Article
Pediatrics
Luping Chen, Bin Mu, Yalong Li, Fangjin Lu, Ping Mu
Summary: The DRR1-CREB axis plays a crucial role in the differentiation of neuroblastoma cells and is associated with the outcome of neuroblastoma patients.
PEDIATRIC RESEARCH
(2023)
Article
Neurosciences
Felix Schneider, Isabell Metz, Marco B. Rust
Summary: Directed outgrowth of axons is crucial for establishing neuronal networks. Growth cones, enriched in filamentous actin, guide axon outgrowth by sensing guidance cues and controlling actin dynamics. Understanding the mechanisms of actin regulation is essential for neuronal network formation, and recent progress in tools and techniques provides new opportunities for research in this field.
BRAIN RESEARCH BULLETIN
(2023)
Article
Cell Biology
Klara Metzner, Omar Darawsha, Mengzhe Wang, Nayana Gaur, Yiming Cheng, Annekathrin Roediger, Christiane Frahm, Otto W. W. Witte, Fabiana Perocchi, Hubertus Axer, Julian Grosskreutz, Monika S. S. Brill
Summary: This study investigated alterations in cytoskeletal content and sensory axon caliber during aging using human skin biopsies. Results showed an increase in cytoskeletal components with aging in both sexes, while elevation in axon diameter was only evident in males. Transcriptomic data from aging males illustrated various patterns in gene expression, suggesting gender-specific changes in peripheral sensory axons during aging that may increase susceptibility to neurodegenerative diseases.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2022)
Article
Neurosciences
Tanushree Kundu, Sooraj Siva Das, Lisas K. Sewatkar, Divya S. Kumar, Dhriti Nagar, Aurnab Ghose
Summary: The study found that Fmn2 regulates the formation of axonal collateral protrusions in chick and zebrafish, localizing to the protrusion-initiating axonal F-actin patches and regulating their lifetime and size. The F-actin nucleation activity of Fmn2 is necessary for patch stability but not for patch formation. Fmn2 insulates the F-actin patches from disassembly by ADF, promoting long-lived, larger patches that can initiate axonal protrusions.
JOURNAL OF NEUROSCIENCE
(2022)
Article
Neurosciences
Hae Young Shin, Min Jung Kwon, Eun Mi Lee, Kyung Kim, Young Joo Oh, Hyung Soon Kim, Dong Hoon Hwang, Byung Gon Kim
Summary: The Myc proto-oncogene acts as a transcriptional hub gene in regulating the expression of a distinct subset of regeneration-associated genes (RAGs) in DRGs following preconditioning nerve injury. Deletion of Myc leads to a decrease in injury-induced expression of a specific subset of RAGs, which overlaps with the list of RAGs upregulated by Myc overexpression. Myc overexpression in DRGs post-spinal cord injury prevents sensory axon retraction through downstream RAG June, highlighting the critical role of Myc in axon regeneration.
JOURNAL OF NEUROSCIENCE
(2021)
Article
Biochemistry & Molecular Biology
Qichao Huang, Dan Wu, Jing Zhao, Zeyu Yan, Lin Chen, Shanshan Guo, Dalin Wang, Chong Yuan, Yinping Wang, Xiaoli Liu, Jinliang Xing
Summary: This study reveals the importance of TFAM in cancer metastasis, showing that TFAM deficiency induces nuclear actin polymerization and enhances the metastatic ability of HCC cells. The deficiency of TFAM blocks the TCA cycle and increases intracellular malonyl-CoA levels, promoting the nuclear translocation of actin and facilitating HCC cell metastasis.
Article
Cell Biology
Luka Sheppard, David G. Green, Gerald Lerchbaumer, Katheryn E. Rothenberg, Rodrigo Fernandez-Gonzalez, Ulrich Tepass
Summary: The M region of alpha-Catenin plays a regulatory role in cell adhesion by recruiting interaction partners to support intercellular connections. Different levels of tension at cell contacts lead to differential recruitment of Vinculin, Ajuba, and Canoe, influencing cell adhesion.
JOURNAL OF CELL BIOLOGY
(2022)
Article
Neurosciences
Yunsong Zhang, Qian Zhao, Qianqian Chen, Lingchi Xu, Sheng Yi
Summary: Transcription factors play important roles in nerve regeneration after peripheral nerve injury, including regulating axon elongation and Schwann cell phenotype modulation. Understanding these transcription factors can help promote functional recovery of injured peripheral nerves.
