Article
Multidisciplinary Sciences
Ou Qiao, Xinyue Wang, Yuru Wang, Ning Li, Yanhua Gong
Summary: This review aims to summarize the evidence of ferroptosis in CS-AKI and its related molecular mechanism, discuss the therapeutic significance of ferroptosis in CS-AKI, and open up new ideas for the treatment of CS-AKI.
JOURNAL OF ADVANCED RESEARCH
(2023)
Article
Critical Care Medicine
Qi Lv, Manman Long, Xin Wang, Jie Shi, Pengtao Wang, Xiaoqin Guo, Jie Song, Adam C. Midgley, Haojun Fan, Shike Hou
Summary: This study demonstrated the correlation between extrusion pressure and the severity of crush injury, as well as the increase in blood serum markers. The increase in extrusion pressure led to organ damage in kidney, muscle, and lung tissues. The identification of treatment candidate alpha 1-AGP was shown to protect against crush syndrome-induced acute kidney injury.
Article
Pediatrics
Deniz Karakaya, Aysun Caltik Yilmaz, Tulin Gungor, Bahriye Uzun Kenan, Evra Celikkaya, Evrim Kargin Cakici
Summary: This study evaluated the risk factors for acute kidney injury (AKI) in pediatric patients with crush syndrome (CS) and developed a new scoring system for dialysis indication. Results showed that renal score, CPK level, and presence of myoglobinuria were the best markers for kidney replacement therapy (KRT) in pediatric CS patients.
PEDIATRIC NEPHROLOGY
(2023)
Article
Pediatrics
Bahriye Atmis, Aysun K. Bayazit, Cagla Cagli Piskin, Emel Saribas, Ferhat Can Piskin, Sevcan Bilen, Ozden Ozgur Horoz, Faruk Ekinci, Ikbal Turker, Hasan Ali Telefon, Ilker Unal, Hayri Levent Yilmaz, Nejat Narli, Dincer Yildizdas
Summary: This study analyzed the clinical and laboratory findings of pediatric earthquake victims with crush syndrome in Turkey and found that elevated creatine kinase levels, body area crushed percentage, and increased phosphorus levels can predict the need for dialysis treatment, while time under the rubble is not indicative of dialysis requirement.
EUROPEAN JOURNAL OF PEDIATRICS
(2023)
Article
Biochemistry & Molecular Biology
Koshu Okubo, Kentaro Takayama, Hiroshi Kawakami, Kiriko Iida, Hiroaki Miyauchi, Yoshimi Roppongi, Hiroaki Ikeyama, Matsuhiko Hayashi, Seitaro Fujishima, Junichi Sasaki, Junji Haruta, Yoshio Hayashi, Junichi Hirahashi
Summary: Crush syndrome induced by skeletal muscle compression causes fatal rhabdomyolysis-induced acute kidney injury (RIAKI), which requires intensive care, including hemodialysis. Access to crucial medical supplies is highly limited while treating earthquake victims trapped under fallen buildings, lowering their chances of survival. Developing a compact, portable, and simple treatment method for RIAKI remains an important challenge.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2023)
Review
Critical Care Medicine
Faeq Husain-Syed, Tomonori Takeuchi, Javier A. Neyra, Gonzalo Ramirez-Guerrero, Mitchell H. Rosner, Claudio Ronco, Ashita J. Tolwani
Summary: Approximately 20% of patients with acute brain injury (ABI) also have acute kidney injury (AKI), which can worsen their outcomes. This review discusses the occurrence and effects of AKI in adults with neurological conditions, highlights the importance of recognizing AKI in managing ABI, and outlines management principles for AKI in ABI patients, including tailored approaches and preventive measures. The review also explores the impact of renal replacement therapy (RRT) on ABI patients and suggests potential modifications for RRT in these patients.
