Article
Cell Biology
Ruiyao Xu, Xianxian Wang, Sadia Safi, Nico Braunegger, Agnes Hipgrave Ederveen, Michelle Rottmann, Joachim Wittbrodt, Manfred Wuhrer, Janine Wesslowski, Gary Davidson
Summary: Reception of Wnt signals is mediated by Frizzled receptors and a co-receptor LRP6 or LRP5. Precise control of receptor activation is crucial to regulate Wnt/beta-catenin signaling for proper cellular function. A glycosyltransferase B3GnT2-like has been identified to modify LRP6 and enhance Wnt/beta-catenin signaling. This study highlights the importance of LRP6 as a regulatory hub in Wnt signaling and provides insight into the selective targeting of a signaling pathway component by a specific glycosyltransferase.
Article
Multidisciplinary Sciences
Ahmet Acar, Ana Hidalgo-Sastre, Michael K. Leverentz, Christopher G. Mills, Simon Woodcock, Martin Baron, Giovanna M. Collu, Keith Brennan
Summary: Notch and Wnt are two essential signaling pathways in animals, with typically opposing effects on cell fate decisions. Notch can limit Wnt signaling through mechanisms at the cell membrane and in the cell nucleus, contributing to the robustness of cell fate decisions by sharpening the distinction between opposing Notch/Wnt responses.
SCIENTIFIC REPORTS
(2021)
Article
Biochemistry & Molecular Biology
Beatriz Martin-Carro, Julia Martin-Virgala, Sara Fernandez-Villabrille, Alejandra Fernandez-Fernandez, Marcos Perez-Basterrechea, Juan F. Navarro-Gonzalez, Javier Donate-Correa, Carmen Mora-Fernandez, Adriana S. Dusso, Natalia Carrillo-Lopez, Sara Panizo, Manuel Naves-Diaz, Jose L. Fernandez-Martin, Jorge B. Cannata-Andia, Cristina Alonso-Montes
Summary: Fibrosis plays a crucial role in the development of diabetic complications and dysfunction in the heart and kidneys. This study investigated the involvement of soluble Klotho, advanced glycation end products/receptor for AGEs, fibrotic Wnt/beta-catenin pathway, and pro-fibrotic pathways in the kidney and heart of diabetic rats. The findings suggested that diabetic rats had elevated levels of urinary sKlotho, AGEs, and sRAGE, and decreased levels of serum sKlotho. Fibrosis and RAGE levels were higher in the heart of diabetic rats compared to controls. The increase in sKlotho and sRAGE excretion may be due to polyuria in diabetic rats.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Oncology
Shuting Liu, Liang Chen, Hua Chen, Kangkang Xu, Xi Peng, Mingchang Zhang
Summary: The study revealed that circ_0119872 is upregulated in UM cell lines and tissues, promoting the malignancy of UM cells. Additionally, circ_0119872 can directly interact with miR-622, acting as a miRNA sponge to regulate the expression of the miR-622 target gene G3BP1 and downstream Wnt/beta-catenin and mTOR signaling pathways.
JOURNAL OF EXPERIMENTAL & CLINICAL CANCER RESEARCH
(2021)
Article
Cell & Tissue Engineering
Kai Hang, Li Ying, Jinwu Bai, Yibo Wang, Zhihui Kuang, Deting Xue, Zhijun Pan
Summary: The study showed that the silencing of SERPINB2 can promote osteogenic differentiation of BMSCs through the Wnt/β-catenin signaling pathway. In vivo experiments demonstrated that silencing SERPINB2 effectively improves bone fracture healing, suggesting that SERPINB2 may be a novel target for bone fracture healing.
STEM CELL RESEARCH & THERAPY
(2021)
Article
Cell Biology
Qiming Gong, Yan Jiang, Xiuhong Pan, Yanwu You
Summary: Fractalkine (FKN) interacts positively with Wnt/beta-catenin signaling in macrophages, playing a crucial role in LPS-induced acute kidney injury (AKI). FKN overexpression can attenuate LPS-induced macrophage apoptosis and promote their transformation into the beneficial M2 type, suggesting a potential therapeutic target for kidney injury.
