Article
Biochemistry & Molecular Biology
Yingjun Zhou, Heng Tao, Nuo Xu, Shichun Zhou, Yuke Peng, Jianxiang Zhu, Shaowei Liu, Yaning Chang
Summary: Chrysin effectively improves obesity, insulin resistance, renal function, and pathological injury in diabetic nephropathy (DN) mice. It regulates lipid metabolism and activated AMPK plays a critical role in the effects of chrysin on DN.
JOURNAL OF FOOD BIOCHEMISTRY
(2022)
Article
Spectroscopy
Refat Nimer, Gihan Kamel, Motaz A. Obeidat, Lina A. Dahabiyeh
Summary: In this study, SR-FTIR microspectroscopy was used to identify molecular changes in the lipid and protein regions in the plasma of patients with different stages of DN and patients with T2DM without DN. The results showed different conformational changes in protein secondary structure between DN stages and between DN and T2DM groups. End-stage DN group exhibited the highest oxidation state compared to other DN stages.
SPECTROCHIMICA ACTA PART A-MOLECULAR AND BIOMOLECULAR SPECTROSCOPY
(2022)
Article
Biochemistry & Molecular Biology
Sufang Zhong, Wenjin Chen, Bocheng Wang, Chao Gao, Xiamin Liu, Yonggui Song, Hui Qi, Hongbing Liu, Tao Wu, Rikang Wang, Baodong Chen
Summary: The AMPK/FoxO3a signaling pathway plays a crucial role in cell metabolism, mitochondrial dysfunction, and oxidative stress response. It is involved in regulating ferroptosis induced by glucose starvation and conferring resistance to ferroptosis in cancer cells.
Article
Endocrinology & Metabolism
Zhiqin Zhang, Lihua Ni, Lian Zhang, Dongqing Zha, Chun Hu, Lingli Zhang, Huiling Feng, Xiaobao Wei, Xiaoyan Wu
Summary: This study investigated the impact of the SGLT2 inhibitor empagliflozin on lipid metabolism in diabetic nephropathy patients, revealing that empagliflozin reduced lipid metabolism through the AdipoR1/P-AMPK/P-ACC pathway and delayed disease progression.
DIABETES METABOLIC SYNDROME AND OBESITY-TARGETS AND THERAPY
(2021)
Article
Endocrinology & Metabolism
Shuqin Du, Hanqiang Shi, Lie Xiong, Ping Wang, Yanbo Shi
Summary: This study suggests that Canagliflozin may alleviate diabetic cardiomyopathy by inhibiting ferroptosis, showing potential benefits for improving cardiac function and reducing cardiac damage.
FRONTIERS IN ENDOCRINOLOGY
(2022)
Article
Pharmacology & Pharmacy
Xiang Wang, Xinxin Chen, Wenqian Zhou, Hongbo Men, Terigen Bao, Yike Sun, Quanwei Wang, Yi Tan, Bradley B. Keller, Qian Tong, Yang Zheng, Lu Cai
Summary: The role of ferroptosis in the pathogenesis of diabetic cardiomyopathy (DCM) was investigated, and it was found that ferroptosis plays an essential role in DCM. Sulforaphane was able to prevent ferroptosis and associated pathogenesis, suggesting a potential therapeutic approach.
ACTA PHARMACEUTICA SINICA B
(2022)
Review
Pharmacology & Pharmacy
Urvi M. Parmar, Manjiri P. Jalgaonkar, Yogesh A. Kulkarni, Manisha J. Oza
Summary: The incidence of diabetes is increasing globally, and it is associated with hyperglycemia and disrupted metabolic pathways. Autophagy plays a crucial role in maintaining cellular homeostasis, but disrupted autophagy contributes to metabolic disorders such as obesity and diabetes. Nutrient-sensing pathways, including SIRT1, mTOR, and AMPK, regulate autophagy and they could be potential therapeutic targets for reducing diabetic complications.
PHARMACOLOGICAL RESEARCH
(2022)
Article
Biochemistry & Molecular Biology
Theodomir Dusabimana, Eun Jung Park, Jihyun Je, Kyuho Jeong, Seung Pil Yun, Hye Jung Kim, Hwajin Kim, Sang Won Park
Summary: Geniposide has been shown to have protective effects in a mouse model of diabetic nephropathy, improving renal function and reducing pathological changes through modulation of AMPK and AKT pathways.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Immunology
Nevertyty M. Mahmoud, Shimaa M. Elshazly, Arwa A. Hassan, Eman Soliman
Summary: Diabetic nephropathy (DN) is a leading cause of end-stage renal disease (ESRD). This study shows that agomelatine has an ameliorative anti-inflammatory effect against DN, which is dependent on the Sirtuin1 (SIRT1) and melatonin receptor activity. Inhibition of SIRT1 and melatonin receptors reduces the ameliorative effect of agomelatine on kidney structure and function.
