Review
Medicine, General & Internal
Fernanda G. Rodrigues, Milene S. Ormanji, Ita P. Heilberg, Stephan J. L. Bakker, Martin H. de Borst
Summary: This article explores the deregulation of gut microbiota in patients with chronic kidney disease (CKD) and its impact on vascular and bone diseases. It discusses the influence of diet, medications, and other factors on gut microbiota composition and subsequently on the overall health of CKD patients.
EUROPEAN JOURNAL OF CLINICAL INVESTIGATION
(2021)
Review
Endocrinology & Metabolism
Nancy Martini, Lucas Streckwall, Antonio Desmond Mccarthy
Summary: In post-menopausal women, aged individuals, and patients with diabetes mellitus or chronic renal disease, bone mineral density decreases while arterial calcifications accumulate. Patients with low BMD and/or fragility fractures have an increased risk for coronary and cerebrovascular events. Similarly, patients with abdominal aorta calcifications show decreased BMD in bones irrigated by branches of the abdominal aorta.
ENDOCRINE CONNECTIONS
(2023)
Article
Urology & Nephrology
Anne Kristine Rondbjerg, Mette Gyldenlove, Dorrit Krustrup, Marianne Rix, Ilse Vejborg, Lars Lonn, Niklas Rye Jorgensen, Andreas Pasch, Lone Skov, Ditte Hansen
Summary: This study investigated the presence of cutaneous calcifications in non-lesional tissue in patients with chronic kidney disease and their relation to systemic vascular calcification. The study found no cutaneous vascular calcifications in non-lesional skin biopsies. However, breast arterial calcification was present in patients with chronic kidney disease and calcific uremic arteriolopathy, but not in the control group. These findings suggest a high burden of systemic vascular calcification in patients with chronic kidney disease.
JOURNAL OF NEPHROLOGY
(2023)
Article
Endocrinology & Metabolism
K. David, V Dubois, A. Verhulst, V Sommers, D. Schollaert, L. Deboel, K. Moermans, G. Carmeliet, P. D'Haese, D. Vanderschueren, F. Claessens, P. Evenepoel, B. Decallonne
Summary: Patients with chronic kidney disease (CKD) often suffer from bone loss and arterial calcifications. This study aimed to investigate the role of hypogonadism in these complications and the potential of androgen therapy in prevention. Male rats with CKD were treated with testosterone or dihydrotestosterone (DHT), while a control group received vehicle. CKD animals exhibited higher levels of serum creatinine and parathyroid hormone, as well as lower levels of testosterone. Androgen treatment restored testosterone levels and organ weights, but did not prevent bone loss or arterial calcifications, especially in the presence of severe hyperparathyroidism.
JOURNAL OF ENDOCRINOLOGY
(2023)
Review
Transplantation
Manuel Alfredo Podesta, David Cucchiari, Paola Ciceri, Piergiorgio Messa, Jose-Vicente Torregrosa, Mario Cozzolino
Summary: Vascular and valvular calcifications are common in kidney transplant recipients and associated with increased risk of cardiovascular events. Despite resolution of uremia-related metabolic derangements, recipients are still exposed to pro-calcifying stimuli, highlighting the need for strategies to correct or minimize their effects.
NEPHROLOGY DIALYSIS TRANSPLANTATION
(2022)
Article
Medical Laboratory Technology
Kun-Lin Wu, Chien-Lung Chen, Mai-Huong Thi Nguyen, Jen-Chieh Tsai, Sun-Chong Wang, Wen-Fang Chiang, Po-Jen Hsiao, Jenq-Shyong Chan, Ju Jung Hou, Nianhan Ma
Summary: The importance of coronary artery disease in chronic kidney disease. Delayed diagnosis due to lack of specific symptoms and decreased accuracy of noninvasive diagnostic tools increases mortality. MicroRNAs are involved in the pathogenesis of CAD and have the potential for clinical application.
CLINICA CHIMICA ACTA
(2023)
Article
Biochemistry & Molecular Biology
Chien-Te Lee, Wei-Hung Kuo, You-Lin Tain, Yi Wang, Wen-Chin Lee
Summary: This study found that exogenous BMP7 administration can improve disturbed CKD-MBD and vascular calcification in adenine-induced chronic uremic rats. The treatment shows potential in alleviating renal dysfunction, hyperphosphatemia, hyperparathyroidism, and skeletal structural abnormalities.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2022)
Review
Biochemistry & Molecular Biology
Catarina Marreiros, Carla Viegas, Dina Simes
Summary: Chronic kidney disease (CKD) patients are at higher risk of developing early cardiovascular disease (CVD), with vascular calcification (VC) being a strong predictor of CVD risk. Diagnosis of VC in CKD population is challenging due to its complexity, but imaging biomarkers and circulating biomarkers play important roles in detection and monitoring, providing valuable insights for management of CVD risk.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Endocrinology & Metabolism
Joao Victor Salgado, Miguel Angelo Goes, Natalino Salgado Filho
Summary: The global nephrology community acknowledges the increasing burden of kidney disease and emphasizes on early diagnosis, understanding of disease progression, and development of new therapeutic interventions. FGF21 is considered a key regulator of lipid, glucose, and energy metabolism, as well as stress responses. While promising results have been shown with FGF21 analogs in metabolic disease, its exact role in kidney function remains poorly understood.
