Journal
NEURAL DEVELOPMENT
Volume 4, Issue -, Pages -Publisher
BMC
DOI: 10.1186/1749-8104-4-28
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Funding
- NIGMS
- NSF/EPSCoR [0447660, MH51699]
- Office Of The Director
- EPSCoR [0447660] Funding Source: National Science Foundation
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Background: Existing quantitative models of mouse cerebral cortical development are not fully constrained by experimental data. Results: Here, we use simple difference equations to model neural progenitor cell fate decisions, incorporating intermediate progenitor cells and initially low rates of neural progenitor cell death. Also, we conduct a sensitivity analysis to investigate possible uncertainty in the fraction of cells that divide, differentiate, and die at each cell cycle. Conclusion: We demonstrate that uniformly low-level neural progenitor cell death, as concluded in previous models, is incompatible with normal mouse cortical development. Levels of neural progenitor cell death up to and exceeding 50% are compatible with normal cortical development and may operate to prevent forebrain overgrowth as observed following cell death attenuation, as occurs in caspase 3-null mutant mice.
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