Article
Neurosciences
Mohammad Amani, Julie C. Lauterborn, Aliza A. Le, Brittney M. Cox, Weisheng Wang, Julian Quintanilla, Conor D. Cox, Christine M. Gall, Gary Lynch
Summary: The deterioration of layers II/III of the entorhinal cortex in the early stages of Alzheimer's disease may be due to impaired presynaptic long-term potentiation, reduced endocannabinoid signaling, and decreased TrkB receptor levels. These changes suggest that synaptic plasticity in EC projections related to memory is particularly sensitive to aging, leading to potential pathogenesis later in life.
JOURNAL OF NEUROSCIENCE
(2021)
Article
Neurosciences
Jennifer M. Yonan, Oswald Steward
Summary: Deletion of the PTEN gene leads to neuronal hypertrophy and formation of abnormal neural networks, resulting in spontaneous seizures. This study demonstrates that PTEN deletion in mature neurons causes growth of cell bodies and dendrites, disrupting connectivity in mature circuits.
NEUROBIOLOGY OF DISEASE
(2023)
Article
Neurosciences
Goran Simic, Zeljka Krsnik, Vinka Knezovic, Zlatko Kelovic, Mathias Lysholt Mathiasen, Alisa Junakovic, Milan Rados, Damir Mulc, Ena Spanic, Giulia Quattrocolo, Vanessa Jane Hall, Laszlo Zaborszky, Mario Vuksic, Francisco Olucha Bordonau, Ivica Kostovic, Menno P. Witter, Patrick R. Hof
Summary: The development of the human entorhinal cortex (EC), a major hub in the brain, has been analyzed in this study. The results show that the cytoarchitectural differentiation of the EC begins early in fetal development and follows a specific pattern. These findings have implications for understanding the normal function of the EC and its role in brain disorders.
JOURNAL OF COMPARATIVE NEUROLOGY
(2022)
Review
Behavioral Sciences
Maxime Levesque, Giuseppe Biagini, Marco de Curtis, Vadym Gnatkovsky, Julika Pitsch, Siyan Wang, Massimo Avoli
Summary: Research on the mechanisms of focal epileptic discharges in mesial temporal lobe epilepsy (MTLE) often utilizes rodent models induced by pilocarpine, revealing specific neuronal events during latent and chronic states, as well as the effects of optogenetic activation on spontaneous seizures.
NEUROSCIENCE AND BIOBEHAVIORAL REVIEWS
(2021)
Article
Geriatrics & Gerontology
Steven J. Granger, Luis Colon-Perez, Myra Sarai Larson, Ilana J. Bennett, Michael Phelan, David B. Keator, John T. Janecek, Mithra T. Sathishkumar, Anna P. Smith, Liv McMillan, Dana Greenia, Maria M. Corrada, Claudia H. Kawas, Michael A. Yassa
Summary: The perforant path, connecting the entorhinal cortex with the hippocampal formation, deteriorates with age-related cognitive decline. Diffusion-weighted MRI has limitations in quantifying the perforant path integrity, so this study used ultra-high resolution diffusion imaging to investigate its structural connectivity and found that older age and poorer delayed recall are associated with reduced connectivity of the path. The findings suggest that intra-MTL connectivity may serve as new candidate biomarkers for age-related cognitive decline.
NEUROBIOLOGY OF AGING
(2023)
Article
Neurosciences
Michael A. Rosario, Kathryn L. Kern, Shiraz Mumtaz, Thomas W. Storer, Karin Schon
Summary: Cardiorespiratory fitness has a significant impact on neurocognitive health, especially the hippocampal memory system. This study found a correlation between cardiorespiratory fitness and left medial temporal lobe neocortical regions in young adults, which is related to their subjective sense of direction.
