Multivoxel 1H MR spectroscopy is superior to contrast-enhanced MRI for response assessment after anti-angiogenic treatment of orthotopic human glioma xenografts and provides handles for metabolic targeting

RTOG 0825: Phase III double-blind placebo-controlled trial evaluating bevacizumab (Bev) in patients (Pts) with newly diagnosed glioblastoma (GBM).

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Targeting Metabolic Remodeling in Glioblastoma Multiforme

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Vascular change measured with independent component analysis of dynamic susceptibility contrast MRI predicts bevacizumab response in high-grade glioma

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Effects of Dual Targeting of Tumor Cells and Stroma in Human Glioblastoma Xenografts with a Tyrosine Kinase Inhibitor against c-MET and VEGFR2

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Tumor angiogenesis and anti-angiogenic therapy in malignant gliomas revisited

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Analysis of Tumor Metabolism Reveals Mitochondrial Glucose Oxidation in Genetically Diverse Human Glioblastomas in the Mouse Brain In Vivo

(2012) Isaac Marin-Valencia et al.   Cell Metabolism

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Targeting glucose metabolism for cancer therapy: Figure 1.

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(2012) Elizabeth A. Maher et al.   NMR IN BIOMEDICINE

Pseudoprogression and Pseudoresponse: Imaging Challenges in the Assessment of Posttreatment Glioma

(2011) L.C. Hygino da Cruz et al.   AMERICAN JOURNAL OF NEURORADIOLOGY

Characterization of bevacizumab dose response relationship in U87 brain tumors using magnetic resonance imaging measures of enhancing tumor volume and relative cerebral blood volume

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Tumor invasion after treatment of glioblastoma with bevacizumab: radiographic and pathologic correlation in humans and mice

(2011) J. F. de Groot et al.   NEURO-ONCOLOGY

DCE and DW-MRI monitoring of vascular disruption following VEGF-Trap treatment of a rat glioma model

(2011) Benjamin A. Hoff et al.   NMR IN BIOMEDICINE

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(2011) Olivier Keunen et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

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Anticancer drugs that target metabolism: Is dichloroacetate the new paradigm?

(2010) Ioanna Papandreou et al.   INTERNATIONAL JOURNAL OF CANCER

Updated Response Assessment Criteria for High-Grade Gliomas: Response Assessment in Neuro-Oncology Working Group

(2010) Patrick Y. Wen et al.   JOURNAL OF CLINICAL ONCOLOGY

Volumetric analysis of functional diffusion maps is a predictive imaging biomarker for cytotoxic and anti-angiogenic treatments in malignant gliomas

(2010) Benjamin M. Ellingson et al.   JOURNAL OF NEURO-ONCOLOGY

Effects of targeting the VEGF and PDGF pathways in diffuse orthotopic glioma models

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Imaging of Brain Tumors: MR Spectroscopy and Metabolic Imaging

(2010) Alena Horská et al.   NEUROIMAGING CLINICS OF NORTH AMERICA

New insights into the physiological role of carbonic anhydrase IX in tumour pH regulation

(2010) P Swietach et al.   ONCOGENE

Metabolic Modulation of Glioblastoma with Dichloroacetate

(2010) E. D. Michelakis et al.   Science Translational Medicine

Concerns about anti-angiogenic treatment in patients with glioblastoma multiforme

(2009) Joost JC Verhoeff et al.   BMC CANCER

Bevacizumab Alone and in Combination With Irinotecan in Recurrent Glioblastoma

(2009) Henry S. Friedman et al.   JOURNAL OF CLINICAL ONCOLOGY

Effects of radiotherapy with concomitant and adjuvant temozolomide versus radiotherapy alone on survival in glioblastoma in a randomised phase III study: 5-year analysis of the EORTC-NCIC trial

(2009) Roger Stupp et al.   LANCET ONCOLOGY

Oxygen Consumption Can Regulate the Growth of Tumors, a New Perspective on the Warburg Effect

(2009) Yijun Chen et al.   PLoS One

Phenotypic and Genotypic Characterization of Orthotopic Human Glioma Models and Its Relevance for the Study of Anti-glioma Therapy

(2008) An Claes et al.   BRAIN PATHOLOGY

Characterisation of tumour vasculature in mouse brain by USPIO contrast-enhanced MRI

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(2008) Andrew D Norden et al.   CURRENT OPINION IN ONCOLOGY

Antiangiogenic therapy using bevacizumab in recurrent high-grade glioma: impact on local control and patient survival

(2008) Ashwatha Narayana et al.   JOURNAL OF NEUROSURGERY

Antiangiogenic compounds interfere with chemotherapy of brain tumors due to vessel normalization

(2008) A. Claes et al.   MOLECULAR CANCER THERAPEUTICS