JOURNAL OF CELLULAR AND MOLECULAR MEDICINE
(2021)
Article
Multidisciplinary Sciences
Yinan Hu, Qi Wang, Jun Yu, Qing Zhou, Yanhan Deng, Juan Liu, Lei Zhang, Yongjian Xu, Weining Xiong, Yi Wang
Summary: This study reveals the involvement of ACP5 in the initiation and progression of pulmonary fibrosis. Acp5 deficiency protects mice from lung injury and fibrosis, and the upregulation of Acp5 by TGF-beta 1 enhances β-catenin signaling, promoting fibroblast differentiation, proliferation, and migration. Furthermore, treatment with Acp5 siRNA or inhibitor can reverse established lung fibrosis.
NATURE COMMUNICATIONS
(2022)
Article
Biochemistry & Molecular Biology
Roland Kotolloshi, Mieczyslaw Gajda, Marc-Oliver Grimm, Daniel Steinbach
Summary: The study revealed that BCL9L and Wnt/beta-catenin signaling play an oncogenic role in bladder cancer cells, and may be associated with the progression of bladder cancer. Mutations in UTRs of BCL9L can affect its activity, thereby influencing cell proliferation, migration, and invasion.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Biochemistry & Molecular Biology
Khalid Saad Alharbi, Tabinda Ali, Yogendra Singh, Ahmed Saleh Ali Al-Ghamdi, Imran Kazmi, Fahad A. Al-Abbasi, Sami I. Alzarea, Obaid Afzal, Abdulmalik Saleh Alfawaz Altamimi, Sachin Kumar Singh, Dinesh Kumar Chellappan, Kamal Dua, Gaurav Gupta
Summary: Acute kidney injury (AKI) has a poor clinical prognosis and increases the risk of chronic kidney failure (CKD). There is currently no treatment for AKI or its progression to CKD, but research is ongoing on the potential therapeutic use of Wnt/beta-catenin inhibitors in preventing renal dysfunction.
CHEMICO-BIOLOGICAL INTERACTIONS
(2022)
Review
Cell Biology
Sandy Winfield Jere, Heidi Abrahamse, Nicolette Nadene Houreld
Summary: Cell signalling plays a crucial role in wound healing, and dysregulation of signalling pathways can lead to chronic wounds. The interaction between the AKT and beta-catenin signalling pathways influences diabetic wound healing, and photobiomodulation can enhance this process.
JOURNAL OF BIOMEDICAL SCIENCE
(2023)
Review
Oncology
Siwei Yu, Ruyue Han, Runliang Gan
Summary: This review aims to analyze the mechanisms of action of related molecules in the Wnt/beta-catenin pathway in hematologic malignancies and explore their feasibility as therapeutic targets.
BIOMARKER RESEARCH
(2022)
Article
Peripheral Vascular Disease
Irena Kasacka, Zaneta Piotrowska, Natalia Domian, Magdalena Acewicz, Alicja Lewandowska
Summary: The study revealed alterations in Wnt/beta-catenin signaling in the kidneys of rats during hypertension, with the severity of these changes depending on the type of hypertension. This study is the first to assess the levels of some elements of the canonical Wnt/beta-catenin signal transduction pathway in various types of arterial hypertension by immunohistochemistry, and may lead to further molecular and functional studies of this pathway in hypertension.
HYPERTENSION RESEARCH
(2021)
Article
Pharmacology & Pharmacy
Yeong Chan Ryu, Dong-Hwan Lee, Jiyong Shim, Jiyeon Park, You-Rin Kim, Sehee Choi, Soon Sun Bak, Young Kwan Sung, Soung-Hoon Lee, Kang-Yell Choi
Summary: KY19382 is identified as a drug that activates Wnt/beta-catenin signaling, promoting hair regeneration and growth with significant effects on DP cells, and demonstrating hair regrowth abilities in mouse models.
BRITISH JOURNAL OF PHARMACOLOGY
(2021)
Article
Biochemistry & Molecular Biology
Lifang He, Qingke Li, Chunyang Du, Yanyun Xue, Pei Yu
Summary: This study found that Glis2 expression was downregulated in Diabetic kidney disease (DKD) and overexpression of Glis2 inhibited the apoptosis and epithelial-to-mesenchymal transition (EMT) of renal tubular epithelial cells (TECs). Furthermore, Glis2 overexpression also suppressed the activation of the beta-catenin signaling pathway, which played a role in protecting against tubular injury.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2022)
Article
Biochemistry & Molecular Biology
Janson Tse, Ryan O'Keefe, Angela Rigopolous, Annalisa L. E. Carli, Jo Waaler, Stefan Krauss, Matthias Ernst, Michael Buchert
Summary: Specific signalling thresholds of the WNT/beta-catenin pathway affect embryogenesis and tissue homeostasis. Currently, there is a lack of specific in vivo assays to evaluate inhibitors of WNT/beta-catenin signalling. We present a simple in vivo assay to assess the efficacy and bioavailability of candidate compounds.
