Journal
NEPHRON EXPERIMENTAL NEPHROLOGY
Volume 108, Issue 4, Pages E69-E73Publisher
KARGER
DOI: 10.1159/000126920
Keywords
mesothelial cells; epithelial-to-mesenchymal transition; senescence; transforming growth factor-beta(1); vascular endothelial growth factor; peritoneal dialysis
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Ultrafiltration failure due to dysfunction of the peritoneum as a dialyzing organ is a major clinical limitation of peritoneal dialysis. It is increasingly clear that mesothelial cells play an important role in fibrogenesis and vasculopathy that underlie peritoneal membrane dysfunction. New and extensively studied aspects of peritoneal mesothelial cell biology include epithelial-to-mesenchymal transition and cellular senescence. We discuss the potential significance of these processes for the peritoneal membrane function. Copyright (C) 2008 S. Karger AG, Basel.
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