Review
Pharmacology & Pharmacy
Yinghui Huang, Wang Xin, Jiachuan Xiong, Mengying Yao, Bo Zhang, Jinghong Zhao
Summary: This review discusses the role of gut microbiota in chronic kidney disease and its associated complications, as well as the significance of the gut-kidney-heart axis hypothesis in the pathophysiological mechanisms of these diseases. Regulating gut microbiota may serve as a novel therapeutic approach for CKD progression.
FRONTIERS IN PHARMACOLOGY
(2022)
Review
Nutrition & Dietetics
Adriana Mocanu, Roxana Alexandra Bogos, Tudor Ilie Lazaruc, Laura Mihaela Trandafir, Vasile Valeriu Lupu, Ileana Ioniuc, Mirabela Alecsa, Anca Ivanov, Ancuta Lupu, Iuliana Magdalena Starcea
Summary: The human intestinal microbiota plays a crucial role in promoting health and preventing disease. It is influenced by factors such as diet, genetics, and environment. In pediatric patients, the gut microbiota is vulnerable to disruption and has been linked to chronic kidney disease.
Review
Food Science & Technology
Taku Kobayashi, Yasunori Iwata, Yusuke Nakade, Takashi Wada
Summary: Recent studies have shown that the gut microbiota is crucial in maintaining both health and disease conditions, including impacting kidney diseases. There is currently no established treatment for AKI, but some gut bacteria and their metabolites are reported to have protective effects against it. Current research provides new insights into the role of the gut microbiota in the pathogenesis of AKI.
Review
Biochemistry & Molecular Biology
Qin Yi Wu, Bi Cheng Liu, Xiong Zhong Ruan, Kun Ling Ma
Summary: This review provides an overview of the structure and biological function of intestinal microbiota-derived membrane vesicles (MVs), highlighting their crucial roles in immunomodulation and maintenance of the intestinal micro-ecosystem. It also explores the relationship between MVs and chronic kidney disease (CKD), as well as the potential pathogenic mechanisms mediated by MVs, which may have significant clinical implications for the diagnosis and treatment of CKD.
BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE
(2022)
Review
Food Science & Technology
Yueqing Hui, Jin Zhao, Zixian Yu, Yuwei Wang, Yunlong Qin, Yumeng Zhang, Yan Xing, Mei Han, Anjing Wang, Shuxian Guo, Jinguo Yuan, Yueru Zhao, Xiaoxuan Ning, Shiren Sun
Summary: Tryptophan metabolism is closely related to the pathophysiology of AKI and CKD, and its metabolites act as biomarkers that facilitate early diagnosis. The accumulation of tryptophan metabolites and gut dysbiosis accelerate the progression of AKI and CKD. Targeting tryptophan metabolism has become a research hotspot for intervention in AKI and CKD.
MOLECULAR NUTRITION & FOOD RESEARCH
(2023)
Review
Nutrition & Dietetics
Paulina Mertowska, Sebastian Mertowski, Julia Wojnicka, Izabela Korona-Glowniak, Ewelina Grywalska, Anna Blazewicz, Wojciech Zaluska
Summary: Chronic kidney disease is a progressive and irreversible condition that can lead to alterations in the gut microbiota and activation of the immune system, with dietary factors playing a significant role in immune cell activation and microbiota balance. Understanding the relationship between intestinal microbiota and kidney dysfunction is crucial in the progression of kidney diseases.
Article
Agriculture, Dairy & Animal Science
Verena Habermaass, Daniela Olivero, Eleonora Gori, Chiara Mariti, Erika Longhi, Veronica Marchetti
Summary: This study evaluated the gut microbiota (GM) in dogs diagnosed with chronic hepatobiliary disease (CHD), particularly cholestatic CHD. The findings suggest that cholestasis is associated with alterations in the gut microbiota, with certain bacterial taxa being decreased and others increased. Clinicians should be aware of the gut-liver interaction leading to dysbiosis in dogs with CHD.
