Review
Medicine, General & Internal
Tineke van de Weijer, Martijn P. G. Broen, Rik P. M. Moonen, Ann Hoeben, Monique Anten, Koos Hovinga, Inge Compter, Jochem A. J. van der Pol, Cristina Mitea, Toine M. Lodewick, Arnaud Jacquerie, Felix M. Mottaghy, Joachim E. Wildberger, Alida A. Postma
Summary: Gliomas, the most frequent primary brain tumors, have prognosis and treatment dependent on grade and molecular markers. Multi-parametric MRI and F-18-FET PET imaging techniques are valuable for the evaluation of gliomas.
Review
Medicine, General & Internal
Giulia Santo, Riccardo Laudicella, Flavia Linguanti, Anna Giulia Nappi, Elisabetta Abenavoli, Vittoria Vergura, Giuseppe Rubini, Roberto Sciagra, Gaspare Arnone, Orazio Schillaci, Fabio Minutoli, Sergio Baldari, Natale Quartuccio, Sotirios Bisdas
Summary: This comprehensive review evaluates the utility of amino acid PET radiotracers compared to MRI in assessing glioma recurrence. The study found that amino acid PET provides complementary and comparable information to standard modalities, making it an essential tool for differentiation between tumor recurrence and other entities.
Article
Computer Science, Interdisciplinary Applications
Christoph W. Lerche, Timon Radomski, Philipp Lohmann, Liliana Caldeira, Claudia Regio Brambilla, Lutz Tellmann, Juergen Scheins, Elena Rota Kops, Norbert Galldiks, Karl-Josef Langen, Hans Herzog, N. Jon Shah
Summary: A linearized model for dynamic PET scans of F-18-FET TACs was derived and validated in this study, showing high agreement with measured TACs and small parameter uncertainties. The model demonstrated good diagnostic performance in discriminating between IDH wildtype and IDH mutant gliomas in adult patients. Voxel-wise fitting within a short computation time and comparable classification accuracy to linear fits based on average TAC values were achievable.
IEEE TRANSACTIONS ON MEDICAL IMAGING
(2021)
Article
Oncology
Bastien Allard, Brieg Dissaux, David Bourhis, Gurvan Dissaux, Ulrike Schick, Pierre-Yves Salaun, Ronan Abgral, Solene Querellou
Summary: Radiolabeled amino acid PET/CT can be used for better tumor delineation and guiding radiation dose escalation in the treatment of high-grade gliomas. This study showed modest similarity between the areas of high uptake on PET/CT, the residual tumor on post-therapy MRI, and the area of recurrence on MRI. The similarities improved in patients who underwent only biopsy or partial surgery.
Article
Radiology, Nuclear Medicine & Medical Imaging
Brieg Dissaux, Doria Mazouz Fatmi, Julien Ognard, Bastien Allard, Nathalie Keromnes, Amina Latreche, Amandine Lepeuve, Ulrike Schick, Vincent Bourbonne, Douraied Ben Salem, Gurvan Dissaux, Solene Querellou
Summary: This study assessed the inter-observer agreement for tumor volume delineations in newly diagnosed, untreated high-grade glioma patients using multiparametric MRI and 18-F-FET-PET/CT. The results showed high inter-observer agreement for 18-F-FET-PET/CT, T1-GD, and T2-FLAIR sequences. However, the DWI (b1000, ADC), rCBV, and K2-based sequences were not sufficiently reproducible for daily practice.
Article
Oncology
Annekatrin Seidlitz, Bettina Beuthien-Baumann, Steffen Loeck, Christina Jentsch, Ivan Platzek, Klaus Zoephel, Annett Linge, Joerg Kotzerke, Jan Petr, Joerg van den Hoff, Joerg Steinbach, Dietmar Krex, Gabriele Schmitz-Schackert, Monique Falk, Michael Baumann, Mechthild Krause
Summary: This study reveals that in patients with glioblastoma, those without increased tracer accumulation in postoperative MET-PET have longer time to recurrence, while residual tumors detected by MRI post-surgery affect time to recurrence. Significant multivariable predictors for time to recurrence include MET accumulation in pre-RCTPET, MRI positivity, and MGMT hypermethylation.
