☆ 4.6 Editorial Material

Immunotherapy for glioblastoma: a long and winding road

NEURO-ONCOLOGY (2010)

Journal

NEURO-ONCOLOGY

Volume 12, Issue 4, Pages 319-319

Publisher

OXFORD UNIV PRESS INC

DOI: 10.1093/neuonc/noq027

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The long and winding road of cardiomyocyte maturation

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From Mixed Hyperplastic/Adenomatous Polyp to Sessile Serrated Lesion A Long and Winding Road for Long and Winding Crypts

Adam L. Booth, Melissa W. Taggart, Yuho Ono, Raul S. Gonzalez

Summary: The current terminology and criteria for sessile serrated lesion remain a point of contention worldwide, despite research shedding light on the characteristic architecture and morphology, immunohistochemical patterns, and molecular alterations that aid in diagnosis. Multiple consensus meetings have developed their own criteria and nomenclature, often leading to clashes or mixing of terms.

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The Long and Winding Road to Cardiac Regeneration

Anna Maria Sacco, Clotilde Castaldo, Franca Di Meglio, Daria Nurzynska, Stefano Palermi, Rocco Spera, Rossana Gnasso, Giorgio Zinno, Veronica Romano, Immacolata Belviso

Summary: Cardiac regeneration is crucial for treating heart diseases, focusing on repairing and enhancing damaged myocardium. Stem cell-based therapies using adult and pluripotent stem cells hold immense potential for replenishing lost cardiomyocytes and facilitating cardiac tissue repair. Tissue engineering employs biomaterials to construct cardiac patches and grafts with suitable properties, and bioreactors to create functional constructs for cardiac recovery, aiming to provide mechanical support and promote tissue healing when transplanted into the heart.

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Editorial Material Biochemical Research Methods

The long and winding road of development: a coordinated song of transcription factors

Aly Makhlouf, Marta N. Shahbazi

Summary: By creating a four-dimensional single-cell atlas of transcription factor expression in Caenorhabditis elegans, novel regulators of embryo development were identified and molecular models of cell fate specification were generated.

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On a Long and Winding Road: Alloantibodies in Organ Transplantation

Georg A. Boehmig, Philip F. Halloran, Helmut E. Feucht

Summary: It is now known that both the humoral and cellular arms of the immune system are involved in severe immunological challenges. The close collaboration between B and T cells plays a crucial role in various natural challenges, such as infections, cancer, and autoimmune diseases. The ongoing COVID-19 pandemic vividly demonstrates the significance and power of humoral immunity. However, it took time for the scientific community to recognize the complex interactions involved and establish widely accepted concepts.

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Seizure forecasting: Bifurcations in the long and winding road

Maxime O. Baud, Timothee Proix, Nicholas M. Gregg, Benjamin H. Brinkmann, Ewan S. Nurse, Mark J. Cook, Philippa J. Karoly

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The long and winding road of designing phosphodiesterase inhibitors for the treatment of heart failure

Nathalia Fonseca Nadur, Luciana Luiz de Azevedo, Lucas Caruso, Cedric Stephan Graebin, Renata Barbosa Lacerda, Arthur Eugen Kummerle

Summary: PDEs play a critical role in the cardiovascular system and are important targets for HF treatment. Changes in the expression and activity of PDEs during HF affect cardiac muscle function. The design and discovery of PDE inhibitors have been a long and winding process.

EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY (2021)

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Dendritic Cell Vaccination of Glioblastoma: Road to Success or Dead End

Angeliki Datsi, Ruediger V. Sorg

Summary: Dendritic cell vaccination (DCV) is a promising immunotherapy for treating glioblastomas, with numerous trials showing potential but some controlled studies failing to detect a survival benefit. Further exploration is needed to fully understand the potential of this therapeutic approach.

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Abuse and Exploitation of Doctoral Students: A Conceptual Model for Traversing a Long and Winding Road to Academia

Aaron Cohen, Yehuda Baruch

Summary: This paper develops a conceptual model on the abuse and exploitation of PhD supervisors towards their students, exploring the reasons and outcomes of such behaviors. The proposed model identifies characteristics of supervisors and factors influencing abuse, with the mediation of perceptions of power and politics. It also suggests institutional policies as moderators and highlights the potential hindrance of students' academic careers due to abuse and exploitation.