INTERNATIONAL IMMUNOPHARMACOLOGY
(2023)
Article
Cardiac & Cardiovascular Systems
Yochai Birnbaum, Huan Chen, Dat Tran, Sven Nylander, Yumei Ye
Summary: The combination of dapagliflozin and ticagrelor has additive effects on diabetic nephropathy progression in BTBR ob/ob mice, associated with AMPK activation, reduced NLRP3 inflammasome activation, and increased Akt activation by dapagliflozin.
CARDIOVASCULAR DRUGS AND THERAPY
(2022)
Article
Endocrinology & Metabolism
Hanfen Tang, Ming Yang, Yinghong Liu, Xuejing Zhu, Shiping Liu, Hong Liu, Lin Sun, Panai Song
Summary: This study demonstrates for the first time that melatonin plays a protective role in diabetic nephropathy through the AMPK-PINK1-mitophagy pathway.
FRONTIERS IN ENDOCRINOLOGY
(2022)
Article
Medicine, Research & Experimental
Na Li, Lin Yin, Jiamin Shang, Meidai Liang, Zhaoyu Liu, Haiguang Yang, Guifen Qiang, Guanhua Du, Xiuying Yang
Summary: Nonalcoholic fatty liver disease (NAFLD) is a common liver disease with limited treatment options, and its prevalence is doubled in type 2 diabetes mellitus (T2DM). Kaempferol (KAP) has been suggested to have beneficial effects on NAFLD, and this study investigated its mechanism of action in vitro and in vivo. The results showed that KAP reduced lipid accumulation in liver cells and improved liver injury in a T2DM animal model. Mechanistic studies revealed that KAP activated Sirt1/AMPK signaling and regulated hepatic lipid accumulation. These findings suggest that KAP may be a potential therapeutic agent for NAFLD associated with T2DM.
BIOMEDICINE & PHARMACOTHERAPY
(2023)
Article
Biochemistry & Molecular Biology
Tung-Wei Hung, Meng-Hsun Yu, Tsung-Yuan Yang, Mon-Yuan Yang, Jia-Yu Chen, Kuei-Chuan Chan, Chau-Jong Wang
Summary: This study investigated the effect of the oral hypoglycemic drug acarbose (Ab) on the progression of diabetic nephropathy (DN) in type 2 diabetes mellitus mice. The results showed that Ab stabilized blood glucose levels and attenuated renal damage caused by diabetes, possibly by inhibiting the expression of fibrosis-related proteins in the kidneys.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Review
Biochemistry & Molecular Biology
Ming Yang, Panai Song, Li Zhao, Xi Wang
Summary: Long-term diabetes can cause renal injury called diabetic nephropathy (DN), which is a major contributor to end-stage renal disease (ESRD). The pathogenesis of DN is not well understood, but recent studies have highlighted the potential role of adipokines secreted by adipose tissue in DN progression. This suggests that targeting the adipose-renal axis may be a promising approach for treating DN.
CURRENT MEDICINAL CHEMISTRY
(2023)
Article
Biochemistry & Molecular Biology
Chen-Jung Wu, A-Chuan Ho, Shih-Ya Chen, Chih-Hong Pan, Hsiao-Chi Chuang, Ching-Huang Lai
Summary: It was found that workers exposed to metal fumes had an increased risk of metabolic syndrome, which was correlated with decreased serum adiponectin levels. Therefore, the study aimed to investigate the impact of heavy metal exposure on adiponectin levels.
Article
Endocrinology & Metabolism
Tomohito Gohda, Yuji Nishizaki, Maki Murakoshi, Shuko Nojiri, Naotake Yanagisawa, Terumi Shibata, Mami Yamashita, Kanako Tanaka, Yoshinori Yamashita, Yusuke Suzuki, Nozomu Kamei
DIABETES RESEARCH AND CLINICAL PRACTICE
(2018)
Article
Multidisciplinary Sciences
Nozomu Kamei, Mami Yamashita, Yuji Nishizaki, Naotake Yanagisawa, Shuko Nojiri, Kanako Tanaka, Yoshinori Yamashita, Terumi Shibata, Maki Murakoshi, Yusuke Suzuki, Tomohito Gohda
SCIENTIFIC REPORTS
(2018)
Article
Multidisciplinary Sciences
Keiko Takahashi, Seiji Ueda, Takashi Kobayashi, Akira Nishiyama, Yoshihide Fujisawa, Takeshi Sugaya, Satomi Shiota, Kazuhisa Takahashi, Tomohito Gohda, Satoshi Horikoshi, Yusuke Suzuki
SCIENTIFIC REPORTS
(2018)
Article
Endocrinology & Metabolism
Tomohito Gohda, Nozomu Kamei, Takeo Koshida, Mitsunobu Kubota, Kanako Tanaka, Yoshinori Yamashita, Eri Adachi, Saki Ichikawa, Maki Murakoshi, Seiji Ueda, Yusuke Suzuki
JOURNAL OF DIABETES INVESTIGATION
(2020)
Review
Biochemistry & Molecular Biology
Maki Murakoshi, Tomohito Gohda, Yusuke Suzuki
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2020)
Article
Biochemistry & Molecular Biology
Saki Ichikawa, Tomohito Gohda, Maki Murakoshi, Li Zi, Eri Adachi, Takeo Koshida, Yusuke Suzuki
Article
Endocrinology & Metabolism
Tomohito Gohda, Nozomu Kamei, Mitsunobu Kubota, Kanako Tanaka, Yoshinori Yamashita, Hiroko Sakuma, Chiaki Kishida, Eri Adachi, Takeo Koshida, Maki Murakoshi, Shinji Hagiwara, Kazuhiko Funabiki, Seiji Ueda, Yusuke Suzuki
Summary: Increased concentrations of serum TNFRs are positively associated with ACR and negatively associated with eGFR in patients with type 2 diabetes. The study shows that serum TNFRs are more strongly correlated with kidney measures, while urinary TNFRs are primarily associated with ACR.