Article
Urology & Nephrology
Ana Gabriela J. T. Melo, Gessica Sabrine B. Barbosa, Daniela Del P. V. R. Cortes, Rayra G. Ribeiro, Luiza K. Araujo, Benedito J. Pereira, Hugo Abensur, Rosa M. A. Moyses, Rosilene M. Elias
Summary: The study compared the prognosis of patients returning to PD after failed kidney transplant with those starting PD for other reasons, finding no significant differences in technique survival, peritonitis-free survival, and residual diuresis between the two groups, suggesting that PD is a viable dialysis option after kidney transplant failure.
INTERNATIONAL UROLOGY AND NEPHROLOGY
(2022)
Article
Medicine, Research & Experimental
Wander Barros do Carmo, Barbara Bruna Abreu Castro, Luisa Cardoso Manso, Priscylla Aparecida Vieira do Carmo, Clovis Antonio Rodrigues, Melani Ribeiro Custodio, Vanda Jorgetti, Helady Sanders-Pinheiro
Summary: The study found that the chitosan-iron III chelator was effective in reducing phosphorus excretion without iron accumulation, paving the way for potential use of this class of chelators in clinical settings in the future.
EXPERIMENTAL BIOLOGY AND MEDICINE
(2022)
Article
Urology & Nephrology
Tiago Emanuel M. Costa, Julia C. Lauar, Mariana L. R. Innecchi, Venceslau A. Coelho, Rosa M. A. Moyses, Rosilene M. Elias
Summary: This study found an association between hyperuricemia and secondary hyperparathyroidism in patients with CKD, suggesting that hyperuricemia may contribute to the development of SHPT.
INTERNATIONAL UROLOGY AND NEPHROLOGY
(2022)
Review
Urology & Nephrology
Eduardo J. Duque, Rosilene M. Elias, Rosa M. A. Moyses
Summary: Phosphate balance is crucial in the treatment of chronic kidney disease (CKD), with current therapy focusing on dietary restrictions, phosphate binders, and optimal removal by dialysis. Future studies may confirm the benefits of phosphate control in CKD patients.
CURRENT OPINION IN NEPHROLOGY AND HYPERTENSION
(2022)
Article
Nutrition & Dietetics
Renata G. Rodrigues, Maria Aparecida Dalboni, Marilia de A. Correia, Luciene M. dos Reis, Rosa M. A. Moyses, Rosilene M. Elias
Summary: This study evaluated whether reduced calf circumference (CC) could predict falls in older patients with chronic kidney disease (CKD) undergoing maintenance hemodialysis. The study found that reduced CC, higher age, and higher body weight were associated with falls. This study suggests that CC measurement is a simple and low-cost tool to predict fall risk in older patients undergoing hemodialysis.
JOURNAL OF RENAL NUTRITION
(2023)
Article
Multidisciplinary Sciences
Lilian Cordeiro, Walther Yoshiharu Ishikawa, Maria Claudia C. Andreoli, Maria Eugenia F. Canziani, Luiza Karla R. P. Araujo, Benedito J. Pereira, Hugo Abensur, Rosa M. A. Moyses, Rosilene M. Elias
Summary: This study aimed to investigate the impact of icodextrin solution compared to glucose solution on left ventricular hypertrophy in peritoneal dialysis patients. The results showed that icodextrin solution was not able to improve left ventricular mass. Further large-scale randomized trials with longer follow-up periods may be needed to observe changes in left ventricular mass in this patient population.
SCIENTIFIC REPORTS
(2022)
Article
Urology & Nephrology
Kalyanna S. Bezerra de Carvalho, Julia C. Lauar, Luciano F. Drager, Rosa M. A. Moyses, Rosilene M. Elias
Summary: There is a discrepancy between self-reported and objectively measured sleep duration in CKD patients. Objective measurements are recommended for accurate assessment of sleep duration in CKD patients.
