Akt- or MEK-mediated mTOR inhibition suppresses Nf1 optic glioma growth

The impact of coexisting genetic mutations on murine optic glioma biology

(2014) Aparna Kaul et al.   NEURO-ONCOLOGY

Handheld Optical Coherence Tomography During Sedation in Young Children With Optic Pathway Gliomas

(2014) Robert A. Avery et al.   JAMA Ophthalmology

Sex Is a major determinant of neuronal dysfunction in neurofibromatosis type 1

(2013) Kelly A. Diggs-Andrews et al.   ANNALS OF NEUROLOGY

NF1 Deletion Generates Multiple Subtypes of Soft-Tissue Sarcoma That Respond to MEK Inhibition

(2013) R. D. Dodd et al.   MOLECULAR CANCER THERAPEUTICS

NG2-cells are not the cell of origin for murine neurofibromatosis-1 (Nf1) optic glioma

(2013) A C Solga et al.   ONCOGENE

Visual acuity of children treated with chemotherapy for optic pathway gliomas

(2013) Evan Kalin-Hajdu et al.   PEDIATRIC BLOOD & CANCER

Pediatric glioma-associated KIAA1549:BRAF expression regulates neuroglial cell growth in a cell type-specific and mTOR-dependent manner

(2012) A. Kaul et al.   GENES & DEVELOPMENT

Sustained MEK inhibition abrogates myeloproliferative disease in Nf1 mutant mice

(2012) Tiffany Chang et al.   JOURNAL OF CLINICAL INVESTIGATION

MEK inhibition exhibits efficacy in human and mouse neurofibromatosis tumors

(2012) Walter J. Jessen et al.   JOURNAL OF CLINICAL INVESTIGATION

Visual outcomes in children with neurofibromatosis type 1-associated optic pathway glioma following chemotherapy: a multicenter retrospective analysis

(2012) M. J. Fisher et al.   NEURO-ONCOLOGY

Multiple increased osteoclast functions in individuals with neurofibromatosis type 1

(2011) David A. Stevenson et al.   AMERICAN JOURNAL OF MEDICAL GENETICS PART A

JNK inhibitors increase osteogenesis in Nf1-deficient cells

(2011) Kate Sullivan et al.   BONE

Antitumor Activity of NVP-BKM120--A Selective Pan Class I PI3 Kinase Inhibitor Showed Differential Forms of Cell Death Based on p53 Status of Glioma Cells

(2011) D. Koul et al.   CLINICAL CANCER RESEARCH

Hyperactivation of mTOR critically regulates abnormal osteoclastogenesis in neurofibromatosis type 1

(2011) Junrong Ma et al.   JOURNAL OF ORTHOPAEDIC RESEARCH

Identification and Characterization of NVP-BKM120, an Orally Available Pan-Class I PI3-Kinase Inhibitor

(2011) S.-M. Maira et al.   MOLECULAR CANCER THERAPEUTICS

Neurofibromatosis-1 regulates mTOR-mediated astrocyte growth and glioma formation in a TSC/Rheb-independent manner

(2011) S. Banerjee et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Defective cAMP Generation Underlies the Sensitivity of CNS Neurons to Neurofibromatosis-1 Heterozygosity

(2010) J. A. Brown et al.   JOURNAL OF NEUROSCIENCE

MK-2206, an Allosteric Akt Inhibitor, Enhances Antitumor Efficacy by Standard Chemotherapeutic Agents or Molecular Targeted Drugs In vitro and In vivo

(2010) H. Hirai et al.   MOLECULAR CANCER THERAPEUTICS

Microarray analyses reveal regional astrocyte heterogeneity with implications for neurofibromatosis type 1 (NF1)-regulated glial proliferation

(2009) Tu-Hsueh Yeh et al.   GLIA

Response and resistance to MEK inhibition in leukaemias initiated by hyperactive Ras

(2009) Jennifer O. Lauchle et al.   NATURE

Pak1 regulates multiple c-Kit mediated Ras-MAPK gain-in-function phenotypes in Nf1+/- mast cells

(2008) A. S. McDaniel et al.   BLOOD

Increased c-Jun-NH2-Kinase Signaling in Neurofibromatosis-1 Heterozygous Microglia Drives Microglia Activation and Promotes Optic Glioma Proliferation

(2008) G. C. Daginakatte et al.   CANCER RESEARCH

Preclinical Cancer Therapy in a Mouse Model of Neurofibromatosis-1 Optic Glioma

(2008) B. Hegedus et al.   CANCER RESEARCH

TORC1 Is Essential for NF1-Associated Malignancies

(2008) Cory M. Johannessen et al.   CURRENT BIOLOGY

Oncogenic MAPK Signaling Stimulates mTORC1 Activity by Promoting RSK-Mediated Raptor Phosphorylation

(2008) Audrey Carrière et al.   CURRENT BIOLOGY

Neurofibromin regulates somatic growth through the hypothalamic–pituitary axis

(2008) Balazs Hegedus et al.   HUMAN MOLECULAR GENETICS

Effective in vivo targeting of the mammalian target of rapamycin pathway in malignant peripheral nerve sheath tumors

(2008) G. Johansson et al.   MOLECULAR CANCER THERAPEUTICS