Article
Neurosciences
Ji Hee Kim, Jae Keun Oh, Jee Hye Wee, Chan Yang Min, Dae Myoung Yoo, Hyo Geun Choi
Summary: This study suggests that anemia may increase the risk of Parkinson's disease, especially in men younger than 70 years. Further research is needed to elucidate the causal relationship between these two diseases.
Article
Biochemistry & Molecular Biology
Matthew K. Boag, Linlin Ma, George D. Mellick, Dean L. Pountney, Yunjiang Feng, Ronald J. Quinn, Alan Wee-Chung Liew, Mahendiran Dharmasivam, Mahan Gholam Azad, Rizwana Afroz, Des R. Richardson
Summary: The study focuses on the role of Ca(V)1.3 channels in calcium and iron uptake, and proposes the potential of using artificial intelligence to design novel channel inhibitors to alleviate PD pathology.
Review
Biochemistry & Molecular Biology
Roberta J. Ward, David T. Dexter, Antonio Martin-Bastida, Robert R. Crichton
Summary: This review explores the iron deposition in the brains of PD patients, the role of neuroinflammation and glia cells, and the potential therapeutic effects of iron chelators. The combination of anti-inflammatory drugs with iron chelators is proposed as a better approach to enhance chelator efficacy in treating PD patients.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Clinical Neurology
Jacob E. Simmering, Michael J. Welsh, Jordan Schultz, Nandakumar S. Narayanan
Summary: This study found that men using terazosin and closely related alpha 1-adrenergic receptor antagonists had a lower risk of developing Parkinson's disease compared to those using tamsulosin or 5 alpha-reductase inhibitors.
MOVEMENT DISORDERS
(2022)
Article
Clinical Neurology
Shige Qi, Peng Yin, Linhong Wang, Ming Qu, Ge Lin Kan, Han Zhang, Qingjun Zhang, Yize Xiao, Ying Deng, Zhong Dong, Yan Shi, Jun Meng, Piu Chan, Zhihui Wang
Summary: A nationwide study in 2015 found that the prevalence of Parkinson's disease in Chinese individuals aged 60 years or older was 1.37%, with an estimated total of 3.62 million people in China living with PD. Although the percentage of PD prevalence did not change significantly, the increasing population has led to a rise in the total number of PD patients, posing a significant challenge in a rapidly aging population.
MOVEMENT DISORDERS
(2021)
Article
Biochemistry & Molecular Biology
Jannik Prasuhn, Martin Goettlich, Friederike Gerkan, Sofia Kourou, Britt Ebeling, Meike Kasten, Henrike Hanssen, Christine Klein, Norbert Brueggemann
Summary: This study aimed to investigate the relationship between subcortical brain iron deposition and bioenergetic status in patients with idiopathic Parkinson's disease. The results showed that subcortical brain iron deposition could predict mitochondrial dysfunction. These findings provide an opportunity to improve mitochondrial bioenergetics in patients with idiopathic Parkinson's disease through the use of chelating therapies.
MOLECULAR MEDICINE
(2022)
Article
Medicine, General & Internal
Svetlana Bivol, George D. Mellick, Jacob Gratten, Richard Parker, Aoibhe Mulcahy, Philip E. Mosley, Peter C. Poortvliet, Adrian Campos, Brittany L. Mitchell, Luis M. Garcia-Marin, Simone Cross, Mary Ferguson, Penelope A. Lind, Danuta Z. Loesch, Peter M. Visscher, Sarah E. Medland, Clemens R. Scherzer, Nicholas G. Martin, Miguel E. Renteria
Summary: The Australian Parkinson's Genetics Study aims to understand the sociodemographic, genetic, and environmental basis of Parkinson's disease (PD) susceptibility, symptoms, and progression by studying genetic and patient-reported data from a large cohort of PD patients in Australia. The study has recruited 1819 participants, mostly men of European descent, with a significant proportion reporting a previous traumatic brain injury. The most commonly reported comorbid conditions include constipation, depression, anxiety, melanoma, and diabetes. Future plans include recruiting unaffected controls, conducting genetic analysis, and collecting additional data on non-motor symptoms and cognitive function.