METABOLISM-CLINICAL AND EXPERIMENTAL
(2021)
Article
Cardiac & Cardiovascular Systems
Andreas Zietzer, Eva Steffen, Sven Niepmann, Philip Duesing, Mohammed Rabiul Hosen, Weiyi Liu, Paul Jamme, Baravan Al-Kassou, Philipp Roger Goody, Sebastian Zimmer, Katrin S. Reiners, Alexander Pfeifer, Michael Boehm, Nikos Werner, Georg Nickenig, Felix Jansen
Summary: The combination of coronary artery disease (CAD) and chronic kidney disease (CKD) affects endothelial function through the intercellular transfer of microRNAs (miRs) via extracellular vesicles (EVs). This study found that CAD + CKD patients had lower levels of vasculo-protective miR-130a-3p and miR-126-3p in their EVs compared to CAD patients and controls. The EVs from CAD + CKD patients impaired endothelial cell proliferation and regeneration, promoting CKD-induced endothelial dysfunction.
CARDIOVASCULAR RESEARCH
(2022)
Review
Clinical Neurology
Kaori Miwa, Kazunori Toyoda
Summary: Chronic kidney disease (CKD) is associated with an increased risk of stroke and dementia, with common structural brain abnormalities observed in patients with CKD. The brain and kidney exhibit similar impairments and susceptibility to vascular injury, suggesting a significant impact of kidney function on brain aging. However, the exact pathophysiology of structural brain abnormalities in CKD remains unclear.
FRONTIERS IN NEUROLOGY
(2022)
Review
Nutrition & Dietetics
Ezequiel Bellorin-Font, Eudocia Rojas, Kevin J. Martin
Summary: Chronic Kidney Disease-Mineral and Bone Disorder (CKD-MBD) involves alterations in calcium, phosphorus, parathyroid hormone (PTH), Vitamin D, and fibroblast growth factor-23 (FGF-23) metabolism, leading to bone fractures and vascular disease. The bone component of CKD-MBD, known as renal osteodystrophy, starts early during CKD progression. Factors such as osteoporosis may also contribute to the risk of bone fracture. After kidney transplantation, these bone alterations may persist, progress, or transform due to new pathogenetic mechanisms. This study reviews the bone lesions that occur during CKD and after kidney transplant.
Review
Genetics & Heredity
Philip Duesing, Andreas Zietzer, Philip Roger Goody, Mohammed Rabiul Hosen, Christian Kurts, Georg Nickenig, Felix Jansen
Summary: CKD and CVD are interlinked, with CKD increasing the risk of cardiovascular disease mainly due to accumulation of uremic toxins, chronic inflammation, and oxidative stress. Vascular alterations, especially atherosclerosis and vascular calcification, play a significant role in the association between CKD and cardiovascular mortality.
JOURNAL OF MOLECULAR MEDICINE-JMM
(2021)
Article
Geriatrics & Gerontology
Si-Chong Ren, Nan Mao, Si Yi, Xin Ma, Jia-Qiong Zou, Xiaoqiang Tang, Jun Ming Fan
Summary: Chronic kidney disease leads to vascular calcification, while aging and metabolic disorders are risk factors. Recent progress has been made in treating vascular calcification, but there is a lack of systematic reviews.
Article
Pharmacology & Pharmacy
Tom G. Jacobs, Marika A. de Hoop-Sommen, Thomas Nieuwenstein, Joyce E. M. van der Heijden, Saskia N. de Wildt, David M. Burger, Angela Colbers, Jolien J. M. Freriksen
Summary: Dose recommendations for lamivudine or emtricitabine in children with HIV and CKD are lacking. Physiologically based pharmacokinetic models were used to develop dosing strategies for these drugs in this population. The models were successfully verified and the simulations showed that GFR-adjusted dosages resulted in adequate drug exposure in children with CKD. Clinical studies are needed to confirm these findings.
