Journal
NEUROBIOLOGY OF AGING
Volume 31, Issue 9, Pages 1532-1542Publisher
ELSEVIER SCIENCE INC
DOI: 10.1016/j.neurobiolaging.2008.08.016
Keywords
fMRI; Cognitive aging; Memory; Blood pressure; Body mass index; Alzheimer's disease
Categories
Funding
- National Institute on Aging [AG18487, AG13308, AG024831, MH52453]
- National Institute of Mental Health [MH52453, MH048156]
- Institute for Study on Aging [FC0387-ER60615]
- National Institutes of Health/National Institute of Neurological Disorders and Stroke [F31 NS45425]
- ARCS Foundation, Inc /The John Douglas French Alzheimer Foundation (with the Erteszck Foundation)
Ask authors/readers for more resources
Vascular problems Increase Alzheimer's disease (AD) risk. but the nature of this relationship remains unclear Older adults having genetic risk for AD show regionally increased functional magnetic resonance imaging (fMRI) activity during memory. possibly representing compensation for a genetically induced neural deficit. We investigated whether vascular health risks, which similarly could lead to neuropsychological deficits. also showed increased fMRI activity during a memory task performed by 30 cognitively intact, primarily normotensive older adults (mean age = 61) Vascular risk measures included systolic blood pressure (sBP), body mass index (BMI), and total cholesterol Higher sBP and BMI (but not total cholesterol) were significantly correlated with increased activation in posterior cingulate cortex and frontal, temporal, and parietal regions In posterior cingulate and parietal cortices. these relationships were evident even within sBP and BMI ranges considered normal, and were independent of hippocampal volume Our results are similar to those in prior AD risk research, and suggest that fMRI reveals an abnormal response to cognitive processes in cognitively intact older adults with increased vascular risk (C) 2008 Elsevier Inc All rights reserved
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available