Article
Neurosciences
Jessica A. Lawrence, Patricia Aguilar-Calvo, Daniel Ojeda-Juarez, Helen Khuu, Katrin Soldau, Donald P. Pizzo, Jin Wang, Adela Malik, Timothy F. Shay, Erin E. Sullivan, Brent Aulston, Seung Min Song, Julia A. Callender, Henry Sanchez, Michael D. Geschwind, Subhojit Roy, Robert A. Rissman, JoAnn Trejo, Nobuyuki Tanaka, Chengbiao Wu, Xu Chen, Gentry N. Patrick, Christina J. Sigurdson
Summary: Endolysosomal defects, including the reduction of Hrs and STAM1, exacerbate synaptic derangements and accelerate neurodegeneration in prion-infected brains. Depletion of neuronal Hrs leads to increased surface levels of PrPC, contributing to the rapidly advancing disease through neurotoxic signaling. The findings highlight the importance of proteostatic pathways and synaptic integrity in prion diseases.
JOURNAL OF NEUROSCIENCE
(2023)
Article
Genetics & Heredity
Min Zhu, Guangneng Liao, Xiaohong Liu, Xu Luo, Gen Chen, Lingyun Wang, Chengshi Wang, Wen Liu, Xin Zeng, Yanrong Lu, Guang Yang, Jingqiu Cheng, Younan Chen
Summary: The loss of beta cell mass and function in aged population is closely related to the prevalence of Type 2 diabetes. This study focuses on the causal relations between aging and age-related pancreatic islets degeneration using rhesus monkeys as an animal model. The findings indicate that the decreased islet size, compromised insulin secretion, and loss of beta cell identity markers are key molecular changes in islet senescence.
Article
Clinical Neurology
Anna Linnea Svenningsson, Erik Stomrud, Sebastian Palmqvist, Oskar Hansson, Rik Ossenkoppele
Summary: This study aimed to identify factors explaining the discrepancy between the degree of cortical atrophy and cognitive decline in cognitively unimpaired elderly individuals. The results showed that axonal degeneration and amyloid pathology independently affect the rate of cognitive decline beyond the degree of cortical atrophy. Furthermore, axonal degeneration mediated the negative effects of age, sex, white matter lesions, and to some extent, amyloid and tau pathology, on cognition over time when accounting for cortical atrophy.
ALZHEIMERS RESEARCH & THERAPY
(2022)
Article
Biochemistry & Molecular Biology
Yan Wang, Xiaoyu Xiu, Shengzhou Wu
Summary: The study suggests a potential link between Dicer1 and Alzheimer's disease, showing that exposure to A13O can affect Dicer1 protein and mRNA levels in neurons. A13O regulates Dicer1 stability in neurons by influencing its phosphorylation level.
NEUROCHEMISTRY INTERNATIONAL
(2021)
Article
Geriatrics & Gerontology
Mark G. Baxter, Mary T. Roberts, Jeffrey A. Roberts, Peter R. Rapp
Summary: Aged rhesus monkeys, like aged humans, show declines in cognitive function. Cognitive test data from a large sample of male and female rhesus monkeys demonstrate that aged monkeys perform worse than young monkeys on multiple cognitive tasks and that cognitive aging is independent in task domains dependent on different brain regions. Sex and chronological age are not reliable predictors of individual differences in cognitive outcome among the aged monkeys.
NEUROBIOLOGY OF AGING
(2023)
Article
Cell Biology
Dylan C. Souder, Isabelle A. Dreischmeier, Alex B. Smith, Samantha Wright, Stephen A. Martin, Md Abdul Kader Sagar, Kevin W. Eliceiri, Shahriar M. Salamat, Barbara B. Bendlin, Ricki J. Colman, T. Mark Beasley, Rozalyn M. Anderson
Summary: Age is a major risk factor for late-onset Alzheimer's disease, and differences in the amyloid plaque microenvironment and the impact of AD pathology on local metabolism and inflammation vary among species, potentially explaining differences in neurodegeneration and functional decline. Using brain tissue from transgenic mice, rhesus monkeys, and human subjects, altered energetics in the plaque microenvironment were observed, highlighting the advantage of nonhuman primates in modeling the disease.
Article
Geriatrics & Gerontology
Tara L. Moore, Damon A. Young, Ronald J. Killiany, Kari R. Fonseca, Dmitri Volfson, David L. Gray, Rita Balice-Gordon, Rouba Kozak
Summary: Age-related declines in cognition, especially in working memory and executive function, are mediated by the prefrontal cortex and the dopamine system within it. Administering the DA D1 R agonist PF-6294 to aged female rhesus monkeys improved memory span on the Delayed Recognition Span Task, particularly on repeated trials.
