Article
Neurosciences
Kuan-Hua Chen, Alice Y. Hua, Sandy J. Lwi, Claudia M. Haase, Howard J. Rosen, Bruce L. Miller, Robert W. Levenson
Summary: This study examined the neuroanatomical correlates of subjective experience of non-target emotions in patients with neurodegenerative diseases. The findings indicated that smaller volume in left hemisphere regions was associated with greater experience of negative non-target emotions, with effects being left-lateralized. No correlates were found for positive non-target emotions.
Article
Multidisciplinary Sciences
Nobukiyo Yoshida, Hajime Kageyama, Hiroyuki Akai, Koichiro Yasaka, Haruto Sugawara, Yukinori Okada, Akira Kunimatsu
Summary: This study evaluates the usefulness of the Pix2Pix network in motion correction for VSRAD analysis. The results show that Pix2Pix successfully corrects motion artifacts and improves the image quality, making it a useful method for VSRAD analysis.
Article
Clinical Neurology
Siddharth Ramanan, Ajay D. Halai, Lorna Garcia-Penton, Alistair G. Perry, Nikil Patel, Katie A. Peterson, Ruth U. Ingram, Ian Storey, Stefano F. Cappa, Eleonora Catricala, Karalyn Patterson, James B. Rowe, Peter Garrard, Matthew A. Lambon Ralph
Summary: The study investigated cognitive-linguistic heterogeneity in PPA using a data-driven approach. The findings revealed language and cognitive differences between different variants of PPA, which were associated with grey/white matter degeneration. By employing a transdiagnostic approach, the study revealed shared clinical and neural profiles across categorically defined variants of PPA.
ALZHEIMERS RESEARCH & THERAPY
(2023)
Article
Clinical Neurology
Kasper Katisko, Antti Cajanus, Nadine Huber, Olli Jaaskelainen, Tarja Kokkola, Virve Karkkainen, Hannah Rostalski, Paivi Hartikainen, Anne M. Koivisto, Sanna Hannonen, Juha-Matti Lehtola, Ville E. Korhonen, Seppo Helisalmi, Heli Koivumaa-Honkanen, Sanna-Kaisa Herukka, Anne M. Remes, Eino Solje, Annakaisa Haapasalo
Summary: This study suggests that GFAP in blood can differentiate between FTLD and PPD patients, predicting shorter survival and more severe brain atrophy in FTLD patients. The levels of sGFAP and bGFAP were elevated in FTLD group compared to PPD or control groups, showing strong correlation and diagnostic potential for differentiating FTLD and PPD.
JOURNAL OF NEUROLOGY NEUROSURGERY AND PSYCHIATRY
(2021)
Article
Multidisciplinary Sciences
Keita Tokumitsu, Norio Yasui-Furukori, Junko Takeuchi, Koji Yachimori, Norio Sugawara, Yoshio Terayama, Nobuyuki Tanaka, Tatsunori Naraoka, Kazutaka Shimoda
Summary: The study found that combining the MMSE score with VSRAD and eZiS quantitative indicators significantly improves the discrimination accuracy between patients with MCI and early AD, which is very helpful for improving the accuracy of dementia diagnosis.
Article
Neurosciences
Sandra Manninen, Tomi Karjalainen, Lauri J. Tuominen, Jarmo Hietala, Valtteri Kaasinen, Juho Joutsa, Juha Rinne, Lauri Nummenmaa
Summary: In a retrospective analysis of brain scans from 328 subjects, grey matter density was found to be correlated with availability of mu-opioid and dopamine D2 receptors, as well as serotonin transporters measured through PET scans. The study suggests that future research should consider the interactive effects of grey matter density and PET outcome measures when comparing different groups such as patients and controls.
