Journal
NEPHROLOGY DIALYSIS TRANSPLANTATION
Volume 26, Issue 6, Pages 2000-2006Publisher
OXFORD UNIV PRESS
DOI: 10.1093/ndt/gfq690
Keywords
inflammation; kidney transplantation; post-transplant anaemia; protein-energy wasting
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Funding
- National Research Fund (OTKA) [F-68841, HUMAN-MB08-A-81231, NKTH-OTKA-EU 7KP-HUMAN-MB08-A-81231]
- ETT [206/09]
- Hungarian Kidney Foundation
- Hungarian Society of Hypertension
- Hungarian Society of Nephrology
- Foundation for Prevention in Medicine
- Hungarian Academy of Sciences
- Hungarian Eotvos Scholarship [MOB/66-2/2010]
- Canadian Home Healthcare Inc.
- Center for Integrative Mood Research, Toronto, Canada
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Background. Post-transplant anaemia (PTA) is common and is associated with adverse consequences. The protein-energy wasting (PEW) syndrome is associated with erythropoietin resistance in patients on maintenance dialysis. We assessed the association between PEW and PTA in a large prevalent cohort of stable kidney-transplanted patients. Methods. Data from 942 prevalent kidney-transplanted patients were analysed. Socio-demographic parameters, laboratory results, transplantation-related data and medication were obtained from the charts. Biomarkers reflecting nutritional status and inflammation [serum leptin, albumin, interleukin-6 (IL-6), tumour necrosis factor-alpha (TNF-alpha) and C-reactive protein] were measured. Anthropometric measures and the malnutrition-inflammation score (MIS) were also tabulated. Anaemia was defined according to the guidelines of the American Society of Transplantation. Results. Mean age was 51 +/- 13 years, 57% were males and 22% had diabetes. The prevalence of PTA was 33%. The haemoglobin (Hb) level significantly and negatively correlated with the MIS (rho = -0.316), marginally with serum TNF-alpha (rho = -0.079) and serum IL-6 (rho = -0.075) and positively with serum transferrin (r = 0.298), serum albumin (r = 0.274), abdominal circumference (r = 0.254) and serum leptin (rho = -0.152), P < 0.05 for all. In a multivariable linear regression model, MIS was independently associated with Hb (beta = -0.118, P = 0.004) in patients with estimated glomerular filtration rate (eGFR) lower than or equal to 60 mL/min/1.73 m(2), but not in patients with higher eGFR. Conclusions. The MIS is independently associated with PTA in the kidney-transplanted population with eGFR lower than or equal to 60 mL/min/1.73 m(2).
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