EUROPEAN JOURNAL OF NEUROSCIENCE
(2023)
Article
Neurosciences
Oswald Steward, Jennifer M. Yonan, Paula M. Falk
Summary: The Wld(s) mutation significantly delays axon degeneration in mice, leading to prolonged synaptic terminal degeneration time and hypertrophy of dendritic spine heads with formation of spinules. This suggests the presence of yet to be characterized signaling processes between amputated but non-degenerating axons and their postsynaptic targets.
FRONTIERS IN MOLECULAR NEUROSCIENCE
(2021)
Article
Neurosciences
Antoine D. Madar, Jesse A. Pfammatter, Jessica Bordenave, Erin I. Plumley, Swetha Ravi, Michael Cowie, Eli P. Wallace, Bruce P. Hermann, Rama K. Maganti, Mathew V. Jones
Summary: Temporal lobe epilepsy affects the function of the dentate gyrus, leading to impaired memory discrimination, which may be related to the abnormal bursting of a subset of granule cells.
JOURNAL OF NEUROSCIENCE
(2021)
Article
Anatomy & Morphology
Tassilo Jungenitz, Alexander Bird, Maren Engelhardt, Peter Jedlicka, Stephan W. Schwarzacher, Thomas Deller
Summary: The axon initial segment (AIS) is a crucial site for action potential initiation and the integration of synaptic input. It is modulated by afferent activity and contributes to the homeostatic control of neuronal excitability. Synaptopodin is a protein expressed in telencephalic neurons and is necessary for the formation of cisternal organelles within the AIS, serving as a marker for these organelles.
FRONTIERS IN NEUROANATOMY
(2023)
Article
Radiology, Nuclear Medicine & Medical Imaging
Chao Zhang, Kai Xu, Haiyan Zhang, Jingyun Sha, Hongyu Yang, Houliang Zhao, Nan Chen, Kuncheng Li
Summary: This study investigated the recovery of the glymphatic system (GS) function in patients with temporal lobe epilepsy (TLE) after anterior temporal lobectomy (ATL) using diffusion tensor image analysis. The results revealed a significant decrease in GS function before surgery in TLE patients compared to healthy controls, but a significant increase after successful ATL. Furthermore, the GS index was significantly correlated with disease duration.
EUROPEAN RADIOLOGY
(2023)
Article
Cell Biology
Lizbeth Garcia-Velazquez, Clorinda Arias
Summary: Entorhinal cortex lesions have been found to affect the reorganization of the dentate gyrus, with Wnt signaling components playing a crucial role in this process. The activation of the canonical Wnt pathway after lesion correlates with structural adaptations in the dentate gyrus, indicating the potential of modulating this pathway for neuronal tissue regeneration.
CELLULAR AND MOLECULAR NEUROBIOLOGY
(2021)
Article
Clinical Neurology
Mauricio Girardi-Schappo, Fatemeh Fadaie, Hyo Min Lee, Benoit Caldairou, Viviane Sziklas, Joelle Crane, Boris C. Bernhardt, Andrea Bernasconi, Neda Bernasconi
Summary: Our study used computational simulations to investigate pathoconnectomics in temporal lobe epilepsy (TLE) from a dynamic perspective. We found that TLE patients show delayed information flow in multiple brain regions, especially in ipsilateral frontotemporal areas, thalamus, and hippocampus. The study also revealed the modulatory effects of structural alterations of the neocortex and hippocampus on network dynamics, and demonstrated that altered whole-brain communication dynamics contribute to common cognitive difficulties in TLE.
Article
Neurosciences
Nick Diederich, Martin Ziegler, Christian Kaernbach
Summary: This paper explores a new simulation model based on signal detection theory to understand the interplay between the entorhinal cortex and hippocampal dentate gyrus during pattern separation tasks. The process of functional memory formation and processing of similar memory content is elucidated from within the system. For the first time, orthogonalized spiking patterns are evaluated using signal detection theory methods and the results are applied to clinically established and novel tests.
