Article
Transplantation
Steven Law, Oliver Cohen, Helen J. Lachmann, Tamer Rezk, Janet A. Gilbertson, Dorota Rowczenio, Ashutosh D. Wechalekar, Philip N. Hawkins, Reza Motallebzadeh, Julian D. Gillmore
Summary: The study found that outcomes of renal transplantation in patients with AA and AL amyloidosis were comparable to those with diabetic nephropathy, but poorer than patients with ADPKD. In AL amyloidosis, factors such as interventricular septum thickness and achievement of deep hematologic response pre-transplant significantly impacted patient survival.
NEPHROLOGY DIALYSIS TRANSPLANTATION
(2021)
Review
Urology & Nephrology
Nikolaos Pyrgidis, Ioannis Mykoniatis, Ioannis Sokolakis, Ioanna Minopoulou, Meletios P. Nigdelis, Petros Sountoulides, Paolo Verze, Georgios Hatzichristodoulou, Dimitrios Hatzichristou
Summary: Renal transplantation improves erectile function and reduces the risk of erectile dysfunction postoperatively compared to preoperatively, although the evidence is mostly based on low quality data due to methodological concerns and high heterogeneity among included studies. More studies with standardized outcomes are needed to validate and strengthen these findings.
JOURNAL OF UROLOGY
(2021)
Article
Cardiac & Cardiovascular Systems
Hope Caughron, Devang Parikh, Zev Allison, Tobias Deuse, Vaikom S. Mahadevan
Summary: This study compared in-hospital, 30-day, and 1-year outcomes post-TAVR in end stage liver disease and/or end stage renal disease patients with those without these comorbidities. The results showed that patients with ESLD and/or ESRD had similar mortality rates at discharge and 30-days compared to patients without these comorbidities, but with a trend towards increased mortality at 1-year, along with higher readmission rates.
CATHETERIZATION AND CARDIOVASCULAR INTERVENTIONS
(2021)
Article
Endocrinology & Metabolism
Cristian Iorga, Cristina Raluca Iorga, Iuliana Andreiana, Iustinian Bengulescu, Traian Constantin, Victor Strambu
Summary: After analyzing the obtained results, it was concluded that total parathyroidectomy is the preferred intervention for patients with secondary hyperparathyroidism when pharmacotherapy fails, in order to prevent disease recurrence and correct metabolic parameters.
FRONTIERS IN ENDOCRINOLOGY
(2023)
Article
Medicine, General & Internal
Christian Sohns, Henrik Fox, Nassir F. Marrouche, Harry J. G. M. Crijns, Angelika Costard-Jaeckle, Leonard Bergau, Gerhard Hindricks, Nikolaos Dagres, Samuel Sossalla, Rene Schramm, Thomas Fink, Mustapha El Hamriti, Maximilian Moersdorf, Vanessa Sciacca, Frank Konietschke, Volker Rudolph, Jan Gummert, Jan G. P. Tijssen, Philipp Sommer, CASTLE HTx Investigators
Summary: Among patients with atrial fibrillation and end-stage heart failure, catheter ablation combined with guideline-directed medical therapy was associated with a lower likelihood of a composite of death from any cause, implantation of a left ventricular assist device, or urgent heart transplantation compared to medical therapy alone.
NEW ENGLAND JOURNAL OF MEDICINE
(2023)
Article
Gastroenterology & Hepatology
Branden D. Tarlow, W. Ray Kim, Ajitha Mannalithara, Paul Y. Kwo, C. Andrew Bonham, Allison Kwong
Summary: This study found that MELD 3.0 scores beyond 40 are associated with increasing waitlist mortality without adversely affecting posttransplant outcomes. Uncapping the MELD score for waitlist candidates may lead to greater survival benefits from liver transplantation.
Article
Hematology
Rajshekhar Chakraborty, Cara Rosenbaum, Gurbakhash Kaur, Divaya Bhutani, Jai Radhakrishnan, Markus Y. Mapara, Mathew Maurer, Suzanne Lentzsch
Summary: Although excluded in the pivotal trial, Dara-VCD has shown promising efficacy and safety in the treatment of stage IIIb AL amyloidosis, as demonstrated by a multicentre retrospective cohort study. The treatment achieved a high overall response rate and rapid haematologic responses, with a majority of patients achieving a very good partial response. Furthermore, cardiac organ responses were observed in a significant percentage of patients. The findings indicate the need for prospective trials to further investigate the potential of Dara-VCD in this patient population.