Article
Geriatrics & Gerontology
Anais Falque, Melanie Jordanis, Lionel Landre, Paulo Loureiro de Sousa, Mary Mondino, Emmanuelle Furcieri, Frederic Blanc
Summary: This study investigates the impairment of narrative discourse comprehension in patients with dementia with Lewy bodies (DLB). The results suggest that DLB patients have difficulty understanding and organizing narrative discourse, which is associated with their executive dysfunction and reduced gray matter volume in the striatum.
FRONTIERS IN AGING NEUROSCIENCE
(2022)
Article
Neurosciences
Valerie Godefroy, Benedicte Batrancourt, Sylvain Charron, Arabella Bouzigues, Idil Sezer, David Bendetowicz, Guilhem Carle, Armelle Rametti-Lacroux, Stephanie Bombois, Emmanuel Cognat, Raffaella Migliaccio, Richard Levy
Summary: This study found distinct clinical subtypes of apathy in bvFTD patients, corresponding to different anatomical subtypes. These findings have important implications for clinicians in personalizing the treatment of apathy.
JOURNAL OF ALZHEIMERS DISEASE
(2022)
Article
Geriatrics & Gerontology
Martina Amanzio, Sara Palermo, Mario Stanziano, Federico D'Agata, Antonello Galati, Salvatore Gentile, Giancarlo Castellano, Massimo Bartoli, Giuseppina Elena Cipriani, Elisa Rubino, Paolo Fonio, Innocenzo Rainero
Summary: Our study reveals a correlation between early frailty in bvFTD patients and a specific pattern of co-occurring GM atrophy and hypometabolism. These findings underscore the potentially critical and precocious role of the insula in the pathogenesis of frailty, combined with executive dysfunction and mood changes, which may lead to a higher risk of poor prognosis.
FRONTIERS IN AGING NEUROSCIENCE
(2021)
Article
Multidisciplinary Sciences
Walter H. L. Pinaya, Cristina Scarpazza, Rafael Garcia-Dias, Sandra Vieira, Lea Baecker, Pedro F. da Costa, Alberto Redolfi, Giovanni B. Frisoni, Michela Pievani, Vince D. Calhoun, Joao R. Sato, Andrea Mechelli
Summary: The study evaluated normative models based on deep autoencoders using structural neuroimaging data from patients with Alzheimer's disease and mild cognitive impairment. Patients exhibited deviations according to the severity of their clinical condition, with key brain regions identified as critical for calculating the deviation score. The normative model demonstrated comparable cross-cohort generalizability to traditional classifiers and the scripts and trained models are available to the wider research community for open science promotion.
SCIENTIFIC REPORTS
(2021)
Article
Multidisciplinary Sciences
Qian Zhang, XiaoLi Yang, ZhongKui Sun
Summary: This study explores the importance of classification features and experimental algorithms in early detection and diagnosis of Alzheimer's disease. The results indicate that the combination of gray matter volume and lateralization index is an effective feature, and different classifier algorithms have varying performances in different subject groups. Combining the lateralization index with gray matter volume can significantly improve classification accuracy.
Article
Neurosciences
Lin Song, Xiaodong Han, Yuanjing Li, Xiaolei Han, Mingqing Zhao, Chunyan Li, Pin Wang, Jiafeng Wang, Yi Dong, Lin Cong, Xiaojuan Han, Tingting Hou, Keke Liu, Yongxiang Wang, Chengxuan Qiu, Yifeng Du
Summary: The KIBRA rs17070145 C-allele is associated with a reduced likelihood of olfactory impairment among older adults, partly mediated through left thalamic gray matter volume.
Article
Behavioral Sciences
Myrthe G. Rijpma, Maxime Montembeault, Suzanne Shdo, Joel H. Kramer, Bruce L. Miller, Katherine P. Rankin
Summary: Attaching semantic meaning to sensory information received from both inside and outside our bodies is a fundamental function of the human brain. The formation of semantic knowledge relies on connections between distributed modality-specific spoke-nodes and a modality-general hub in the anterior temporal lobes (ATLs). In addition to the ATL semantic hub, a social semantic task also requires input from hedonic evaluation structures.
