Article
Medicine, General & Internal
Anna Sjostrom, Simona Chisalita, Charlotte Hoybye
Summary: Growth hormone treatment increases copeptin levels, potentially compensating for the anti-natriuretic effect of the treatment. It also has an impact on body composition and water balance.
JOURNAL OF CLINICAL MEDICINE
(2022)
Article
Urology & Nephrology
Frank Geurts, Laixi Xue, Bart J. Kramers, Robert Zietse, Ron T. Gansevoort, Robert A. Fenton, Esther Meijer, Mahdi Salih, Ewout J. Hoorn, DIPAK Consortium
Summary: This study found that higher urinary excretions of PGE2 and PGEM in patients with ADPKD are associated with impaired osmoregulation, disease severity, and progression.
CLINICAL JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY
(2023)
Article
Endocrinology & Metabolism
Emanuele Varaldo, Fabio Bioletto, Daniela Cuboni, Nunzia Prencipe, Chiara Bona, Marco Barale, Ezio Ghigo, Silvia Grottoli, Alessandro Maria Berton, Valentina Gasco
Summary: This study aimed to investigate the potential use of intranasal glucagon as a stimulus test for the evaluation of pituitary function. The results showed that intranasal glucagon administration is not effective for pituitary secretion and can lead to hypokalemia as a complication.
EUROPEAN JOURNAL OF ENDOCRINOLOGY
(2023)
Review
Endocrinology & Metabolism
Mengyang Li
Summary: The GH/IGF system plays a role in growth regulation in the body. By studying the basal chordate amphioxus, it was discovered that most members of the GH/IGF system are present in amphioxus, providing strong evidence for the origin of this system in amphioxus.
FRONTIERS IN ENDOCRINOLOGY
(2022)
Article
Biochemistry & Molecular Biology
Katarzyna Malicka, Wojciech Horzelski, Andrzej Lewinski, Krzysztof C. C. Lewandowski
Summary: The study results indicate that AVP is not crucial in the stimulation of ACTH-cortisol, but it may play an important role in GH secretion.
Editorial Material
Biology
Zhe Yang, Tongtong Wang, Yuki Oka
Summary: The passage indicates that two neural circuits control the release of vasopressin in response to eating and drinking, even before there are any detectable changes in blood water levels.
Article
Biology
Angela Kim, Joseph C. Madara, Chen Wu, Mark L. Andermann, Bradford B. Lowell
Summary: This study reveals a division of labor in the neural circuits that regulate vasopressin neurons, with two distinct sets of neurons dedicated to relaying anticipatory information about water or food intake. These findings provide insight into the maintenance of healthy water levels in the body and the neural mechanisms underlying anticipatory forms of regulation.
Article
Endocrinology & Metabolism
Cihan Atila, Odile Gaisl, Deborah R. Vogt, Laura Werlen, Gabor Szinnai, Mirjam Christ-Crain
Summary: The study demonstrates that glucagon stimulates copeptin release, and copeptin response can be used to differentiate between different forms of diabetes insipidus and primary polydipsia.
EUROPEAN JOURNAL OF ENDOCRINOLOGY
(2022)
Article
Endocrinology & Metabolism
Emily K. Brooks, Warrick J. Inder
Summary: Transsphenoidal surgery is the first-line treatment for pituitary tumors and sellar lesions. Postoperative salt and water balance disorders, such as central diabetes insipidus and hyponatremia, are relatively common and can prolong hospital stay and increase the risk of readmission.
JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM
(2022)
Article
Agronomy
Lili Tan, Puyu Feng, Baoguo Li, Feng Huang, De Li Liu, Pinpin Ren, Haipeng Liu, Raghavan Srinivasan, Yong Chen
Summary: This study assessed the impacts of future climate change on water cycle and crop growth in the Haihe River Basin, China, using an improved SWAT model and MAD auto-irrigation method. The results showed an increase in crop yields, precipitation, and percolation, as well as a decrease in irrigation amount. These findings have positive effects on the sustainable development of the region.