JORNAL BRASILEIRO DE NEFROLOGIA
(2023)
Biographical-Item
Endocrinology & Metabolism
Vanda Jorgetti, Sampaio-Barros Pd, Shinjo Sk, Eloisa Bonfa
JOURNAL OF BONE AND MINERAL RESEARCH
(2023)
Article
Endocrinology & Metabolism
Maria Clara Teixeira Piraciaba, Lilian Cordeiro, Erica Adelina Guimaraes, Hugo Abensur, Benedito Jorge Pereira, Vanda Jorgetti, Rosa Maria Affonso Moyses, Rosilene Motta Elias
Summary: Reducing the dialysate calcium concentration (D[Ca]) in peritoneal dialysis patients is a safe and beneficial option to prevent a rise in parathyroid hormone (PTH) levels.
Article
Urology & Nephrology
Cinthia E. M. Carbonara, Noemi A. V. Roza, Luciene M. dos Reis, Aluizio B. Carvalho, Vanda Jorgetti, Rodrigo Bueno de Oliveira
Summary: The Brazilian Registry of Bone Biopsy (REBRABO) is a national multicenter cohort that provides clinical information on renal osteodystrophy (ROD). This subanalysis described the profile of ROD, including the most frequent diagnoses and associated findings. The results showed a high proportion of patients with osteoporosis, vascular calcification, and clinical symptoms.
JORNAL BRASILEIRO DE NEFROLOGIA
(2023)
Article
Medicine, Research & Experimental
Marta Martinez-Calle, Guillaume Courbon, Bridget Hunt-Tobey, Connor Francis, Jadeah Spindler, Xueyan Wang, Luciene M. dos Reis, Carolina S. W. Martins, Isidro B. Salusky, Hartmut Malluche, Thomas L. Nickolas, Rosa M. A. Moyses, Valentin David, Aline Martin
Summary: Renal osteodystrophy (ROD) is a bone metabolism disorder that affects patients with chronic kidney disease (CKD) and is associated with negative clinical outcomes. The study found that hepatocyte nuclear factor 4α (HNF4α), expressed mostly in the liver, is also expressed in bone and its reduced expression is observed in ROD patients and mice. Deletion of Hnf4α in osteoblasts led to impaired osteogenesis. Multi-omics analyses showed that the main isoform of HNF4α regulating osteogenesis, cell metabolism, and cell death is HNF4α2. Osteoblast-specific overexpression of HNF4α2 prevented bone loss in CKD mice.
JOURNAL OF CLINICAL INVESTIGATION
(2023)
Article
Urology & Nephrology
Paula M. R. Pina, Luis Carlos Arcon, Roberto Zatz, Rosa M. A. Moyses, Rosilene M. Elias
Summary: Although factors related to CKD progression have been extensively studied, little is known about renal function decline specifically in older individuals. This study found that older patients with CKD exhibit slower progression of the disease, even after adjusting for multiple factors. These findings have important implications for the management and planning of dialysis in older CKD patients.
INTERNATIONAL UROLOGY AND NEPHROLOGY
(2023)
Article
Endocrinology & Metabolism
Maria Beatriz C. N. Pessoa, Ruth Miyuki Santo, Aline A. de Deus, Eduardo J. Duque, Shirley F. Crispilho, Vanda Jorgetti, Maria Aparecida Dalboni, Carlos Eduardo Rochitte, Rosa M. A. Moyses, Rosilene M. Elias
Summary: This cross-sectional study aimed to investigate the relationship between corneal and conjunctival calcification (CCC) and coronary artery calcification in patients with chronic kidney disease. The study found that CCC was frequent in this population but did not correlate with coronary artery calcification. Hyperphosphatemia appeared to contribute to CCC.
Article
Nutrition & Dietetics
Luana Cristina A. de Silva, Marilia A. de Correia, Renata Daniel Gouveia, Mayara S. Souza, Carlos P. Isaac Jr, Fernando Parrillo, Rosa M. A. Moyses, Maria Aparecida Dalboni, Rosilene M. Elias
Summary: Malnutrition is common in older patients with end-stage renal disease, and nutritional supplementation can mitigate the loss of the SMM index and improve survival rate. However, the effects on sarcopenia were not significant in this study.
CLINICAL NUTRITION ESPEN
(2023)