Article
Geriatrics & Gerontology
Richard Agren, Amar Awad, Patric Blomstedt, Anders Fytagoridis
Summary: Comparison of cerebellar lobule volumes between ET patients and HCs using automated segmentation revealed smaller volumes in ET patients, opposing the hypothesis of localized atrophy in cerebellar motor areas in ET. However, the possibility of cerebellar pathophysiology in ET was not ruled out. Further prospective investigations using alternative neuroimaging modalities may help elucidate the pathophysiology of ET and guide diagnostic and therapeutic approaches.
FRONTIERS IN AGING NEUROSCIENCE
(2021)
Review
Behavioral Sciences
Mary Clare McKenna, Jasmin Lope, Peter Bede, Ee Ling Tan
Summary: Frontotemporal dementia (FTD) phenotypes are characterized by cortical atrophy and regional hypometabolism, but the cognitive and behavioral manifestations in FTD result from dysfunction in multisynaptic networks. The thalamus plays a key role in several important circuits involved in FTD. This paper reviews evidence for thalamic pathology in FTD and outlines future research directions and priorities.
BRAIN AND BEHAVIOR
(2023)
Article
Clinical Neurology
Janina Krell-Roesch, Martin Rakusa, Jeremy A. Syrjanen, Argonde C. van Harten, Val J. Lowe, Clifford R. Jack, Walter K. Kremers, David S. Knopman, Gorazd B. Stokin, Ronald C. Petersen, Maria Vassilaki, Yonas E. Geda
Summary: This study examined the association between CSF biomarkers of Alzheimer's disease and neuropsychiatric symptoms in older non-demented adults. The results showed that lower CSF Aβ42 and higher t-tau/Aβ42 and p-tau/Aβ42 ratios were associated with depression, anxiety, and other NPS.
ALZHEIMERS & DEMENTIA
(2023)
Article
Clinical Neurology
Patrick H. Luckett, Charlie Chen, Brian A. Gordon, Julie Wisch, Sarah B. Berman, Jasmeer P. Chhatwal, Carlos Cruchaga, Anne M. Fagan, Martin R. Farlow, Nick C. Fox, Mathias Jucker, Johannes Levin, Colin L. Masters, Hiroshi Mori, James M. Noble, Stephen Salloway, Peter R. Schofield, Adam M. Brickman, William S. Brooks, David M. Cash, Michael J. Fulham, Bernardino Ghetti, Clifford R. Jack, Jonathan Voeglein, William E. Klunk, Robert Koeppe, Yi Su, Michael Weiner, Qing Wang, Daniel Marcus, Deborah Koudelis, Nelly Joseph-Mathurin, Lisa Cash, Russ Hornbeck, Chengjie Xiong, Richard J. Perrin, Celeste M. Karch, Jason Hassenstab, Eric McDade, John C. Morris, Tammie L. S. Benzinger, Randall J. Bateman, Beau M. Ances
Summary: This study analyzed 19 biomarkers of Alzheimer's disease using hierarchical clustering and feature selection, and found that amyloid and tau measures were the primary predictors. Emerging biomarkers of neuronal integrity and inflammation showed weaker predictive ability.
ALZHEIMERS & DEMENTIA
(2023)
Article
Geriatrics & Gerontology
Juraj Sprung, Mariana L. Laporta, David S. Knopman, Ronald C. Petersen, Michelle M. Mielke, Clifford R. Jack, David P. Martin, Andrew C. Hanson, Darrell R. Schroeder, Phillip J. Schulte, Scott A. Przybelski, Diana J. Valencia Morales, Toby N. Weingarten, Prashanthi Vemuri, David O. Warner
Summary: This study found that hospitalization in older adults is associated with accelerated cortical thinning, amyloid accumulation, and white matter hyperintensities (WMH) increases, especially in medical hospitalizations. However, these changes were modest and did not translate to an increased risk of crossing the abnormality threshold.