AGRICULTURAL WATER MANAGEMENT
(2022)
Review
Immunology
Nimisha Mathur, Syed F. Mehdi, Manasa Anipindi, Monowar Aziz, Sawleha A. Khan, Hema Kondakindi, Barbara Lowell, Ping Wang, Jesse Roth
Summary: Sepsis triggers widespread inflammation, illness, and death, leading to intensive research on causes and treatments. Ghrelin, an endogenous peptide with anti-inflammatory properties, stimulates growth hormone release and appetite while also inhibiting pro-inflammatory forces, showing promising results in preclinical animal models and potentially benefiting sepsis patients.
FRONTIERS IN IMMUNOLOGY
(2021)
Review
Immunology
Ling Yang, Yao Meng, Yuxiang Shi, Hongxu Fang, Leying Zhang
Summary: This review focuses on the anatomical and immunological adaptations of the maternal liver during pregnancy, as well as the associated diseases. It also presents the factors that regulate hepatic immunology during pregnancy. These findings are important for the prevention of embryo loss, abortion, and pregnancy-associated liver diseases.
FRONTIERS IN IMMUNOLOGY
(2023)
Article
Biochemical Research Methods
Jong-Heon Kim, Ruqayya Afridi, Eunji Cho, Jong Hyuk Yoon, Yong-Hyun Lim, Ho-Won Lee, Hoon Ryu, Kyoungho Suk
Summary: Astrocytes, major supportive glia and immune modulators in the brain, communicate with other cell types through their secreted proteomes. The renin-angiotensin system (RAS) plays an important role in this communication, exacerbating neuroinflammation. This study found that soluble form of aminopeptidase N (sANPEP) and angiotensin IV (Ang IV) released by astrocytes increase neuroinflammation by interacting with angiotensin type 1 receptor on microglial cells.
MOLECULAR & CELLULAR PROTEOMICS
(2022)
Article
Immunology
Shayne Lavondua Ford, Terkild Brink Buus, Claudia Nastasi, Carsten Geisler, Charlotte Menne Bonefeld, Niels Odum, Anders Woetmann
Summary: This study reveals that human memory CD4(+) T cells can produce hepatocyte growth factor (HGF), which affects various tissues through c-Met signaling. In vitro differentiation experiments showed an increase in HGF-producing T cells under Th1 conditions. HGF production was enriched by targeting cells with surface CD30 expression, identified through single-cell RNA sequencing. Inhibition of PI3K or mTOR suppressed HGF mRNA and protein, while Akt inhibition increased their levels. These findings suggest the involvement of HGF-producing T cells in Th1-related diseases.
FRONTIERS IN IMMUNOLOGY
(2023)
Article
Biochemistry & Molecular Biology
Yoshifumi Horie, Kensuke Mitsunaga, Chee Kong Yap
Summary: Pyriproxyfen, an agricultural pesticide, was found to have a lethal effect on zebrafish in a concentration-dependent manner. The study also revealed that pyriproxyfen disrupts thyroid hormone activity in zebrafish and inhibits their growth by suppressing the expression of growth hormone.
COMPARATIVE BIOCHEMISTRY AND PHYSIOLOGY C-TOXICOLOGY & PHARMACOLOGY
(2023)
Article
Geriatrics & Gerontology
Sarah N. Kraeutner, Cristina Rubino, Jennifer K. Ferris, Shie Rinat, Lauren Penko, Larissa Chiu, Brian Greeley, Christina B. Jones, Beverley C. Larssen, Lara A. Boyd
Summary: This study examined the age-related changes in brain function and baseline brain structure that support motor skill acquisition. The findings showed that older adults experienced decreases in functional connectivity during motor skill acquisition, while younger adults experienced increases. Additionally, regardless of age group, lower baseline microstructure in a frontoparietal tract was associated with slower motor skill acquisition.