Article
Medicine, General & Internal
A. E. Lang, A. D. Siderowf, E. A. Macklin, W. Poewe, D. J. Brooks, H. H. Fernandez, O. Rascol, N. Giladi, F. Stocchi, C. M. Tanner, R. B. Postuma, D. K. Simon, E. Tolosa, B. Mollenhauer, J. M. Cedarbaum, K. Fraser, J. Xiao, K. C. Evans, D. L. Graham, I Sapir, J. Inra, R. M. Hutchison, M. Yang, T. Fox, S. Budd Haeberlein, T. Dam
Summary: In participants with early Parkinson's disease, the effects of cinpanemab on clinical measures of disease progression and changes in DaT-SPECT imaging did not differ from those of placebo over a 52-week period.
NEW ENGLAND JOURNAL OF MEDICINE
(2022)
Article
Clinical Neurology
Ioanna Markaki, Theodora Ntetsika, Kimmo Sorjonen, Per Svenningsson
Summary: This study found that both low and high levels of HbA1c may be associated with motor symptom progression in Parkinson's disease patients, while diabetes mellitus was not an independent predictor of unfavorable motor outcome. Further studies are needed to confirm these findings and enhance understanding of causality.
MOVEMENT DISORDERS
(2021)
Article
Geriatrics & Gerontology
Jinghui Xu, Chi Xiao, Weizheng Song, Xiangqin Cui, Mengqiu Pan, Qun Wang, Yanqiu Feng, Yunqi Xu
Summary: This study found that in Parkinson's disease (PD) patients, there is a significant elevation of serum HO-1 concentration, increase in brain iron deposition, and decrease in HGB level. The levels of serum HO-1 showed a positive correlation with iron deposition and a negative correlation with HGB levels in PD patients. This study also observed similar findings in a PD mouse model, indicating that HO-1 may play a role in the mechanism of iron deposition and anemia in PD.
FRONTIERS IN AGING NEUROSCIENCE
(2021)
Article
Clinical Neurology
Emma Biondetti, Mathieu D. Santin, Romain Valabregue, Graziella Mangone, Rahul Gaurav, Nadya Pyatigorskaya, Matthew Hutchison, Lydia Yahia-Cherif, Nicolas Villain, Marie-Odile Habert, Isabelle Arnulf, Smaranda Leu-Semenescu, Pauline Dodet, Miquel Vila, Jean-Christophe Corvol, Marie Vidailhet, Stephane Lehericy
Summary: In Parkinson's disease, there is a progressive reduction in striatal dopaminergic function, loss of neuromelanin-containing dopaminergic neurons, and increased iron deposition in the substantia nigra. This study found that the temporal ordering of dopaminergic changes followed a spatial pattern of progression involving different territories of the nigrostriatal system, and revealed an interrelationship between dopaminergic dysfunction, cell loss in the substantia nigra pars compacta, and increased iron content in the substantia nigra.
Article
Biochemistry & Molecular Biology
Ana Catarina Martins, Illyane Sofia Lima, Ana Catarina Pego, Ines Sa Pereira, Gracelino Martins, Antonino Kapitao, Raffaella Gozzelino
Summary: Parkinson's disease is a neurodegenerative disorder characterized by loss of dopaminergic neurons. Aging is a major risk factor for idiopathic PD, but immunity and inflammation also play a crucial role in its pathogenesis.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Nutrition & Dietetics
Anne-Sophie Resseguier, Candy Guiguet-Auclair, Anne Debost-Legrand, Anne-Francoise Serre-Sapin, Laurent Gerbaud, Francoise Vendittelli, Marc Ruivard
Summary: This study aimed to estimate the prevalence of anemia in the third trimester of pregnancy and identify predictive parameters for anemia in the first trimester. The results showed that clinical, social, and biochemical parameters were not effective in predicting anemia in the third trimester. It was suggested to perform a simple blood count in the first trimester and offer oral iron supplementation for women with Hb < 120 g/L.
Review
Biochemistry & Molecular Biology
Ran Zheng, Yiqun Yan, Jiali Pu, Baorong Zhang
Summary: The expression of Hemoglobin (Hb) in neurons, particularly in vulnerable mesencephalic dopaminergic neurons, is linked to Parkinson's disease (PD). The levels of neuronal Hb in PD patients have shown controversial results, as they may decrease in PD patients but higher levels of Hb in elderly men increase the risk of developing PD. Alpha-synuclein, a key protein in PD pathology, directly interacts with Hb and forms complexes in erythrocytes and brains. Understanding the relationship between neuronal Hb and PD development involves investigating mitochondrial homeostasis, alpha-synuclein accumulation, iron metabolism, and hormone-regulated signaling pathways.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Microbiology
Illyane S. Lima, Ana C. Pego, Ana C. Martins, Ana R. Prada, Joao Tomas Barros, Gracelino Martins, Raffaella Gozzelino
Summary: Age-related dysbiosis can lead to sub-chronic inflammation, which primes the brain for neuroinflammation and neurodegenerative diseases. This study confirmed that the effects induced by age-related dysbiosis, rather than aging itself, increase the risk of Parkinson's disease (PD) onset. Germ-free (GF) mice were resistant to PD, but this resistance was reversed when they were colonized with stool from conventional old animals. Changes in gut microbiota composition can be targeted preventively by iron chelators to protect against neuroinflammation and the development of severe PD.
