Article
Biochemistry & Molecular Biology
Kuo-Hua Lee, Yuan-Chia Chu, Ming-Tsun Tsai, Wei-Cheng Tseng, Yao-Ping Lin, Shuo-Ming Ou, Der-Cherng Tarng
Summary: This study used machine learning to predict the risk of end-stage renal disease (ESRD) in sepsis survivors. The researchers found that estimated glomerular filtration rates, hemoglobin, and proteinuria were important predictors of ESRD development.
Article
Biochemistry & Molecular Biology
Mahmoud M. Zakaria, Safaa A. Derbala, Ayman E. Salem, Amgad E. EL-Agroudy, Fatma M. El-Tantawy
Summary: The study found that ESRD patients have a significantly lower number of T-cell subsets compared to CKD patients, which is related to a higher degree of apoptosis in these cells.
MOLECULAR BIOLOGY REPORTS
(2021)
Review
Psychology, Clinical
Simone Jayakumar, Stacey Jennings, Kristoffer Halvorsrud, Christophe Clesse, Muhammad Magdi Yaqoob, Livia A. Carvalho, Kamaldeep Bhui
Summary: This study reviewed and analyzed multiple studies to find that depression in CKD/ESKF patients is associated with increased inflammation levels and decreased levels of anti-inflammatory cytokines.
PSYCHOLOGICAL MEDICINE
(2023)
Article
Biochemistry & Molecular Biology
Alessandra Fortunata Perna, Luigi Russo, Vittoria D'Esposito, Pietro Formisano, Dario Bruzzese, Carmela Vigorito, Annapaola Coppola, Patrizia Lombari, Domenico Russo, Diego Ingrosso
Summary: Vascular calcification is a risk factor for cardiovascular events and mortality in chronic kidney disease. Inflammation, particularly involving uremic toxin lanthionine, IL-8, and Eotaxin, plays a significant role in the occurrence and progression of vascular calcification in CKD patients.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Infectious Diseases
Jose Molto, Fredzzia Graterol, Adrian Curran, Natalia Ramos, Arkaitz Imaz, Diego Sandoval, Francisco Perez, Lucia Bailon, Saye Khoo, Laura Else, Roger Paredes
Summary: This study evaluated the effect of haemodialysis on doravirine concentrations in people living with HIV (PLWH) undergoing routine haemodialysis. The results showed that despite moderate removal of doravirine by haemodialysis, trough doravirine concentrations in plasma after the haemodialysis sessions remained in excess of the protein-binding-adjusted EC50 (5 ng/mL). Therefore, doravirine dosage adjustments are unnecessary in PLWH undergoing intermittent haemodialysis.
JOURNAL OF ANTIMICROBIAL CHEMOTHERAPY
(2022)
Article
Biochemistry & Molecular Biology
Ziad M. El-Zaatari, Luan D. Truong
Summary: Renal cell carcinoma (RCC) occurring in the setting of end-stage renal disease (ESRD) shows unique clinicopathological characteristics, with acquired cystic kidney disease-associated renal cell carcinoma (ACKD-RCC) and clear-cell papillary renal cell carcinoma (ccpRCC) being the most frequent types. Other types of RCC also occur in ESRD, albeit with different frequencies from the non-ESRD general population. While the histological features of RCC do not vary in the setting of ESRD vs. non-ESRD, other findings, such as multifocality and multiple tumor types, are more frequent in ESRD. Studies have generated novel and important knowledge of the etiology, epidemiology, diagnosis, treatment, immunophenotype, and molecular characteristics of ESRD-associated RCC.
Article
Endocrinology & Metabolism
Rodolfo J. Galindo, Francisco J. Pasquel, Priyathama Vellanki, Cesar Zambrano, Bonnie Albury, Citlalli Perez-Guzman, Zheng Ziduo, Guillermo E. Umpierrez
Summary: This study revealed significant metabolic differences among DKA patients with different levels of renal function, with beta-hydroxybutyrate levels potentially assisting in confirming the diagnosis of DKA in ESKD patients.
JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM
(2021)
Article
Cell Biology
Zaipul I. Md Dom, Eiichiro Satake, Jan Skupien, Bozena Krolewski, Kristina O'Neil, Jill A. Willency, Simon T. Dillon, Jonathan M. Wilson, Hiroki Kobayashi, Katsuhito Ihara, Towia A. Libermann, Marlon Pragnell, Kevin L. Duffin, Andrzej S. Krolewski
Summary: This study identified three elevated plasma proteins associated with protection against progressive renal decline and progression to endstage renal disease in individuals with diabetes. These protective proteins may serve as biomarkers for stratifying diabetic individuals by their risk of developing ESRD, and could be explored as potential therapeutics to delay or prevent ESRD onset.
