beverley C. Larssen, Lara A. Boyd
Summary: This study examined the age-related changes in brain function and baseline brain structure that support motor skill acquisition. The findings showed that older adults experienced decreases in functional connectivity during motor skill acquisition, while younger adults experienced increases. Additionally, regardless of age group, lower baseline microstructure in a frontoparietal tract was associated with slower motor skill acquisition.
NEUROBIOLOGY OF AGING
(2024)
Article
Geriatrics & Gerontology
Karen Nuytemans, Farid Rajabli, Melissa Jean-Francois, Jiji Thulaseedhara Kurup, Larry D. Adams, Takiyah D. Starks, Patrice L. Whitehead, Brian W. Kunkle, Allison Caban-Holt, Jonathan L. Haines, Michael L. Cuccaro, Jeffery M. Vance, Goldie S. Byrd, Gary W. Beecham, Christiane Reitz, Margaret A. Pericak-Vance
Summary: This study conducted genetic research on African American AD families and identified a significant linkage signal associated with AD, highlighting the importance of diverse population-level genetic data in understanding the genetic determinants of AD.
NEUROBIOLOGY OF AGING
(2024)
Article
Geriatrics & Gerontology
Kazuya Suwabe, Ryuta Kuwamizu, Kazuki Hyodo, Toru Yoshikawa, Takeshi Otsuki, Asako Zempo-Miyaki, Michael A. Yassa, Hideaki Soya
Summary: Physical exercise has a positive impact on hippocampal memory decline with aging. Recent studies have shown that even light exercise can improve memory and this improvement is mediated by the ascending arousal system. This study aimed to investigate the effects of light-intensity exercise on hippocampal memory function in healthy older adults and found that pupil dilation during exercise played a role in the memory improvement.
NEUROBIOLOGY OF AGING
(2024)
Article
Geriatrics & Gerontology
Ajay Sood, Ana Werneck Capuano, Robert Smith Wilson, Lisa Laverne Barnes, Alifiya Kapasi, David Alan Bennett, Zoe Arvanitakis
Summary: The objective of this study was to explore the impact of metformin on cognition and brain pathology. The results showed that metformin users had slower decline in global cognition, episodic memory, and semantic memory compared to non-users. However, the relationship between metformin use and certain brain pathology remains uncertain.
NEUROBIOLOGY OF AGING
(2024)
Article
Geriatrics & Gerontology
Brian N. Lee, Junwen Wang, Molly A. Hall, Dokyoon Kim, Shana D. Stites, Li Shen
Summary: Alzheimer's disease (AD) is a neurodegenerative disorder characterized by memory and functional impairments. This study analyzed participants from the Alzheimer's Disease Neuroimaging Initiative and found differential associations between cerebral spinal fluid (CSF)/neuroimaging biomarkers and cognitive/functional outcomes, as well as variations between sexes. These findings suggest that sex differences may play a role in the development of AD.
NEUROBIOLOGY OF AGING
(2024)
Article
Geriatrics & Gerontology
Madeline R. Hale, Rebecca Langhough, Lianlian Du, Bruce P. Hermann, Carol A. Van Hulle, Margherita Carboni, Gwendlyn Kollmorgenj, Kristin E. Basche, Davide Bruno, Leah Sanson-Miles, Erin M. Jonaitis, Nathaniel A. Chin, Ozioma C. Okonkwo, Barbara B. Bendlin, Cynthia M. Carlsson, Henrik Zetterberg, Kaj Blennow, Tobey J. Betthauser, Sterling C. Johnson, Kimberly D. Mueller
Summary: This study demonstrates a relationship between cerebrospinal fluid biomarkers and the ability to recall proper names in the preclinical phase of Alzheimer's disease.
NEUROBIOLOGY OF AGING
(2024)
Article
Geriatrics & Gerontology
Thomas T. Austin, Christian L. Thomas, Ben Warren
Summary: This study investigated the effects of age on the robustness and resilience of auditory system using the desert locust. The researchers found that gene expression changes were mainly influenced by age rather than noise exposure. Both young and aged locusts were able to recover their auditory nerve function within 48 hours of noise exposure, but the recovery of transduction current magnitude was impaired in aged locusts. Key genes responsible for robustness to noise exposure in young locusts and potential candidates for compensatory mechanisms in auditory neurons of aged locusts were identified.
NEUROBIOLOGY OF AGING
(2024)