Article
Cardiac & Cardiovascular Systems
Lisa Pennells, Stephen Kaptoge, Angela Wood, Mike Sweeting, Xiaohui Zhao, Ian White, Stephen Burgess, Peter Willeit, Thomas Bolton, Karel G. M. Moons, Yvonne T. van der Schouw, Randi Selmer, Kay-Tee Khaw, Vilmundur Gudnason, Gerd Assmann, Philippe Amouyel, Veikko Salomaa, Mika Kivimaki, Borge G. Nordestgaard, Michael J. Blaha, Lewis H. Kuller, Hermann Brenner, Richard F. Gillum, Christa Meisinger, Ian Ford, Matthew W. Knuiman, Annika Rosengren, Debbie A. Lawlor, Henry Volzke, Cyrus Cooper, Alejandro Marin Ibanez, Edoardo Casiglia, Jussi Kauhanen, Jackie A. Cooper, Beatriz Rodriguez, Johan Sundstrom, Elizabeth Barrett-Connor, Rachel Dankner, Paul J. Nietert, Karina W. Davidson, Robert B. Wallace, Dan G. Blazer, Cecilia Bjorkelund, Chiara Donfrancesco, Harlan M. Krumholz, Aulikki Nissinen, Barry R. Davis, Sean Coady, Peter H. Whincup, Torben Jorgensen, Pierre Ducimetiere, Maurizio Trevisan, Gunnar Engstrom, Carlos J. Crespo, Tomw. Meade, Marjolein Visser, Daan Kromhout, Stefan Kiechl, Makoto Daimon, Jackie F. Price, Agustin Gomez de la Camara, J. Wouter Jukema, Benoit Lamarche, Altan Onat, Leon A. Simons, Maryam Kavousi, Yoav Ben-Shlomo, John Gallacher, Jacqueline M. Dekker, Hisatomi Arima, Nawar Shara, RobertW. Tipping, Ronan Roussel, Eric J. Brunner, Wolfgang Koenig, Masaru Sakurai, Jelena Pavlovic, Ron T. Gansevoort, Dorothea Nagel, Uri Goldbourt, Elizabeth L. M. Barr, Luigi Palmieri, Inger Njolstad, Shinichi Sato, W. M. Monique Verschuren, Cherian V. Varghese, Ian Graham, Oyere Onuma, Philip Greenland, Mark Woodward, Majid Ezzati, Bruce M. Psaty, Naveed Sattar, Rod Jackson, Paul M. Ridker, Nancy R. Cook, Ralph B. D'Agostino, Simon G. Thompson, John Danesh, Emanuele Di Angelantonio, Robert W. Tipping, Lara M. Simpson, Sara L. Pressel, David J. Couper, Vijay Nambi, Kunihiro Matsushita, Aaron R. Folsom, Jonathan E. Shaw, Dianna J. Magliano, Paul Z. Zimmet, Matthew W. Knuiman, Peter H. Whincup, S. Goya Wannamethee, Johann Willeit, Peter Santer, Georg Egger, Juan Pablo Casas, Antointtte Amuzu, Yoav Ben-Shlomo, John Gallacher, Valerie Tikhonoff, Edoardo Casiglia, Susan E. Sutherland, Paul J. Nietert, Mary Cushman, Bruce M. Psaty, Anne Johanne Sogaard, Lise Lund Haheim, Inger Ariansen, Anne Tybjaerg-Hansen, Gorm B. Jensen, Peter Schnohr, Simona Giampaoli, Diego Vanuzzo, Salvatore Panico, Luigi Palmieri, Beverley Balkau, Fabrice Bonnet, Michel Marre, Agustin Gomez de la Camara, Miguel Angel Rubio Herrera, Yechiel Friedlander, John McCallum, Stela McLachlan, Jack Guralnik, Caroline L. Phillips, Jack Guralnik, Kay-Tee Khaw, Nick Wareham, Ben Schottker, Kai-Uwe Saum, Bernd Holleczek, Aulikki Nissinen, Hanna Tolonen, Simona Giampaoli, Chiara Donfrancesco, Pekka Jousilahti, Kennet Harald, Ralph B. D'Agostino, Joseph M. Massaro, Michael Pencina, Ramachandran Vasan, Joseph M. Massaro, Michael Pencina, Ramachandran