Article
Gastroenterology & Hepatology
Ronja Doerk, Penelope Pelczar, Ahmad M. Shiri, Annika Volmari, Elisabeth Zierz, Anastasios Giannou, Marius Boettcher, Lidia Bosurgi, Samuel Huber, Carolin F. Manthey
Summary: The absence of myeloid PDGFR-alpha increases susceptibility to acute colitis by causing an increase in gut permeability and impairment in phagocytosis. PDGFR-alpha plays a protective role in maintaining gut homeostasis by promoting a beneficial gut microbiota and providing an anti-inflammatory macrophage phenotype.
JOURNAL OF CROHNS & COLITIS
(2023)
Letter
Oncology
Simone Romagnoli, Niccolo Bartalucci, Francesca Gesullo, Manjola Balliu, Stefania Bonifacio, Anair Graciela Lema Fernandez, Francesco Mannelli, Davide Bolognini, Elisabetta Pelo, Cristina Mecucci, Paola Guglielmelli, Alessandro Maria Vannucchi
Summary: Eosinophilia is a group of diseases with heterogeneous pathobiology, with gene fusions playing a key role in diagnosis. Current cytogenetics methods may have limitations in diagnostic accuracy due to the heterogeneity of genomic aberrations. Nanopore-based sequencing technology can efficiently identify genomic fusions, enhancing diagnostic efficiency.
BIOMARKER RESEARCH
(2021)
Article
Oncology
Gong Peng, Yin Wang, Pengfei Ge, Christopher Bailey, Peng Zhang, Di Zhang, Zhaoli Meng, Chong Qi, Qian Chen, Jingtao Chen, Junqi Niu, Pan Zheng, Yang Liu, Yan Liu
Summary: The study found that HIF1 alpha plays a crucial role in GBM by regulating the expression of PDGF-D and PDGFR alpha to maintain the constitutive activation of the AKT pathway, which is essential for GBM malignancy. Therapies targeting HIF1 alpha may provide effective treatment for GBM.
JOURNAL OF EXPERIMENTAL & CLINICAL CANCER RESEARCH
(2021)
Article
Biochemistry & Molecular Biology
Hsiao-Chi Lai, Pei-Hsuan Chen, Chia-Hua Tang, Lee-Wei Chen
Summary: DPP4 stimulation may be a novel therapy to increase local adipogenesis and systemic adiponectin levels, as it increases the expression of adipogenesis-related genes and the population of DPP4(+) cells among PDGFR alpha(+) cells.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Biochemistry & Molecular Biology
Irina Schaefer, Clement Verkest, Lucas Vespermann, Thomas Mair, Hannah Voss, Nadja Zeitzschel, Stefan G. Lechner
Summary: PKA is a downstream effector of inflammatory mediators that increase pain hypersensitivity. This study investigates how PKA modulates the mechanosensitivity of the ion channel PIEZO2, which is crucial for nociceptor function. The research identifies multiple PKA phosphorylation sites on PIEZO2 and demonstrates that mutations in these sites abolish PKA-dependent modulation. The study also reveals functional differences between PIEZO1 and PIEZO2 and suggests that PIEZO2 is a polymodal mechanosensor.
JOURNAL OF BIOLOGICAL CHEMISTRY
(2023)
Article
Biochemistry & Molecular Biology
Haifeng Zheng, Lauren Peri, Grace K. Ward, Kenton M. Sanders, Sean M. Ward
Summary: This study investigates the distribution and functional role of PDGFR alpha(+) cells in the heart and finds that they are widely distributed within the atria, ventricle, and sino-atrial node tissues. These cells generate inward currents and membrane potential changes, suggesting their involvement in the regulation of cardiac excitability.
Article
Biochemistry & Molecular Biology
Veronika Aleksandrovych, Anna Wrona, Tomasz Bereza, Kazimierz Pitynski, Krzysztof Gil
Summary: Tubal factor infertility can be caused by various factors, including impaired muscular contractility and ciliary beating, immunological imbalance, and chronic inflammation. Telocytes in the fallopian tubes play a crucial role in regulating physiological processes such as local innervation, sensitivity to hypoxia, and hormone balances. Their involvement in nerve conduction and integration in contractions and cilia physiology highlight their significance in fertility research.
Article
Biochemistry & Molecular Biology
Yichun Wang, Diyu Chen, Han Xie, Shuhua Zhou, Mingwang Jia, Xiaobo He, Feifei Guo, Yihuan Lai, Xiao Xiao Tang
Summary: This study investigates the role of lncRNA GAS5 in myofibroblast transformation during IPF progression. GAS5 is found to repress pericyte-myofibroblast transformation by inhibiting PDGFR alpha/beta expression via KDM5B-mediated H3K4me2/3 demethylation. Therefore, GAS5 may serve as an intervention target for IPF.