Review
Biochemistry & Molecular Biology
Marta Glowacka, Sara Lipka, Ewelina Mlynarska, Beata Franczyk, Jacek Rysz
Summary: COVID-19, primarily known as a respiratory illness, can also target the kidneys through the ACE2 receptor, leading to acute kidney injury. The development of AKI in COVID-19 patients is strongly associated with higher mortality, not only due to direct invasion of renal cells by the virus, but also involving mechanisms like hypovolemia and cytokine storm.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Review
Medicine, General & Internal
Sana Farooq Khan
Summary: This review discusses the current status and feasibility of peritoneal dialysis for the treatment of acute kidney injury, and calls for more standardized reporting of trial design, techniques, complications, and outcomes.
JOURNAL OF CLINICAL MEDICINE
(2022)
Review
Urology & Nephrology
Brett Cullis
Summary: Peritoneal dialysis (PD) for acute kidney injury (AKI) has experienced a resurgence in the past decade, thanks to the efforts of nephrology organizations, guideline standardization, and the impact of the COVID-19 pandemic. Available evidence demonstrates that acute PD is a safe and lifesaving therapy with comparable outcomes to other treatment modalities.
CLINICAL KIDNEY JOURNAL
(2023)
Article
Biochemistry & Molecular Biology
Pai-Chin Hsu, Chih-Han Liu, Wen-Chin Lee, Chien-Hsing Wu, Chien-Te Lee, Chien-Hao Su, Yu-Chin Lily Wang, Kai-Fan Tsai, Terry Ting-Yu Chiou
Summary: This study found that the use of offending drugs, AKI severity, and early dialysis requirement were independent predictors of AKD severity. Higher AKD severity was associated with negative outcomes in post-AKI patients.
Review
Medicine, General & Internal
Hanna Cholerzynska, Wiktoria Zasada, Hanna Michalak, Milosz Miedziaszczyk, Andrzej Oko, Ilona Idasiak-Piechocka
Summary: Acute kidney injury (AKI) and sudden exacerbation of chronic kidney disease (CKD) often require urgent kidney replacement therapy (UKRT). Peritoneal dialysis (PD) is seen as a viable option for managing these patients. This review examines recent literature on the clinical outcomes of urgent-start peritoneal dialysis (USPD) in CKD and AKI.
JOURNAL OF CLINICAL MEDICINE
(2023)
Article
Urology & Nephrology
Conrado Lysandro Rodrigues Gomes, Thais Lyra Cleto-Yamane, Frederico Ruzani, Jose Hermogenes Rocco Suassuna
Summary: Although socioeconomic deprivation is associated with a higher incidence of acute kidney injury (AKI) and worse outcomes in high-income countries, the impact of these epidemiologic factors in developing countries is limited. This study analyzed pediatric and adult patients with dialysis-requiring AKI in private and public hospitals in Brazil and found no independent influence of hospital governance or socioeconomic factors on mortality. Baseline characteristics and disease severity primarily determined the prognosis of AKI.
KIDNEY INTERNATIONAL REPORTS
(2023)
Review
Urology & Nephrology
Sidar Copur, Metehan Berkkan, Nuri B. Hasbal, Carlo Basile, Mehmet Kanbay
Summary: Abdominal compartment syndrome is organ dysfunction caused by intra-abdominal hypertension, which may lead to high morbidity and mortality if diagnosis is delayed. Acute kidney injury is a common complication associated with intra-abdominal hypertension, although research on its pathophysiology is limited. However, treatment and reversal of intra-abdominal hypertension are feasible.
JOURNAL OF NEPHROLOGY
(2022)
Review
Physiology
Steven Menez, Chirag R. Parikh
Summary: Since the onset of the COVID-19 pandemic, various kidney complications associated with SARS-CoV-2 infection have been documented, such as proteinuria, hematuria, and acute kidney injury. The risk factors, pathogenesis, and management strategies of COVID-19-related AKI have been extensively studied, emphasizing the importance of early identification and post-acute care for patients.
AMERICAN JOURNAL OF PHYSIOLOGY-RENAL PHYSIOLOGY
(2021)
Article
Medicine, General & Internal
Ashraf O. Oweis, Sameeha A. Alshelleh, Lubna Hawasly, Ghalia Alsabbagh, Karem H. Alzoubi
Summary: This retrospective study focused on the occurrence of acute kidney injury (AKI) in hospitalized COVID-19 patients. The study found that AKI occurred in 25.3% of the patients, with older age, diabetes mellitus, hypertension, ACEI/ARB use, erythrocyte-sedimentation rate, CRP, and ferritin being predictors of AKI. The mortality rate was high among AKI patients, with 75.9% dying in comparison to 24.1% of non-AKI patients. Among COVID-19 patients admitted to the ICU, 80.5% died, with 70.5% from the AKI group and 29.5% from the non-AKI group.