Vasan, Takamasa Kayama, Takeo Kato, Toshihide Oizumi, Jorgen Jespersen, Lars Moller, Else Marie Bladbjerg, A. Chetrit, Annika Rosengren, Lars Wilhelmsen, Cecilia Bjorkelund, Lauren Lissner, Dorothea Nagel, Elaine Dennison, Yutaka Kiyohara, Toshiharu Ninomiya, Yasufumi Doi, Beatriz Rodriguez, Giel Nijpels, Coen D. A. Stehouwer, Shinichi Sato, Yamagishi Kazumasa, Hiroyasu Iso, Uri Goldbourt, Veikko Salomaa, Erkki Vartiainen, Sudhir Kurl, Tomi-Pekka Tuomainen, Jukka T. Salonen, Marjolein Visser, Dorly J. H. Deeg, Tomw. Meade, Peter M. Nilsson, Bo Hedblad, Olle Melander, Ian H. De Boer, Andrew Paul DeFilippis, W. M. Monique Verschuren, Naveed Sattar, Graham Watt, Christa Meisinger, Wolfgang Koenig, Monique Verschuren, Annika Rosengren, Lewis H. Kuller, Aage Tverdal, Richard F. Gillum, Jackie A. Cooper, Susan Kirkland, Daichi Shimbo, Jonathan Shaffer, Shinichi Sato, Yamagishi Kazumasa, Hiroyasu Iso, Pierre Ducimetiere, Stephan J. L. Bakker, Pim van der Harst, Hans L. Hillege, Carlos J. Crespo, Philippe Amouyel, Jean Dallongeville, Gerd Assmann, Helmut Schulte, Stella Trompet, Roelof A. J. Smit, David J. Stott, Yvonne T. van der Schouw, Jean-Pierre Despres, Bernard Cantin, Gilles R. Dagenais, Gail Laughlin, Deborah Wingard, Kay-Tee Khaw, Maurizio Trevisan, Thor Aspelund, Gudny Eiriksdottir, Elias Freyr Gudmundsson, Arfan Ikram, Frank J. A. van Rooij, Oscar H. Franco, Oscar L. Rueda-Ochoa, Taulant Muka, Marija Glisic, Hugh Tunstall-Pedoe, Henry Volzke, Barbara V. Howard, Ying Zhang, Stacey Jolly, John Gallacher, George Davey-Smith, Gunay Can, Husniye Yuksel, Hideaki Nakagawa, Yuko Morikawa, Katsuyuki Miura, Inger Njolstad, Martin Ingelsson, Vilmantas Giedraitis, Paul M. Ridker, J. Michael Gaziano, Mika Kivimaki, Martin Shipley, Eric J. Brunner, Volker Arndt, Hermann Brenner, Nancy Cook, Paul M. Ridker, Ian Ford, Naveed Sattar, Alejandro Marin Ibanez, Johanna M. Geleijnse
EUROPEAN HEART JOURNAL
(2019)
Article
Cardiac & Cardiovascular Systems
John Gregson, Stephen Kaptoge, Thomas Bolton, Lisa Pennells, Peter Willeit, Stephen Burgess, Steven Bell, Michael Sweeting, Eric B. Rimm, Christopher Kabrhel, Bengt Zoller, Gerd Assmann, Vilmundur Gudnason, Aaron R. Folsom, Volker Arndt, Astrid Fletcher, Paul E. Norman, Borge G. Nordestgaard, Akihiko Kitamura, Bakhtawar K. Mahmoodi, Peter H. Whincup, Matthew Knuiman, Veikko Salomaa, Christa Meisinger, Wolfgang Koenig, Maryam Kavousi, Henry Voelzke, Jackie A. Cooper, Toshiharu Ninomiya, Edoardo Casiglia, Beatriz Rodriguez, Yoav Ben-Shlomo, Jean-Pierre Despres, Leon Simons, Elizabeth Barrett-Connor, Cecilia Bjorkelund, Marlene Notdurfter, Daan Kromhout, Jackie Price, Susan E. Sutherland, Johan Sundstroem, Jussi Kauhanen, John Gallacher, Joline W. J. Beulens, Rachel Dankner, Cyrus Cooper, Simona Giampaoli, Jason F. Deen, Agustin Gomez de la Camara, Lewis H. Kuller, Annika Rosengren, Peter J. Svensson, Dorothea Nagel, Carlos