FRONTIERS IN AGING NEUROSCIENCE
(2021)
Article
Biochemistry & Molecular Biology
Soumyabrata Banerjee, Biswajit Mukherjee, Mrinal K. Poddar, Gary L. Dunbar
Summary: The study found that carnosine treatments improved cognitive function deficits induced by aging, reduced beta-sheets in the secondary structure of A beta protein, and mitigated the decrease in carnosine levels and spine density in the examined brain regions. These results suggest that carnosine can attenuate aging-induced conformational changes in A beta secondary structure and cognitive impairment.
JOURNAL OF NEUROCHEMISTRY
(2021)
Review
Medicine, Research & Experimental
Caitlin S. Latimer, Katherine L. Lucot, C. Dirk Keene, Brenna Cholerton, Thomas J. Montine
Summary: Alzheimer's disease is a pervasive, relentlessly progressive neurodegenerative disorder that requires autopsy confirmation for diagnosis. Significant progress has been made in understanding the disease, largely due to research on genetic pathways.
ANNUAL REVIEW OF PATHOLOGY: MECHANISMS OF DISEASE, VOL 16, 2021
(2021)
Review
Cell Biology
Kumari Preeti, Anika Sood, Valencia Fernandes
Summary: Alzheimer's disease is an aging-related neurodegenerative disorder characterized by memory loss and impaired cognitive function. Neurons and glial cells have different metabolic profiles, especially under metabolic dysregulation or aging, affecting their unique genetic makeup. Mitochondrial dynamics play a crucial role in aging-related brain health, impacting various cellular functions and potentially accelerating Alzheimer's disease pathology.
CELLULAR AND MOLECULAR NEUROBIOLOGY
(2022)
Review
Geriatrics & Gerontology
Gail A. Stonebarger, Heather A. Bimonte-Nelson, Henryk F. Urbanski
Summary: This article discusses the current understanding of human brain aging and neurodegeneration, with a focus on Alzheimer's disease. It also examines the use of rhesus macaque monkeys as a translational animal model to study causal mechanisms. The discussion highlights behavioral and protein-level brain changes in aged monkeys compared to clinically normative aging and AD in humans.
FRONTIERS IN AGING NEUROSCIENCE
(2021)
Article
Cell Biology
Henry Patrick Oamen, Nathaly Romero Romero, Philip Knuckles, Juha Saarikangas, Marta Radman-Livaja, Yuhong Dong, Fabrice Caudron
Summary: This study found that the natural lipid tripentadecanoin can delay the formation of protein aggregates and extend cellular lifespan, offering a potential treatment for neurodegenerative diseases. Tripentadecanoin can also protect neurons from amyloid toxicity and promote the recovery of retinal cells.
Article
Cell Biology
Guo-Chen Zhu, Da-Jiang Xiao, Bi-Wen Zhu, Yan Xiao
Summary: Acellular nerve allografts achieved satisfactory results in bridging facial nerve defects, but limited allogeneic donors are available. This experiment constructed a monkey model of whole nerve defect and studied xenogeneic acellular nerve grafts. The results showed that xenogeneic acellular nerve grafts were safe and effective for repairing facial nerve defects, similar to autografts.
NEURAL REGENERATION RESEARCH
(2022)
Article
Biochemistry & Molecular Biology
Ceyhan Hacioglu, Fatih Kar, Ezgi Kar, Yakup Kara, Gungor Kanbak
Summary: Synaptosomes serve as a valuable ex vivo model for studying neuronal transmission and neurodegenerative processes. The study found that boric acid and curcumin have protective effects on rat brain synaptosomes against A beta 1-42 induced damage. Boric acid and curcumin treatment can prevent alterations in the cholinergic system and inhibit oxidative stress in synapses of the cerebral cortex exposed to A beta 1-42.
BIOLOGICAL TRACE ELEMENT RESEARCH
(2021)
Article
Psychology, Multidisciplinary
Karra D. Harrington, Andrew J. Aschenbrenner, Paul Maruff, Colin L. Masters, Anne M. Fagan, Tammie L. S. Benzinger, Brian A. Gordon, Carlos Cruchaga, John C. Morris, Jason Hassenstab
Summary: Neurodegenerative disease is common among older adults and can bias estimates of cognitive change towards decline in otherwise healthy older adults when the presence of early neurodegenerative disease is not accounted for. By adjusting for biomarker status, it was found that cognitively normal older adults did not show decline in any cognitive domain.
