Article
Neurosciences
J. M. Wilcox, D. C. Consoli, A. A. Tienda, S. Dixit, R. A. Buchanan, J. M. May, W. P. Nobis, F. E. Harrison
Summary: Repeated low-dose kainic acid treatment triggered non-convulsive epileptiform activity in APP/PSEN1 mice, leading to memory impairment and hippocampal long-term potentiation deficits. The high excitability in Alzheimer's disease may contribute to cognitive decline independently of beta-amyloid-plaque load, especially in younger mice without plaques.
NEUROBIOLOGY OF DISEASE
(2021)
Article
Clinical Neurology
Fran C. van Heusden, Anne M. van Nifterick, Bryan C. Souza, Arthur S. C. Franca, Ilse M. Nauta, Cornelis J. Stam, Philip Scheltens, August B. Smit, Alida A. Gouw, Ronald E. van Kesteren
Summary: Studies in mice and humans carrying APP and/or PSEN1 mutations show abnormal neurophysiological activity, but certain measures do not translate directly between species.
ALZHEIMERS RESEARCH & THERAPY
(2023)
Article
Neurosciences
Xuewen Xiao, Hui Liu, Lu Zhou, Xixi Liu, Tianyan Xu, Yuan Zhu, Qijie Yang, Xiaoli Hao, Yingzi Liu, Weiwei Zhang, Yafang Zhou, Junling Wang, Jinchen Li, Bin Jiao, Lu Shen, Xinxin Liao
Summary: This study suggests that non-pathogenic variants in PSEN2 and APP may be involved in the pathogenesis of AD in the Chinese population.
CNS NEUROSCIENCE & THERAPEUTICS
(2023)
Article
Biochemistry & Molecular Biology
David C. Consoli, Lillian J. Brady, Aaron B. Bowman, Erin S. Calipari, Fiona E. Harrison
Summary: Research has shown that both ASC deficiency and AD pathology independently decrease dopamine release in the nucleus accumbens, a key area for motivation and reward behavior. Low ASC levels and APP/PSEN1 genotype contribute to decreased enzyme activity, resulting in deficits in dopaminergic neurotransmission. These findings suggest that low ASC levels may exacerbate the effects of age and disease on dopamine availability and synaptic transmission, potentially leading to behavioral changes seen in AD patients such as decreased motivation, anhedonia, and sleep disorders.
JOURNAL OF NEUROCHEMISTRY
(2021)
Article
Geriatrics & Gerontology
Xuewen Xiao, Hui Liu, Xixi Liu, Weiwei Zhang, Sizhe Zhang, Bin Jiao
Summary: The study systematically re-evaluated APP, PSEN1, and PSEN2 variants, showing that PSEN1 carried the most prevalent pathogenic/likely pathogenic variants, emphasizing the importance of interpreting these variants with caution according to ACMG-AMP guidelines.
FRONTIERS IN AGING NEUROSCIENCE
(2021)
Article
Clinical Neurology
Ove Almkvist, Charlotte Johansson, Jose Laffita-Mesa, Steinunn Thordardottir, Caroline Graff
Summary: The study aimed to investigate the effect of the APOE ε4 allele on cognitive decline in adAD. The presence of the APOE ε4 allele was found to have a positive influence on cognitive decline in APP mutation carriers and a negative influence in PSEN1 mutation carriers with adAD.
EUROPEAN JOURNAL OF NEUROLOGY
(2022)
Article
Chemistry, Multidisciplinary
Xue Wang, Yu-ting Zhu, Yi Zhu, Yan-ling Sun, Jun Huang, Zhe Li, Yan Wang, Jun-chao Wu, Zheng-hong Qin, Fang Lin
Summary: This study demonstrates that long-term running exercise can significantly alleviate cognitive dysfunction in AD mice by enhancing lysosomal function and promoting the clearance of A beta in the brain. Exercise promotes the nuclear translocation of TFEB and increases the interaction between nuclear TFEB and AMPK-mediated acetyl-CoA synthetase 2, enhancing the transcription of genes associated with lysosomal biogenesis. It also leads to increased levels of mature cathepsin D and cathepsin L, suggesting enhanced degradation of A beta peptides in activated lysosomes.