J. Crespo, Hermann Brenner, Juan R. Albertorio-Diaz, Robert Atkins, Eric J. Brunner, Martin Shipley, Inger Njolstad, Deborah A. Lawlor, Yvonne T. van der Schouw, Randi Marie Selmer, Maurizio Trevisan, W. M. Monique Verschuren, Philip Greenland, Sylvia Wassertheil-Smoller, Gordon D. O. Lowe, Angela M. Wood, Adam S. Butterworth, Simon G. Thompson, John Danesh, Emanuele Di Angelantonio, Tom Meade, Wayne Rosamond, Eric Whitsel, Mary Cushman, Elizabeth L. M. Barr, Jonathan E. Shaw, Paul Z. Zimmet, Stefan Kiechl, Siegfried Weger, Johann Willeit, Antoinette Amuzu, Caroline Dale, Juan P. Casas, Valerie Tikhonoff, Paul Nietert, Anne Tybjaerg-Hansen, Ruth Frikke-Schmidt, Gorm B. Jensen, David Lora Pablos, Pilar Cancelas Navia, Stela McLachlan, Ben Schoettker, Kai-Uwe Saum, Bernd Holleczek, Inger Ariansen, Haakon E. Meyer, Lise Lund Haheim, Erkki Vartiainen, Pekka Jousilahti, Kennet Harald, Lars Wilhelmsen, Elaine Dennison, Holly Syddall, Leo Westbury, Leon Flicker, Graeme J. Hankey, Jonathan Golledge, Yasufumi Doi, Yutaka Kiyohara, Petra Elders, Coen Stehouwer, Majken Jensen, Hiroyasu Iso, Kazumasa Yamagishi, Kurl Sudhir, Tomi-Pekka Tuomainen, Jukka T. Salonen, Jolanda M. A. Boer, Anneke Blokstra, Olle Melander, Peter M. Nilsson, Gunnar Engstrom, Luigi Palmieri, Diego Vanuzzo, Annette Peters, Barbara Thorand, Margit Heier, Frank B. Hu, JoAnn E. Manson, Karina Meijer, Ron T. Gansevoort, Helmut Schulte, Ivonne Sluijs, Bernard Cantin, Benoit Lamarche, Gilles R. Dagenais, Linda McEvoy, Gail Laughlin, Lori B. Daniels, Thor Aspelund, Elias Freyr Gudmundsson, Bolli Thorsson, Maarten J. G. Leening, M. Arfan Ikram, Oscar H. Franco, Hugh Tunstall-Pedoe, Andre Werner, Richard Devereux, Stacey Jolly, George Davey Smith, Gunay Can, Husniye Yuksel, Servet Altay, Martin Ingelsson, Vilmantas Giedraitis, Heiner Claessen, Dietrich Rothenbacher, Nisha Parikh, Charles Eaton, Mika Kivimaki, Edith Feskens, Johanna M. Geleijnse, Sarah Spackman, Matthew Walker
Article
Cardiac & Cardiovascular Systems
Zara K. Berg, Beatriz Rodriguez, James Davis, Alan R. Katz, Robert V. Cooney, Kamal Masaki
JOURNAL OF THE AMERICAN HEART ASSOCIATION
(2019)
Article
Public, Environmental & Occupational Health
Emanuele Di Angelantonio, Stephen Kaptoge, Lisa Pennells, Dirk De Bacquer, Marie Therese Cooney, Maryam Kavousi, Gretchen Stevens, Leanne Riley, Stefan Savin, Servet Altay, Philippe Amouyel, Gerd Assmann, Steven Bell, Yoav Ben-Shlomo, Lisa Berkman, Joline W. Beulens, Cecilia Bjorkelund, Michael J. Blaha, Dan G. Blazer, Thomas Bolton, Ruth Bonita, Beaglehole Hermann Brenner, Eric J. Brunner, Edoardo Casiglia, Parinya Chamnan, Yeun-Hyang Choi, Rajiv Chowdhury, Sean Coady, Carlos J. Crespo, Mary Cushman, Gilles R. Dagenais, Ralph B. D'Agostino, Makoto Daimon, Karina W. Davidson, Gunnar Engstrom, Xianghua Fang, Ian Ford, John Gallacher, Ron T. Gansevoort, Thomas Andrew Gaziano, Simona Giampaoli, Greg