MOLECULAR NEUROBIOLOGY
(2023)
Article
Multidisciplinary Sciences
Kaya J. E. Matson, Daniel E. Russ, Claudia Kathe, Isabelle Hua, Dragan Maric, Yi Ding, Jonathan Krynitsky, Randall Pursley, Anupama Sathyamurthy, Jordan W. Squair, Boaz P. Levi, Gregoire Courtine, Ariel J. Levine
Summary: After spinal cord injury, certain cells in the injured area show potential for regeneration. By analyzing different cell types in the spinal cord of mice, this study identifies spinal neurons that express regeneration characteristics and describes their anatomical features. The study provides a valuable resource for understanding cellular responses to injury and highlights the spontaneous plasticity of spinocerebellar neurons as a potential target for targeted therapy.
NATURE COMMUNICATIONS
(2022)
Article
Agronomy
Qi Mi, Hongqian Pang, Feishi Luan, Peng Gao, Shi Liu
Summary: The scc locus of the watermelon seed coat crack trait was fine mapped on chromosome 3, and Cla97C03G056110 was identified as the most likely candidate gene. The expression of Cla97C03G056110 was higher in non-scc lines and specifically expressed in seed coat tissue.
THEORETICAL AND APPLIED GENETICS
(2023)
Article
Biology
Oshri Avraham, Rui Feng, Eric Edward Ewan, Justin Rustenhoven, Guoyan Zhao, Valeria Cavalli
Summary: Peripheral nerve injuries lead to the appearance of a distinct subset of satellite glial cells in DRG and activation of the PPAR alpha signaling pathway, promoting axon regeneration. Central axon injuries do not trigger the same response, highlighting the potential for manipulating non-neuronal cells to promote functional recovery after CNS injuries or disease.
Review
Anatomy & Morphology
Gemma Nomdedeu-Sancho, Berta Alsina
Summary: This article aims to unify and summarize the available information regarding the molecular mechanisms guiding the different afferent sensory axons of the head. It found that similar guidance cues are used in different sensory systems but with distinct combinations. The role of glia and mechanical forces in shaping the axon paths is also discussed, along with outstanding questions in the field.
DEVELOPMENTAL DYNAMICS
(2023)
Article
Medicine, Research & Experimental
Zhen-Zhen Li, Wen-Juan Han, Zhi-Chuan Sun, Yun Chen, Jun-Yi Sun, Guo-Hong Cai, Wan-Neng Liu, Tao-Zhi Wang, Yang-Dan Xie, Hong-Hui Mao, Fei Wang, Sui-Bin Ma, Fu-Dong Wang, Rou-Gang Xie, Sheng-Xi Wu, Ceng Luo
Summary: Patients with neuropathic pain often have comorbid psychiatric disorders. The study revealed that LAMB1 in the ECM plays a crucial role in modulating pain plasticity through signal transduction pathways, highlighting a potential therapeutic target for neuropathic pain treatment.
JOURNAL OF CLINICAL INVESTIGATION
(2021)
Article
Neurosciences
Javier Valdes-Aleman, Richard D. Fetter, Emily C. Sales, Emily L. Heckman, Lalanti Venkatasubramanian, Chris Q. Doe, Matthias Landgraf, Albert Cardona, Marta Zlatic
Summary: The study reveals that in the embryonic nerve cord of Drosophila, postsynaptic partners are able to find and connect to their presynaptic partners even when they have been shifted to ectopic locations or silenced. However, orderly positioning of axon terminals by positional cues and synaptic activity is crucial for appropriate numbers of connections between specific partners.
Article
Cell Biology
Chen Chen, Chien-Hsi Chu, Ying Chu, Ting-Ya Chang, Sheng-Wen Chen, Shu-Yang Liang, Yun-Chi Tsai, Bi-Chang Chen, Hsiung-Lin Tu, Pei-Lin Cheng
Summary: Soft tissue environments play an important role in neuronal morphogenesis. This study reveals that drebrin, a growth cone T-zone protein, modulates growth cone turning in response to brain-derived neurotrophic factor (BDNF) on soft substrates. Structurally, axonal growth cones on soft hydrogels have an expanded T zone with integrated drebrin, F-actin and microtubules. Biochemically, paxillin interacts with drebrin specifically on soft hydrogels. Functionally, BDNF-induced growth cone turning and force generation on soft substrates require phosphorylation of drebrin and association of paxillin with drebrin.