NEUROBIOLOGY OF AGING
(2024)
Article
Geriatrics & Gerontology
Karen Nuytemans, Farid Rajabli, Melissa Jean-Francois, Jiji Thulaseedhara Kurup, Larry D. Adams, Takiyah D. Starks, Patrice L. Whitehead, Brian W. Kunkle, Allison Caban-Holt, Jonathan L. Haines, Michael L. Cuccaro, Jeffery M. Vance, Goldie S. Byrd, Gary W. Beecham, Christiane Reitz, Margaret A. Pericak-Vance
Summary: This study conducted genetic research on African American AD families and identified a significant linkage signal associated with AD, highlighting the importance of diverse population-level genetic data in understanding the genetic determinants of AD.
NEUROBIOLOGY OF AGING
(2024)
Article
Geriatrics & Gerontology
Kazuya Suwabe, Ryuta Kuwamizu, Kazuki Hyodo, Toru Yoshikawa, Takeshi Otsuki, Asako Zempo-Miyaki, Michael A. Yassa, Hideaki Soya
Summary: Physical exercise has a positive impact on hippocampal memory decline with aging. Recent studies have shown that even light exercise can improve memory and this improvement is mediated by the ascending arousal system. This study aimed to investigate the effects of light-intensity exercise on hippocampal memory function in healthy older adults and found that pupil dilation during exercise played a role in the memory improvement.
NEUROBIOLOGY OF AGING
(2024)
Article
Geriatrics & Gerontology
Ajay Sood, Ana Werneck Capuano, Robert Smith Wilson, Lisa Laverne Barnes, Alifiya Kapasi, David Alan Bennett, Zoe Arvanitakis
Summary: The objective of this study was to explore the impact of metformin on cognition and brain pathology. The results showed that metformin users had slower decline in global cognition, episodic memory, and semantic memory compared to non-users. However, the relationship between metformin use and certain brain pathology remains uncertain.
NEUROBIOLOGY OF AGING
(2024)
Article
Geriatrics & Gerontology
Brian N. Lee, Junwen Wang, Molly A. Hall, Dokyoon Kim, Shana D. Stites, Li Shen
Summary: Alzheimer's disease (AD) is a neurodegenerative disorder characterized by memory and functional impairments. This study analyzed participants from the Alzheimer's Disease Neuroimaging Initiative and found differential associations between cerebral spinal fluid (CSF)/neuroimaging biomarkers and cognitive/functional outcomes, as well as variations between sexes. These findings suggest that sex differences may play a role in the development of AD.
NEUROBIOLOGY OF AGING
(2024)
Article
Geriatrics & Gerontology
Madeline R. Hale, Rebecca Langhough, Lianlian Du, Bruce P. Hermann, Carol A. Van Hulle, Margherita Carboni, Gwendlyn Kollmorgenj, Kristin E. Basche, Davide Bruno, Leah Sanson-Miles, Erin M. Jonaitis, Nathaniel A. Chin, Ozioma C. Okonkwo, Barbara B. Bendlin, Cynthia M. Carlsson, Henrik Zetterberg, Kaj Blennow, Tobey J. Betthauser, Sterling C. Johnson, Kimberly D. Mueller
Summary: This study demonstrates a relationship between cerebrospinal fluid biomarkers and the ability to recall proper names in the preclinical phase of Alzheimer's disease.
NEUROBIOLOGY OF AGING
(2024)
Article
Geriatrics & Gerontology
Thomas T. Austin, Christian L. Thomas, Ben Warren
Summary: This study investigated the effects of age on the robustness and resilience of auditory system using the desert locust. The researchers found that gene expression changes were mainly influenced by age rather than noise exposure. Both young and aged locusts were able to recover their auditory nerve function within 48 hours of noise exposure, but the recovery of transduction current magnitude was impaired in aged locusts. Key genes responsible for robustness to noise exposure in young locusts and potential candidates for compensatory mechanisms in auditory neurons of aged locusts were identified.
NEUROBIOLOGY OF AGING
(2024)