JOURNAL OF NEUROPHYSIOLOGY
(2022)
Review
Geriatrics & Gerontology
Zhi-Hang Zhen, Mo-Ran Guo, He-Ming Li, Ou-Yang Guo, Jun-Li Zhen, Jian Fu, Guo-Jun Tan
Summary: Hippocampal sharp wave ripples (SWRs) serve as an electrophysiological biomarker for episodic memory encoding and behavioral planning. Disrupted SWRs may indicate neural network dysfunction and offer insights into cognitive impairment in early-stage Alzheimer's disease (AD) and temporal lobe epilepsy (TLE). SWRs are believed to reflect rapid network interactions among neurons and may play a role in memory consolidation.
FRONTIERS IN AGING NEUROSCIENCE
(2021)
Article
Multidisciplinary Sciences
Po-Wei Cheng, Tzi-Dar Chiueh, Jyh-Horng Chen
Summary: The proposed Coherent Wideband method can enhance neuro-architecture studies by separating multiple excited slices, and is applicable to any existing MRI instrument, even those without array coils. This method also improves scan efficiency and image quality, providing faster, higher resolution, thinner slice, or higher SNR imaging for precision neuro-architecture studies.
SCIENTIFIC REPORTS
(2021)
Article
Psychology, Clinical
Corinne Pettigrew, Rostislav Brichko, Betty Black, Maureen K. O'Connor, Mary Guerriero Austrom, Maisha T. Robinson, Allison Lindauer, Raj C. Shah, Guerry M. Peavy, Kayla Meyer, Frederick A. Schmitt, Jennifer H. Lingler, Kimiko Domoto-Reilly, Dorothy Farrar-Edwards, Marilyn Albert
INTERNATIONAL PSYCHOGERIATRICS
(2020)
Article
Peripheral Vascular Disease
Enayet K. Chowdhury, Mark R. Nelson, Michael E. Ernst, Karen L. Margolis, Lawrence J. Beilin, Colin I. Johnston, Robyn L. Woods, Anne M. Murray, Rory Wolfe, Elsdon Storey, Raj C. Shah, Jessica E. Lockery, Andrew M. Tonkin, Anne B. Newman, Jeff D. Williamson, Walter P. Abhayaratna, Nigel P. Stocks, Sharyn M. Fitzgerald, Suzanne G. Orchard, Ruth E. Trevaks, Geoffrey A. Donnan, Richard Grimm, John J. McNeil, Christopher M. Reid
AMERICAN JOURNAL OF HYPERTENSION
(2020)
Article
Psychology, Clinical
Joanne Ryan, Robyn L. Woods, Anne M. Murray, Raj C. Shah, Carlene J. Britt, Christopher M. Reid, Rory Wolfe, Mark R. Nelson, Jessica E. Lockery, Suzanne G. Orchard, Ruth E. Trevaks, Trevor J. Chong, John J. McNeil, Elsdon Storey
Summary: The study aimed to provide normative performance data on the HVLT-R for community-dwelling older individuals in Australia and the United States, based on ethno-racial group, age, gender, and education level. Results showed that performance on the HVLT-R differed by demographic variables, with female gender, younger age, and higher education associated with better cognitive performance in this population.