SCIENCE TRANSLATIONAL MEDICINE
(2021)
Review
Pharmacology & Pharmacy
Yinghui Wang, Lu Gao
Summary: Chronic kidney disease and cardiac insufficiency often co-exist, especially in uremic patients on hemodialysis. Impaired renal function is often indicative of poor prognosis in patients with cardiac insufficiency. Inflammation plays a significant role in the development of cardiovascular complications in patients with chronic kidney disease and is indicative of prognosis.
FRONTIERS IN PHARMACOLOGY
(2022)
Article
Medicine, General & Internal
Lorry Aitkens, Jennifer L. Waller, Stephanie L. Baer, Azeem Mohammed, Sarah Tran, Budder Siddiqui, Sandeep Padala, Lufei Young, Mufaddal Kheda, Wendy B. Bollag
Summary: This study found that psoriasis is protective against pneumonia in patients with end-stage renal disease, with other factors such as the Charlson Comorbidity Index (CCI) and tobacco use being more strongly associated with increased risk for pneumonia.
AMERICAN JOURNAL OF THE MEDICAL SCIENCES
(2022)
Review
Medicine, General & Internal
Xu Jing, Wen Zhuyuan, Chen Aijun, Xiong Jianxia, Huang Kun, Wang Ping
Summary: Previous studies have shown that patients with psoriasis are at higher risk of developing CKD and ESRD compared with the general population, but data on the differences in occurrence between psoriasis and non-psoriatic controls are limited and inconsistent. This study conducted a meta-analysis of cohort studies to compare the probability of suffering CKD and ESRD in patients with or without psoriasis.
FRONTIERS IN MEDICINE
(2023)
Article
Urology & Nephrology
Janos Docs, Gyula Kovacs, Lehel Peterfi
Summary: This study analyzed the gene expression involved in kidney remodeling in end-stage kidney disease and the development of preneoplastic lesions and tumors. The results showed that both cellular (aSMA positive naive activated fibroblasts, endothelial cells, macrophages) and non-cellular components (cytokines IL6, TGF beta, IL1 beta, CSF2, fibronectin, laminin, and matrix modifier proteases MMP9 and MMP12) of the inflammatory microenvironment were present in the kidneys of patients with end-stage kidney disease. The inflammatory and fibrotic processes in end-stage kidney disease may explain the frequent development of kidney cancer.
JOURNAL OF NEPHROLOGY
(2023)
Article
Clinical Neurology
Chang Min Heo, Won Ho Lee, Bong Soo Park, Yoo Jin Lee, Sihyung Park, Yang Wook Kim, Dong Ah Lee, Byeong Cheol Yoo, Kang Min Park
Summary: This study compares glymphatic dysfunction between patients with end-stage renal disease (ESRD) and healthy controls, and reveals the presence of glymphatic dysfunction in patients with ESRD as demonstrated by the DTI-ALPS index. Additionally, a significant positive correlation is found between the DTI-ALPS index and serum parathyroid hormone levels in ESRD patients.
FRONTIERS IN NEUROLOGY
(2022)
Article
Pharmacology & Pharmacy
Fung-Chang Sung, Ying-Chin Jong, Chih-Hsin Muo, Chih-Cheng Hsu, Wen-Chen Tsai, Yueh-Han Hsu
Summary: Through analyzing insurance claims data from Taiwan, we found that statin therapy may reduce mortality risks for hyperlipidemic patients, especially in those with end-stage renal disease. Hydrophilic statin therapy showed superior effects in reducing all-cause mortality and deaths from cancer.
FRONTIERS IN PHARMACOLOGY
(2022)
Article
Multidisciplinary Sciences
Jong Joo Moon, Yong Woo Kim, Baek-Lok Oh, Kyungdo Han, Dong Ki Kim, Kwon Wook Joo, Yon Su Kim, Ki Ho Park, Hajeong Lee, Yong Chul Kim, Jin Wook Jeoung
Summary: This nationwide cohort study found that the incidence of primary open-angle glaucoma (POAG) was higher in patients with end stage renal disease (ESRD) and kidney transplantation recipients (KTRs) compared to healthy controls, but adjusting for confounding factors did not show a significant increase in risk. The incidence of primary angle-closure glaucoma (PACG) was higher in ESRD patients compared to healthy controls, while KTRs had a lower risk of PACG compared to ESRD patients.