BRITISH JOURNAL OF HAEMATOLOGY
(2023)
Article
Medicine, General & Internal
Chun Yuan Khoo, Fei Gao, Hui Lin Choong, Wei Xian Tan Alex, Riece Koniman, Jiang Ming Fam, Khung Keong Yeo
Summary: Cardiovascular morbidity and mortality are high in ESRF patients in Singapore. Age, ischemic heart disease, diabetes, stroke, peripheral vascular disease, and dialysis modality are independent predictors of death and acute myocardial infarction (AMI).
ANNALS ACADEMY OF MEDICINE SINGAPORE
(2022)
Article
Peripheral Vascular Disease
Chang Seong Kim, Bongseong Kim, Hong Sang Choi, Eun Hui Bae, Seong Kwon Ma, Kyung-Do Han, Soo Wan Kim
Summary: Hypertension burden is positively associated with an increased risk of end-stage renal disease (ESRD), with a dose-dependent relationship between the two. Assessing hypertension burden over a certain period may be useful in predicting the risk of ESRD in large population-based cohorts.
HYPERTENSION RESEARCH
(2021)
Article
Cardiac & Cardiovascular Systems
Donna Shu-Han Lin, Fang-Ju Lin, Yu-Sheng Lin, Jen-Kuang Lee, Yen-Hung Lin
Summary: This study aimed to evaluate the effects of mineralocorticoid receptor antagonists (MRAs) on cardiovascular outcomes in patients with heart failure undergoing maintenance dialysis. The results showed that the use of MRAs was associated with lower risks of all-cause mortality and cardiovascular death in these patients. This suggests that MRAs may have potential benefits in heart failure patients undergoing maintenance dialysis.
EUROPEAN JOURNAL OF HEART FAILURE
(2023)
Review
Cardiac & Cardiovascular Systems
Sofia Lakhdar, Chandan Buttar, Mahmood Nassar, Camelia Ciobanu, Rima Patel, Most Sirajum Munira
Summary: The study evaluated the outcomes of heart transplantation in cardiac amyloidosis. Previous studies have shown poor outcomes for amyloidosis patients after heart transplantation, but recent advancements in treatments have significantly improved the prognosis. The results of multiple studies were pooled and showed that with current treatments and a multidisciplinary approach, heart transplantation in amyloidosis patients may lead to encouraging outcomes in the current era.
HEART FAILURE REVIEWS
(2022)
Review
Cardiac & Cardiovascular Systems
Takahide Ito, Kanako Akamatsu
Summary: End-stage renal disease (ESRD) is a clinical condition associated with high morbidity and mortality. It is characterized by myocardial hypertrophy, heart failure, valvular calcification, and pericardial effusion. Multiple factors contribute to these abnormalities, including pressure/volume overload, oxidative stress, and neurohormonal imbalances.
HEART FAILURE REVIEWS
(2023)
Article
Medicine, General & Internal
Eszter Toth, Jennifer L. Waller, Wendy B. Bollag, Budder Siddiqui, Azeem Mohammed, Mufaddal Kheda, Sandeep Padala, Lufei Young, Stephanie L. Baer, Sarah Tran
Summary: NTM disease in the population with end-stage renal disease (ESRD) was investigated to determine risk factors and mortality. Hemodialysis and white race were found to be protective factors, while HIV infection, history of any transplant, diabetes, rheumatologic disease, and liver disease were associated with increased risk for NTM diagnosis. Any NTM diagnosis was significantly associated with increased mortality.
JOURNAL OF INVESTIGATIVE MEDICINE
(2023)
Article
Cardiac & Cardiovascular Systems
David Grundmann, Matthias Linder, Alina Gossling, Lisa Voigtlaender, Sebastian Ludwig, Lara Waldschmidt, Till Demal, Oliver D. Bhadra, Andreas Schaefer, Johannes Schirmer, Hermann Reichenspurner, Stefan Blankenberg, Dirk Westermann, Niklas Schofer, Lenard Conradi, Moritz Seiffert
Summary: This study examined patients with chronic hemodialysis and severely impaired kidney function undergoing trans-catheter aortic valve implantation, finding differences in operative risk, vascular calcification, and survival rates among these patient populations.
CLINICAL RESEARCH IN CARDIOLOGY
(2022)
Article
Biotechnology & Applied Microbiology
Satoshi Kainuma, Shigeru Miyagawa, Koichi Toda, Yasushi Yoshikawa, Hiroki Hata, Daisuke Yoshioka, Takuji Kawamura, Ai Kawamura, Noriyuki Kashiyama, Yoshito Ito, Hiroko Iseoka, Takayoshi Ueno, Toru Kuratani, Kei Nakamoto, Fusako Sera, Tomohito Ohtani, Tomomi Yamada, Yasushi Sakata, Yoshiki Sawa
Summary: This study evaluated the recovery of cardiac function in patients with ischemic cardiomyopathy following skeletal myoblast cell-sheet transplantation, with positive outcomes in long-term survival. Some patients showed good responses to the treatment, and preoperative renal and left ventricular function may predict the response to this therapy.
