4.6 Editorial Material

Is there a difference in metabolic burden between men and women?

Journal

NEPHROLOGY DIALYSIS TRANSPLANTATION
Volume 29, Issue 6, Pages 1110-1112

Publisher

OXFORD UNIV PRESS
DOI: 10.1093/ndt/gft518

Keywords

-

Ask authors/readers for more resources

Authors

I am an author on this paper
Click your name to claim this paper and add it to your profile.

Reviews

Primary Rating

4.6
Not enough ratings

Secondary Ratings

Novelty
-
Significance
-
Scientific rigor
-
Rate this paper

Recommended

Review Urology & Nephrology

Defining measures of kidney function in observational studies using routine health care data: methodological and reporting considerations

Juan Jesus Carrero, Edouard L. Fu, Soren V. Vestergaard, Simon Kok Jensen, Alessandro Gasparini, Viyaasan Mahalingasivam, Samira Bell, Henrik Birn, Uffe Heide-Jorgensen, Catherine M. Clase, Faye Cleary, Josef Coresh, Friedo W. Dekker, Ron T. Gansevoort, Brenda R. Hemmelgarn, Kitty J. Jager, Tazeen H. Jafar, Csaba P. Kovesdy, Manish M. Sood, Benedicte Stengel, Christian F. Christiansen, Masao Iwagami, Dorothea Nitsch

Summary: The availability of electronic health records and routine measurements in kidney disease research provide opportunities but also pose challenges in terms of patient identification, marker usage, and outcome evaluation. The heterogeneity of definitions and the need to address biases are discussed, along with a proposed framework for reporting exposures and outcomes.

KIDNEY INTERNATIONAL (2023)

Article Public, Environmental & Occupational Health

Twenty-four-Year Trends in Incidence and Mortality of Nephrotic Syndrome: A Population-Based Cohort Study

Soren Viborg Vestergaard, Henrik Birn, Simon Kok Jensen, Henrik Toft Sorensen, Dorothea Nitsch, Christian Fynbo Christiansen

Summary: This study aimed to investigate the incidence, histopathology, and mortality of adult nephrotic syndrome over a 24-year period. The study found a slight increase in the incidence of adult nephrotic syndrome and a significant decrease in mortality. These findings may reflect changes in epidemiology or awareness and coding of nephrotic syndrome.

EPIDEMIOLOGY (2023)

Editorial Material Transplantation

The need for a multi-disciplinary reflection about frailty and cognitive impairment in chronic kidney disease

Michele Farisco, Irene Zecchino, Giovambattista Capasso, CONNECT Consortium

NEPHROLOGY DIALYSIS TRANSPLANTATION (2023)

Article Urology & Nephrology

Kidney function before and after acute kidney injury: a nationwide population-based cohort study

Simon Kok Jensen, Uffe Heide-Jorgensen, Soren Viborg Vestergaard, Henrik Gammelager, Henrik Birn, Dorothea Nitsch, Christian Fynbo Christiansen

Summary: This study examined the long-term changes in kidney function following acute kidney injury (AKI). It found that AKI had an impact on estimated glomerular filtration rate (eGFR) levels and slopes. The results showed a decrease in eGFR levels and changes in slopes, which depended on the baseline eGFR before AKI.

CLINICAL KIDNEY JOURNAL (2023)

Article Nutrition & Dietetics

Associations of weight and body composition at birth with body composition and cardiometabolic markers in children aged 10 y: the Ethiopian infant anthropometry and body composition birth cohort study

Bikila S. Megersa, Beakal Zinab, Rahma Ali, Elias Kedir, Tsinuel Girma, Melkamu Berhane, Bitiya Admassu, Henrik Friis, Mubarek Abera, Mette F. Olsen, Suzanne Filteau, Dorothea Nitsch, Daniel Yilma, Jonathan CK. Wells, Gregers S. Andersen, Rasmus Wibaek

Summary: This study found that birth weight and birth fat mass were associated with height and body composition at 10 years of age, while birth fat-free mass was not. Children with higher birth weight and birth fat mass had higher insulin levels and insulin resistance at 10 years old.

