PDGF and the progression of renal disease

Development of a Fully Human Anti-PDGFRβ Antibody That Suppresses Growth of Human Tumor Xenografts and Enhances Antitumor Activity of an Anti-VEGFR2 Antibody

(2015) Juqun Shen et al.   NEOPLASIA

LRP-6 is a coreceptor for multiple fibrogenic signaling pathways in pericytes and myofibroblasts that are inhibited by DKK-1

(2013) Shuyu Ren et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Randomized Controlled Trials in Nephrology: State of the Evidence and Critiquing the Evidence

(2012) Joshua A. Samuels et al.   ADVANCES IN CHRONIC KIDNEY DISEASE

A Novel, Dual Role of CCN3 in Experimental Glomerulonephritis

(2012) Claudia R.C. van Roeyen et al.   AMERICAN JOURNAL OF PATHOLOGY

Platelet-Derived Growth Factor (PDGF)-C Neutralization Reveals Differential Roles of PDGF Receptors in Liver and Kidney Fibrosis

(2012) Ina V. Martin et al.   AMERICAN JOURNAL OF PATHOLOGY

Targeting PDGF pathway in pulmonary arterial hypertension

(2012) Sabina Antonela Antoniu   EXPERT OPINION ON THERAPEUTIC TARGETS

Growth arrest–specific protein 1 is a novel endogenous inhibitor of glomerular cell activation and proliferation

(2012) Claudia R.C. van Roeyen et al.   KIDNEY INTERNATIONAL

Long- and short-term treatment with imatinib attenuates the development of chronic kidney disease in experimental anti-glomerular basement membrane nephritis

(2012) Masayuki Iyoda et al.   NEPHROLOGY DIALYSIS TRANSPLANTATION

Biological responses to PDGF-AA versus PDGF-CC in renal fibroblasts

(2012) C. Seikrit et al.   NEPHROLOGY DIALYSIS TRANSPLANTATION

A one-year, phase I/IIa, open-label pilot trial of imatinib mesylate in the treatment of systemic sclerosis-associated active interstitial lung disease

(2011) Dinesh Khanna et al.   ARTHRITIS AND RHEUMATISM

Structure and properties of the Ca2+-binding CUB domain, a widespread ligand-recognition unit involved in major biological functions

(2011) Christine Gaboriaud et al.   BIOCHEMICAL JOURNAL

Deletion of platelet-derived growth factor receptor-β improves diabetic nephropathy in Ca2+/calmodulin-dependent protein kinase IIα (Thr286Asp) transgenic mice

(2011) H. Suzuki et al.   DIABETOLOGIA

Imatinib mesylate for the treatment of pulmonary arterial hypertension

(2011) Henrik ten Freyhaus et al.   EXPERT OPINION ON INVESTIGATIONAL DRUGS

A Phase I study of CR002, a fully-human monoclonal antibody against platelet-derived growth factor-D

(2011) T. Hawthorne et al.   INTERNATIONAL JOURNAL OF CLINICAL PHARMACOLOGY AND THERAPEUTICS

Delayed Administration of Suramin Attenuates the Progression of Renal Fibrosis in Obstructive Nephropathy

(2011) N. Liu et al.   JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS

Suramin Inhibits Renal Fibrosis in Chronic Kidney Disease

(2011) N. Liu et al.   JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY

Induction of progressive glomerulonephritis by podocyte-specific overexpression of platelet-derived growth factor-D

(2011) Claudia R.C. van Roeyen et al.   KIDNEY INTERNATIONAL

Platelet-derived growth factor receptor signaling activates pericyte–myofibroblast transition in obstructive and post-ischemic kidney fibrosis

(2011) Yi-Ting Chen et al.   KIDNEY INTERNATIONAL

PDGF signalling controls age-dependent proliferation in pancreatic β-cells

(2011) Hainan Chen et al.   NATURE

The PDGF family in renal fibrosis

(2011) Tammo Ostendorf et al.   PEDIATRIC NEPHROLOGY

PDGF-C Mediates Glomerular Capillary Repair

(2010) Peter Boor et al.   AMERICAN JOURNAL OF PATHOLOGY

Renal fibrosis: novel insights into mechanisms and therapeutic targets

(2010) Peter Boor et al.   Nature Reviews Nephrology

Roles of PDGF receptor-beta in the structure and function of postnatal kidney glomerulus

(2010) T. Nakagawa et al.   NEPHROLOGY DIALYSIS TRANSPLANTATION

CCN3 (NOV) Is a Negative Regulator of CCN2 (CTGF) and a Novel Endogenous Inhibitor of the Fibrotic Pathway in an in Vitro Model of Renal Disease

(2009) Bruce L. Riser et al.   AMERICAN JOURNAL OF PATHOLOGY

Increased PDGFRα Activation Disrupts Connective Tissue Development and Drives Systemic Fibrosis

(2009) Lorin E. Olson et al.   DEVELOPMENTAL CELL

Phase I Study of the Safety, Tolerability, and Pharmacokinetics of Oral CP-868,596, a Highly Specific Platelet-Derived Growth Factor Receptor Tyrosine Kinase Inhibitor in Patients With Advanced Cancers

(2009) Nancy L. Lewis et al.   JOURNAL OF CLINICAL ONCOLOGY

Preventive and therapeutic effects of imatinib in Wistar-Kyoto rats with anti-glomerular basement membrane glomerulonephritis

(2009) Masayuki Iyoda et al.   KIDNEY INTERNATIONAL

Phase I Study of H5.020CMV.PDGF-β to Treat Venous Leg Ulcer Disease

(2009) David J Margolis et al.   MOLECULAR THERAPY

Patients with IgA nephropathy exhibit high systemic PDGF-DD levels

(2009) P. Boor et al.   NEPHROLOGY DIALYSIS TRANSPLANTATION

Identification of platelet-derived growth factor D in human chronic allograft nephropathy

(2008) Gang Liu et al.   HUMAN PATHOLOGY

PDGF-C Is a Proinflammatory Cytokine that Mediates Renal Interstitial Fibrosis

(2008) F. Eitner et al.   JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY

Imatinib Suppresses Cryoglobulinemia and Secondary Membranoproliferative Glomerulonephritis

(2008) M. Iyoda et al.   JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY

A New Look at Platelet-Derived Growth Factor in Renal Disease

(2007) J. Floege et al.   JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY

CCN3 is a novel endogenous PDGF-regulated inhibitor of glomerular cell proliferation

(2007) C.R.C. van Roeyen et al.   KIDNEY INTERNATIONAL