ACTA PHARMACOLOGICA SINICA
(2022)
Article
Genetics & Heredity
Ove Almkvist, Caroline Graff
Summary: The study found that gene-gene interactions between APOE and APP/PSEN1 genes have significant effects on cognition in autosomal-dominant Alzheimer's disease patients, especially on memory function. Epistasis between APOE and the APP vs. PSEN1 genes differentiated cognitive effects in mutation carriers, indicating distinct impacts on cognitive performance.
Article
Biochemistry & Molecular Biology
Kyu Hwan Shim, Sangjoon Kang, Seong Soo A. An, Min Ju Kang
Summary: A PSEN1 gene mutation was discovered in a Korean patient with early-onset AD, suggesting its association with AD pathogenesis and the need for routine screening in this population. The mutated amino acid may destabilize gamma-secretase. In the future, a gene panel incorporating the APOE4 gene may predict AD onset and facilitate personalized treatment.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Geriatrics & Gerontology
Qi Qin, Liping Fu, Ruimin Wang, Jihui Lyu, Huixuan Ma, Minmin Zhan, Aihong Zhou, Fen Wang, Xiumei Zuo, Cuibai Wei
Summary: This study found that amyloid distribution in patients with EOFAD differs from late-onset sporadic AD, with higher deposits in the striatum. However, the degree and pattern of amyloid deposition were not correlated with cognitive deficits. Positive correlations in C-11-PiB retention between the striatum and other cortical areas were also demonstrated.
FRONTIERS IN AGING NEUROSCIENCE
(2021)
Review
Biochemistry & Molecular Biology
Jaya Bagaria, Eva Bagyinszky, Seong Soo A. An
Summary: PSEN1 plays a crucial role in early onset Alzheimer's disease, affecting various processes beyond amyloid precursor protein cleavage. Numerous mutations have been identified in PSEN1, leading to diverse clinical phenotypes. The pathogenic nature of these mutations can be categorized according to guidelines, though some remain unclassified due to their rarity and potential involvement of genetic modifiers.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Neurosciences
Sandra Schilling, Ajay Pradhan, Amelie Heesch, Andrea Helbig, Kaj Blennow, Christian Koch, Lea Bertgen, Edward H. Koo, Gunnar Brinkmalm, Henrik Zetterberg, Stefan Kins, Simone Eggert
Summary: This study compares the effects of different APP genetic mutations on their processing and pathogenic mechanisms in Alzheimer's disease. The results show significant differences in the underlying mechanisms for familial AD mutations located at the alpha-, beta-, and gamma-secretase cleavage sites. Different mutations have different effects on APP processing and the generation of A β peptides.
ACTA NEUROPATHOLOGICA COMMUNICATIONS
(2023)
Article
Clinical Neurology
Meredith M. Course, Kathryn Gudsnuk, C. Dirk Keene, Thomas D. Bird, Suman Jayadev, Paul N. Valdmanis
Summary: Course et al. performed targeted long-read isoform-sequencing of PSEN1 and PSEN2 in individuals with sporadic Alzheimer's disease, familial Alzheimer's disease with PSEN1 and PSEN2 pathogenic variants, and controls. The study revealed unique aberrant splicing of PSEN2 in sporadic Alzheimer's disease, expanding our understanding of PSEN1 and PSEN2 variants in Alzheimer's disease and suggesting novel mechanisms of Alzheimer's disease pathogenesis.