Article
Transplantation
Sandra Berody, Laurence Heidet, Olivier Gribouval, Jerome Harambat, Patrick Niaudet, Veronique Baudouin, Justine Bacchetta, Bernard Boudaillez, Maud Dehennault, Loic de Parscau, Olivier Dunand, Hugues Flodrops, Marc Fila, Arnaud Garnier, Ferielle Louillet, Marie-Alice Macher, Adrien May, Elodie Merieau, Francoise Monceaux, Christine Pietrement, Caroline Rousset-Rouviere, Gwenaelle Roussey, Sophie Taque, Julie Tenenbaum, Tim Ulinski, Rachel Vieux, Ariane Zaloszyc, Vincent Moriniere, Remi Salomon, Olivia Boyer
NEPHROLOGY DIALYSIS TRANSPLANTATION
(2019)
Article
Transplantation
Stephanie Dufek, Tuula Holtta, Agnes Trautmann, Elisa Ylinen, Harika Alpay, Gema Ariceta, Christoph Aufricht, Justine Bacchetta, Sevcan A. Bakkaloglu, Aysun Bayazit, Rumeysa Yasemin Cicek, Ismail Dursun, Ali Duzova, Mesiha Ekim, Daniela Iancu, Augustina Jankauskiene, Guenter Klaus, Fabio Paglialonga, Andrea Pasini, Nikoleta Printza, Valerie Said Conti, Maria do Sameiro Faria, Claus Peter Schmitt, Constantinos J. Stefanidis, Enrico Verrina, Enrico Vidal, Karel Vondrak, Hazel Webb, Argyroula Zampetoglou, Detlef Bockenhauer, Alberto Edefonti, Rukshana Shroff
NEPHROLOGY DIALYSIS TRANSPLANTATION
(2019)
Article
Endocrinology & Metabolism
Anya Rothenbuhler, Nathalie Fadel, Yahya Debza, Justine Bacchetta, Mamadou Tidiane Diallo, Catherine Adamsbaum, Agnes Linglart, Federico Di Rocco
JOURNAL OF BONE AND MINERAL RESEARCH
(2019)
Review
Endocrinology & Metabolism
Justine Bacchetta, Claire Bardet, Dominique Prie
METABOLISM-CLINICAL AND EXPERIMENTAL
(2020)
Article
Pediatrics
Stephanie Dufek, Elisa Ylinen, Agnes Trautmann, Harika Alpay, Gema Ariceta, Christoph Aufricht, Justine Bacchetta, Sevcan Bakkaloglu, Aysun Bayazit, Salim Caliskan, Maria do Sameiro Faria, Ismail Dursun, Mesiha Ekim, Augustina Jankauskiene, Guenter Klaus, Fabio Paglialonga, Andrea Pasini, Nikoleta Printza, Valerie Said Conti, Claus Peter Schmitt, Constantinos Stefanidis, Enrico Verrina, Enrico Vidal, Hazel Webb, Argyroula Zampetoglou, Alberto Edefonti, Tuula Holtta, Rukshana Shroff
PEDIATRIC NEPHROLOGY
(2019)
Review
Pediatrics
Pierre Cochat, Olivia Febvey, Justine Bacchetta, Etienne Berard, Natalia Cabrera, Laurence Dubourg
PEDIATRIC NEPHROLOGY
(2019)
Article
Pediatrics
Alexandra Bruel, Justine Bacchetta, Tiphanie Ginhoux, Christelle Rodier-Bonifas, Anne-Laure Sellier-Leclerc, Berengere Fromy, Pierre Cochat, Dominique Sigaudo-Roussel, Laurence Dubourg
PEDIATRIC NEPHROLOGY
(2019)
Article
Urology & Nephrology
Aurelia Berthlet-Thomas, Nathalie Tram, Laurence Dubourg, Sandrine Lemoine, Arnaud Molin, Justine Bacchetta
AMERICAN JOURNAL OF KIDNEY DISEASES
(2019)
Article
Pediatrics
Justine Bacchetta, Tiphanie Ginhoux, Delphine Bernoux, Laurence Dubourg, Bruno Ranchin, Christelle Roger
Article
Urology & Nephrology