Article
Urology & Nephrology
Ashik Hayat, David W. Johnson, Carmel M. Hawley, Lauren R. Jaffrey, Usman Mahmood, Sarah Saw Yu Mon, Yeoungjee Cho
Summary: This study aimed to compare the associations, microbiologic profiles, and outcomes between pre-training peritonitis (PTP) and post-training peritonitis in patients with kidney failure. The results showed that PTP was closely associated with prior exit-site infection, often had culture-negative peritonitis, and was associated with worse outcomes of hemodialysis transfer or death.
PERITONEAL DIALYSIS INTERNATIONAL
(2023)
Article
Health Policy & Services
Dharmenaan Palamuthusingam, Elaine M. Pascoe, Carmel M. Hawley, David W. Johnson, Gishan Ratnayake, Stephen McDonald, Neil Boudville, Matthew Jose, Magid Fahim
Summary: This study assessed the concordance between comorbidities recorded in the Australia and New Zealand Dialysis and Transplant (ANZDATA) Registry and those in state-based hospital admission datasets. The results showed that the accuracy of diabetes mellitus recording was the highest, while the accuracy of cerebrovascular disease recording was the lowest.
HEALTH INFORMATION MANAGEMENT JOURNAL
(2023)
Article
Urology & Nephrology
Eric W. Young, Junhui Zhao, Ronald L. Pisoni, Beth M. Piraino, Jenny I. Shen, Neil Boudville, Martin J. Schreiber, Isaac Teitelbaum, Jeffrey Perl, Keith McCullough
Summary: This study measured the occurrence rate of peritoneal dialysis associated peritonitis using Medicare claims data and identified its clinical risk factors. The results showed that the peritonitis rate declined over time and was lower among older patients. A claims-based approach offers a promising framework for the study of peritoneal dialysis associated peritonitis.
AMERICAN JOURNAL OF KIDNEY DISEASES
(2023)
Article
Urology & Nephrology
Wai H. Lim, Jenny H. C. Chen, Kimberley Minas, David W. Johnson, Maleeka Ladhani, Esther Ooi, Neil Boudville, Carmel Hawley, Andrea K. Viecelli, Matthew Roberts, Kate Wyburn, Rachael Walker, Monique Borlace, Helen Pilmore, Christopher E. Davies, Charmaine E. Lok, Armando Teixeira-Pinto, Germaine Wong
Summary: This study investigates the cause-specific mortality rates between male and female dialysis patients in Australia and New Zealand from 1998 to 2018. It found that female patients had a higher risk of all-cause mortality in the first 5 years after dialysis initiation, primarily due to mortality from infections and dialysis withdrawals.
AMERICAN JOURNAL OF KIDNEY DISEASES
(2023)
Article
Pediatrics
Chandana Guha, Rabia Khalid, Anita van Zwieten, Anna Francis, Carmel M. Hawley, Allison Jaure, Armando Teixeira-Pinto, Alistair R. Mallard, Amelie Bernier-Jean, David W. Johnson, Deirdre Hahn, Donna Reidlinger, Elaine M. Pascoe, Elizabeth G. Ryan, Fiona Mackie, Hugh J. McCarthy, Jonathan C. Craig, Julie Varghese, Charani Kiriwandeniya, Kirsten Howard, Nicholas G. Larkins, Luke Macauley, Amanda Walker, Martin Howell, Michelle Irving, Patrina H. Y. Caldwell, Reginald Woodleigh, Shilpanjali Jesudason, Simon A. Carter, Sean E. Kennedy, Stephen Alexander, Steven McTaggart, Germaine Wong
Summary: This study aims to evaluate the effectiveness of a patient navigator program in children with chronic kidney disease. A total of 162 patients were enrolled and randomized into immediate intervention and waitlisted groups. The results of the study will be completed by October 2022.
PEDIATRIC NEPHROLOGY
(2023)
Review
Urology & Nephrology
Ashik Hayat, Rachael C. Walker, Andrea K. Viecelli, Karine E. Manera, Allison Jaure, Rathika Krishnasamy, Elaine M. Pascoe, Yeoungjee Cho, David W. Johnson
Summary: This study assessed the range and consistency of gastrointestinal (GI) outcomes reported in contemporary peritoneal dialysis (PD) trials. It found that only 19% of PD trials reported GI outcomes, with nausea, diarrhea, vomiting, constipation, and abdominal pain being the most frequently reported outcomes. The majority of GI outcomes were patient-reported adverse events with no defined metrics.