SCIENTIFIC REPORTS
(2021)
Article
Immunology
Fazilet Dede, Sabriye Karadenizli, Ozgur Doga Ozsoy, Fatma Ceyla Eraldemir, Deniz Sahin, Nurbay Ates
JOURNAL OF NEUROIMMUNOLOGY
(2019)
Article
Psychology, Biological
Semil Selcen Gocmez, Tugce Demirtas Sahin, Yusufhan Yazir, Gokhan Duruksu, Fatma Ceyla Eraldemir, Selen Polat, Tijen Utkan
PHYSIOLOGY & BEHAVIOR
(2019)
Article
Dermatology
Evren Odyakmaz Demirsoy, Dilek Bayramgurler, Cigdem Caglayan, Nilgun Bilen, Aysun Sikar Akturk, Rebiay Kiran
JOURNAL OF CUTANEOUS MEDICINE AND SURGERY
(2019)
Article
Public, Environmental & Occupational Health
Theo Bodin, Cigdem Caglayan, Anne Helene Garde, Marco Gnesi, Johanna Jonsson, Sibel Kiran, Bertina Kreshpaj, Taina Leinonen, Ingrid S. Mehlum, Evangelia Nena, Cecilia Orellana, Trevor Peckham, Noah Seixas, Christophe Vanroelen, Mireia Julia
SCANDINAVIAN JOURNAL OF WORK ENVIRONMENT & HEALTH
(2020)
Review
Public, Environmental & Occupational Health
Irina Guseva Canu, Sandy Carla Marca, Francesca Dell'Oro, Adam Balazs, Enrico Bergamaschi, Christine Besse, Renzo Bianchi, Jovanka Bislimovska, Adrijana Koscec Bjelajac, Merete Bugge, Carmen Iliana Busneag, Cigdem Caglayan, Mariana Cernitanu, Cristiana Costa Pereira, Natasa Dernovscek Hafner, Nadia Droz, Maija Eglite, Lode Godderis, Harald Gundel, Jari J. Hakanen, Raluca Maria Iordache, Imane Khireddine-Medouni, Sibel Kiran, Francesca Larese-Filon, Catherine Lazor-Blanchet, Patrick Legeron, Tom Loney, Nicole Majery, Eda Merisalu, Ingrid Sivesind Mehlum, Laurent Michaud, Dragan Mijakoski, Jordan Minov, Alberto Modenese, Marija Molan, Henk van der Molen, Evangelia Nena, Dusan Nolimal, Marina Otelea, Elisabeta Pletea, Nurka Pranjic, David Rebergen, Jelena Reste, Eva Schernhammer, Anny Wahlen
Summary: This study aimed to harmonize the definition of occupational burnout through systematic review and semantic analysis, resulting in a consistent definition approved by a panel of experts. The Delphi consensus showed 82% agreement among experts on the proposed definition, indicating a successful harmonization process.
SCANDINAVIAN JOURNAL OF WORK ENVIRONMENT & HEALTH
(2021)
Article
Environmental Sciences
Gamze Varol, Burcu Tokuc, Serhat Ozkaya, Cigdem Caglayan
Summary: The study demonstrated significant impact of air pollution on human health, especially the increased risk of cardiovascular and respiratory diseases from PM2.5. Using the AirQ+ method, it was calculated that 25.2% of deaths were related to air pollution.
AIR QUALITY ATMOSPHERE AND HEALTH
(2021)
Article
Andrology
Osman Can, Lutfi Canat, Fatma Ceyla Eraldemir, Esra Acar, Funda Yildirim, Kivilcim Sonmez, Alper Otunctemur, Fatih Altunrende
Summary: The study evaluated the protective effect of oltipraz in testicular ischaemia/reperfusion damage, showing a significant decrease in TGF-β1, GSH, and MDA values in the oltipraz treatment groups. Oltipraz treatment has a significant protective effect against testicular ischaemia/reperfusion damage.
Review
Environmental Sciences
Yara Shoman, Emna El May, Sandy Carla Marca, Pascal Wild, Renzo Bianchi, Merete Drevvatne Bugge, Cigdem Caglayan, Dimitru Cheptea, Marco Gnesi, Lode Godderis, Sibel Kiran, Damien M. McElvenny, Zakia Mediouni, Ingrid Sivesind Mehlum, Dragan Mijakoski, Jordan Minov, Henk F. van der Molen, Evangelia Nena, Marina Otelea, Irina Guseva Canu
Summary: This study reviewed occupational burnout predictors and found that job demands and negative job attitudes have harmful effects, while adaptive coping and leisure have protective effects. Interventions targeting these predictors could benefit in preventing occupational burnout.
INTERNATIONAL JOURNAL OF ENVIRONMENTAL RESEARCH AND PUBLIC HEALTH
(2021)
Article
Medicine, General & Internal
Gul Anil Anakok, Susanne F. Awad, Cigdem Caglayan, Peijue Huangfu, Laith J. Abu-Raddad, Belgin Unal, Julia Alison Critchley
Summary: Using a mathematical model, this study predicts the future prevalence of type 2 diabetes and modifiable risk factors in Turkey. The results highlight the significant impact of obesity, especially among women, and suggest that interventions targeting obesity could reduce the disease burden.