Article
Neurosciences
Sanaz Arezoumandan, Xuezhu Cai, Praveen Kalkarni, Stephani A. Davis, Katherine Wilson, Craig F. Ferris, Nigel J. Cairns, Michael A. Gitcho
Summary: This study found that loss of functional coupling in the hippocampus and amygdala in a mouse model with TDP-43 proteinopathy in the background of APP/PSEN1 led to severe neuronal loss, accompanied by increased beta-amyloid plaques and sparse phosphorylated TDP-43 pathology.
NEUROSCIENCE LETTERS
(2021)
Review
Biochemistry & Molecular Biology
Jose J. M. Vitoria, Diogo Trigo, Odete A. B. da Cruz e Silva
Summary: Alzheimer's disease is the leading cause of dementia worldwide, characterized by the accumulation of beta-amyloid peptide in the brain. This review focuses on the effects of isoform-specific RAR modulation on APP secretases and discusses its advantages and drawbacks in subcellular AD related events.
CELLULAR AND MOLECULAR LIFE SCIENCES
(2022)
Article
Psychology, Clinical
Michelle A. Babicz, Steven Paul Woods, Anastasia Matchanova, Luis D. Medina, Kenneth Podell, Rheeda L. Walker, Adam Fetterman, Samina Rahman, Briana Johnson, Jennifer L. Thompson, Kelli L. Sullivan, Ilex Beltran-Najera, Jasmin Brooks, Yenifer Morales, Gunes Avci
Summary: The study showed that neurocognition was related to COVID-19 knowledge, while health literacy was associated with various aspects of COVID-19 health information. There was no interaction between neurocognition and health literacy in the COVID-19 health domain.
JOURNAL OF CLINICAL AND EXPERIMENTAL NEUROPSYCHOLOGY
(2021)
Article
Public, Environmental & Occupational Health
Anastasia Matchanova, David P. Sheppard, Luis D. Medina, Erin E. Morgan, Steven Paul Woods
Summary: This study examines the relationship between educational attainment and online pharmacy skills in older persons with HIV disease, and finds that health literacy plays a mediating role in this relationship. Education has a significant indirect effect on online pharmacy accuracy and medication management ability through health literacy, but has no direct or indirect effect on online pharmacy speed.
PSYCHOLOGY & HEALTH
(2023)
Article
Clinical Neurology
Joshua M. Garcia, Matthew W. Gallagher, Sid E. O'Bryant, Luis D. Medina
Summary: The study conducted DIF analysis on the BAI in a sample from rural communities in West Texas, USA, revealing significant bias in 10 out of 21 items. Although no adverse impact was found when demographics were assessed individually, only one participant was identified with adverse DIF when all demographics were aggregated.
JOURNAL OF AFFECTIVE DISORDERS
(2021)
Review
Clinical Neurology
Andrea Ochoa Lopez, Michelle N. Martinez, Joshua M. Garcia, Mark E. Kunik, Luis D. Medina
Summary: The available self-report depression screening measures are considered to have acceptable applicability among older Hispanic/Latin American individuals, but their utility may vary depending on the intended use, as different populations and settings may influence their effectiveness. Modifying cutoff scores for these measures could potentially maximize their utility when given to diverse older adults.
JOURNAL OF AFFECTIVE DISORDERS
(2021)
Article
Neurosciences
Jennifer L. Thompson, Steven Paul Woods, Luis D. Medina, Troy A. Webber
Summary: Older age and HIV disease are independent risk factors for problems in everyday functioning. This study examined the combined effects of age and HIV serostatus on changes in everyday functioning and its associations with changes in neurocognition over a 1-year period. The results showed that older individuals with HIV reported the poorest everyday functioning, which remained stable over time, while younger individuals with HIV showed mild improvements. The study also found that problems with everyday functioning may precede declines in neurocognition. Further research is needed to understand the long-term trajectory of neurocognitive and functional changes in older individuals with HIV.