CLINICAL NEUROPSYCHOLOGIST
(2021)
Article
Multidisciplinary Sciences
Mark Pinese, Paul Lacaze, Emma M. Rath, Andrew Stone, Marie-Jo Brion, Adam Ameur, Sini Nagpal, Clare Puttick, Shane Husson, Dmitry Degrave, Tina Navin Cristina, Vivian F. S. Kahl, Aaron L. Statham, Robyn L. Woods, John J. McNeil, Moeen Riaz, Margo Barr, Mark R. Nelson, Christopher M. Reid, Anne M. Murray, Raj C. Shah, Rory Wolfe, Joshua R. Atkins, Chantel Fitzsimmons, Heath M. Cairns, Melissa J. Green, Vaughan J. Carr, Mark J. Cowley, Hilda A. Pickett, Paul A. James, Joseph E. Powell, Warren Kaplan, Greg Gibson, Ulf Gyllensten, Murray J. Cairns, Martin McNamara, Marcel E. Dinger, David M. Thomas
NATURE COMMUNICATIONS
(2020)
Editorial Material
Medicine, General & Internal
Raj C. Shah, David A. Bennett
ANNALS OF INTERNAL MEDICINE
(2020)
Article
Oncology
John J. McNeil, Peter Gibbs, Suzanne G. Orchard, Jessica E. Lockery, Wendy B. Bernstein, Yin Cao, Leslie Ford, Andrew Haydon, Brenda Kirpach, Finlay Macrae, Catriona McLean, Jeremy Millar, Anne M. Murray, Mark R. Nelson, Galina Polekhina, Christopher M. Reid, Ellen Richmond, Luz Maria Rodriguez, Raj C. Shah, Jeanne Tie, Asad Umar, G. J. van Londen, Kathlyn Ronaldson, Rory Wolfe, Robyn L. Woods, John Zalcberg, Andrew T. Chan
Summary: The study found that long-term use of low-dose aspirin in older adults may increase the risk of cancer metastasis and late-stage diagnosis, leading to higher mortality rates in cancer patients.
JNCI-JOURNAL OF THE NATIONAL CANCER INSTITUTE
(2021)
Article
Public, Environmental & Occupational Health
J. Bishop-Royse, B. Lange-Maia, L. Murray, R. C. Shah, F. DeMaio
Summary: The study examined the relationship between IMRs and structural racism and socio-economic marginalization in Chicago, showing a significant association between ICE measures and community-level IMRs. Neighbourhoods with higher concentrations of Black residents compared to White residents had significantly higher IMRs, indicating the impact of structural racism on health outcomes.
Article
Biochemistry & Molecular Biology
Michael Berk, Bruno Agustini, Robyn L. Woods, Mark R. Nelson, Raj C. Shah, Christopher M. Reid, Elsdon Storey, Sharyn M. Fitzgerald, Jessica E. Lockery, Rory Wolfe, Mohammadreza Mohebbi, Seetal Dodd, Anne M. Murray, Nigel Stocks, Paul B. Fitzgerald, Catherine Mazza, John J. McNeil
Summary: The study found that aspirin did not have any long-term benefits on late-life depression in a sample of older adults over a 5-year period. On the contrary, it showed a negative impact on the course of depression in those with pre-existing depressive symptoms.
MOLECULAR PSYCHIATRY
(2021)
Article
Geriatrics & Gerontology
Xiaoping Lin, Jane Banaszak-Holl, Jing Xie, Stephanie A. Ward, Henry Brodaty, Elsdon Storey, Raj C. Shah, Anne Murray, Joanne Ryan, Suzanne G. Orchard, Sharyn M. Fitzgerald, John J. McNeil
Summary: Older adults with newly detected cognitive impairment or dementia in the ASPREE trial had a higher mortality risk compared to those without cognitive impairment. The mortality rates were similar between those meeting DSM-IV criteria for dementia and those who triggered for a dementia evaluation but did not meet the criteria. This group was more likely to die from sepsis, respiratory disease, and dementia, but less likely to die from cancer compared to the group without triggers.
JOURNAL OF THE AMERICAN GERIATRICS SOCIETY
(2021)
Article
Geriatrics & Gerontology
Jo Wrigglesworth, Nurathifah Yaacob, Phillip Ward, Robyn L. Woods, John McNeil, Elsdon Storey, Gary Egan, Anne Murray, Raj C. Shah, Sharna D. Jamadar, Ruth Trevaks, Stephanie Ward, Ian H. Harding, Joanne Ryan
Summary: In this study, the difference between brain age and chronological age (brain-PAD) was found to be negatively associated with psychomotor speed in relatively healthy older adults, but not with other cognitive functions at baseline or longitudinally. Further research into longitudinal changes in brain-PAD is needed to fully understand its relationship with cognitive function.