JOURNALS OF GERONTOLOGY SERIES A-BIOLOGICAL SCIENCES AND MEDICAL SCIENCES
(2023)
Article
Clinical Neurology
Michael W. Weiner, Danielle Harvey, Susan M. Landau, Dallas P. Veitch, Thomas C. Neylan, Jordan H. Grafman, Paul S. Aisen, Ronald C. Petersen, Clifford R. Jack, Duygu Tosun, Leslie M. Shaw, John Q. Trojanowski, Andrew J. Saykin, Jacqueline Hayes, Charles De Carli
Summary: The study found no significant association between TBI and/or PTSD and biomarker-defined AD. Veterans with TBI and/or PTSD had poorer cognitive status, which may be attributed to other comorbid pathologies.
ALZHEIMERS & DEMENTIA
(2023)
Article
Radiology, Nuclear Medicine & Medical Imaging
Emanuele Camerucci, Jonathan Graff-Radford, David T. Jones, Benjamin D. Elder, Jeffrey L. Gunter, Jeremy K. Cutsforth-Gregory, Hugo Botha, Matthew C. Murphy, Derek R. Johnson, Caroline Davidge-Pitts, Clifford R. Jack, John Huston, Petrice M. Cogswell
Summary: This study evaluated the change in size of focally enlarged sulci (FES) and pituitary height after shunt placement in patients with idiopathic normal pressure hydrocephalus (iNPH). The results showed a significant decrease in FES volume and a significant increase in pituitary gland size after shunt placement.
JOURNAL OF MAGNETIC RESONANCE IMAGING
(2023)
Article
Oncology
Firat Kara, Christine M. Lohse, Anna M. Castillo, Nirubol Tosakulwong, Timothy G. Lesnick, Clifford R. Jack, Ronald C. Petersen, Janet E. Olson, Fergus J. Couch, Kathryn J. Ruddy, Kejal Kantarci, Michelle M. Mielke
Summary: This study aimed to investigate whether the use of selective estrogen receptor modifiers (SERMs), including tamoxifen and raloxifene, was associated with cognitive performance and markers of neurodegeneration associated with Alzheimer's disease. The results showed no significant associations between the use of SERMs and cognition or MCI in both breast cancer patients and women without a history of cancer.
Article
Clinical Neurology
Clifford R. Jack Jr, Heather J. Wiste, Alicia Algeciras-Schimnich, Dan J. Figdore, Christopher G. Schwarz, Val J. Lowe, Vijay K. Ramanan, Prashanthi Vemuri, Michelle M. Mielke, David S. Knopman, Jonathan Graff-Radford, Bradley F. Boeve, Kejal Kantarci, Petrice M. Cogswell, Matthew L. Senjem, Jeffrey L. Gunter, Terry M. Therneau, Ronald C. Petersen
Summary: Staging the severity of Alzheimer's disease pathology is important for therapeutic trials and clinical prognosis. Biomarkers such as amyloid and tau PET can be used for disease staging, but plasma biomarkers would be more practical.
Article
Clinical Neurology
Vijay K. Ramanan, Robel K. Gebre, Jonathan Graff-Radford, Ekaterina Hofrenning, Alicia Algeciras-Schimnich, Daniel J. Figdore, Val J. Lowe, Michelle M. Mielke, David S. Knopman, Owen A. Ross, Clifford R. Jack Jr, Ronald C. Petersen, Prashanthi Vemuri
Summary: Ramanan et al. found that integrating genetic risk scores improves the diagnostic value of plasma biomarkers for Alzheimer's disease, especially in predicting amyloid PET positivity. However, more advances are needed before these biomarkers can be widely used. By analyzing a large sample, they discovered that the AD-GRS is independently associated with amyloid PET levels and significantly enhances the classification accuracy of amyloid PET positivity when combined with high plasma p-tau(181). Machine learning methods that incorporate plasma biomarkers, demographics, and the AD-GRS show high accuracy in predicting amyloid PET levels.
