Review
Medicine, General & Internal
Fabio Angeli, Gianpaolo Reboldi, Francesco Giuseppe Solano, Antonietta Prosciutto, Antonella Paolini, Martina Zappa, Claudia Bartolini, Andrea Santucci, Stefano Coiro, Paolo Verdecchia
Summary: Several outcome-based prospective investigations have shown the prognostic value of 24-hour ambulatory blood pressure monitoring in cardiovascular risk stratification. Average 24-hour, daytime, and nighttime blood pressures are essential components that improve risk assessment beyond traditional factors. However, the interpretation and clinical use of ambulatory blood pressure monitoring need standardization, and implementing its results in individual patient management remains challenging.
Article
Peripheral Vascular Disease
Mark M. Mitsnefes, Yunwen Xu, Derek K. Ng, Garick Hill, Thomas Kimball, Susan L. Furth, Bradley A. Warady
Summary: Diastolic dysfunction is an early cardiac abnormality in patients with chronic kidney disease, with E/e' ratio being a marker to assess it. Abnormal E/e' ratio is associated with younger age, lower glomerular filtration rate, lower hemoglobin, hypertension, left ventricular hypertrophy, and sustained hypertension. Ambulatory blood pressure may better identify chronic kidney disease in children at risk for subclinical cardiac dysfunction compared to casual blood pressure.
Article
Peripheral Vascular Disease
Giuseppe Mancia, Rita Facchetti, Gino Seravalle, Cesare Cuspidi, Giovanni Corrao, Guido Grassi
Summary: The addition of home and 24-hour blood pressure to office blood pressure significantly improves the prediction of cardiovascular and all-cause mortality, especially with the addition of home blood pressure. However, the quantitative improvement is modest, raising questions about the extended use of these methods in clinical practice.
Article
Pediatrics
Reut Pagi, Ora Yadin, Katherine Wesseling-Perry, Keith Norris, Marciana Lee Laster
Summary: Black children with CKD have higher blood pressure and higher rates of abnormal dipping during sleep compared to white children. Further studies are needed to understand the reasons behind these differences and the implications for clinical practice.
PEDIATRIC NEPHROLOGY
(2023)
Review
Clinical Neurology
Ramon C. Hermida, Artemio Mojon, Ramon G. Hermida-Ayala, Michael H. Smolensky, Jose R. Fernandez
Summary: The evidence suggests that elevated asleep blood pressure and blunted sleep-time relative blood pressure decline are significant independent prognostic markers of cardiovascular disease risk. Treating hypertension at bedtime/evening instead of upon-waking/morning schedule produces better clinical benefits. Current guidelines do not adequately address this issue.
SLEEP MEDICINE REVIEWS
(2021)
Review
Medicine, General & Internal
Yibang Cheng, Yan Li, Jiguang Wang
Summary: Ambulatory blood pressure monitoring is crucial in the management of hypertension, as it aids in accurate diagnosis and cardiovascular risk assessment.
CHINESE MEDICAL JOURNAL
(2022)
Article
Peripheral Vascular Disease
Simon Correa, Xavier E. Guerra-Torres, Sushrut S. Waikar, Finnian R. Mc Causland
Summary: In patients with CKD, higher serum magnesium levels are associated with lower systolic and diastolic blood pressure, as well as a reduced risk of hypertension and CKD progression. Further research is needed to investigate whether magnesium supplementation could optimize blood pressure control and prevent disease progression in this population.
Article
Transplantation
Silvio Borrelli, Carlo Garofalo, Francis B. Gabbai, Maria Elena Liberti, Paolo Chiodini, Vittorio Simeon, Luca De Nicola, Roberto Minutolo
Summary: The progression of chronic kidney disease (CKD) is faster in men than in women, but it remains unclear if the same applies to cardiovascular risk. A study found that women with CKD have a lower cardiovascular risk than men, but this advantage diminishes as systolic blood pressure (SBP) increases.
NEPHROLOGY DIALYSIS TRANSPLANTATION
(2023)
Review
Peripheral Vascular Disease
Maria Cepeda, Patrick Pham, Daichi Shimbo
Summary: Diagnosis and management of hypertension based solely on office blood pressure (BP) measurements may be inadequate as BP can significantly differ outside the office setting. Ambulatory BP monitoring (ABPM) and home BP monitoring (HBPM) are validated approaches for out-of-office BP measurement. ABPM is recommended as the reference standard for out-of-office BP monitoring, while HBPM is suggested as an alternative approach when ABPM is not available or well tolerated.
HYPERTENSION RESEARCH
(2023)
Article
Peripheral Vascular Disease
Chloe Douglas, Jennifer T. Roem, Joseph L. Flynn, Susan A. Furth, Bradley M. Warady, Susan Halbach
Summary: Using data from the CKiD Study, this study found that younger children with chronic kidney disease are more likely to have unrecognized and untreated hypertensive blood pressure, highlighting the need for efforts to improve blood pressure control in this population.