JOURNAL OF NEUROVIROLOGY
(2022)
Article
Immunology
A. Martinez-Hernandez, E. E. Perez-Guerrero, M. A. Macias-Islas, C. A. Nava-Valdivia, A. Villagomez-Vega, B. Contreras-Haro, Y. E. Garcia-Ortega, Y. Esparza-Guerrero, S. G. Gallardo-Moya, J. I. Gamez-Nava, L. Gonzalez-Lopez, E. Oliva-Flores, N. A. Rodriguez-Jimenez, F. Cortes-Enriquez, A. M. Saldana-Cruz
Summary: This study found that lower serum 25(OH) vitamin D levels were observed in MS patients compared to controls. The A allele frequency of CYP2R1 gene rs10766197 was significantly higher in MS patients, but these polymorphisms were not associated with the severity of disease progression in MS.
JOURNAL OF IMMUNOLOGY RESEARCH
(2021)
Review
Clinical Neurology
Yakeel T. Quiroz, Michele Solis, Maria P. Aranda, Alicia I. Arbaje, Mirna Arroyo-Miranda, Laura Y. Cabrera, Minerva Maria Carrasquillo, Maria M. Corrada, Lucia Crivelli, Erica D. Diminich, Karen A. Dorsman, Mitzi Gonzales, Hector M. Gonzalez, Ana L. Gonzalez-Seda, Lea T. Grinberg, Lourdes R. Guerrero, Carl V. Hill, Ivonne Z. Jimenez-Velazquez, Jorge J. Llibre Guerra, Francisco Lopera, Gladys Maestre, Luis D. Medina, Sid O'Bryant, Claudia Penaloza, Maria Mora Pinzon, Rosa V. Pirela Mavarez, Celina F. Pluim, Rema Raman, Katya Rascovsky, Dorene M. Rentz, Yarissa Reyes, Monica Rosselli, Malu Gamez Tansey, Clara Vila-Castelar, Megan Zuelsdorff, Maria Carrillo, Claire Sexton
Summary: The Alzheimer's Association hosted the second Latinos & Alzheimer's Symposium, highlighting the research advancements and issues concerning Alzheimer's disease in the Latino population. Latinos are projected to have a higher risk of Alzheimer's disease in the next 40 years, and they are currently underrepresented in clinical research.
ALZHEIMERS & DEMENTIA
(2022)
Article
Neurosciences
Isabelle Buard, Natalie Lopez-Esquibel, Finnuella J. Carey, Mark S. Brown, Luis D. Medina, Eugene Kronberg, Christine S. Martin, Sarah Rogers, Samantha K. Holden, Michael R. Greher, Benzi M. Kluger
Summary: Cognitive impairment in Parkinson's disease (PD) could be related to fluctuations in prefrontal glutamate metabolism. These preliminary findings suggest that prefrontal glutamate may serve as a biomarker for the progression of cognitive impairments in PD.
FRONTIERS IN HUMAN NEUROSCIENCE
(2022)
Article
Clinical Neurology
Edgar R. Valdivia-Tangarife, Jorge Gamez-Nava, Fernando Cortes-Enriquez, Mario A. Mireles-Ramirez, Laura Gonzalez-Lopez, Ana M. Saldana-Cruz, Miguel Angel Macias-Islas
Summary: This study assessed the risk factors associated with permanent disability (PD) in patients with neuromyelitis optica spectrum disorders (NMOSD). The results showed that age, delay in diagnosis, and severe relapses during disease evolution were the strongest risk factors for PD.