Article
Clinical Neurology
Diego Z. Carvalho, Stuart J. McCarter, Erik K. St Louis, Scott A. Przybelski, Kohl Johnson L. Sparrman, Virend K. Somers, Bradley F. Boeve, Ronald C. Petersen, Clifford R. Jack Jr, Jonathan Graff-Radford, Prashanthi Vemuri
Summary: This study aimed to investigate the association between polysomnographic (PSG) sleep parameters and neuroimaging biomarkers of cerebrovascular disease (CVD) in older adults with obstructive sleep apnea (OSA). The results showed that reduced slow-wave sleep and severe OSA were associated with increased burden of white matter abnormalities in older adults, which may contribute to a higher risk of cognitive impairment, dementia, and stroke.
Article
Clinical Neurology
Neha Atulkumar Singh, Peter R. Martin, Jonathan Graff-Radford, Irene Sintini, Mary M. Machulda, Joseph R. Duffy, Jeffrey L. Gunter, Hugo Botha, David T. Jones, Val J. Lowe, Clifford R. JackJr, Keith A. Josephs, Jennifer L. Whitwell
Summary: Posterior cortical atrophy and logopenic progressive aphasia are atypical clinical presentations of Alzheimer's disease, both showing disruptions in functional networks. The language network is affected in logopenic progressive aphasia, while the visual network is affected in posterior cortical atrophy. However, there is limited knowledge about the differences in connectivity within and between brain networks in these atypical Alzheimer's disease phenotypes.
BRAIN COMMUNICATIONS
(2023)
Article
Clinical Neurology
Nick Corriveau-Lecavalier, Jeffrey L. Gunter, Michael Kamykowski, Ellen Dicks, Hugo Botha, Walter K. Kremers, Jonathan Graff-Radford, Daniela A. Wiepert, Christopher G. Schwarz, Essa Yacoub, David S. Knopman, Bradley F. Boeve, Kamil Ugurbil, Ronald C. Petersen, Clifford R. Jack, Melissa J. Terpstra, David T. Jones
Summary: From a complex systems perspective, clinical syndromes emerging from neurodegenerative diseases are thought to result from multiscale interactions between aggregates of misfolded proteins and the disequilibrium of large-scale networks coordinating functional operations underpinning cognitive phenomena. Age-related disruption of the default mode network is accelerated by amyloid deposition in all syndromic presentations of Alzheimer's disease, while syndromic variability may reflect selective neurodegeneration of modular networks supporting specific cognitive abilities. This study investigates the use of a biomarker of default mode network dysfunction, the network failure quotient, to assess Alzheimer's disease in a normative cohort and differentiate between different phenotypes of the disease. The study provides important insights into the shared pathophysiological mechanisms and distinct neurodegenerative processes involved in Alzheimer's disease.
BRAIN COMMUNICATIONS
(2023)
Article
Neurosciences
Nicole S. McKay, Brian A. Gordon, Russ C. Hornbeck, Aylin Dincer, Shaney Flores, Sarah J. Keefe, Nelly Joseph-Mathurin, Clifford R. Jack, Robert Koeppe, Peter R. Millar, Beau M. Ances, Charles D. Chen, Alisha Daniels, Diana A. Hobbs, Kelley Jackson, Deborah Koudelis, Parinaz Massoumzadeh, Austin McCullough, Michael L. Nickels, Farzaneh Rahmani, Laura Swisher, Qing Wang, Ricardo F. Allegri, Sarah B. Berman, Adam M. Brickman, William S. Brooks, David M. Cash, Jasmeer P. Chhatwal, Gregory S. Day, Martin R. Farlow, Christian la Fougere, Nick C. Fox, Michael Fulham, Bernardino Ghetti, Neill Graff-Radford, Takeshi Ikeuchi, William Klunk, Jae-Hong Lee, Johannes Levin, Ralph Martins, Colin L. Masters, Jonathan McConathy, Hiroshi Mori, James Noble, Gerald Reischl, Christopher Rowe, Stephen Salloway, Raquel Sanchez-Valle, Peter R. Schofield, Hiroyuki Shimada, Mikio Shoji, Yi Su, Kazushi Suzuki, Jonathan Voeglein, Igor Yakushev, Carlos Cruchaga, Jason Hassenstab, Celeste Karch, Eric McDade, Richard J. Perrin, Chengjie Xiong, John C. Morris, Randall J. Bateman, Tammie L. S. Benzinger
Summary: The Dominantly Inherited Alzheimer Network (DIAN) is an international collaboration that studies autosomal dominant Alzheimer disease (ADAD). ADAD arises from mutations in three genes. Non-carrier siblings from ADAD families can be recruited for case-control studies. The predictable age of onset in ADAD allows for mapping candidate AD biomarkers during the preclinical phase. This study provides valuable data for understanding early disease stages of both ADAD and sporadic AD, as well as for research in healthy aging.