AMERICAN JOURNAL OF CLINICAL NUTRITION (2023)

Review Clinical Neurology

Cognitive disorders in patients with chronic kidney disease: Approaches to prevention and treatment

Marion Pepin, Aleksandra Klimkowicz-Mrowiec, Olivier Godefroy, Pilar Delgado, Sol Carriazo, Ana Carina Ferreira, Aleksandra Golenia, Jolanta Malyszko, Tomasz Grodzicki, Konstantinos Giannakou, Giuseppe Paolisso, Michelangela Barbieri, Liliana Garneata, Carmen Antonia Mocanu, Sophie Liabeuf, Goce Spasovski, Carmine Zoccali, Annette Bruchfeld, Ana Farinha, Mustafa Arici, Giovambattista Capasso, Andrzej A. Wiecek, Ziad Massy

Summary: Cognitive impairment is common in patients with chronic kidney disease (CKD). This article reviews interventions for the complications of CKD and prevention of vascular events, which may potentially also be protective against cognitive impairment. Nonpharmacological and pharmacological methods to prevent cognitive impairment and/or minimize its impact on CKD patients' daily lives are discussed. It is necessary to conduct studies assessing the effect of interventions on the cognitive function of patients with CKD.

EUROPEAN JOURNAL OF NEUROLOGY (2023)

Article Urology & Nephrology

What data collection methods work best for COVID19 outbreak surveillance for people with end stage kidney disease? An observational cohort study using the UK Renal Registry

Shalini Santhakumaran, Manuela Savino, Fran Benoy-Deeney, Retha Steenkamp, James Medcalf, Dorothea Nitsch

Summary: This study compared two methods of data collection for COVID-19 infections among patients on kidney replacement therapy in England. The results showed that direct submission of data by renal centers allowed real-time monitoring for patients undergoing in-center hemodialysis treatment. For other kidney replacement therapy modalities, using a national swab test dataset through frequent linkage may be the most effective method. Optimizing central surveillance can improve patient care by informing interventions and assisting planning at local, regional, and national levels.

BMC NEPHROLOGY (2023)

Article Urology & Nephrology

Seasonal mortality trends for hospitalised patients with acute kidney injury across England

Esther Wong, Javeria Peracha, David Pitcher, Anna Casula, Retha Steenkamp, James F. Medcalf, Dorothea Nitsch

Summary: A study in the English National Health Service found that the mortality rate for patients with acute kidney injury is higher in winter compared to summer by 33%. Furthermore, the mortality rate varied across different NHS trusts, with 9 out of 90 centers being outliers. Despite adjusting for clinical and demographic factors, the reasons for increased mortality in winter remain unclear and warrant further investigation into other factors such as winter pressures.

BMC NEPHROLOGY (2023)

Article Medicine, General & Internal

The causal effects of lipid traits on kidney function in Africans: bidirectional and multivariable Mendelian-randomization study

Christopher Kintu, Opeyemi Soremekun, Abram B. Kamiza, Allan Kalungi, Richard Mayanja, Robert Kalyesubula, S. Bernard Bagaya, Daudi Jjingo, June Fabian, Dipender Gill, Moffat Nyirenda, Dorothea Nitsch, Tinashe Chikowore, Segun Fatumo

Summary: In individuals of African ancestry, genetically predicted lower LDL-C and TC are causally associated with higher eGFR levels in a U-shaped manner. Lowering LDL-C does not necessarily improve the risk of kidney disease. Further research is needed to confirm the potential association between lipid traits and the risk of kidney disease in individuals of African ancestry.

EBIOMEDICINE (2023)

Article Oncology

The risk of acute kidney injury in colorectal cancer survivors: an english population-based matched cohort study

Kirsty Andresen, Helena Carreira, Helen Strongman, Helen I. Mcdonald, Sara Benitez-Majano, Kathryn E. Mansfield, Dorothea Nitsch, Laurie A. Tomlinson, Krishnan Bhaskaran

Summary: A retrospective matched cohort study found that colorectal cancer survivors had an increased risk of acute kidney injury (AKI) for several years after cancer diagnosis. The results highlight the importance of monitoring, preventing, and managing kidney problems in this group of cancer survivors.