NEUROBIOLOGY OF AGING
(2022)
Article
Pharmacology & Pharmacy
Jonathan C. Broder, Joanne Ryan, Raj C. Shah, Jessica E. Lockery, Suzanne G. Orchard, Julia F. M. Gilmartin-Thomas, Michelle A. Fravel, Alice J. Owen, Robyn L. Woods, Rory Wolfe, Elsdon Storey, Anne M. Murray, Michael E. Ernst
Summary: The study found that anticholinergic burden is associated with cognitive decline in older adults, particularly affecting executive function and memory function.
Article
Multidisciplinary Sciences
Ana W. Capuano, Raj C. Shah, Paul Blanche, Robert S. Wilson, Lisa L. Barnes, David A. Bennett, Zoe Arvanitakis
Summary: This study aimed to develop a rapid and simple assessment tool for predicting dementia risk in older adults and validate it. The results showed that this assessment tool could effectively predict dementia risk in older adults within 3 years.
Article
Geriatrics & Gerontology
Melinda C. Power, Victoria Willens, Christina Prather, Ali Moghtaderi, Yi Chen, Kan Z. Gianattasio, Francine Grodstein, Raj C. Shah, Bryan D. James
Summary: Diagnostic delay in dementia is common in the U.S. and is driven by misconceptions, stigma, concerns about autonomy, the nature of the diagnostic process, and provider-related factors. More research is needed to understand the benefits and harms of early diagnosis.
GERONTOLOGY AND GERIATRIC MEDICINE
(2023)
Article
Cell Biology
Bruno Agustini, Mojtaba Lotfaliany, Mohammadreza Mohebbi, Robyn L. Woods, John J. McNeil, Mark R. Nelson, Raj C. Shah, Anne M. Murray, Christopher M. Reid, Andrew Tonkin, Joanne Ryan, Lana J. Williams, Malcolm P. Forbes, Michael Berk
Summary: With the progressive aging of the world's population, prolongation of a healthy lifespan in old age has become a medical research priority. The presence of depressive symptoms in later life is associated with poor health prognosis and increased mortality. Here we explore distinct trajectories of depressive symptoms in later life and their association with several health-related outcomes in 19,110 older individuals followed for a median of 4.7 years. Membership of any group with depressive symptoms was associated with a higher likelihood of health events, including physical disability, cancer, and major bleeding episodes. The course of depressive symptoms in older individuals can vary widely and depend on several factors. The presence of depressive symptoms, including those that do not meet criteria for major depression, can flag a poor prognosis and risk for specific health conditions. Systematic assessment of depressive symptoms may facilitate early identification of at-risk populations.
Article
Gerontology
Fayron Epps, Glenna Brewster, Judy S. Phillips, Rachel Nash, Raj C. Shah, Kenneth Hepburn
Summary: The Handshake Protocol successfully increased the enrollment rate of minority participants through warm handoffs. Within the first month of implementation, the team achieved a 97% efficiency in meeting its goals, showcasing the success of this innovative approach.
JOURNAL OF APPLIED GERONTOLOGY
(2022)
Article
Geriatrics & Gerontology
Sarah N. Kraeutner, Cristina Rubino, Jennifer K. Ferris, Shie Rinat, Lauren Penko, Larissa Chiu, Brian Greeley, Christina B. Jones, Beverley C. Larssen, Lara A. Boyd
Summary: This study examined the age-related changes in brain function and baseline brain structure that support motor skill acquisition. The findings showed that older adults experienced decreases in functional connectivity during motor skill acquisition, while younger adults experienced increases. Additionally, regardless of age group, lower baseline microstructure in a frontoparietal tract was associated with slower motor skill acquisition.