NATURE NEUROSCIENCE
(2023)
Article
Clinical Neurology
Srishti Shrestha, Xiaoqian Zhu, Kevin J. Sullivan, Chad Blackshear, Jennifer A. Deal, A. Richey Sharrett, Vidyulata Kamath, Andrea L. C. Schneider, Clifford R. Jack, Juebin Huang, Priya Palta, Robert I. Reid, David S. Knopman, Rebecca F. Gottesman, Honglei Chen, B. Gwen Windham, Michael E. Griswold, Jr Thomas H. Mosley
Summary: Research shows that neuronal microstructural integrity in multiple brain regions, particularly the medial temporal lobe (MTL), is associated with odor identification ability. The associations between microstructural integrity and olfaction are stronger in individuals with mild cognitive impairment (MCI) compared to those with normal cognition, suggesting different effects of dementia pathogenesis.
Article
Clinical Neurology
Keenan A. Walker, Ron C. Hoogeveen, Aaron R. Folsom, Christie M. Ballantyne, David S. Knopman, B. Gwen Windham, Clifford R. Jack Jr, Rebecca F. Gottesman
Summary: In the article "Midlife Systemic Inflammatory Markers Are Associated With Late-Life Brain Volume: The ARIC Study" by Walker et al., coding errors were found to have affected the statistical analyses. The authors have corrected the errors and reanalyzed the data, stating that the errors did not change the overall message of the article. The identified errors include misclassification of a nominal covariate, use of incorrect alcohol use covariate, and an error in the scaling of beta coefficients.
Article
Clinical Neurology
Rioghna R. Pittock, Jeremiah A. Aakre, Anna M. Castillo, Vijay K. Ramanan, Walter K. Kremers, Clifford R. Jack Jr, Prashanthi Vemuri, Val J. Lowe, David S. Knopman, Ronald C. Petersen, Jonathan Graff-Radford, Maria Vassilaki
Summary: Treatment options for Alzheimer's disease are limited, and research on the applicability of anti-beta-amyloid monoclonal antibodies in the general population is lacking. This study aims to assess the generalizability of anti-amyloid treatment and apply the eligibility criteria of two clinical trials to a population-based sample.
Article
Geriatrics & Gerontology
Sarah N. Kraeutner, Cristina Rubino, Jennifer K. Ferris, Shie Rinat, Lauren Penko, Larissa Chiu, Brian Greeley, Christina B. Jones, Beverley C. Larssen, Lara A. Boyd
Summary: This study examined the age-related changes in brain function and baseline brain structure that support motor skill acquisition. The findings showed that older adults experienced decreases in functional connectivity during motor skill acquisition, while younger adults experienced increases. Additionally, regardless of age group, lower baseline microstructure in a frontoparietal tract was associated with slower motor skill acquisition.
