Article
Urology & Nephrology
Jeffrey Perl, Edwina A. Brown, Christopher T. Chan, Cecile Couchoud, Simon J. Davies, Rumeyza Kazancioglu, Scott Klarenbach, Adrian Liew, Daniel E. Weiner, Michael Cheung, Michel Jadoul, Wolfgang C. Winkelmayer, Martin E. Wilkie
Summary: Home dialysis modalities offer greater patient autonomy and satisfaction, but their utilization worldwide is low. Expanding home-dialysis use requires alignment of policy, resources, structure, incentives, and accountability. Choice among available modalities should consider quality of life, clinical characteristics, support, and living environment. Education and support for healthcare professionals, patients, and care-partners are priorities to facilitate access to home therapy.
KIDNEY INTERNATIONAL
(2023)
Article
Urology & Nephrology
Jodie L. Babitt, Michele F. Eisenga, Volker H. Haase, Abhijit Kshirsagar, Adeera Levin, Francesco Locatelli, Jolanta Malyszko, Dorine W. Swinkels, Der-Cherng Tarng, Michael Cheung, Michel Jadoul, Wolfgang C. Winkelmayer, Tilman B. Drueke
Summary: Chronic kidney disease is often associated with anemia and disordered iron homeostasis, which have significant adverse consequences. In 2012, KDIGO issued guidelines for managing anemia in chronic kidney disease, and in 2019, they convened conferences to review new evidence and controversies related to iron and anemia treatment. The first conference focused on iron-related issues like diagnostic challenges, treatment options and patient outcomes.
KIDNEY INTERNATIONAL
(2021)
Article
Clinical Neurology
Dearbhla M. Kelly, Zanfina Ademi, Wolfram Doehner, Gregory Y. H. Lip, Patrick Mark, Kazunori Toyoda, Christopher X. Wong, Mark Sarnak, Michael Cheung, Charles A. Herzog, Kirsten L. Johansen, Holger Reinecke, Manish M. Sood
Summary: Chronic kidney disease is a significant risk factor for cerebrovascular disease, with various potential mechanisms linking the two, including traditional and nontraditional risk factors. The presence of chronic kidney disease complicates stroke risk prediction, diagnosis, and management, leading to more severe strokes and a higher burden on patients.
Article
Urology & Nephrology
Caitlin W. Hicks, Timothy W. I. Clark, Christopher J. Cooper, Aine M. de Bhailis, Marco De Carlo, Darren Green, Jolanta Malyszko, Marius Miglinas, Stephen C. Textor, Charles A. Herzog, Kirsten L. Johansen, Holger Reinecke, Philip A. Kalra
Summary: The diagnosis and management of atherosclerotic renovascular disease (ARVD) is complex and controversial. Despite studies showing that percutaneous renal artery revascularization does not improve major outcomes, medical therapy has evolved and is now considered the primary means of treating hypertension in ARVD.
AMERICAN JOURNAL OF KIDNEY DISEASES
(2022)
Article
Urology & Nephrology
Anna Koettgen, Emilie Cornec-Le Gall, Jan Halbritter, Krzysztof Kiryluk, Andrew J. Mallett, Rulan S. Parekh, Hila Milo Rasouly, Matthew G. Sampson, Adrienne Tin, Corinne Antignac, Elisabet Ars, Carsten Bergmann, Anthony J. Bleyer, Detlef Bockenhauer, Olivier Devuyst, Jose C. Florez, Kevin J. Fowler, Nora Franceschini, Masafumi Fukagawa, Daniel P. Gale, Rasheed A. Gbadegesin, David B. Goldstein, Morgan E. Grams, Anna Greka, Oliver Gross, Lisa M. Guay-Woodford, Peter C. Harris, Julia Hoefele, Adriana M. Hung, Nine V. A. M. Knoers, Jeffrey B. Kopp, Matthias Kretzler, Matthew B. Lanktree, Beata S. Lipska-Zietkiewicz, Kathleen Nicholls, Kandai Nozu, Akinlolu Ojo, Afshin Parsa, Cristian Pattaro, York Pei, Martin R. Pollak, Eugene P. Rhee, Simone Sanna-Cherchi, Judy Savige, John A. Sayer, Francesco Scolari, John R. Sedor, Xueling Sim, Stefan Somlo, Katalin Susztak, Bamidele O. Tayo, Roser Torra, Albertien M. van Eerde, Andre Weinstock, Cheryl A. Winkler, Matthias Wuttke, Hong Zhang, Jennifer M. King, Michael Cheung, Michel Jadoul, Wolfgang C. Winkelmayer, Ali G. Gharavi
Summary: Genetic research plays an important role in the clinical management of kidney diseases, providing insights for diagnosis, treatment selection, and family counseling. However, accurate interpretation of genetic data remains a challenge, highlighting the need to enhance genetic literacy among healthcare professionals and develop guidelines for testing and treatment to optimize the use of genetics in nephrology.