Review
Biochemistry & Molecular Biology
Alexandru Cosmin Pantazi, Mustafa Ali Kassim Kassim, Wassan Nori, Liliana Ana Tuta, Cristina Maria Mihai, Tatiana Chisnoiu, Adriana Luminita Balasa, Larisia Mihai, Ancuta Lupu, Corina Elena Frecus, Vasile Valeriu Lupu, Sergiu Ioachim Chirila, Anca Gabriela Badescu, Laurentiu-Tony Hangan, Simona Claudia Cambrea
Summary: The gut microbiota plays a vital role in kidney disease, and interventions targeting the gut microbiota show promising results. Challenges remain in terms of patient variability and safety concerns. Further research is needed to understand the mechanisms and validate personalized interventions through clinical trials.
Review
Physiology
Chujin Cao, Ying Yao, Rui Zeng
Summary: Acute kidney injury (AKI) and chronic kidney disease (CKD) are major global health concerns, with the immune system playing a crucial role. Lymphocytes are key players in inflammation and kidney injury, with different subtypes having distinct roles in kidney protection and damage.
FRONTIERS IN PHYSIOLOGY
(2021)
Review
Medicine, General & Internal
Fernanda G. Rodrigues, Milene S. Ormanji, Ita P. Heilberg, Stephan J. L. Bakker, Martin H. de Borst
Summary: This article explores the deregulation of gut microbiota in patients with chronic kidney disease (CKD) and its impact on vascular and bone diseases. It discusses the influence of diet, medications, and other factors on gut microbiota composition and subsequently on the overall health of CKD patients.
EUROPEAN JOURNAL OF CLINICAL INVESTIGATION
(2021)
Article
Biochemistry & Molecular Biology
Ashani Lecamwasam, Tiffanie M. Nelson, Leni Rivera, Elif I. Ekinci, Richard Saffery, Karen M. Dwyer
Summary: Individuals with diabetes and chronic kidney disease show gut dysbiosis, with Firmicutes and Bacteroidetes as predominant phyla. The relative abundance of these gut microbes does not change across the early and late stages of diabetic chronic kidney disease, suggesting it is an early event in disease development.
Review
Food Science & Technology
Mateo Ondrussek-Sekac, Diana Navas-Carrillo, Esteban Orenes-Pinero
Summary: In chronic kidney disease, dysbiosis of intestinal microbiota can lead to uremic toxicity, inflammation and disease progression. Modulating gut microbiota through dietary changes and using probiotics, prebiotics, and low protein diets can offer therapeutic interventions to improve this imbalance and manage chronic kidney disease effectively.
CRITICAL REVIEWS IN FOOD SCIENCE AND NUTRITION
(2021)
Review
Multidisciplinary Sciences
Siamak Amini Khiabani, Mohammad Asgharzadeh, Hossein Samadi Kafil
Summary: Chronic kidney disease (CKD) is a range of pathological processes correlated with abnormal renal function and progressive loss in GFR. Gut dysbiosis in CKD patients is associated with elevated levels of uremic toxins, which in turn accelerates the progression of CKD.
Article
Agriculture, Multidisciplinary
Yang Yang, Jing Yu, Jiayao Huo, Yaping Yan
Summary: This study investigated the effects of sesamolin on kidney injury, intestinal barrier dysfunction, and gut microbiota imbalance in high-fat and high-fructose (HF-HF) diet-fed mice and explored the underlying correlations among them. The results indicated that sesamolin suppressed metabolic disorders and renal function parameters and mitigated renal epithelial cell degeneration and brush border damage. Furthermore, sesamolin improved intestinal barrier function and the composition of gut microbiota. The study suggests that sesamolin attenuates kidney injuries by reducing endotoxemia and related metabolic disorders through restoring the intestinal barrier and modulating gut microbiota.
JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY
(2023)
Article
Pharmacology & Pharmacy
Libin Pan, Hang Yu, Jie Fu, Jiachun Hu, Hui Xu, Zhengwei Zhang, Mengmeng Bu, Xinyu Yang, Haojian Zhang, Jinyue Lu, Jiandong Jiang, Yan Wang
Summary: Studies on the gut-kidney axis have shown that berberine, a natural drug, can significantly improve chronic kidney disease by altering the gut microbiota composition and inhibiting the production of gut-derived uremic toxins. Berberine also increases the content of butyric acid-producing bacteria and butyric acid, while decreasing the renal toxic trimethylamine N-oxide.
ACTA PHARMACEUTICA SINICA B
(2023)