NEUROBIOLOGY OF AGING
(2024)
Article
Geriatrics & Gerontology
Karen Nuytemans, Farid Rajabli, Melissa Jean-Francois, Jiji Thulaseedhara Kurup, Larry D. Adams, Takiyah D. Starks, Patrice L. Whitehead, Brian W. Kunkle, Allison Caban-Holt, Jonathan L. Haines, Michael L. Cuccaro, Jeffery M. Vance, Goldie S. Byrd, Gary W. Beecham, Christiane Reitz, Margaret A. Pericak-Vance
Summary: This study conducted genetic research on African American AD families and identified a significant linkage signal associated with AD, highlighting the importance of diverse population-level genetic data in understanding the genetic determinants of AD.
NEUROBIOLOGY OF AGING
(2024)
Article
Geriatrics & Gerontology
Kazuya Suwabe, Ryuta Kuwamizu, Kazuki Hyodo, Toru Yoshikawa, Takeshi Otsuki, Asako Zempo-Miyaki, Michael A. Yassa, Hideaki Soya
Summary: Physical exercise has a positive impact on hippocampal memory decline with aging. Recent studies have shown that even light exercise can improve memory and this improvement is mediated by the ascending arousal system. This study aimed to investigate the effects of light-intensity exercise on hippocampal memory function in healthy older adults and found that pupil dilation during exercise played a role in the memory improvement.
NEUROBIOLOGY OF AGING
(2024)
Article
Geriatrics & Gerontology
Ajay Sood, Ana Werneck Capuano, Robert Smith Wilson, Lisa Laverne Barnes, Alifiya Kapasi, David Alan Bennett, Zoe Arvanitakis
Summary: The objective of this study was to explore the impact of metformin on cognition and brain pathology. The results showed that metformin users had slower decline in global cognition, episodic memory, and semantic memory compared to non-users. However, the relationship between metformin use and certain brain pathology remains uncertain.
NEUROBIOLOGY OF AGING
(2024)
Article
Geriatrics & Gerontology
Brian N. Lee, Junwen Wang, Molly A. Hall, Dokyoon Kim, Shana D. Stites, Li Shen
Summary: Alzheimer's disease (AD) is a neurodegenerative disorder characterized by memory and functional impairments. This study analyzed participants from the Alzheimer's Disease Neuroimaging Initiative and found differential associations between cerebral spinal fluid (CSF)/neuroimaging biomarkers and cognitive/functional outcomes, as well as variations between sexes. These findings suggest that sex differences may play a role in the development of AD.
NEUROBIOLOGY OF AGING
(2024)
Article
Geriatrics & Gerontology
Madeline R. Hale, Rebecca Langhough, Lianlian Du, Bruce P. Hermann, Carol A. Van Hulle, Margherita Carboni, Gwendlyn Kollmorgenj, Kristin E. Basche, Davide Bruno, Leah Sanson-Miles, Erin M. Jonaitis, Nathaniel A. Chin, Ozioma C. Okonkwo, Barbara B. Bendlin, Cynthia M. Carlsson, Henrik Zetterberg, Kaj Blennow, Tobey J. Betthauser, Sterling C. Johnson, Kimberly D. Mueller
Summary: This study demonstrates a relationship between cerebrospinal fluid biomarkers and the ability to recall proper names in the preclinical phase of Alzheimer's disease.
NEUROBIOLOGY OF AGING
(2024)
Article
Geriatrics & Gerontology
Thomas T. Austin, Christian L. Thomas, Ben Warren
Summary: This study investigated the effects of age on the robustness and resilience of auditory system using the desert locust. The researchers found that gene expression changes were mainly influenced by age rather than noise exposure. Both young and aged locusts were able to recover their auditory nerve function within 48 hours of noise exposure, but the recovery of transduction current magnitude was impaired in aged locusts. Key genes responsible for robustness to noise exposure in young locusts and potential candidates for compensatory mechanisms in auditory neurons of aged locusts were identified.
NEUROBIOLOGY OF AGING
(2024)