Article
Pediatrics
Sanober Sadiq, Elizabeth Black, Aris Oates
Summary: ABPM is a useful tool for diagnosing and managing hypertension in CKD patients, with no specific barriers identified in this study. No demographic or disease characteristics were found to impact the likelihood of obtaining ABPM, suggesting a need for further patient and provider education for improvement.
Article
Medicine, General & Internal
Di Zhao, Hui Liu, Pingshuan Dong
Summary: This meta-analysis found that bedtime dosing with ARBs is more effective in lowering sleep-time blood pressure in patients with essential hypertension. However, the effects of different timing of dosing on daytime blood pressure were similar. More extensive multi-ethnic studies are needed to further investigate the chronotherapy of hypertension.
AMERICAN JOURNAL OF THE MEDICAL SCIENCES
(2021)
Review
Peripheral Vascular Disease
Qi-Fang Huang, Wen-Yi Yang, Kei Asayama, Zhen-Yu Zhang, Lutgarde Thijs, Yan Li, Eoin O'Brien, Jan A. Staessen
Summary: Ambulatory blood pressure monitoring has become the preferred method for assessing blood pressure and rational use of antihypertensive drugs. Studies have shown a closer association of cardiovascular complications with 24-hour and nighttime blood pressure compared to office blood pressure. Different types of hypertension, such as white-coat hypertension and masked hypertension, can be identified through a combination of ambulatory and office blood pressure thresholds. The focus should be on the levels of 24-hour and nighttime blood pressure, as additional blood pressure indexes derived from 24-hour monitoring recordings do not significantly add to risk stratification or hypertension management.
Article
Medicine, General & Internal
Ran Abuhasira, Yosef S. Haviv, Merav Leiba, Adi Leiba, Larisa Ryvo, Victor Novack
Summary: The study showed that in older adults with hypertension, cannabis treatment for 3 months was associated with a reduction in 24-hour average systolic and diastolic blood pressure values, with the lowest point occurring at 3 hours post-administration of cannabis.
EUROPEAN JOURNAL OF INTERNAL MEDICINE
(2021)
Article
Cardiac & Cardiovascular Systems
Giulia Rivasi, Antonella Groppelli, Michele Brignole, Davide Soranna, Antonella Zambon, Grzegorz Bilo, Martino Pengo, Bashaaer Sharad, Viktor Hamrefors, Martina Rafanelli, Giuseppe Dario Testa, Ciara Rice, Rose Anne Kenny, Richard Sutton, Andrea Ungar, Artur Fedorowski, Gianfranco Parati
Summary: This study found that patients with reflex syncope have a higher prevalence of systolic blood pressure drops during ambulatory blood pressure monitoring (ABPM). Cut-off values for these drops were defined, expanding the current indications for ABPM in patients with reflex syncope.
EUROPEAN HEART JOURNAL
(2022)
Article
Biology
Alfredo De Giorgi, Fabio Fabbian, Rosaria Cappadona, Ruana Tiseo, Christian Molino, Elisa Misurati, Edoardo Gambuti, Caterina Savrie, Benedetta Boari, Valeria Raparelli, Roberto Manfredini
Summary: The study evaluated sex-related differences and factors associated with in-hospital mortality in elderly patients with cancer, finding high comorbidity burden and increased risk of all-cause mortality in this population.
Review
Biology
Ramon C. Hermida, Artemio Mojon, Jose R. Fernandez, Ramon G. Hermida-Ayala, Juan J. Crespo, Maria T. Rios, Manuel Dominguez-Sardina, Alfonso Otero, Michael H. Smolensky
Summary: Elevated asleep blood pressure and blunted sleep-time relative systolic blood pressure decline are significant prognostic markers of cardiovascular disease risk. Current hypertension guidelines overlook the importance of asleep blood pressure and recommend diagnosis based on office blood pressure measurements. Studies have shown that taking blood pressure-lowering medications at bedtime results in greater reduction of blood pressure and improved cardiovascular outcomes compared to morning intake.
CHRONOBIOLOGY INTERNATIONAL
(2023)
Review
Biology
Ramon C. Hermida, Ramon G. Hermida-Ayala, Artemio Mojon, Michael H. Smolensky, Jose R. Fernandez
Summary: Taking hypertension medications at bedtime/evening rather than upon-waking/morning can lead to significant benefits, such as reduced mean asleep blood pressure, decreased cardiovascular risk, improved kidney function, and reduced cardiac pathology. However, some past trials have inconsistent results mainly due to disparities and deficiencies in investigative protocols.
CHRONOBIOLOGY INTERNATIONAL
(2021)
Editorial Material
Peripheral Vascular Disease
Ramon C. Hermida, Artemio Mojon, Michael H. Smolensky, Jose R. Fernandez
Review
Biology
Ramon G. Hermida-Ayala, Artemio Mojon, Jose R. Fernandez, Michael H. Smolensky, Ramon C. Hermida
Summary: Research shows that taking dual-combination hypertension medications at bedtime/evening can lead to more significant benefits, including reduced asleep blood pressure, decreased prevalence of non-dipping blood pressure, fewer adverse effects, improved kidney function, and reduced cardiac pathology, compared to taking them upon waking/morning.