KIDNEY INTERNATIONAL
(2022)
Review
Cardiac & Cardiovascular Systems
Pantelis Sarafidis, Sven Martens, Athanasios Saratzis, Daniella Kadian-Dodov, Patrick T. Murray, Catherine M. Shanahan, Allen D. Hamdan, Daniel T. Engelman, Ulf Teichgraber, Charles A. Herzog, Michael Cheung, Michel Jadoul, Wolfgang C. Winkelmayer, Holger Reinecke, Kirsten Johansen
Summary: Chronic kidney disease is an independent risk factor for abdominal aortic aneurysm, cardiovascular events, and all-cause mortality after AAA or thoracic aortic dissection surgery. Acute kidney injury (AKI) after aortic surgery occurs at a high rate and is linked to future cardiovascular events and mortality. The development of AKI and long-term kidney function differ based on the type of AAA intervention. Knowledge about AAA in the general population may not be applicable to CKD patients, who have higher co-morbidity prevalence and perioperative complication risks. This review summarizes the epidemiology, pathophysiology, diagnosis, and treatment of Aortic Diseases in CKD, highlighting knowledge gaps and areas of controversy for future research.
CARDIOVASCULAR RESEARCH
(2022)
Article
Urology & Nephrology
Elaine Ku, Lucia Del Vecchio, Kai-Uwe Eckardt, Volker H. Haase, Kirsten L. Johansen, Masaomi Nangaku, Navdeep Tangri, Sushrut S. Waikar, Andrzej Wiecek, Michael Cheung, Michel Jadoul, Wolfgang C. Winkelmayer, David C. Wheeler
Summary: Anemia is common in chronic kidney disease patients and is associated with adverse clinical outcomes. Recent research has focused on hypoxia-inducible factor-prolyl hydroxylase inhibitors (HIF-PHIs) as a potential treatment for anemia in these patients.
KIDNEY INTERNATIONAL
(2023)
Article
Urology & Nephrology
Izak A. R. Yasrebi-de Kom, Dave A. Dongelmans, Ameen Abu-Hanna, Martijn C. Schut, Nicolette F. de Keizer, John A. Kellum, Kitty J. Jager, Joanna E. Klopotowska
Summary: Recent research has identified substantial heterogeneity in the implementation of the Kidney Disease: Improving Global Outcomes (KDIGO) acute kidney injury (AKI) diagnosis and staging criteria in clinical research. This study highlights an additional issue concerning the incorrect description and application of a stage 3 serum creatinine (SCr) criterion, demonstrating its implications for AKI staging and epidemiology.
CLINICAL KIDNEY JOURNAL
(2022)
Article
Urology & Nephrology
Rajnish Mehrotra, Sara N. Davison, Ken Farrington, Jennifer E. Flythe, Marjorie Foo, Magdalena Madero, Rachael L. Morton, Yusuke Tsukamoto, Mark L. Unruh, Michael Cheung, Michel Jadoul, Wolfgang C. Winkelmayer, Edwina A. Brown, Conference Participants
Summary: Patients with kidney failure undergoing maintenance dialysis often experience a high symptom burden that affects functioning and life satisfaction. The focus of nephrology care has traditionally been on laboratory targets and outcomes, with limited attention to symptom assessment and management. A conference was held in May 2022 to address the optimal means for diagnosing and managing symptom-based complications in dialysis patients, outlining foundational principles and identifying research priorities.
KIDNEY INTERNATIONAL
(2023)
Review
Cardiac & Cardiovascular Systems
Nicky Janssen, Jean H. T. Daemen, Elise J. van Polen, Nadine A. Coorens, Yanina J. L. Jansen, Aimee J. P. M. Franssen, Karel W. E. Hulsewe, Yvonne L. J. Vissers, Frank -Martin Haecker, Jose R. Milanez de Campos, Erik R. de Loos, Chest Wall Int Grp Collaborator Grp
Summary: This study aims to evaluate the consensus and controversies regarding the diagnostic protocol, indications for surgical correction, and postoperative evaluation of pectus excavatum. Through multiple rounds of survey, consensus was reached on certain topics, aiding in the standardization of pectus excavatum care.
