Journal
NEURAL REGENERATION RESEARCH
Volume 9, Issue 6, Pages 602-609Publisher
MEDKNOW PUBLICATIONS & MEDIA PVT LTD
DOI: 10.4103/1673-5374.130101
Keywords
nerve regeneration; peripheral nerve injury; rapamycin; FK506; Schwann cell; cell migration; nerve growth factor; growth-associated protein 43; NSFC grant; neural regeneration
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Funding
- Major State Basic Research Development Program of China (973 Program) [2011CB606205]
- National Natural Science Foundation of China [51172171, 51103112]
- Key Project of Chinese Ministry of Education [313041]
- Natural Science Foundation of Hubei Province [2013CFB354]
- Fundamental Research Funds for the Central Universities [WUT: 2013-IV-099]
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Rapamycin, similar to FK506, can promote neural regeneration in vitro. We assumed that the mechanisms of action of rapamycin and FK506 in promoting peripheral nerve regeneration were similar. This study compared the effects of different concentrations of rapamycin and FK506 on Sc hwann cells and investigated effects and mechanisms of rapamycin on improving peripheral nerve regeneration. Results demonstrated that the lowest rapamycin concentration (1.53 nmol/L) more significantly promoted Schwann cell migration than the highest FK506 concentration (100 mu mol/L). Rapamycin promoted the secretion of nerve growth factors and upregulated growth-associated protein 43 expression in Schwann cells, but did not significantly affect Schwann cell proliferation. Therefore, rapamycin has potential application in peripheral nerve regeneration therapy.
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