MOLECULAR MEDICINE
(2023)
Article
Biochemistry & Molecular Biology
Guadalupe Garcia, Karina A. Mendez-Resendiz, Norma Oviedo, Janet Murbartian
Summary: PKC and PKA phosphorylation inhibit TREK-1 channels downstream of G(s) protein-coupled receptor activation in vitro. This study investigated the role of phosphorylation of TREK-1 in neuropathic pain, finding that PKC and PKA modulators can alter TREK-1 function to contribute to antiallodynia in neuropathic rats, potentially through the phosphorylation sites S300 and S333.
JOURNAL OF NEUROCHEMISTRY
(2021)
Article
Cell Biology
Xiaokan Zhang, Bryan Z. Wang, Michael Kim, Trevor R. Nash, Bohao Liu, Jenny Rao, Roberta Lock, Manuel Tamargo, Rajesh Kumar Soni, John Belov, Eric Li, Gordana Vunjak-Novakovic, Barry Fine
Summary: Protein kinase A (PKA) is critical for cardiac function, but its activity is tightly regulated. In this study, we identified STK25 as a kinase of PRKAR1A, a regulatory subunit of PKA. Phosphorylation of PRKAR1A inhibits PKA activity and increases binding to the catalytic subunit. Knockout of Stk25 in mice leads to decreased Prkar1a phosphorylation, increased Pka activity, and enhanced response to beta-adrenergic stimulation. These findings suggest that STK25 acts as a negative regulator of PKA signaling through phosphorylation of PRKAR1A.
Article
Agriculture, Multidisciplinary
Xin Wang, Hao Cai, Shanshan Shui, Yan Lin, Fangbin Wang, Lu Wang, Juan Chen, Jian Liu
Summary: Chrysin, a natural flavonoid, alleviates adiposity and insulin resistance in mice fed a high-fat diet. It promotes subcutaneous adipocyte browning and systemic energy expenditure by regulating PDGFR alpha and microRNA expressions in the SAT.
JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY
(2021)
Article
Biochemistry & Molecular Biology
Abhijit Nirwane, Yao Yao
Summary: Through lineage tracing technique, it was found that SMA(low/undetectable) pericytes and fibroblasts proliferated significantly after ischemic stroke, and SMA(low/undetectable) pericytes differentiated into microglial cells and macrophages. These results indicate the importance of targeting these pericytes in the treatment of ischemic stroke.
CELLULAR AND MOLECULAR LIFE SCIENCES
(2022)
Article
Cell Biology
Xi Zheng, Fengjiao Wang, Xiaoxiao Hu, Hua Li, Zhen Guan, Yanding Zhang, Xuefeng Hu
Summary: Specific ablation of Pdgfr alpha in the sinoatrial node (SAN) of mice did not result in any malformation in SAN morphology. Adult mutant mice had normal cardiac function and unaltered Nkx2.5 expression in the SAN, indicating that Pdgfr alpha is dispensable for SAN development after its fate commitment in mice.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2021)
Article
Biochemistry & Molecular Biology
Soohyun P. Kim, Hao Da, Lei Wang, Makoto M. Taketo, Mei Wan, Ryan C. Riddle
Summary: Sclerostin, an antagonist of the Wnt signaling pathway, regulates the communication between bone and adipose tissue, influencing adipocyte formation and metabolism through various mechanisms. Studies have shown that deficiency of sclerostin can lead to an increase in adipocyte progenitors, a decrease in fat mass, and improved glucose metabolism.
Article
Biochemistry & Molecular Biology
Bin Gao, Xiaolin Wang, Wonhyo Seo, Seol Hee Park, Yaojie Fu, Seonghwan Hwang, Robim M. Rodrigues, Dechun Feng, Bin Gao, Yong He
Summary: miR-223 restricts liver fibrosis by targeting multiple genes in hepatocytes and HSCs, providing potential therapeutic targets for the treatment of liver fibrosis.
INTERNATIONAL JOURNAL OF BIOLOGICAL SCIENCES
(2021)
Editorial Material
Oncology
Deanna Marie Tiek, Shi-Yuan Cheng
Correction
Chemistry, Multidisciplinary
Bo Yu, Fei Luo, Bowen Sun, Wenxue Liu, Qiqi Shi, Shi-Yuan Cheng, Ceshi Chen, Guoqiang Chen, Yanxin Li, Haizhong Feng
Article
Cell & Tissue Engineering
Shanshan Li, Lili Song, Yingwen Zhang, Zhiyan Zhan, Yi Yang, Lisha Yu, Hua Zhu, Weihua Huang, Wanqiao Wang, Haizhong Feng, Yanxin Li
Summary: This study describes a reliable method to produce functional macrophages through the differentiation of human induced pluripotent stem cells (hiPSCs). By optimizing the size control of embryoid bodies (EBs), the differentiation process of macrophages was accelerated and the production increased without attenuating macrophage functions. The final yield of macrophages was close to 50-fold of starting iPSCs, and the macrophages showed phagocytic capacity in vitro and in a xenograft tumor model.
