Local Mineralocorticoid Receptor Activation and the Role of Rac1 in Obesity-Related Diabetic Kidney Disease

ARHGDIA mutations cause nephrotic syndrome via defective RHO GTPase signaling

(2013) Heon Yung Gee et al.   JOURNAL OF CLINICAL INVESTIGATION

Role of Rac1–mineralocorticoid-receptor signalling in renal and cardiac disease

(2013) Miki Nagase et al.   Nature Reviews Nephrology

Oxidative Stress Causes Mineralocorticoid Receptor Activation in Rat Cardiomyocytes

(2012) Miki Nagase et al.   HYPERTENSION

Angiotensin II- and Salt-Induced Kidney Injury through Rac1-Mediated Mineralocorticoid Receptor Activation

(2012) W. Kawarazaki et al.   JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY

Aldosterone blockade and the mineralocorticoid receptor in the management of chronic kidney disease: current concepts and emerging treatment paradigms

(2012) Linda Shavit et al.   KIDNEY INTERNATIONAL

Rac1 GTPase in rodent kidneys is essential for salt-sensitive hypertension via a mineralocorticoid receptor–dependent pathway

(2011) Shigeru Shibata et al.   JOURNAL OF CLINICAL INVESTIGATION

National, regional, and global trends in body-mass index since 1980: systematic analysis of health examination surveys and epidemiological studies with 960 country-years and 9·1 million participants

(2011) Mariel M Finucane et al.   LANCET

Spironolactone inhibits hyperglycemia-induced podocyte injury by attenuating ROS production

(2011) J. Toyonaga et al.   NEPHROLOGY DIALYSIS TRANSPLANTATION

Aldosterone and inflammation

(2011) Kimberly C Gilbert et al.   Current Opinion in Endocrinology Diabetes and Obesity

Mineralocorticoid receptor activation contributes to salt-induced hypertension and renal injury in prepubertal Dahl salt-sensitive rats

(2010) H. Kawarazaki et al.   NEPHROLOGY DIALYSIS TRANSPLANTATION

Rac1 Is Required for Cardiomyocyte Apoptosis During Hyperglycemia

(2009) E. Shen et al.   DIABETES

Albuminuria: A Great Risk Marker, but an Underestimated Target in Diabetes

(2008) D. de Zeeuw et al.   DIABETES CARE

Superoxide Destabilization of β-Catenin Augments Apoptosis of High-Glucose-Stressed Mesangial Cells

(2008) Chun-Liang Lin et al.   ENDOCRINOLOGY

Aldosterone-Stimulated SGK1 Activity Mediates Profibrotic Signaling in the Mesangium

(2008) Y. Terada et al.   JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY

Modification of mineralocorticoid receptor function by Rac1 GTPase: implication in proteinuric kidney disease

(2008) Shigeru Shibata et al.   NATURE MEDICINE

Podocyte Injury Induced by Albumin Overload in vivo and in vitro: Involvement of TGF-Beta and p38 MAPK

(2008) Shigetaka Yoshida et al.   NEPHRON EXPERIMENTAL NEPHROLOGY