Grandits, Sameline Grimsgaard, Diederick E. Grobbee, Vilmundur Gudnason, Qi Guo, Steve Humphries, Hiroyasu Iso, J. Wouter Jukema, Jussi Kauhanen, Andre Pascal Kengne, Davood Khalili, Taskeen Khan, Matthew Knuiman, Wolfgang Koenig, Daan Kromhout, Harlan M. Krumholz, T. H. Lam, Gail Laughlin, Alejandro Marin Ibanez, Karel G. M. Moons, Paul J. Nietert, Borge G. Nordestgaard, Christopher O'Donnell, Luigi Palmieri, Anushka Patel, Pablo Perel, Jackie F. Price, Rui Bebiano Da Providencia E. Costa, Paul M. Ridker, Beatriz Rodriguez, Annika Rosengren, Ronan Roussel, Masaru Sakurai, Veikko Salomaa, Shinichi Sato, Ben Schottker, Nawar Shara, Jonathan E. Shaw, Hee-Choon Shin, Leon A. Simons, Eleni Sofianopoulou, Johan Sundstrom, Hanna Tolonen, Hirotsugu Ueshima, Henry Volzke, Robert B. Wallace, Nicholas J. Wareham, Peter Willeit, David Wood, Angela Wood, Dong Zhao, Oyere Onuma, Mark Woodward, Goodarz Danaei, Gregory Roth, Shanthi Mendis, Ian Graham, Cherian Varghese, Majid Ezzati, Rod Jackson, John Danesh, Emanuele Di Angelantonio, Vijay Nambi, Kunihiro Matsushita, David Couper, Australian Diabetes, Paul Z. Zimmet, Elizabeth L. M. Barr, Robert Atkins, Peter H. Whincup, Bruneck Study, Stefan Kiechl, Johann Willeit, Gregorio Rungger, Reecha Sofat, Caroline Dale, J. P. Casas, Yoav Ben-Shlomo, Valerie Tikhonoff, Edoardo Casiglia, Kelly J. Hunt, Susan E. Sutherland, Paul J. Nietert, Bruce M. Psaty, Russell Tracy, Ruth Frikke-Schmidt, Gorm B. Jensen, Peter Schnohr, Luigi Palmieri, Chiara Donfrancesco, Diego Vanuzzo, Salvatore Panico, Simona Giampaoli, Beverley Balkau, Fabrice Bonnet, Frederic Fumeron, Judith Simons, Stela McLachlan, Jack Guralnik, Kay-Tee Khaw, Hermann Brenner, Yan Zhang, Bernd Holleczek, Finrisk Cohort, Veikko Salomaa, Erkki Vartiainen, Pekka Jousilahti, Kennet Harald, Joseph J. Massaro, Michael Pencina, Vasan Ramachandran, Shinji Susa, Toshihide Oizumi, Takamasa Kayama, Annika Rosengren, Lars Wilhelmsen, Lauren Lissner, Dominique Hange, Kirsten Mehlig, Jun Hata, Daigo Yoshida, Yoichiro Hirakawa, Beatriz Rodriguez, Femke Rutters, Petra J. M. Elders, Ikawa Kyowa, Masahiko Kiyama, Kazumasa Yamagishi, Hiroyasu Iso, Tomi-Pekka Tuomainen, Jyrki Virtanen, Jukka T. Salonen, Tom W. Meade, Peter M. Nilsson, Olle Melander, Ian H. de Boer, Andrew Paul DeFilippis, Lewis H. Kuller, Survey I. Juan, Richard F. Gillum, Steve Humphries, Susan Kirkland, Daichi Shimbo, Joseph E. Schwartz, Masahiko Kiyama, Hironori Imano, Hiroyasu Iso, Pim van der Harst, Johannes L. Hillige, Stephan Jl Bakker, Carlos J. Crespo, Jean Dallongeville, Jean Ferrieres, Marie Moitry, David J. Stott, Jean-Pierre Despres, Gail A. Laughlin, Lori B. Daniels, Linda K. McEvoy, Thor Aspelund, Bolli Thorsson, Elias Freyr Gudmundsson, Elif Aribas, Oscar L. Rueda-Ochoa, M. Kamran Ikram, Alis Heshmatollah, M. Arfan Ikram, Mark Woodward, Marcus Dorr, Matthias Nauck, Barbara Howard, Ying Zhang, Yoav