Jens Drube, Mandy Wan, Marjolein Bonthuis, Elke Wuhl, Justine Bacchetta, Fernando Santos, Ryszard Grenda, Alberto Edefonti, Jerome Harambat, Rukshana Shroff, Burkhard Tonshoff, Dieter Haffner, D. Schnabel, A. Linglart, L. Rees, P. Cochat, C. Brauner, D. Renault, L. N. Romano, G. Colling, A. Prytula, M. Leifheit-Nestler, G. Klaus, C. P. Schmitt, S. Stabouli, G. Reusz, E. Verrina, J. Groothoff, M. Anton-Gamero, E. Petrosyan, S. A. Bakkaloglu, I. Dursun, C. Booth, C. Aufricht, J. Vande Walle, K. Vondrak, T. Holtta, B. Ranchin, M. Fischbach, C. P. Schmitt, G. Klaus, C. Stefanidis, A. Kyriakou, S. Stabouli, N. Printza, F. Paglialonga, E. Verrina, E. Vidal, M. Allinovi, A. Jankauskiene, A. Zurowska, M. Do Sameiro Faria, G. Ariceta, L. Sartz, S. Bakkaloglu, A. K. Bayazit, A. Duzova, N. Knops, A. Raees, J. Zieg, L. Pape, A. Melk, L. Dello, I. Guzzo, L. Ghio, L. Murer, L. Peruzzi, A. Bouts, M. Cornelissen, E. Petrosyan, Victor Lopez-Baez, G. Ariceta, O. Soylemezoglu, R. Topaloglu, A. K. Bayazit, A. Duzova, M. Christian, S. Marks
NATURE REVIEWS NEPHROLOGY
(2019)
Article
Pediatrics
Rouven Behnisch, Marietta Kirchner, Ali Anarat, Justine Bacchetta, Rukshana Shroff, Yelda Bilginer, Sevgi Mir, Salim Caliskan, Dusan Paripovic, Jerome Harambat, Francesca Mencarelli, Rainer Buescher, Klaus Arbeiter, Oguz Soylemezoglu, Ariane Zaloszyc, Aleksandra Zurowska, Anette Melk, Uwe Querfeld, Franz Schaefer
FRONTIERS IN PEDIATRICS
(2019)
Article
Endocrinology & Metabolism
Katharina Hohenfellner, Frank Rauch, Gema Ariceta, Atif Awan, Justine Bacchetta, Carsten Bergmann, Susanne Bechtold, Noelle Cassidy, Geroges Deschenes, Ewa Elenberg, William A. Gahl, Oliver Greil, Erik Harms, Nadine Herzig, Bernd Hoppe, Christian Koeppl, Malcolm A. Lewis, Elena Levtchenko, Galina Nesterova, Fernando Santos, Karl P. Schlingmann, Aude Servais, Neveen A. Soliman, Guenther Steidle, Clodagh Sweeney, Ulrike Treikauskas, Rezan Topaloglu, Alexey Tsygin, Koenraad Veys, Rodo von Vigier, Jozef Zustin, Dieter Haffner
JOURNAL OF INHERITED METABOLIC DISEASE
(2019)
Article
Transplantation
Justine Bacchetta, Claus Peter Schmitt, Gema Ariceta, Sevcan A. Bakkaloglu, Jaap Groothoff, Mandy Wan, Marc Vervloet, Rukshana Shroff, Dieter Haffner
NEPHROLOGY DIALYSIS TRANSPLANTATION
(2020)
Article
Multidisciplinary Sciences
Christelle Arrondel, Sophia Missoury, Rozemarijn Snoek, Julie Patat, Giulia Menara, Bruno Collinet, Dominique Liger, Dominique Durand, Olivier Gribouval, Olivia Boyer, Laurine Buscara, Gaelle Martin, Eduardo Machuca, Fabien Nevo, Ewen Lescop, Daniela A. Braun, Anne-Claire Boschat, Sylvia Sanquer, Ida Chiara Guerrera, Patrick Revy, Mlanie Parisot, Ccile Masson, Nathalie Boddaert, Marina Charbit, Stphane Decramer, Robert Novo, Marie-Alice Macher, Bruno Ranchin, Justine Bacchetta, Audrey Laurent, Sophie Collardeau-Frachon, Albertien M. van Eerde, Friedhelm Hildebrandt, Daniella Magen, Corinne Antignac, Herman van Tilbeurgh, Geraldine Mollet
NATURE COMMUNICATIONS
(2019)
Article
Biochemistry & Molecular Biology
Ariane Zaloszyc, Philippe Choquet, Amira Sayeh, Maria Bartosova, Betti Schaefer, Ulrike Huegel, Gaelle Aubertin-Kirch, Christopher Healy, Francois Severac, Sebastien Rizzo, Georges Boivin, Franz Schaefer, Michel Fischbach, Justine Bacchetta, Seiamak Bahram, Claus Peter Schmitt
Summary: Chronic kidney disease often leads to bone disorders and cardiovascular mortality, and the G alpha(q/11)/PKC pathway in osteoblasts plays an important role in CKD-MBD.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)