BMC CANCER (2023)

Article Public, Environmental & Occupational Health

Comparative Effectiveness of Dynamic Treatment Strategies for Medication Use and Dosage: Emulating a Target Trial Using Observational Data

Kate Birnie, Charles Tomson, Fergus J. Caskey, Yoav Ben-Shlomo, Dorothea Nitsch, Anna Casula, Eleanor J. Murray, Jonathan A. C. Sterne

Summary: The availability of electronic health records data has provided opportunities to examine the comparative effectiveness of dynamic treatment strategies. However, when dealing with continuous treatments, model checking and monitoring of large weights are essential to accurately estimate treatment effects.

EPIDEMIOLOGY (2023)

Article Urology & Nephrology

Do outcomes for patients with hospital-acquired Acute Kidney Injury (H-AKI) vary across specialties in England?

Winnie Magadi, Javeria Peracha, William S. McKane, Manuela Savino, Fiona Braddon, Retha Steenkamp, Dorothea Nitsch

Summary: In this study, differences in burden of hospital-acquired acute kidney injury (H-AKI) and mortality risk across different treatment specialties in the English National Health Service (NHS) were identified. It was found that patients in surgical specialties had a lower 30-day mortality risk compared to general medicine, while critical care and oncology patients had the highest mortality risk.

BMC NEPHROLOGY (2023)

Article Multidisciplinary Sciences

Bias assessment of a test-negative design study of COVID-19 vaccine effectiveness used in national policymaking

Sophie Graham, Elise Tessier, Julia Stowe, Jamie Lopez Bernal, Edward P. K. Parker, Dorothea Nitsch, Elizabeth Miller, Nick Andrews, Jemma L. Walker, Helen I. McDonald

Summary: National test-negative-case-control studies are conducted in the UK to monitor the effectiveness of COVID-19 vaccines. A questionnaire was sent to participants of the first published study to assess potential biases and changes in behavior related to vaccination. The findings showed a slight decrease in vaccine effectiveness after two doses of BNT162b2, but minimal evidence of riskier behavior after vaccination. These results provide reassurance to policymakers and clinicians.

NATURE COMMUNICATIONS (2023)

Article Psychiatry

A Mendelian randomization study of genetic liability to post-traumatic stress disorder and risk of ischemic stroke

Opeyemi Soremekun, Clarisse Musanabaganwa, Annette Uwineza, Maddalena Ardissino, Skanda Rajasundaram, Agaz H. Wani, Stefan Jansen, Jean Mutabaruka, Eugene Rutembesa, Chisom Soremekun, Cisse Cheickna, Mamadou Wele, Joseph Mugisha, Oyekanmi Nash, Eugene Kinyanda, Dorothea Nitsch, Myriam Fornage, Tinashe Chikowore, Dipender Gill, Derek E. Wildman, Leon Mutesa, Monica Uddin, Segun Fatumo

Summary: Observational studies have shown a link between PTSD and IS, but it is unclear if this association is causal. Using Mendelian randomization, the researchers found evidence that genetic liability to specific sub-phenotypes of PTSD, such as hyperarousal and avoidance, may have a causal effect on the risk of IS in individuals of European and African ancestry.

TRANSLATIONAL PSYCHIATRY (2023)

Article Medical Informatics

Identifying and visualising multimorbidity and comorbidity patterns in patients in the English National Health Service: a population-based study

Valerie Kuan, Spiros Denaxas, Praveetha Patalay, Dorothea Nitsch, Rohini Mathur, Arturo Gonzalez-Izquierdo, Reecha Sofat, Linda Partridge, Amanda Roberts, Ian C. K. Wong, Melanie Hingorani, Nishi Chaturvedi, Harry Hemingway, Aroon Hingorani, MMTRC

Summary: This study provides important data on multimorbidity and comorbidity in diverse populations, highlighting non-random disease associations and patterns. It offers valuable resources for patients, clinicians, researchers, and policymakers to improve prevention, detection, and management of comorbid conditions. The findings also have implications for biomedical research and the development of clinical trials.

LANCET DIGITAL HEALTH (2023)

No Data Available