Journal
NEURAL REGENERATION RESEARCH
Volume 9, Issue 16, Pages 1514-1517Publisher
WOLTERS KLUWER MEDKNOW PUBLICATIONS
DOI: 10.4103/1673-5374.139476
Keywords
naringin; parkinson's disease; GDNF; inflammation; mTORCI; neurodegeneration
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Funding
- National Research Foundation of Korea (NRF) grant - Korea government [2008-0061888, 2012R1A1A1039140]
- National Research Foundation of Korea [2008-0061888, 2012R1A1A1039140] Funding Source: Korea Institute of Science & Technology Information (KISTI), National Science & Technology Information Service (NTIS)
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Recently, we have demonstrated the ability of naringin, a well-known flavanone glycoside of grapefruits and citrus fruits, to prevent neurodegeneration in a neurotoxin model of Parkinson's disease. Intraperitoneal injection of naringin protected the nigrostriatal dopaminergic projection by increasing glial cell line-derived neurotrophic factor expression and decreasing the level of tumor necrosis factor-alpha in dopaminergic neurons and microglia, respectively. These results suggest that naringin can impart to the adult dopaminergic neurons the ability to produce glial cell line-derived neurotrophic factor against Parkinson's disease with anti-inflammatory effects. Based on these results, we would like to describe an important perspective on its possibility as a therapeutic agent for Parkinson's disease.
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