INTERNATIONAL JOURNAL OF GENERAL MEDICINE
(2022)
Article
Transplantation
Emily J. See, Aminu K. Bello, Adeera Levin, Meaghan Lunney, Mohamed A. Osman, Feng Ye, Gloria E. Ashuntantang, Ezequiel Bellorin-Font, Mohammed Benghanem Gharbi, Sara Davison, Mohammad Ghnaimat, Paul Harden, Htay Htay, Vivekanand Jha, Kamyar Kalantar-Zadeh, Peter G. Kerr, Scott Klarenbach, Csaba P. Kovesdy, Valerie Luyckx, Brendon Neuen, Donal O'Donoghue, Shahrzad Ossareh, Jeffrey Perl, Harun Ur Rashid, Eric Rondeau, Saad Syed, Laura Sola, Irma Tchokhonelidze, Vladimir Tesar, Kriang Tungsanga, Rumeyza Turan Kazancioglu, Angela Yee-Moon Wang, Chih-Wei Yang, Alexander Zemchenkov, Ming-Hui Zhao, Kitty J. Jager, Fergus Caskey, Vlado Perkovic, Kailash K. Jindal, Ikechi G. Okpechi, Marcello Tonelli, John Feehally, David C. Harris, David W. Johnson
Summary: There are significant differences in the coverage and scope of global Health Information Systems (HIS) for kidney disease. KRT registries are available in almost all high-income countries, but rare in low-income countries. Registries for non-dialysis CKD or AKI are also rare. In high-income countries, registries tend to be national, while in low-income countries they often operate at a local or regional level.
NEPHROLOGY DIALYSIS TRANSPLANTATION
(2022)
Correction
Urology & Nephrology
Duvuru Geetha, Andreas Kronbichler, Megan Rutter, Divya Bajpai, Steven Menez, Annemarie Weissenbacher, Shuchi Anand, Eugene Lin, Nicholas Carlson, Stephen Sozio, Kevin Fowler, Ray Bignall, Kathryn Ducharlet, Elliot K. Tannor, Eranga Wijewickrama, Muhammad I. A. Hafidz, Vladimir Tesar, Robert Hoover, Deidra Crews, Charles Varnell, Lara Danziger-Isakov, Vivekanand Jha, Sumit Mohan, Chirag Parikh, Valerie Luyckx
NATURE REVIEWS NEPHROLOGY
(2022)
Editorial Material
Urology & Nephrology
Ziyad Al-Aly, Anupam Agarwal, Nisreen Alwan, Valerie A. Luyckx
NATURE REVIEWS NEPHROLOGY
(2023)
Article
Transplantation
Mehmet S. Sever, Raymond Vanholder, Valerie Luyckx, Kai-Uwe Eckardt, Mykola Kolesnyk, Andrzej Wiecek, Ewa Pawlowicz-Szlarska, Daniel Gallego, Rukshana Shroff, Andrej Skoberne, Ionut Nistor, Mohamed Sekkarie, Dmytro Ivanov, Edita Noruisiene, Serhan Tuglular
Summary: During conflicts, people with kidney disease may face additional threats due to medical and logistical challenges. Acute kidney injury and treatment interruptions can worsen kidney function, and limitations in dialysis and availability of immunosuppressive medications increase the risk of complications. Local preparedness, adjustments in treatment, telemedicine support, and referrals to higher-level hospitals are important measures to address these challenges.
NEPHROLOGY DIALYSIS TRANSPLANTATION
(2023)
Review
Public, Environmental & Occupational Health
James Tataw Ashu, Jackline Mwangi, Supriya Subramani, Daniel Kaseje, Gloria Ashuntantang, Valerie A. Luyckx
Summary: Realizing the right to health in resource-limited settings like sub-Saharan Africa is challenging, as illustrated by the example of dialysis in this paper. Limited resources and high demand for expensive care create inequities in access to healthcare. Recognizing the right to health includes protecting health through prevention, providing universal health coverage, and ensuring equitable access to expensive care. This process requires good governance, transparency, and commitment to progress.