CLINICAL CANCER RESEARCH
(2021)
Article
Radiology, Nuclear Medicine & Medical Imaging
Zhicong Li, Adrien Holzgreve, Lena M. Unterrainer, Viktoria C. Ruf, Stefanie Quach, Laura M. Bartos, Bogdana Suchorska, Maximilian Niyazi, Vera Wenter, Jochen Herms, Peter Bartenstein, Joerg-Christian Tonn, Marcus Unterrainer, Nathalie L. Albert, Lena Kaiser
Summary: This study built and evaluated a prediction model using clinical parameters and radiomic features extracted from [F-18]FET PET for survival stratification in patients with newly diagnosed IDH-wildtype glioblastoma. The model achieved high predictability of short-term survival and improved patient stratification beyond established prognostic markers.
EUROPEAN JOURNAL OF NUCLEAR MEDICINE AND MOLECULAR IMAGING
(2023)
Article
Oncology
Lena M. Mittlmeier, Bogdana Suchorska, Viktoria Ruf, Adrien Holzgreve, Matthias Brendel, Jochen Herms, Peter Bartenstein, Joerg C. Tonn, Marcus Unterrainer, Nathalie L. Albert
Summary: IDHwt gliomas with long-term survival have younger age, higher rate of WHO grade III gliomas, higher MGMT promoter methylation, and lack of TERTp mutations. In imaging, long-term survivors show smaller biological tumor volume and significantly longer time-to-peak on F-18-FET PET, with no difference in uptake intensity.
Article
Radiology, Nuclear Medicine & Medical Imaging
Zhicong Li, Lena Kaiser, Adrien Holzgreve, Viktoria C. Ruf, Bogdana Suchorska, Vera Wenter, Stefanie Quach, Jochen Herms, Peter Bartenstein, Joerg-Christian Tonn, Marcus Unterrainer, Nathalie L. Albert
Summary: The study aimed to evaluate radiomic features extracted from dynamic [F-18]FET PET images for predicting TERTp-mutation status in patients with IDH-wildtype high-grade glioma, with the time-to-peak model showing the highest predictability.
EUROPEAN JOURNAL OF NUCLEAR MEDICINE AND MOLECULAR IMAGING
(2021)
Article
Oncology
Ye Cheng, Shuangshuang Song, Yukui Wei, Geng Xu, Yang An, Jie Ma, Hongwei Yang, Zhigang Qi, Xinru Xiao, Jie Bai, Lixin Xu, Zeliang Hu, Tingting Sun, Leiming Wang, Jie Lu, Qingtang Lin
Summary: This study established accurate diagnostic criteria for gliomas based on FET-PET and DWI, identifying correlations between different gene mutations and imaging values, providing higher diagnostic accuracy for high-grade gliomas with IDH1, hTERT, and EGFR mutations.
FRONTIERS IN ONCOLOGY
(2021)
Article
Biochemistry & Molecular Biology
Marija Skoblar Vidmar, Andrej Doma, Uros Smrdel, Katarina Zevnik, Andrej Studen
Summary: This study assessed the diagnostic performance of F-18-FET PET in the evaluation of treatment response in glioma patients and found that its diagnostic value differs based on the IDH mutation status of the tumor. Dynamic imaging is less useful for IDH mutant tumors.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Radiology, Nuclear Medicine & Medical Imaging
Amarnath Jena, Sangeeta Taneja, Anna Ara Khan, Shanti K. Sogani
Summary: This study aims to distinguish between true recurrence and radiation necrosis of brain tumors using a combination of PET imaging and advanced MRI parameters, achieving high accuracy, sensitivity, and specificity. Further large-scale prospective studies with neuropathological validations are needed to confirm these findings.
CLINICAL NUCLEAR MEDICINE
(2021)
Review
Oncology
Orit Kaidar-Person, Birgitte V. Offersen, Liesbeth Boersma, Icro Meattini, David Dodwell, Lynda Wyld, Marianne Aznar, Tibor Major, Thorsten Kuehn, Vratislav Strnad, Miika Palmu, Sandra Hol, Philip Poortmans
Summary: Delineation of target and 'organ at risk' volumes is crucial in modern radiation therapy planning, especially for treating breast cancer. This paper provides tips and tricks for optimal target volume definition and delineation in postoperative breast cancer irradiation.
RADIOTHERAPY AND ONCOLOGY
(2021)
Article
Radiology, Nuclear Medicine & Medical Imaging
Caterina Brighi, Simon Puttick, Shenpeng Li, Paul Keall, Katherine Neville, David Waddington, Pierrick Bourgeat, Ashley Gillman, Michael Fay
Summary: This study aims to eliminate methodological errors in background activity definition through the introduction of a semiautomated method for region of interest selection. The proposed semiautomated method showed significantly lower variability in background activity and BTV definition compared to the current state-of-the-art method involving manual drawing of reference regions.