NEUROBIOLOGY OF AGING
(2024)
Article
Geriatrics & Gerontology
Karen Nuytemans, Farid Rajabli, Melissa Jean-Francois, Jiji Thulaseedhara Kurup, Larry D. Adams, Takiyah D. Starks, Patrice L. Whitehead, Brian W. Kunkle, Allison Caban-Holt, Jonathan L. Haines, Michael L. Cuccaro, Jeffery M. Vance, Goldie S. Byrd, Gary W. Beecham, Christiane Reitz, Margaret A. Pericak-Vance
Summary: This study conducted genetic research on African American AD families and identified a significant linkage signal associated with AD, highlighting the importance of diverse population-level genetic data in understanding the genetic determinants of AD.
NEUROBIOLOGY OF AGING
(2024)
Article
Geriatrics & Gerontology
Kazuya Suwabe, Ryuta Kuwamizu, Kazuki Hyodo, Toru Yoshikawa, Takeshi Otsuki, Asako Zempo-Miyaki, Michael A. Yassa, Hideaki Soya
Summary: Physical exercise has a positive impact on hippocampal memory decline with aging. Recent studies have shown that even light exercise can improve memory and this improvement is mediated by the ascending arousal system. This study aimed to investigate the effects of light-intensity exercise on hippocampal memory function in healthy older adults and found that pupil dilation during exercise played a role in the memory improvement.
NEUROBIOLOGY OF AGING
(2024)
Article
Geriatrics & Gerontology
Ajay Sood, Ana Werneck Capuano, Robert Smith Wilson, Lisa Laverne Barnes, Alifiya Kapasi, David Alan Bennett, Zoe Arvanitakis
Summary: The objective of this study was to explore the impact of metformin on cognition and brain pathology. The results showed that metformin users had slower decline in global cognition, episodic memory, and semantic memory compared to non-users. However, the relationship between metformin use and certain brain pathology remains uncertain.
NEUROBIOLOGY OF AGING
(2024)
Article
Geriatrics & Gerontology
Brian N. Lee, Junwen Wang, Molly A. Hall, Dokyoon Kim, Shana D. Stites, Li Shen
Summary: Alzheimer's disease (AD) is a neurodegenerative disorder characterized by memory and functional impairments. This study analyzed participants from the Alzheimer's Disease Neuroimaging Initiative and found differential associations between cerebral spinal fluid (CSF)/neuroimaging biomarkers and cognitive/functional outcomes, as well as variations between sexes. These findings suggest that sex differences may play a role in the development of AD.
NEUROBIOLOGY OF AGING
(2024)
Article
Geriatrics & Gerontology
Madeline R. Hale, Rebecca Langhough, Lianlian Du, Bruce P. Hermann, Carol A. Van Hulle, Margherita Carboni, Gwendlyn Kollmorgenj, Kristin E. Basche, Davide Bruno, Leah Sanson-Miles, Erin M. Jonaitis, Nathaniel A. Chin, Ozioma C. Okonkwo, Barbara B. Bendlin, Cynthia M. Carlsson, Henrik Zetterberg, Kaj Blennow, Tobey J. Betthauser, Sterling C. Johnson, Kimberly D. Mueller
Summary: This study demonstrates a relationship between cerebrospinal fluid biomarkers and the ability to recall proper names in the preclinical phase of Alzheimer's disease.
NEUROBIOLOGY OF AGING
(2024)
Article
Geriatrics & Gerontology
Thomas T. Austin, Christian L. Thomas, Ben Warren
Summary: This study investigated the effects of age on the robustness and resilience of auditory system using the desert locust. The researchers found that gene expression changes were mainly influenced by age rather than noise exposure. Both young and aged locusts were able to recover their auditory nerve function within 48 hours of noise exposure, but the recovery of transduction current magnitude was impaired in aged locusts. Key genes responsible for robustness to noise exposure in young locusts and potential candidates for compensatory mechanisms in auditory neurons of aged locusts were identified.
NEUROBIOLOGY OF AGING
(2024)