INTERNATIONAL JOURNAL FOR EQUITY IN HEALTH
(2022)
Article
Medicine, General & Internal
Eranga S. Wijewickrama, Muhammad Iqbal Abdul Hafidz, Bruce M. Robinson, David W. Johnson, Adrian Liew, Gavin Dreyer, Fergus J. Caskey, Aminu K. Bello, Deenaz Zaidi, Sandrine Damster, Silvia Salaro, Valerie Ann Luyckx, Divya Bajpai
Summary: Patients with advanced CKD or KFRT were prioritized for COVID-19 vaccination in most countries, but there were significant barriers and variations in access and success, with high-income countries having the most opportunities for vaccination.
Editorial Material
Urology & Nephrology
Valerie A. Luyckx, Ziyad Al-Aly
JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY
(2023)
Article
Transplantation
Serhan Tuglular, Valerie Luyckx, Raymond Vanholder, Andrej Skoberne, Andrzej Wiecek, Ionut Nistor, Ewa Pawlowicz-Szlarska, Rukshana Shroff, Dmytro Ivanov, Kai-Uwe Eckardt, Edita Noruisiene, Daniel Gallego, Olena Loboda, Mehmet S. Sever
Summary: People living with kidney disease are highly vulnerable during natural or man-made disasters, particularly in war zones. The ongoing war in Ukraine highlights the importance of preparedness and support for this group. The European Renal Association has established a task force to help those with kidney disease in Ukraine, and this report summarizes the challenges faced and actions taken. The experience gained from this initiative can be used to improve preparedness and mitigate the effects of armed conflicts on the kidney community globally.
NEPHROLOGY DIALYSIS TRANSPLANTATION
(2023)
Editorial Material
Transplantation
Valerie A. Luyckx
NEPHROLOGY DIALYSIS TRANSPLANTATION
(2023)
Editorial Material
Urology & Nephrology
Sami Alasfar, Ephrem Berhe, Sabine Karam, Valerie Luyckx
Summary: Among global destabilizing events, natural disasters tend to dominate the attention while prolonged conflicts and economic crises are overlooked. Low- and middle-income countries are disproportionately impacted and face weakened health systems as a result. Collaboration is urgently needed to ensure equitable and sustainable dialysis care during such crises.
NATURE REVIEWS NEPHROLOGY
(2023)
Article
Biophysics
Abdias Hurtado-Arestegui, Karina Rosales-Mendoza, Yanissa Venegas-Justiniano, Jose Gonzales-Polar, Rina Barreto-Jara, Alaciel Melissa Palacios-Guillen
Summary: This study investigated the hemoglobin levels of Peruvian patients with chronic kidney disease (CKD) at different altitudes and found that patients living at high altitudes had higher hemoglobin levels.
HIGH ALTITUDE MEDICINE & BIOLOGY
(2023)
Meeting Abstract
Medicine, General & Internal
Paul de Zwart, Thomas Mueller, Guiseppina Sparta, Valerie Luyckx
SWISS MEDICAL WEEKLY
(2022)
Meeting Abstract
Medicine, General & Internal
Katrina Evers, Valerie Luyckx, Daniel Trachsel
SWISS MEDICAL WEEKLY
(2022)
Meeting Abstract
Medicine, General & Internal
Chiara Sonnessa, Celine Kaegi, Valerie Ann Luyckx
SWISS MEDICAL WEEKLY
(2022)
Article
Biophysics
Cristhian A. Vizcarra-Vizcarra, Eduardo Chavez-Velazquez, Carmen Asato-Higa, Abdias Hurtado-Arestegui
Summary: This study reports a case of a female patient with high altitude polycythemia and nephrotic syndrome. Acetazolamide treatment effectively reduced proteinuria and hemoglobin levels.
HIGH ALTITUDE MEDICINE & BIOLOGY
(2022)