ANNALS OF THORACIC SURGERY
(2023)
Article
Urology & Nephrology
Kirsten L. Johansen, Pranav S. Garimella, Caitlin W. Hicks, Philip A. Kalra, Dearbhla M. Kelly, Sven Martens, Kunihiro Matsushita, Pantelis Sarafidis, Manish M. Sood, Charles A. Herzog, Michael Cheung, Michel Jadoul, Wolfgang C. Winkelmayer, Holger Reinecke
Summary: This report highlights the impact of chronic kidney disease on cardiovascular health and emphasizes the importance of addressing knowledge gaps and optimal treatment for CKD patients. The clinical controversies conference held in Ireland aimed to identify key issues related to detection, management, and treatment of vascular diseases in the setting of CKD, with a diverse panel of experts contributing to the discussion.
KIDNEY INTERNATIONAL
(2021)
Article
Urology & Nephrology
Kai -Uwe Eckardt, Cynthia Delgado, Hiddo J. L. Heerspink, Roberto Pecoits-Filho, Ana C. Ricardo, Benedicte Stengel, Marcello Tonelli, Michael Cheung, Michel Jadoul, Wolfgang C. Winkelmayer, Holly Kramer
Summary: Chronic kidney disease affects a large number of people globally, calling for urgent prevention and management. New tools and interventions, such as biomarkers and artificial intelligence techniques, have emerged to improve the quality and precision of care for CKD. The 2022 KDIGO Controversies Conference discussed best practices and identified knowledge gaps in CKD diagnosis, treatment, and care delivery.
KIDNEY INTERNATIONAL
(2023)
Article
Urology & Nephrology
Michael G. Shlipak, Sri Lekha Tummalapalli, L. Ebony Boulware, Morgan E. Grams, Joachim H. Ix, Vivekanand Jha, Andre-Pascal Kengne, Magdalena Madero, Borislava Mihaylova, Navdeep Tangri, Michael Cheung, Michel Jadoul, Wolfgang C. Winkelmayer, Sophia Zoungas, Georgi Abraham, Zanfina Ademi, Radica Z. Alicic, Ian de Boer, Raj Deo, Xiaoqiang Ding, Natalie Ebert, Kevin J. Fowler, Linda F. Fried, Ron T. Gansevoort, Guillermo Garcia-Garcia, Brenda R. Hemmelgarn, Jessica Lee Harding, Joanna Q. Hudson, Kunitoshi Iseki, Vasantha Jotwani, Leah S. Karliner, Andrew S. Levey, Adrian Liew, Peter J. Lin, Andrea O. Y. Luk, Veronica Martinez, Andrew E. Moran, Mai Nguyen, Gregorio T. Obrador, Donal O'Donoghue, Meda E. Pavkov, Jessie Pavlinac, Neil R. Powe, Jesse C. Seegmiller, Jenny Shen, Rukshana Shroff, Laura Sol, Maarten W. Taal, James Tattersall, Joseph A. Vassalotti, Matthew R. Weir, Ella Zomer
Summary: Chronic kidney disease (CKD) is a significant global burden associated with higher morbidity and mortality, especially among individuals with lower socioeconomic status. Despite the availability of guidelines for evaluating and managing early CKD, there is still a lack of consensus on prioritizing early identification and intervention for CKD without incentives or quality measures.
KIDNEY INTERNATIONAL
(2021)
Article
Green & Sustainable Science & Technology
Jan Svanberg, Tohid Ardeshiri, Isak Samsten, Peter Ohman, Tarek Rana, Mats Danielson
Summary: This study discusses a new direction for developing corporate environmental performance (CEP) ratings by anchoring them in environmental controversies, thus addressing the limited validity of current ESG ratings. Using a novel machine learning approach, the study makes the ratings more comprehensive and transparent by handling nonlinearity in aggregating ESG indicators. The findings show that controversies can be a good proxy for non-compliance with environmental responsibilities, contributing to the predictive validity of the developed environmental performance ratings.
JOURNAL OF CLEANER PRODUCTION
(2022)
Article
Urology & Nephrology
Kathryn E. Foti, Dan Wang, Alexander R. Chang, Elizabeth Selyin, Mark J. Sarnak, Tara Chang, Paul Muntner, Josef Coresh
Summary: The 2021 KDIGO guideline recommends a target systolic blood pressure under 120 mmHg for adults with CKD, with a focus on ACEi/ARB use for those with albuminuria; the study found that more patients in the United States meet the criteria for blood pressure lowering according to the new guideline.
KIDNEY INTERNATIONAL
(2021)