Ben-Shlomo, Gunay Can, Masao Ishizaki, Tom Wilsgaard, Ellisiv Mathiesen, Vilmantas Giedraitis, Martin Ingelsson, Nancy Cook, Julie Buring, Yvonne T. van der Schouw, Heiner Claessen, Dietrich Rothenbacher, Volker Arndt, Whitehall Ii Study, Martin Shipley, Julie Buring, Chris Packard, Michele Robertson, Robin Young, Edith Feskens, Johanna M. Geleijnse, X. Fang, D. F. Gu, R. Huxley, Y. Imai, H. C. Kim, T. H. Lam, W. H. Pan, A. Rodgers, I. Suh, H. Ueshima, M. Woodward, Aito Town, A. Okayama, H. Ueshima, H. Maegawa, M. Nakamura, N. Aoki, Z. S. Wu, C. H. Yao, Z. S. Wu, Mary Luszcz, Z. Tang, L. S. Liu, J. X. Xie, R. Norton, S. Ameratunga, S. MacMahon, G. Whitlock, M. W. Knuiman, H. Christensen, X. G. Wu, J. Zhou, X. H. Yu, Workers A. Tamakoshi, W. H. Pan, Z. L. Wu, L. Q. Chen, G. L. Shan, P. Sritara, D. F. Gu, X. F. Duan, S. MacMahon, R. Norton, G. Whitlock, R. Jackson, Y. H. Li, T. H. Lam, C. Q. Jiang, T. Ninomiya, J. Hata, Y. Hirakawa, J. Woo, S. C. Ho, Z. Hong, M. S. Huang, B. Zhou, J. L. Fuh, H. Ueshima, Y. Kita, S. R. Choudhury, I. Suh, S. H. Jee, I. S. Kim, G. G. Giles, T. Hashimoto, K. Sakata, A. Dobson, Y. Imai, T. Ohkubo, A. Hozawa, K. Jamrozik, M. W. Knuiman, M. Hobbs, R. Broadhurst, K. Nakachi, X. H. Fang, S. C. Li, Q. D. Yang, Z. M. Chen, Shibata H. Tanaka, Shigaraki Town, Y. Kita, H. Ueshima, H. Horibe, Y. Matsutani, M. Kagaya, K. Hughes, J. Lee, D. Heng, S. K. Chew, B. F. Zhou, H. Y. Zhang, K. Shimamoto, S. Saitoh, Z. Z. Li, H. Y. Zhang, S. Saitoh, Z. Z. Li, H. Y. Zhang, P. Norman, K. Jamrozik, Y. He, T. H. Lam, S. X. Yao, Miao Wang, Jing Liu, Xingguang Zhang, Weera Mahavanakul, Benjawan Wettana, Prasit Boonkert, Katrina Poppe, Fereidoun Azizi, Azita Zadehvakili, Farzad Hadaegh
LANCET GLOBAL HEALTH
(2019)
Article
Public, Environmental & Occupational Health
Kaela Connors, Mario H. Flores-Torres, Dalia Stern, Unnur Valdimarsdottir, Jennifer R. Rider, Ruy Lopez-Ridaura, Clemens Kirschbaum, Carlos Cantu-Brito, Andres Catzin-Kuhlmann, Beatriz L. Rodriguez, Catalina Perez Correa, Martin Lajous
AMERICAN JOURNAL OF PUBLIC HEALTH
(2020)
Article
Multidisciplinary Sciences
Priscilla Espinosa-Tamez, Martin Lajous, Carlos Cantu-Brito, Ruy Lopez-Ridaura, Adriana Monge, Elsa Yunes, Beatriz L. Rodriguez, Luis Espinosa, Jose Sifuentes-Osornio, Andres Catzin-Kuhlmann
Summary: This study found that recurrent infectious events in young adult women are associated with greater sCVD, supporting the hypothesis of low-grade chronic inflammation in the pathophysiology of cardiovascular disease.
Article
Cardiac & Cardiovascular Systems
Adrian Cortes-Valencia, Adriana Monge, Marcela Tamayo-Ortiz, Ruy Lopez-Ridaura, Beatriz L. Rodriguez, Carlos Cantu-Brito, Andres Catzin-Kuhlmann, Martin Lajous
Summary: This study found that total dairy consumption was associated with carotid wall thickening, while yogurt consumption was related to lower subclinical atherosclerosis.
