Article
Clinical Neurology
Kihwan Hwang, Yong Hwy Kim, Jung Hee Kim, Jung Hyun Lee, Hee Kyung Yang, Jeong-Min Hwang, Chae-Yong Kim, Jung Ho Han
Summary: The study on the natural history of asymptomatic nonfunctioning pituitary adenomas (NFPAs) with optic nerve compression showed that close follow-up and timely surgical intervention can effectively prevent visual and endocrine issues for cases with optic nerve compression, and conservative management is also acceptable for these tumors. Careful follow-up is necessary for tumors with cavernous sinus invasion.
JOURNAL OF NEUROSURGERY
(2021)
Article
Clinical Neurology
Mohamed H. Khattab, Alexander D. Sherry, Mark C. Xu, Patrick Kelly, Joshua L. Anderson, Guozhen Luo, Lola B. Chambless, Anthony J. Cmelak, Albert Attia
Summary: HSRT is a safe and effective treatment option for patients with large NFPAs with chiasm involvement. Local control and toxicity rates are similar between HSRT and single-fraction stereotactic radiosurgery. Further studies are needed to optimize fractionated approaches and patient selection.
JOURNAL OF NEUROLOGICAL SURGERY PART B-SKULL BASE
(2021)
Article
Oncology
Michael T. Milano, Jimm Grimm, Scott G. Soltys, Ellen Yorke, Vitali Moiseenko, Wolfgang A. Tome, Arjun Sahgal, Jinyu Xue, Lijun Ma, Timothy D. Solberg, John P. Kirkpatrick, Louis S. Constine, John C. Flickinger, Lawrence B. Marks, Issam El Naqa
Summary: This study analyzed dosimetric and clinical predictors of radiation-induced optic nerve/chiasm neuropathy after single-fraction stereotactic radiosurgery or hypofractionated radiosurgery. The results showed that the maximum point dose to the optic apparatus was related to RION risk, providing insight into NTCP risks.
INTERNATIONAL JOURNAL OF RADIATION ONCOLOGY BIOLOGY PHYSICS
(2021)
Article
Neurosciences
Eric J. Lehrer, Roman O. Kowalchuk, Daniel M. Trifiletti, Jason P. Sheehan
Summary: Pituitary adenomas are common benign brain tumors, comprising 10%-20% of all central nervous system neoplasms. Stereotactic radiosurgery (SRS) has emerged as an effective treatment option for these tumors, with high tumor control rates. However, potential side effects such as endocrine dysfunction and visual deficits need to be considered. Hypofractionated SRS, delivered in multiple fractions, is an alternative treatment option for patients who are not suitable for single fraction SRS.
Article
Oncology
Thomas Charleux, Veronique Vendrely, Aymeri Huchet, Renaud Trouette, Amandine Ferriere, Antoine Tabarin, Vincent Jecko, Hugues Loiseau, Charles Dupin
Summary: The first line of treatment for nonfunctioning pituitary adenoma (NFPA) is surgery. Adjuvant radiotherapy or surveillance and new treatment (second surgical operation or salvage radiotherapy) in case of recurrence are options discussed at the multidisciplinary tumor board. The purpose of this study was to evaluate the therapeutic outcome for each option. Results showed that adjuvant radiotherapy was not superior to salvage radiotherapy in preventing recurrence, therefore salvage radiotherapy is recommended in case of recurrence or progression to avoid a second surgical operation.
RADIATION ONCOLOGY
(2022)
Article
Endocrinology & Metabolism
Ashley J. Han, Elena V. Varlamov, Maria Fleseriu
Summary: This study characterized the clinical features and natural history of nonfunctioning pituitary microadenomas and found that they are generally benign. It suggests that the initial MRI follow-up interval for these tumors can be extended up to 3 years, unless there are specific concerns.
JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM
(2022)
Article
Endocrinology & Metabolism
Khi Yung Fong, Mervyn Jun Rui Lim, Shuning Fu, Chen Ee Low, Yiong Huak Chan, Doddabele Srinivasa Deepak, Xinni Xu, Mark Thong, Swati Jain, Kejia Teo, Paul A. Gardner, Carl H. Snyderman, Vincent Diong Weng Nga, Tseng Tsai Yeo
Summary: This study analyzed the impact of surgical approach, completeness of resection, and postoperative radiotherapy on long-term progression-free survival (PFS) of symptomatic nonfunctioning pituitary adenomas (NFPA) using individual patient data (IPD) meta-analysis. The results showed that gross total resection (GTR) had a significantly higher PFS compared to subtotal resection (STR), and postoperative radiotherapy improved PFS, especially for patients with STR. The surgical approach did not significantly affect long-term prognosis.