CHRONOBIOLOGY INTERNATIONAL
(2022)
Review
Pediatrics
Francisco Jose Rodriguez-Cortes, Ignacio Morales-Cane, Pedro Manuel Rodriguez-Munoz, Rosaria Cappadona, Alfredo De Giorgi, Roberto Manfredini, Maria Aurora Rodriguez-Borrego, Fabio Fabbian, Pablo Jesus Lopez-Soto
Summary: Children and adolescents with an evening chronotype are more prone to incorrect eating behaviors and are more likely to suffer from overweight/obesity. The association between chronotype, eating disorders, and obesity should take into account environmental and lifestyle factors.
Letter
Cardiac & Cardiovascular Systems
Ramon C. Hermida, Artemio Mojon, Michael H. Smolensky, Jose R. Fernandez
REVISTA ESPANOLA DE CARDIOLOGIA
(2022)
Review
Nutrition & Dietetics
Gloria Liquori, Aurora De Leo, Daniele De Nuzzo, Victoria D'Inzeo, Rosario Marco Arancio, Emanuele Di Simone, Sara Dionisi, Noemi Giannetta, Francesco Ricciardi, Fabio Fabbian, Giovanni Battista Orsi, Marco Di Muzio, Christian Napoli
Summary: Cognitive impairment and dementia can negatively affect older people's nutritional capacities, leading to malnutrition which is common in hospitalized frail elderly people with cognitive impairment and negatively affects prognosis. This scoping review aimed to identify factors affecting the risk of malnutrition and preventive strategies in hospitalized patients with cognitive impairment, focusing on nursing interventions. The results show that nursing interventions can recognize and reduce the risk of malnutrition, positively impacting clinical outcomes.
Review
Clinical Neurology
Michael H. Smolensky, Ami P. Shah, Jose R. Fernandez, Linda Sackett-Lundeen, Ramon C. Hermida
Summary: The aim of this study was to substantiate the 24-hour pattern in the occurrence of childhood febrile seizures (CFSs) and discuss its potential circadian rhythm-dependencies. Eight articles were included in a comprehensive search of the literature, with a total of 2461 CFSs cases from different countries. A 24-hour pattern in the onset of CFSs was validated, with the highest proportion occurring at 18:04 and the lowest at 06:00. The time-of-day risk of CFSs is likely influenced by multiple circadian rhythms, including cytokines and melatonin.
Review
Biochemistry & Molecular Biology
Salvatore Greco, Nicolo Fabbri, Riccardo Spaggiari, Alfredo De Giorgi, Fabio Fabbian, Antonio Giovine
Summary: Triple-negative breast cancer (TNBC) is characterized by high rates of relapse and metastasis, with limited treatment options available. Immunotherapy has revolutionized TNBC treatment in recent years, although targeted therapies are still lacking. The National Comprehensive Cancer Network (NCCN) released updated guidelines in 2023, providing insights into the management of metastatic TNBC. This comprehensive review summarizes the latest findings and introduces promising molecules that target TNBC biomarkers.
Review
Biology
Ramon C. Hermida, Michael H. Smolensky, Artemio Mojon, Jose R. Fernandez
Summary: The research on molecular and laboratory animal circadian rhythm has greatly increased in the past few decades. However, the lack of formal training and expertise in human circadian rhythm research among investigators conducting translational circadian medicine trials has led to deficient design and questionable findings. This has caused unnecessary controversy and hindered advances in patient care. Overall rating: 7/10
CHRONOBIOLOGY INTERNATIONAL
(2023)
Article
Urology & Nephrology
Alfredo De Giorgi, Alda Storari, Pedro Manuel Rodriguez-Munoz, Rosaria Cappadona, Nicola Lamberti, Fabio Manfredini, Pablo Jesus Lopez-Soto, Roberto Manfredini, Fabio Fabbian
Summary: This study aims to evaluate the possible relationship between seasons and in-hospital mortality (IHM) in elderly hospitalized patients with acute kidney injury (AKI). The results suggest that autumn and winter months are independent risk factors for IHM in patients with AKI, while summer reduces the risk of death during hospitalizations with AKI.
INTERNATIONAL UROLOGY AND NEPHROLOGY
(2022)
Correction
Biology
Ramon C. Hermida, Ramon G. Hermida-Ayala, Artemio Mojon, Michael H. Smolensky, Jose R. Fernandez
CHRONOBIOLOGY INTERNATIONAL
(2021)
Article
Health Care Sciences & Services
Fabio Fabbian, Alfredo De Giorgi, Silvia Ferro, Domenico Lacavalla, Dario Andreotti, Simona Ascanelli, Stefano Volpato, Savino Occhionorelli
Summary: This study evaluated the predictive ability of Charlson comorbidity index (CCI) for all-cause mortality in elderly patients undergoing emergency abdominal surgery. The results showed that in patients with CCI >= 4, the survival rate was lower, and open surgery and high CCI values were associated with all-cause death.