STEM CELLS INTERNATIONAL
(2022)
Editorial Material
Oncology
Anshika Goenka, Shi-Yuan Cheng
Article
Oncology
Matthew McCord, Elizabeth Bartom, Kirsten Burdett, Aneta Baran, Frank D. Eckerdt, Irina Balyasnikova, Kathleen McCortney, Thomas Sears, Shi-Yuan Cheng, Jann N. Sarkaria, Roger Stupp, Amy B. Heimberger, Atique Ahmed, Charles David James, Craig Horbinski
Summary: This study developed therapy-resistant glioblastoma patient-derived xenografts (PDX) by exposing them to radiation and temozolomide. These PDX models reflect key features of recurrent glioblastoma and can serve as valuable tools for testing new therapies.
Article
Oncology
Ayechew A. Getu, Ming Zhou, Shi-Yuan Cheng, Ming Tan
Summary: Cancer, a complex and dynamic disease, remains a leading cause of death in humans. The Mammalian Sterile 20-Like Kinase 4 (MST4 or STK26) plays a crucial role in cell migration and polarity, and is involved in various processes such as tumor cell proliferation, migration, invasion, survival, and cancer metastasis. MST4 interacts with PDCD10 to promote tumor growth and migration, and phosphorylates ATG4B to mediate autophagy signaling and contribute to treatment resistance. Overall, MST4 functions as an oncogene and shows potential as a therapeutic target.
Article
Oncology
Anshika Goenka, Xiao Song, Deanna Tiek, Rebeca Piatniczka Iglesia, Minghui Lu, Chang Zeng, Craig Horbinski, Wei Zhang, Bo Hu, Shi-Yuan Cheng
Summary: In this study, a novel oncogenic long noncoding RNA (lncRNA) called LINC02283 was identified. It is highly expressed in glioma patients with PDGFRA mutation and is associated with poor prognosis. LINC02283 interacts with PDGFRA to enhance its signaling pathway and promote oncogenesis in glioblastoma. These findings provide strong evidence for the potential of lncRNAs as therapeutic targets.
Article
Oncology
Michael A. Sun, Rui Yang, Heng Liu, Wenzhe Wang, Xiao Song, Bo Hu, Nathan Reynolds, Kristen Roso, Lee H. Chen, Paula K. Greer, Stephen T. Keir, Roger E. McLendon, Shi-Yuan Cheng, Darell D. Bigner, David M. Ashley, Christopher J. Pirozzi, Yiping He
Summary: In this study, researchers discovered that clemastine, a non-oncology drug for allergy relief, can inhibit the proliferation and promote differentiation of brain tumor-initiating cells (BTICs). They also identified the essential role of Emopamil-binding protein (EBP) in maintaining the BTIC population. These findings provide valuable insights for developing new treatments for glioblastoma.
Meeting Abstract
Oncology
Michael Sun, Rui Yang, Heng Liu, Wenzhe Wang, Xiao Song, Bo Hu, Nathan Reynolds, Kristen Roso, Lee Chen, Paula Greer, Shi-Yuan Cheng, David Ashley, Christopher Pirozzi, Yiping He
Meeting Abstract
Oncology
Deanna Tiek, Shi-Yuan Cheng, Xiao Song, Anshika Goenka, Rebeca Iglesia, Bo Hu, Rebecca Riggins
Meeting Abstract
Oncology
Anshika Goenka, Xiao Song, Deanna Tiek, Bo Hu, Shi-Yuan Cheng
Meeting Abstract
Clinical Neurology
Deanna Tiek, Xiao Song, Anshika Goenka, Rebeca Iglesia, Bo Hu, Rebecca Riggins, Shi-Yuan Cheng
ANNALS OF NEUROLOGY
(2022)
Meeting Abstract
Clinical Neurology
Xiao Song, Tianzhi Huang, Deanna Tiek, Shunichiro Miki, Anshika Goenka, Rebeca Iglesia, Frank B. Furnari, Bo Hu, Shi-Yuan Cheng
ANNALS OF NEUROLOGY
(2022)
Meeting Abstract
Clinical Neurology
Anshika Goenka, Xiao Song, Deanna M. Tiek, Bo Hu, Shi-Yuan Cheng
ANNALS OF NEUROLOGY
(2022)
Review
Oncology
Deanna Tiek, Shi-Yuan Cheng
Summary: This review discusses different strategies to combat cancer drug resistance, including synthetic lethality and modulation of the tumor microenvironment. By understanding the relationship between targetable mutations and metabolism in tumor cells and their surrounding microenvironment, smarter drugs can be designed to fight cancer drug resistance.
CANCER DRUG RESISTANCE
(2022)