PERITONEAL DIALYSIS INTERNATIONAL
(2023)
Article
Orthopedics
Ian A. Harris, Michelle F. Lorimer, Christopher E. Davies, Dominic Keuskamp, Kathryn B. Dansie, Peter L. Lewis, Stephen E. Graves, Stephen P. McDonald
Summary: This study compared the rate of revision surgery and mortality following THA between patients who have kidney failure receiving long term dialysis or who had a kidney transplant and those who did not have kidney failure. The results showed that patients on dialysis had a higher risk of mortality after THA compared to those with a functioning kidney transplant or no kidney failure, but there was no early excess mortality due to the surgery.
JOURNAL OF ARTHROPLASTY
(2023)
Article
Ethics
Alison C. Weightman, Simon Coghlan, Philip A. Clayton
Summary: The refusal of doctors to accept donations from living kidney donors with certain comorbidities is unjustified according to this paper. The paper argues for greater acceptance of such donations to address the ongoing shortage of kidney transplants.
MONASH BIOETHICS REVIEW
(2023)
Article
Urology & Nephrology
Ashik Hayat, Yeoungjee Cho, Carmel M. Hawley, Htay Htay, Rathika Krishnasamy, Elaine Pascoe, Isaac Teitelbaum, Marliene Varnfield, David W. Johnson
Summary: Comparing with full-dose PD start, incremental PD start shows similar declines in RKF and UV.
PERITONEAL DIALYSIS INTERNATIONAL
(2023)
Article
Urology & Nephrology
Yeoungjee Cho, Kai-Ming Chow, Philip Kam-Tao Li, Naomi Runnegar, David W. Johnson
Summary: Peritoneal dialysis is an important treatment option for patients with kidney failure, providing various benefits such as enhanced participation in daily activities, flexibility in schedules, cost savings, and improved quality of life. However, the utilization of peritoneal dialysis has remained static or declining in certain regions due to concerns about PD-related infections. This review aims to provide an overview of the definition, epidemiology, risk factors, prevention, and treatment of PD-related infections based on current evidence.
CLINICAL JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY
(2023)
Editorial Material
Urology & Nephrology
Stephen P. Mcdonald, Katie Cundale, Kelli J. Owen, Matilda D'Antoine, Jaquelyne T. Hughes
Summary: Indigenous people in Australia are disadvantaged in accessing kidney transplantation. The National Indigenous Kidney Transplant Taskforce was established to address this issue by providing support to clinicians, implementing and evaluating innovative practices, and developing strategies to overcome barriers in the care system.
NATURE REVIEWS NEPHROLOGY
(2023)
Article
Urology & Nephrology
Yu-Hui Zhang, Xiao Xu, Hai-Chen Pi, Zhi-Kai Yang, David W. Johnson, Jie Dong
Summary: This study aimed to examine the effects of vitamin D supplementation on the risk of PD-related peritonitis. The results showed that oral natural vitamin D supplementation can increase serum 25(OH)D levels in PD patients, without affecting the occurrence or outcome of peritonitis. The study suggests that conducting this type of randomized controlled trial is feasible and safe.
PERITONEAL DIALYSIS INTERNATIONAL
(2023)
Article
Biology
Ken-Soon Tan, Stephen McDonald, Wendy Hoy
Summary: This study compared the performance of a clinical diagnosis to biopsy-proven diagnosis of diabetic kidney disease (DKD) and found that a clinical diagnosis has high sensitivity but low specificity, indicating the possibility of overdiagnosis.
Article
Medicine, Research & Experimental
Josephine S. F. Chow, Neil Boudville, Yeoungjee Cho, Suetonia Palmer, Elaine M. Pascoe, Carmel M. Hawley, Donna M. Reidlinger, Laura E. Hickey, Ruth Stastny, Andrea Valks, Liza Vergara, Ramya Movva, Charani Kiriwandeniya, Hayley Candler, Gabor Mihala, Bernadette Buisman, Keri-Lu Equinox, Ana E. Figueiredo, Trudi Fuge, Kirsten Howard, Martin Howell, Allison Jaure, Matthew D. Jose, Anna Lee, Susana S. Miguel, Jo-anne Moodie, Thu T. Nguyen, Geraldine Pinlac, Annie Reynolds, Walaa W. M. Saweirs, Genevieve Z. Steiner-Lim, Bronwen TeWhare, Melinda Tomlins, Megan Upjohn, David Voss, Rachael C. Walker, Joanne Wilson, David W. Johnson
Summary: The TEACH-PD trial is a registry-based, cluster-randomized pragmatic trial that aims to provide high-certainty evidence about whether an ISPD guideline-informed standardized PD training curriculum for PD nurse trainers and adult patients prevents PD-related infections.