NUTRITION METABOLISM AND CARDIOVASCULAR DISEASES
(2021)
Article
Nutrition & Dietetics
Queenie Chan, Gina M. Wren, Chung-Ho E. Lau, Timothy M. D. Ebbels, Rachel Gibson, Ruey Leng Loo, Ghadeer S. Aljuraiban, Joram M. Posma, Alan R. Dyer, Lyn M. Steffen, Beatriz L. Rodriguez, Lawrence J. Appel, Martha L. Daviglus, Paul Elliott, Jeremiah Stamler, Elaine Holmes, Linda Van Horn
Summary: Adherence to the DASH diet is associated with lower blood pressure and increased potassium intake. The DASH diet recommends consuming more fruits, vegetables, and potassium-rich foods to replace sodium-rich processed foods and influence blood pressure through metabolic pathways.
AMERICAN JOURNAL OF CLINICAL NUTRITION
(2022)
Article
Public, Environmental & Occupational Health
Kaela Connors, Mario H. Flores-Torres, Adrian Cortes-Valencia, Tonatiuh Barrientos-Gutierrez, Carlos Cantu-Brito, Beatriz Rodriguez, Martin Lajous, Unnur Valdimarsdottir, Andres Catzin-Kuhlmann
Summary: This study investigates the association between serious financial difficulties (SFD), stress, and cardiovascular health in women. The results indicate that women exposed to SFD have an increased risk of carotid atherosclerosis and higher intima-media thickness. The association is stronger in women with longer duration of the event and higher emotional burden. Perceived stress and body mass index may mediate these associations.
ANNALS OF EPIDEMIOLOGY
(2022)
Article
Pharmacology & Pharmacy
Naoko Miyagawa, Akira Sekikawa, Katsuyuki Miura, Rhobert W. Evans, Nagako Okuda, Akira Fujiyoshi, Katsushi Yoshita, Queenie Chan, Yukiko Okami, Aya Kadota, Bradley Willcox, Kamal Masaki, Beatriz Rodriguez, Kiyomi Sakata, Hideaki Nakagawa, Shigeyuki Saitoh, Akira Okayama, Lewis H. Kuller, Paul Elliott, Jeremiah Stamler, Hirotsugu Ueshima
Summary: This study examined the association between plasma phospholipid fatty acid levels and dietary intake of fatty acids. The results showed a correlation between intake and circulating fatty acid levels, especially for marine-derived fatty acids. Plasma phospholipid measurements of marine-derived fatty acids can be used as a reliable biomarker for assessing dietary intake.
JOURNAL OF CLINICAL LIPIDOLOGY
(2023)
Article
Public, Environmental & Occupational Health
Mercedes Aguilar, Paloma Munoz-Aguirre, Adrian Cortes-Valencia, Mario H. Flores-Torres, Andres Catzin-Kuhlmann, Ruy Lopez-Ridaura, Martin Lajous, Beatriz L. Rodriguez, Carlos Cantu-Brito, Edgar Denova-Gutierrez
Summary: This study aimed to determine whether long-term sun exposure has a protective role in subclinical cardiovascular disease in adult Mexican women. The results showed an inverse association between sun exposure and carotid intima-media thickness (IMT) as well as subclinical carotid atherosclerosis. If further studies confirm these findings for other cardiovascular outcomes, sun exposure could be an affordable strategy to lower overall cardiovascular risk.
JOURNAL OF WOMENS HEALTH
(2023)
Article
Geriatrics & Gerontology
Rachael K. Aquino, Michael Perez, Payel Sil, Terry Shintani, Rosanne Harrigan, Beatriz Rodriguez
Article
Geriatrics & Gerontology
Chieko Kimata, Bradley Willcox, Beatriz L. Rodriguez
Article
Geriatrics & Gerontology
Nazneem Wahab, Randi Chen, Jess David Curb, Bradley J. Willcox, Beatriz L. Rodriguez
Meeting Abstract
Cardiac & Cardiovascular Systems
Jazmin Mata, Andres Catzin-Kulhmann, Eduardo Ortiz-Panozo, Carlos Cantu-Brito, Luis Espinosa, Beatriz Rodriguez, Martin Lajous, Ruy Lopez-Ridaura