Review
Environmental Sciences
Dragan Mijakoski, Dumitru Cheptea, Sandy Carla Marca, Yara Shoman, Cigdem Caglayan, Merete Drevvatne Bugge, Marco Gnesi, Lode Godderis, Sibel Kiran, Damien M. McElvenny, Zakia Mediouni, Olivia Mesot, Jordan Minov, Evangelia Nena, Marina Otelea, Nurka Pranjic, Ingrid Sivesind Mehlum, Henk F. van der Molen, Irina Guseva Canu
Summary: This study aimed to review the determinants of burnout onset in teachers. Through a qualitative and quantitative analysis of 33 longitudinal studies, four types of determinants for teacher burnout were identified and detrimental determinants were found.
INTERNATIONAL JOURNAL OF ENVIRONMENTAL RESEARCH AND PUBLIC HEALTH
(2022)
Article
Medicine, Research & Experimental
Tonguc Utku Yilmaz, Eda Yirmibesoglu Erkal, Saffet cinar, Ceyla Eraldemir, Cigdem Vural, Ezgi Ucar Tas, Nihat Zafer Utkan
Summary: This study evaluates the effects of intra-rectal ozone application on rectal anastomoses after radiotherapy and finds that intra-rectal ozone application significantly improves the anastomotic healing process after radiation exposure.
ADVANCES IN CLINICAL AND EXPERIMENTAL MEDICINE
(2022)
Article
Education, Scientific Disciplines
Erhan Eser, Elif Cil, Nesibe Efruz Sen Gundogan, Meltem Col, Elif Nur Yildirim Ozturk, David Terence Thomas, Ahmet Tevfik Sunter, Hatice Nilden Arslan, Riza Citil, Yalcin Onder, Metin Picakciefe, Bahadir Dede, Can Demirel, Neriman Aydin, Cigdem Caglayan, Ahmet Alp Aker, Arda Borlu, Hasan Durmus, Gunay Can, Esin Siddikoglu, Ergun Haldun Sumer, Tunahan Uygun, Seval Alkoy, Kubra Aktas Aycan, Ibrahim Koruk, Rustem Kuzan, Lutfi Saltuk Demir, Esra Hacilar, Hidir Sari, Zehra Kilinc, Ozgur Onal, Edanur Dogan, Mestan Emek, Ridvan Terzioglu, Gulcin Yapici, Deniz Erdal, Sultan Eser, Emine Ayhan Akman, Zahide Kosan, Sinan Yilmaz, Ferruh Niyazi Ayoglu, Bilgehan Acikgoz, Berna Musal, Ahmet Furkan Suner, Aysegul Erdogan, Idris Cilburunoglu, Meral Saygun, Didem Daymaz, Didem Arslantas, Muhammed Fatih Onsuz, Nazim Ercument Beyhun, Medine Gozde Ustundag, Galip Ekuklu, Fulya Ozder Tas, Filiz Abacigil, Selcen Oncu, Seyhan Hidiroglu, Ayse Nilufer Ozaydin, Edibe Pirincci, Irem Bulut, Mustafa Tozun, Muzaffer Eskiocak, Pinar Gunel, Sebahat Dilek Torun, Melike Yavuz, Metin Hasde, Derya Camur, Gulsen Gunes, Burak Kurt, Nuket Guler Baysoy, Nadi Bakirci, Figen Demir, Binali Catak, Ferda Ozyurda, Mustafa Turan
Summary: This study investigated the tendency of senior medical students in Turkey to pursue their professional careers abroad and the factors related to their migration decisions. The findings showed that a significant percentage of medical students had emigration intentions, with a majority wanting to permanently stay abroad. Factors such as working conditions, social environment/lifestyle abroad, and the quality of medical schools were found to have a significant impact on their decisions.
TEACHING AND LEARNING IN MEDICINE
(2023)
Article
Medicine, General & Internal
Kubra Kavram Sarihan, Melda Yardimoglu Yilmaz, Fatma Ceyla Eraldemir, Yusufhan Yazir, Esra Acar
TURKISH JOURNAL OF MEDICAL SCIENCES
(2020)
Article
Psychiatry
Elif Karagun, Mustafa Yildiz, Cigdem Caglayan, Zekiye Basaran
INTERNATIONAL JOURNAL OF SOCIAL PSYCHIATRY
(2020)
Article
Biochemistry & Molecular Biology
Fatma Ceyla Eraldemir, Nihal Uren, Tugba Kum, Burcu Erbay, Deniz Sahin, Emel Ergul, Esra Acar, Doga Ozsoy, Mustafa Cekmen, Hale Kir, Zafer Utkan
JOURNAL OF MEDICAL BIOCHEMISTRY
(2019)