MULTIPLE SCLEROSIS AND RELATED DISORDERS
(2022)
Article
Biochemistry & Molecular Biology
Gabriela del Carmen Lopez-Armas, Martha Eloisa Ramos-Marquez, Monica Navarro-Meza, Miguel Angel Macias-Islas, Ana Miriam Saldana-Cruz, Abraham Zepeda-Moreno, Fernando Siller-Lopez, Jose Alfonso Cruz-Ramos
Summary: This study evaluated the peripheral blood leukocyte telomere length (LTL) and mitochondrial DNA copy number (mtDNA-CN) in patients with relapsing-remitting multiple sclerosis (RRMS). The results showed a linear correlation between LTL and mtDNA-CN in mild-moderate disability RRMS patients. Moreover, LTL can predict the severity of disability in RRMS patients, and the prediction accuracy can be improved by combining LTL with age.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Psychology, Developmental
Savanna M. Tierney, Victoria M. Kordovski, Samina Rahman, Luis D. Medina, Rodica I. Damian, Robert L. Collins, Steven Paul Woods
Summary: This study examined the differences between older and younger adults in terms of internet use and online transit planning. The results showed that older adults experience difficulties in efficiently using transit websites and this difficulty is associated with poorer cognitive functions, particularly in memory.
AGING NEUROPSYCHOLOGY AND COGNITION
(2022)
Article
Psychology, Clinical
Anastasia Matchanova, Michelle A. Babicz, Luis D. Medina, Samina Rahman, Briana Johnson, Jennifer L. Thompson, Ilex Beltran-Najera, Jasmin Brooks, Kelli L. Sullivan, Rheeda L. Walker, Kenneth Podell, Steven Paul Woods
Summary: This study examined the factor structure and sociodemographic correlates of a battery of clinical neuropsychological tests administered in-home and via telephone. The results showed that a three-factor model comprised of executive functions, memory, and attention demonstrated the best fit to the data. Factor scores were variably associated with education, race/ethnicity, and IQ, but not with sex or age.
ARCHIVES OF CLINICAL NEUROPSYCHOLOGY
(2021)
Review
Clinical Neurology
Luis D. Medina, Stephanie Torres, Anthony Gioia, Andrea Ochoa Lopez, James Wang, Paul T. Cirino
Summary: The reporting of demographic data in neuropsychological research is slowly improving, with key variables such as age, gender, and education being frequently reported. However, there are still deficiencies in reporting language, race/ethnicity, and socioeconomic status.
JOURNAL OF THE INTERNATIONAL NEUROPSYCHOLOGICAL SOCIETY
(2021)
Article
Psychology, Clinical
Anastasia Matchanova, Steven Paul Woods, Clint Cushman, Erin E. Morgan, Luis D. Medina, Michelle A. Babicz, Marizela Verduzco, Shayne Loft
Summary: The study investigated the relationship between prospective memory and online pharmacy navigation skills in persons with HIV disease. Results showed that lower prospective memory was moderately associated with poorer medication management and online pharmacy accuracy, independent of other neurocognitive functions. The association between prospective memory and online pharmacy accuracy was driven by omission errors and was not significantly affected by whether the intention was cued by time or event.
CLINICAL NEUROPSYCHOLOGIST
(2021)
Article
Public, Environmental & Occupational Health
Anastasia Matchanova, Michelle Babicz, Luis D. Medina, Pariya L. Fazeli, David E. Vance, Steven Paul Woods
Summary: The study found that health literacy in PLWH is lower compared to seronegatives, and is independently associated with health management and decision-making abilities.
PSYCHOLOGY & HEALTH
(2021)
Article
Geriatrics & Gerontology
Sarah N. Kraeutner, Cristina Rubino, Jennifer K. Ferris, Shie Rinat, Lauren Penko, Larissa Chiu, Brian Greeley, Christina B. Jones, Beverley C. Larssen, Lara A. Boyd
Summary: This study examined the age-related changes in brain function and baseline brain structure that support motor skill acquisition. The findings showed that older adults experienced decreases in functional connectivity during motor skill acquisition, while younger adults experienced increases. Additionally, regardless of age group, lower baseline microstructure in a frontoparietal tract was associated with slower motor skill acquisition.
