Article
Biochemistry & Molecular Biology
Sauradipta Banerjee
Summary: The study characterized MG-modified myoglobin in a time-dependent manner, with mass spectrometric studies indicating modifications at Lys-87 and Lys-133. Far-UV CD studies revealed alterations in protein structure and surface hydrophobicity as a result of MG modification. These findings suggest that MG-derived AGE adducts significantly impact the structure of Mb.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2021)
Article
Food Science & Technology
Jana Raupbach, Stephan K. Mueller, Vanessa Schnell, Suse Friedrich, Anne Hellwig, Tilman Grune, Thomas Henle
Summary: This study investigates the effect of individual lysine modifications in free form or bound to casein on human colon cancer cells. The results show that modified casein containing protein-bound pyrraline activates Nrf2, while FL or CML have no effect on NF-κB activation. This suggests that studies on the biological effects of glycated proteins require an individual consideration of defined structures.
MOLECULAR NUTRITION & FOOD RESEARCH
(2023)
Review
Biochemistry & Molecular Biology
Charlotte Delrue, Reinhart Speeckaert, Joris R. Delanghe, Marijn M. Speeckaert
Summary: Advanced glycation end products (AGEs) are compounds formed by nonenzymatic reactions between reducing sugars and proteins, lipids, or nucleic acids. These AGEs can alter protein structure and activate the receptor for advanced glycation end products (RAGE). RAGE is expressed by various cells and plays a role in chronic inflammatory autoimmune disorders. Soluble RAGE (sRAGE) acts as a decoy and inhibits pro-inflammatory processes mediated by RAGE. AGE overproduction, low sRAGE concentrations, and certain RAGE polymorphisms are associated with rheumatic diseases and cardiovascular risk.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Food Science & Technology
Haonan Shi, Ruike Qin, Runlin Wu, Jianhua Rong, Caihua Jia, Ru Liu
Summary: The study investigated the effects of different cryoprotectants on the formation of advanced glycation end products and acrylamide in fried fish cakes. Sorbitol significantly reduced AA and fluorescent AGE contents, while polyphosphates reduced CML and fluorescent AGE but increased AA. A combination of cryoprotectants led to the highest CML content, suggesting that certain combinations should be avoided in fried surimi products.
Article
Medicine, General & Internal
Eder H. Cativo, Persio D. Lopez, Diana P. Cativo, Steven A. Atlas, Clive Rosendorff
Summary: This study found that inhibitors of the renin-angiotensin system are more effective than calcium channel blockers in reducing albuminuria in patients with nephropathy due to hypertension and diabetes mellitus. However, there was no significant difference between the two drug classes in terms of markers of renal function.
AMERICAN JOURNAL OF MEDICINE
(2021)
Article
Food Science & Technology
Mingyu Li, Jingnan Lu, Yousheng Huang, Wenjing Wang, Jianhua Xie, Mingyong Xie, Mingyue Shen
Summary: The aim of this study was to investigate the occurrence of Maillard reaction products in different types of commercially available cheeses. The content of these products in hard and semi-hard cheeses were significantly higher than those in soft and semi-soft cheeses.
Review
Biochemistry & Molecular Biology
Frederic J. Tessier, Eric Boulanger, Michael Howsam
Summary: The Maillard reaction is a major chemical reaction responsible for most yellow-to-brown colors and aromas in cooked foods, leading to the formation of structurally-modified amino acids. High or chronic exposure to dietary AGEs may be potentially detrimental to human health, prompting research in food safety to focus on the metabolic transit of AGEs.
GLYCOCONJUGATE JOURNAL
(2021)
Article
Cell Biology
Agnieszka Nowak, Brygida Przywara-Chowaniec, Aleksandra Damasiewicz-Bodzek, Dominika Blachut, Ewa Nowalany-Kozielska, Krystyna Tyrpien-Golder
Summary: Systemic lupus erythematosus (SLE) study found that SLE patients have higher concentrations of AGEs and lower concentrations of sRAGE in serum, which may pose a risk for exacerbating the disease course, but the compounds contributing to the increase of AGEs in blood are not clear at the moment.