PSYCHOLOGICAL SCIENCE
(2021)
Article
Geriatrics & Gerontology
Gary W. Small, Vladimir Kepe, Prabha Siddarth, Linda M. Ercoli, David A. Merrill, Natacha Donoghue, Susan Y. Bookheimer, Jacqueline Martinez, Bennet Omalu, Julian Bailes, Jorge R. Barrio
AMERICAN JOURNAL OF GERIATRIC PSYCHIATRY
(2013)
Article
Geriatrics & Gerontology
Stephen T. Chen, Prabha Siddarth, Nathan Y. Saito, Flori Rueda, Taylor Haight, Linda M. Ercoli, Karen J. Miller, Helen Lavretsky, Jorge R. Barrio, Susan Y. Bookheimer, Gary W. Small, David A. Merrill
AMERICAN JOURNAL OF GERIATRIC PSYCHIATRY
(2014)
Article
Psychology, Clinical
David A. Merrill, Prabha Siddarth, Nathan Y. Saito, Linda M. Ercoli, Alison C. Burggren, Vladimir Kepe, Helen Lavretsky, Karen J. Miller, Jeanne Kim, S. C. Huang, Susan Y. Bookheimer, Jorge R. Barrio, Gary W. Small
INTERNATIONAL PSYCHOGERIATRICS
(2012)
Article
Psychology, Clinical
Gary W. Small, Prabha Siddarth, Linda M. Ercoli, Stephen T. Chen, David A. Merrill, Fernando Torres-Gil
INTERNATIONAL PSYCHOGERIATRICS
(2013)
Article
Neurosciences
David A. Merrill, Prabha Siddarth, Vladimir Kepe, Pushpa V. Raja, Nathan Saito, Linda M. Ercoli, Karen J. Miller, Helen Lavretsky, Susan Y. Bookheimer, Jorge R. Barrio, Gary W. Small
JOURNAL OF ALZHEIMERS DISEASE
(2013)
Article
Neurosciences
James M. Conner, Kevin M. Franks, Andrea K. Titterness, Kyle Russell, David A. Merrill, Brian R. Christie, Terrence J. Sejnowski, Mark H. Tuszynski
JOURNAL OF NEUROSCIENCE
(2009)
Article
Biochemistry & Molecular Biology
Alan H. Nagahara, David A. Merrill, Giovanni Coppola, Shingo Tsukada, Brock E. Schroeder, Gideon M. Shaked, Ling Wang, Armin Blesch, Albert Kim, James M. Conner, Edward Rockenstein, Moses V. Chao, Edward H. Koo, Daniel Geschwind, Eliezer Masliah, Andrea A. Chiba, Mark H. Tuszynski
Article
Multidisciplinary Sciences
Stephen T. Chen, Prabha Siddarth, Linda M. Ercoli, David A. Merrill, Fernando Torres-Gil, Gary W. Small
Article
Geriatrics & Gerontology
Somayeh Meysami, Cyrus A. Raji, David A. Merrill, Verna R. Porter, Mario F. Mendez
Summary: Investigators found that early onset Alzheimer's Disease (EOAD) patients have greater parietal tau deposition and alternate frontoparietal network involvement compared to typical late onset AD (LOAD) patients. Additionally, EOAD patients show smaller parietal lobes on clinical MRI scans, while late onset AD patients have smaller left putamen and hippocampus. This study suggests that parietal atrophy less than 30% of normal on clinical MRI scans may be indicative of EOAD compared to LOAD.
AMERICAN JOURNAL OF ALZHEIMERS DISEASE AND OTHER DEMENTIAS
(2021)
Article
Psychiatry
David A. Merrill, Gary W. Small
PSYCHIATRIC CLINICS OF NORTH AMERICA
(2011)
Article
Neurosciences
DA Merrill, R Karim, M Darraq, AA Chiba, MH Tuszynski
JOURNAL OF COMPARATIVE NEUROLOGY
(2003)
Article
Neurosciences
DA Merrill, AA Chiba, MH Tuszynski
JOURNAL OF COMPARATIVE NEUROLOGY
(2001)
Article
Neurosciences
DA Merrill, JA Roberts, MH Tuszynski
JOURNAL OF COMPARATIVE NEUROLOGY
(2000)
Article
Geriatrics & Gerontology
Sarah N. Kraeutner, Cristina Rubino, Jennifer K. Ferris, Shie Rinat, Lauren Penko, Larissa Chiu, Brian Greeley, Christina B. Jones, Beverley C. Larssen, Lara A. Boyd
Summary: This study examined the age-related changes in brain function and baseline brain structure that support motor skill acquisition. The findings showed that older adults experienced decreases in functional connectivity during motor skill acquisition, while younger adults experienced increases. Additionally, regardless of age group, lower baseline microstructure in a frontoparietal tract was associated with slower motor skill acquisition.