NEUROBIOLOGY OF AGING
(2024)
Article
Geriatrics & Gerontology
Karen Nuytemans, Farid Rajabli, Melissa Jean-Francois, Jiji Thulaseedhara Kurup, Larry D. Adams, Takiyah D. Starks, Patrice L. Whitehead, Brian W. Kunkle, Allison Caban-Holt, Jonathan L. Haines, Michael L. Cuccaro, Jeffery M. Vance, Goldie S. Byrd, Gary W. Beecham, Christiane Reitz, Margaret A. Pericak-Vance
Summary: This study conducted genetic research on African American AD families and identified a significant linkage signal associated with AD, highlighting the importance of diverse population-level genetic data in understanding the genetic determinants of AD.
NEUROBIOLOGY OF AGING
(2024)
Article
Geriatrics & Gerontology
Kazuya Suwabe, Ryuta Kuwamizu, Kazuki Hyodo, Toru Yoshikawa, Takeshi Otsuki, Asako Zempo-Miyaki, Michael A. Yassa, Hideaki Soya
Summary: Physical exercise has a positive impact on hippocampal memory decline with aging. Recent studies have shown that even light exercise can improve memory and this improvement is mediated by the ascending arousal system. This study aimed to investigate the effects of light-intensity exercise on hippocampal memory function in healthy older adults and found that pupil dilation during exercise played a role in the memory improvement.
NEUROBIOLOGY OF AGING
(2024)
Article
Geriatrics & Gerontology
Ajay Sood, Ana Werneck Capuano, Robert Smith Wilson, Lisa Laverne Barnes, Alifiya Kapasi, David Alan Bennett, Zoe Arvanitakis
Summary: The objective of this study was to explore the impact of metformin on cognition and brain pathology. The results showed that metformin users had slower decline in global cognition, episodic memory, and semantic memory compared to non-users. However, the relationship between metformin use and certain brain pathology remains uncertain.
NEUROBIOLOGY OF AGING
(2024)
Article
Geriatrics & Gerontology
Brian N. Lee, Junwen Wang, Molly A. Hall, Dokyoon Kim, Shana D. Stites, Li Shen
Summary: Alzheimer's disease (AD) is a neurodegenerative disorder characterized by memory and functional impairments. This study analyzed participants from the Alzheimer's Disease Neuroimaging Initiative and found differential associations between cerebral spinal fluid (CSF)/neuroimaging biomarkers and cognitive/functional outcomes, as well as variations between sexes. These findings suggest that sex differences may play a role in the development of AD.
NEUROBIOLOGY OF AGING
(2024)
Article
Geriatrics & Gerontology
Madeline R. Hale, Rebecca Langhough, Lianlian Du, Bruce P. Hermann, Carol A. Van Hulle, Margherita Carboni, Gwendlyn Kollmorgenj, Kristin E. Basche, Davide Bruno, Leah Sanson-Miles, Erin M. Jonaitis, Nathaniel A. Chin, Ozioma C. Okonkwo, Barbara B. Bendlin, Cynthia M. Carlsson, Henrik Zetterberg, Kaj Blennow, Tobey J. Betthauser, Sterling C. Johnson, Kimberly D. Mueller
Summary: This study demonstrates a relationship between cerebrospinal fluid biomarkers and the ability to recall proper names in the preclinical phase of Alzheimer's disease.
NEUROBIOLOGY OF AGING
(2024)
Article
Geriatrics & Gerontology
Thomas T. Austin, Christian L. Thomas, Ben Warren
Summary: This study investigated the effects of age on the robustness and resilience of auditory system using the desert locust. The researchers found that gene expression changes were mainly influenced by age rather than noise exposure. Both young and aged locusts were able to recover their auditory nerve function within 48 hours of noise exposure, but the recovery of transduction current magnitude was impaired in aged locusts. Key genes responsible for robustness to noise exposure in young locusts and potential candidates for compensatory mechanisms in auditory neurons of aged locusts were identified.
NEUROBIOLOGY OF AGING
(2024)