Article
Clinical Neurology
Jacek Furtak, Jozefina Rakowska, Tadeusz Szylberg, Marek Harat, Bogdan Malkowski, Maciej Harat
Summary: Neuroimaging using FET-PET provides additional information on tumor grade and extent compared with MRI. Dual time-point FET-PET-based biopsies can offer valuable clinical information for glioma diagnosis and treatment planning. Target selection based on dual time-point images may be useful for identifying the most malignant tumor areas.
FRONTIERS IN NEUROLOGY
(2021)
Article
Oncology
Lena Nenoff, Michael Matter, Agnes Geetanjali Jarhall, Carla Winterhalter, Jenny Gorgisyan, Mirjana Josipovic, Gitte F. Persson, Per Munck af Rosenschold, Damien Charles Weber, Antony John Lomax, Francesca Albertini
INTERNATIONAL JOURNAL OF RADIATION ONCOLOGY BIOLOGY PHYSICS
(2020)
Review
Oncology
M. Unterrainer, C. Eze, H. Ilhan, S. Marschner, O. Roengvoraphoj, N. S. Schmidt-Hegemann, F. Walter, W. G. Kunz, P. Munck af Rosenschold, R. Jeraj, N. L. Albert, A. L. Grosu, M. Niyazi, P. Bartenstein, C. Belka
RADIATION ONCOLOGY
(2020)
Article
Oncology
Daniel Gram, Andre Haraldsson, N. Patrik Brodin, Karsten Nysom, Thomas Bjork-Eriksson, Per Munck af Rosenschold
RADIATION ONCOLOGY
(2020)
Article
Environmental Sciences
Irene B. Jensen, Elisabeth Bjork Bramberg, Charlotte Wahlin, Christina Bjorklund, Ulric Hermansson, Malin Lohela Karlson, Liselotte Schafer Elinder, Peter Munck af Rosenschold, Tarja Nevala, Ned Carter, Bodil Mellblom, Lydia Kwak
INTERNATIONAL JOURNAL OF ENVIRONMENTAL RESEARCH AND PUBLIC HEALTH
(2020)
Article
Multidisciplinary Sciences
Anders E. Hansen, Jonas R. Henriksen, Rasmus Jolck, Frederikke P. Fliedner, Linda M. Bruun, Jonas Scherman, Andreas Jensen, Per Munck Af Rosenschold, Lilah Moorman, Sorel Kurbegovic, Steen R. de Blanck, Klaus R. Larsen, Paul F. Clementsen, Anders N. Christensen, Mads H. Clausen, Wenbo Wang, Paul Kempen, Merete Christensen, Niels-Erik Viby, Gitte Persson, Rasmus Larsen, Knut Conradsen, Fintan J. McEvoy, Andreas Kjaer, Thomas Eriksen, Thomas L. Andresen
Article
Radiology, Nuclear Medicine & Medical Imaging
Paul J. Keall, Amit Sawant, Ross Berbeco, Jeremy T. Booth, Byungchul Cho, Laura Cervino, Eileen Cirino, Sonja Dieterich, Martin F. Fast, Peter B. Greer, Per Munck Af Rosenschold, Parag J. Parikh, Per Rugaard Poulsen, Lakshmi Santanam, George W. Sherouse, Jie Shi, Sotirios Stathakis
Summary: MLC tracking is a widely available radiotherapy technology that has been extensively researched and implemented, providing the radiation oncology community with new clinical implementation guidelines and quality assurance recommendations.
Article
Oncology
Anni Young Lundgaard, Lisa Lyngsie Hjalgrim, Laura Ann Rechner, Michael Lundemann, N. Patrik Brodin, Morten Joergensen, Lena Specht, Maja Vestmoe Maraldo
Summary: The study analyzed adolescent young adults with Hodgkin lymphoma treated with radiation therapy according to pediatric or adult protocols. It found that patients on pediatric regimens had more advanced disease, leading to higher risks of radiation-induced late effects and corresponding life years lost compared to adult regimens.
STRAHLENTHERAPIE UND ONKOLOGIE
(2021)
Article
Oncology
Elise Konradsson, Maja L. Arendt, Kristine Bastholm Jensen, Betina Borresen, Anders E. Hansen, Sven Back, Annemarie T. Kristensen, Per Munck af Rosenschold, Crister Ceberg, Kristoffer Petersson
Summary: The study of FLASH radiotherapy in canine cancer patients showed promising feasibility and efficacy, with proper dose control and safety monitoring in place. Adverse events were mild and manageable, paving the way for further research in veterinary and human clinical trials.