NEUROBIOLOGY OF AGING
(2024)
Article
Geriatrics & Gerontology
Karen Nuytemans, Farid Rajabli, Melissa Jean-Francois, Jiji Thulaseedhara Kurup, Larry D. Adams, Takiyah D. Starks, Patrice L. Whitehead, Brian W. Kunkle, Allison Caban-Holt, Jonathan L. Haines, Michael L. Cuccaro, Jeffery M. Vance, Goldie S. Byrd, Gary W. Beecham, Christiane Reitz, Margaret A. Pericak-Vance
Summary: This study conducted genetic research on African American AD families and identified a significant linkage signal associated with AD, highlighting the importance of diverse population-level genetic data in understanding the genetic determinants of AD.
NEUROBIOLOGY OF AGING
(2024)
Article
Geriatrics & Gerontology
Kazuya Suwabe, Ryuta Kuwamizu, Kazuki Hyodo, Toru Yoshikawa, Takeshi Otsuki, Asako Zempo-Miyaki, Michael A. Yassa, Hideaki Soya
Summary: Physical exercise has a positive impact on hippocampal memory decline with aging. Recent studies have shown that even light exercise can improve memory and this improvement is mediated by the ascending arousal system. This study aimed to investigate the effects of light-intensity exercise on hippocampal memory function in healthy older adults and found that pupil dilation during exercise played a role in the memory improvement.
NEUROBIOLOGY OF AGING
(2024)
Article
Geriatrics & Gerontology
Ajay Sood, Ana Werneck Capuano, Robert Smith Wilson, Lisa Laverne Barnes, Alifiya Kapasi, David Alan Bennett, Zoe Arvanitakis
Summary: The objective of this study was to explore the impact of metformin on cognition and brain pathology. The results showed that metformin users had slower decline in global cognition, episodic memory, and semantic memory compared to non-users. However, the relationship between metformin use and certain brain pathology remains uncertain.
NEUROBIOLOGY OF AGING
(2024)
Article
Geriatrics & Gerontology
Brian N. Lee, Junwen Wang, Molly A. Hall, Dokyoon Kim, Shana D. Stites, Li Shen
Summary: Alzheimer's disease (AD) is a neurodegenerative disorder characterized by memory and functional impairments. This study analyzed participants from the Alzheimer's Disease Neuroimaging Initiative and found differential associations between cerebral spinal fluid (CSF)/neuroimaging biomarkers and cognitive/functional outcomes, as well as variations between sexes. These findings suggest that sex differences may play a role in the development of AD.
NEUROBIOLOGY OF AGING
(2024)
Article
Geriatrics & Gerontology
Madeline R. Hale, Rebecca Langhough, Lianlian Du, Bruce P. Hermann, Carol A. Van Hulle, Margherita Carboni, Gwendlyn Kollmorgenj, Kristin E. Basche, Davide Bruno, Leah Sanson-Miles, Erin M. Jonaitis, Nathaniel A. Chin, Ozioma C. Okonkwo, Barbara B. Bendlin, Cynthia M. Carlsson, Henrik Zetterberg, Kaj Blennow, Tobey J. Betthauser, Sterling C. Johnson, Kimberly D. Mueller
Summary: This study demonstrates a relationship between cerebrospinal fluid biomarkers and the ability to recall proper names in the preclinical phase of Alzheimer's disease.
NEUROBIOLOGY OF AGING
(2024)
Article
Geriatrics & Gerontology
Thomas T. Austin, Christian L. Thomas, Ben Warren
Summary: This study investigated the effects of age on the robustness and resilience of auditory system using the desert locust. The researchers found that gene expression changes were mainly influenced by age rather than noise exposure. Both young and aged locusts were able to recover their auditory nerve function within 48 hours of noise exposure, but the recovery of transduction current magnitude was impaired in aged locusts. Key genes responsible for robustness to noise exposure in young locusts and potential candidates for compensatory mechanisms in auditory neurons of aged locusts were identified.
NEUROBIOLOGY OF AGING
(2024)