Article
Multidisciplinary Sciences
Gao-Xiang Wang, Ze-Bin Fang, Jun-Tong Li, Bao-Li Huang, De-Liang Liu, Shu-Fang Chu, Hui-Lin Li
Summary: This study aimed to investigate the correlation between serum albumin and diabetic retinopathy (DR) in patients with type 2 diabetes mellitus (T2DM). The results showed a significant negative correlation between serum albumin levels and DR, suggesting that serum albumin levels can be used as a reference point for long-term follow-up of patients with T2DM.
Article
Geriatrics & Gerontology
Tomohiko Urano, Masataka Shiraki, Takumi Imai, Norio Iinuma, Tatsuhiko Kuroda, Shiro Tanaka, Mitsuru Saito
Summary: The study aimed to evaluate the impact of AGEs on the history of vascular events in postmenopausal women excluding those with diabetes or renal insufficiency. Serum CML levels were found to be significantly associated with the presence of vascular event history, suggesting a potential role of serum CML in vascular events.
GERIATRICS & GERONTOLOGY INTERNATIONAL
(2021)
Article
Nutrition & Dietetics
Constance Dubois, Rachel Litke, Stephane Rianha, Charles Paul-Constant, Jean-Marc Lo Guidice, Solenne Taront, Frederic J. Tessier, Eric Boulanger, Chantal Fradin
Summary: In this study, a new route for the intestinal absorption of dietary CML (dCML) in Caenorhabditis elegans was identified through endocytosis, which may be mediated by scavenger receptors. Exposure to dCML induced reproductive defects and a transcriptional response reflecting oxidative, carbonyl, and protein folding stresses in the worms. These findings open up new perspectives for better characterizing the pathophysiological mechanisms of dietary advanced glycation end products (dAGEs).
Article
Biochemistry & Molecular Biology
Deepesh D. Gaikwad, Nilima S. Bangar, Mayura M. Apte, Armaan Gvalani, Rashmi S. Tupe
Summary: This study discovers that the interaction between aldosterone and glycated albumin in diabetic nephropathy can cause oxidative stress, reduce levels of antioxidants and glycation detoxifying enzymes, and result in renal cell damage.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2022)
Article
Biochemistry & Molecular Biology
Cong-Jin Liu, Xiao Yang, Shou-Hui Wang, Xin-Tong Wu, Yan Mao, Jing-Wen Shi, Yu-Bo Fan, Lian-Wen Sun
Summary: Bone loss occurs in astronauts during long-term space flight, and this study investigated the improvement effects of blocking AGEs formation on microgravity-induced bone loss using the AGES formation inhibitor, irbesartan. Results showed that irbesartan significantly inhibited AGEs and 8-OHdG expression, improving bone quality and bone formation process.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Medicine, Research & Experimental
Nada H. Eisa, Ahmed E. Khodir, Mohamed El-Sherbiny, Nehal M. Elsherbiny, Eman Said
Summary: PEITC showed renal protective effects against DN in rats induced by STZ, improving kidney and liver functions, histopathological features, tissue fibrosis, macrophage infiltration, and blood glucose levels. The mechanisms involved modulation of glycation, oxidative stress, and inflammatory response, including activation of GLO1 and Nrf2 pathways and suppression of NLRP3 inflammasome activation.
BIOMEDICINE & PHARMACOTHERAPY
(2021)
Article
Endocrinology & Metabolism
Komal Waqas, Jinluan Chen, T. Lu, B. C. J. van der Eerden, Fernando Rivadeneira, Andre G. Uitterlinden, Trudy Voortman, M. Carola Zillikens
Summary: A study investigated the relationship between dietary intake of carboxymethyllysine (dCML) and risk of sarcopenia and frailty. The researchers found an association between dAGEs and prevalent sarcopenia, but no association with incident sarcopenia or frailty.