FRONTIERS IN ONCOLOGY
(2021)
Article
Oncology
Michael Lempart, Martin P. Nilsson, Jonas Scherman, Christian Jamtheim Gustafsson, Mikael Nilsson, Sara Alkner, Jens Engleson, Gabriel Adrian, Per Munck af Rosenschold, Lars E. Olsson
Summary: This study developed a deep learning model, named Pelvic U-Net, for the automated and improved segmentations of organs at risk (OAR) in the pelvic region. The model showed credible and clinically applicable results, with improved performance compared to previous studies. Additionally, the model reduced segmentation time by 70%, allowing for an accelerated radiation therapy treatment planning workflow for anal cancer patients.
RADIATION ONCOLOGY
(2022)
Article
Oncology
Hanna Ek, Ingrid Fagerstrom Kristensen, Lars Stenberg, Sara Kinhult, Hunor Benedek, Simon Ek, Svend Aage Engelholm, Silke Engelholm, Per Munck af Rosenschold
Summary: This study investigated the characteristics and treatment outcomes of patients selected for proton radiation therapy (PT) for lower-grade gliomas. The study found no difference in the risk of pseudo-progression (PsP) between PT and photon therapy (XRT), and PT was associated with lower rates of fatigue within three months after treatment and better survival outcomes.
Article
Oncology
Daniel Gram, N. Patrik Brodin, Thomas Bjork-Eriksson, Karsten Nysom, Per Munck af Rosenschold
Summary: This study investigated the risk of neurocognitive impairment caused by craniospinal irradiation (CSI) and the feasibility and effects of hippocampal sparing. The results show that by sparing the hippocampus, the risk of neurocognitive impairment can be significantly reduced without compromising tumor control.
Article
Clinical Neurology
Ingrid Tonning Olsson, Johan Lundgren, Lars Hjorth, Per Munck Af Rosenschold, Asa Hammar, Sean Perrin
Summary: This study aimed to statistically model neurocognitive development in survivors of pediatric brain tumors (PBTs), both irradiated and non-irradiated, and identify clinical variables associated with decline in neurocognitive scores. The study found that survivors of PBTs experience a decline in neurocognitive scores regardless of treatment received, indicating the need for routine screening for neurocognitive rehabilitation. However, survivors treated with whole-brain radiation therapy (WBRT) and/or ventriculo-peritoneal (VP) shunting showed a faster decline and are at higher risk for negative neurocognitive outcomes.
CHILD NEUROPSYCHOLOGY
(2023)
Article
Oncology
Maximilian Niyazi, Nicolaus Andratschke, Martin Bendszus, Anthony J. Chalmers, Sara C. Erridge, Norbert Galldiks, Frank J. Lagerwaard, Pierina Navarria, Per Munck af Rosenschoeld, Umberto Ricardi, Martin J. van den Bent, Michael Weller, Claus Belka, Giuseppe Minniti
Summary: This guideline aims to update the existing European consensus on delineation of the clinical target volume (CTV) in adult glioblastoma patients. It discusses key issues including pre-treatment steps, target delineation, and technical aspects of treatment. Based on the EORTC recommendation, a single CTV definition using post-operative contrast-enhanced T1 abnormalities is recommended, without the need to cone down. The PTV margin should be based on individual mask system and IGRT procedures, usually no greater than 3 mm.
RADIOTHERAPY AND ONCOLOGY
(2023)
Meeting Abstract
Oncology
M. Lempart, M. P. Nilsson, J. Scherman, M. Nilsson, C. J. Gustafsson, C. J. Gustafsson, P. Munck af Rosenschold, L. E. Olsson
RADIOTHERAPY AND ONCOLOGY
(2021)
Article
Oncology
Michael Lempart, Hunor Benedek, Christian Jamtheim Gustafsson, Mikael Nilsson, Niklas Eliasson, Sven Back, Per Munck af Rosenschold, Lars E. Olsson
Summary: A new study trained a deep learning model based on triplets to predict VMAT dose distributions for prostate cancer patients, showing improved accuracy and efficiency in dose predictions, which were successfully transformed into deliverable treatment plans. The research suggests that triplet-based training can enhance the accuracy and efficiency of VMAT dose predictions.
PHYSICS & IMAGING IN RADIATION ONCOLOGY
(2021)