Article
Endocrinology & Metabolism
Nasrin Al-Shamkhi, Katarina Berinder, Henrik Borg, Pia Burman, Per Dahlqvist, Charlotte Hoybye, Daniel S. Olsson, Oskar Ragnarsson, Bertil Ekman, Britt Eden Engstrom
Summary: Objective data on pituitary function before and after transsphenoidal surgery in nonfunctioning pituitary adenomas were inconsistent. This study found that adrenocorticotrophic hormone deficiency increased significantly at 1 year postoperatively, while other axis function changes were not significant. Therefore, continuous individual evaluations are needed during longer follow-up of patients operated for NFPA.
EUROPEAN JOURNAL OF ENDOCRINOLOGY
(2023)
Article
Clinical Neurology
Georgios Mantziaris, Stylianos Pikis, Tomas Chytka, Roman Liscak, Kimball Sheehan, Darrah Sheehan, Selcuk Peker, Yavuz Samanci, Shray K. Bindal, Ajay Niranjan, L. Dade Lunsford, Rupinder Kaur, Renu Madan, Manjul Tripathi, Dhiraj J. Pangal, Ben A. Strickland, Gabriel Zada, Anne-Marie Langlois, David Mathieu, Ronald E. Warnick, Samir Patel, Zayda Minier, Herwin Speckter, Zhiyuan Xu, Rithika Kormath Anand, Jason P. Sheehan
Summary: This study analyzed 375 patients with residual nonfunctioning pituitary adenomas (NFPAs) who were treated with stereotactic radiosurgery (SRS) and compared the outcomes between early treatment and treatment at progression. The results showed that there was no significant difference in tumor control and preservation of hormonal/visual function between SRS at residual NFPA progression and adjuvant SRS. Deferring radiosurgical management to the time of radiological progression could prolong the onset of radiosurgically induced pituitary dysfunction.
JOURNAL OF NEUROSURGERY
(2023)
Article
Oncology
S. Sumodhee, V. Atallah, R. Kinj, J. Doyen, B. L'Homel, P. Gillon, P. Paquis, F. Almairac, S. Hieronimus, R. Schiappa, J. -l. Sadoul, D. Sumodhee, N. Pontikos, Q. Richier, J. -m. Hannoun-Levi, C. Scouarnec, N. Chevalier, P. -Y. Bondiau
Summary: This study evaluated the efficacy and toxicity of hypofractionated stereotactic radiotherapy (HSRT) for pituitary adenoma (PA) and found that delivering 35 Gy in 5 fractions is a feasible treatment option that can reduce hormonal overproduction and improve local control.
CANCER RADIOTHERAPIE
(2022)
Article
Medicine, General & Internal
Yoon-Hee Choo, Youngbeom Seo, Oh-Lyong Kim
Summary: This study retrospectively analyzed the outcomes of the transsphenoidal approach for nonfunctioning pituitary adenomas treated at a single institute. The study found that the transsphenoidal approach is an effective and safe treatment, improving visual impairment and restoring endocrine function. Diabetes insipidus was the most common complication, and complete resection during surgery helped to lower the risk of recurrence.
ANNALS OF MEDICINE
(2022)
Article
Endocrinology & Metabolism
Tobias Hallen, Gudmundur Johannsson, Rahil Dahlen, Camilla A. M. Glad, Charlotte Orndal, Angelica Engvall, Helena Caren, Thomas Skoglund, Daniel S. Olsson
Summary: This study explored DNA methylation patterns associated with tumor progression in patients with nonfunctioning pituitary adenomas (NFPAs). The results showed that some methylation sites were associated with tumor progression and could potentially serve as biomarkers for early identification of tumor progression.
JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM
(2022)
Article
Clinical Neurology
Aiko Hata, Masaya Oda, Takahiro Ono, Akira Suzuki, Noriaki Hanyu, Masataka Takahashi, Toshio Sasajima, Manabu Hashimoto, Taizen Nakase, Hiroaki Shimizu
Summary: The long-term follow-up study on HFSRT for perioptic NFPAs showed a successful tumor size control rate of 97%, with 60% of patients maintaining unchanged visual functions, 34% showing improvement, and 6% experiencing deterioration without any complications related to the treatment.
NEUROLOGIA MEDICO-CHIRURGICA
(2021)
Article
Oncology
Sergej Telentschak, Daniel Ruess, Stefan Grau, Roland Goldbrunner, Niklas von Spreckelsen, Karolina Jablonska, Harald Treuer, Martin Kocher, Maximilian Ruge
Summary: The study retrospectively analyzed 34 patients treated with CK-hSRS, showing good treatment effectiveness with high local control rates but a 12% complication rate.
JOURNAL OF CANCER RESEARCH AND CLINICAL ONCOLOGY
(2021)
Article
Clinical Neurology
Yasuyuki Kinoshita, Akira Taguchi, Atsushi Tominaga, Kazunori Arita, Fumiyuki Yamasaki
Summary: Recovery from AGHD after initial TSS is more likely in younger female patients with higher peak GH levels assessed by preoperative PPT. Patients aged <= 62.2 years and with a peak GH level of >= 0.74 μg/L based on preoperative PPT are likely to recover from AGHD.
JOURNAL OF NEUROSURGERY
(2021)