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Review Medicine, General & Internal

The long and winding road to target protein misfolding in cardiovascular diseases

Thamonwan Diteepeng, Federica del Monte, Marco Luciani

Summary: This review discusses the recent progress in understanding protein misfolding and compromised protein quality control in cardiovascular diseases, highlighting the lack of successful translation from preclinical models to clinical settings. More collaboration between basic scientists and clinicians is needed to develop specific biomarkers and therapeutic strategies to target proteotoxicity in CVD patients.

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Editorial Material Biochemistry & Molecular Biology

The winding road toward transcriptional repression

Qingzhou Zhang, Marjorie Brand

Summary: Enhancers play a role in transcriptional activation. The study by Vermunt et al.1 reveals that genes can undergo sequential transitions between enhancers, leading to progressive downregulation of expression.

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Positive AMPA receptor modulation in the treatment of neuropsychiatric disorders: long and winding road

Bashkim Kadriu, Laura Musazzi, Jenessa N. Johnston, Lisa E. Kalynchuk, Hector J. Caruncho, Maurizio Popoli, Carlos A. Zarate

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The 'long and winding road' for digital accessibility

Stacy Scott

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Article Oncology

Prognostic Significance of DNA Methylation Profiles at MRI Enhancing Tumor Recurrence: a Report from the EORTC 26091 TAVAREC Trial

Kaspar Draaisma, C. Mircea S. Tesileanu, Iris de Heer, Martin Klein, Marion Smits, Jaap C. Reijneveld, Paul M. Clement, Filip Y. F. de Vos, Antje Wick, Paul J. Mulholland, Martin J. B. Taphoorn, Michael Weller, Olivier L. Chinot, Johan M. Kros, Tina Verschuere, Corneel Coens, Vassilis Golfinopoulos, Thierry Gorlia, Ahmed Idbaih, Pierre A. Robe, Martin J. van den Bent, Pim J. French

Summary: The study evaluated the prognostic significance of genomewide DNA methylation profiles and copy-number variations in patients with gliomas. It found that the Heidelberg DNA methylation classification lost its predictive value at the time of enhancing recurrence, while the TCGA classification remained prognostic. Additionally, homozygous deletions in CDKN2A/B were predictive of survival from progression in IDH-mutated tumors.

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Article Oncology

Radiotherapy combined with nivolumab or temozolomide for newly diagnosed glioblastoma with unmethylated MGMT promoter: An international randomized phase III trial

Antonio Omuro, Alba A. Brandes, Antoine F. Carpentier, Ahmed Idbaih, David A. Reardon, Timothy Cloughesy, Ashley Sumrall, Joachim Baehring, Martin van den Bent, Oliver Bahr, Giuseppe Lombardi, Paul Mulholland, Ghazaleh Tabatabai, Ulrik Lassen, Juan Manuel Sepulveda, Mustafa Khasraw, Elodie Vauleon, Yoshihiro Muragaki, Anna Maria Di Giacomo, Nicholas Butowski, Patrick Roth, Xiaozhong Qian, Alex Z. Fu, Yanfang Liu, Von Potter, Alexandros-Georgios Chalamandaris, Kay Tatsuoka, Michael Lim, Michael Weller

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Immunotherapy for brain metastases and primary brain tumors

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Association of antidepressant drug use with outcome of patients with glioblastoma

Corinna Seliger, Felix Boakye Oppong, Florence Lefranc, Olivier Chinot, Roger Stupp, Burt Nabors, Thierry Gorlia, Michael Weller, EORTC Brain Tumor Group

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Differential roles of type I interferon signaling in tumor versus host cells in experimental glioma models

Evelina Blomberg, Manuela Silginer, Patrick Roth, Michael Weller

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TRANSLATIONAL ONCOLOGY (2023)

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Article Multidisciplinary Sciences

A risk model for prediction of diagnosis of cancer after ischemic stroke

Katharina Seystahl, Dorothee Gramatzki, Miriam Wanner, Sung Ju Weber, Alessia Hug, Andreas R. Luft, Sabine Rohrmann, Susanne Wegener, Michael Weller

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SCIENTIFIC REPORTS (2023)

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Article Oncology

Programmed death ligand 1 gene silencing in murine glioma models reveals cell line-specific modulation of tumor growth in vivo

Evelina Blomberg, Manuela Silginer, Patrick Roth, Michael Weller

Summary: This study found heterogeneous expression of PD-L1 in murine glioma cell lines, which was inducible by interferon. Co-culture with splenocytes induced PD-L1 expression in an interferon gamma-dependent manner. Gene silencing of Pdl1 conferred a survival benefit in the CT-2A model, but not in the other two models.

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Immunotherapy for glioblastoma: a long and winding road

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OXFORD UNIV PRESS INC

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