JOURNAL OF DIABETES INVESTIGATION
(2021)
Article
Biochemistry & Molecular Biology
Zi Li, Maki Murakoshi, Saki Ichikawa, Takeo Koshida, Eri Adachi, Chigure Suzuki, Seiji Ueda, Tomohito Gohda, Yusuke Suzuki
Article
Multidisciplinary Sciences
Tomohito Gohda, Maki Murakoshi, Yusuke Suzuki, Makoto Hiki, Toshio Naito, Kazuhisa Takahashi, Yoko Tabe
Summary: This study aimed to investigate the relationship between TNF-related biomarkers and mortality or disease severity in COVID-19 patients. The results showed that TNFR2 levels were associated with mortality in COVID-19 patients and may be helpful in predicting disease severity.
Review
Biochemistry & Molecular Biology
Tomohito Gohda, Maki Murakoshi
Summary: Diabetic kidney disease (DKD) is a major cause of chronic kidney disease (CKD) and end-stage kidney disease. Early diagnosis, treatment, and risk factor management are important for preventing DKD progression. While current biomarkers for DKD diagnosis and prognosis are limited, measuring TNFRs in serum can help predict CKD prognosis. Cardiorenal risk factor management and certain medications are effective in slowing DKD progression, but there is still a high residual risk. Emerging therapies like SGLT2 inhibitors show promise for preventing DKD progression in patients with type 2 diabetes.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Medicine, General & Internal
Maki Murakoshi, Takumi Iwasawa, Takeo Koshida, Yusuke Suzuki, Tomohito Gohda, Kazunori Kato
Summary: A novel ELISA method targeting EphA2 was validated and used to measure circulating EphA2 levels in hypertensive patients with kidney function decline, showing a potential application as a clinical biomarker for CKD presence.
Article
Biochemistry & Molecular Biology
Takeo Koshida, Tomohito Gohda, Takuya Sugimoto, Takashi Asahara, Rin Asao, Isao Ohsawa, Hiromichi Gotoh, Maki Murakoshi, Yusuke Suzuki, Yuichiro Yamashiro
Summary: The composition of the gut microbiome differs between patients with chronic kidney disease (CKD) undergoing hemodialysis (HD) and those with normal renal function (NRF). This difference is associated with altered levels of stool organic acids, systemic inflammation, and accumulation of uremic toxins (UTs). Furthermore, the levels of UTs, inflammatory markers, and stool organic acids differ significantly between patients with NRF and those undergoing HD.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Urology & Nephrology
Maki Murakoshi, Takashi Kobayashi, Masao Kihara, Seiji Ueda, Yusuke Suzuki, Tomohito Gohda
Summary: This study aimed to identify the clinical characteristics of patients with chronic kidney disease (CKD) who showed decreased proteinuria in response to dapagliflozin treatment. The results showed that the changes in urinary protein-to-creatinine ratio were positively associated with the initial decline rate in estimated glomerular filtration rate (eGFR) after 1 month of treatment.
Article
Medicine, Research & Experimental
Daisuke Sato, Tomohito Gohda, Masao Kihara, Yasuhiko Kanaguchi, Takashi Kobayashi, Satoshi Mano, Yu Sasaki, Nao Nohara, Maki Murakoshi, Junichiro Nakata, Hitoshi Suzuki, Seiji Ueda, Satoshi Horikoshi, Yusuke Suzuki
ACTA MEDICA OKAYAMA
(2018)
Article
Urology & Nephrology
Miho Shimizu, Kengo Furuichi, Tadashi Toyama, Tomoaki Funamoto, Shinji Kitajima, Akinori Hara, Daisuke Ogawa, Daisuke Koya, Kenzo Ikeda, Yoshitaka Koshino, Yukie Kurokawa, Hideharu Abe, Kiyoshi Mori, Masaaki Nakayama, Yoshio Konishi, Ken-ichi Samejima, Masaru Matsui, Hiroyuki Yamauchi, Tomohito Gohda, Kei Fukami, Daisuke Nagata, Hidenori Yamazaki, Yukio Yuzawa, Yoshiki Suzuki, Shouichi Fujimoto, Shoichi Maruyama, Sawako Kato, Takero Naito, Kenichi Yoshimura, Hitoshi Yokoyama, Takashi Wada
CLINICAL AND EXPERIMENTAL NEPHROLOGY
(2018)