Review
Immunology
Husheem Michael, Joshua O. Amimo, Gireesh Rajashekara, Linda J. Saif, Anastasia N. Vlasova
Summary: Malnutrition increases the risk of infections and leads to impaired immune function and micronutrient deficiencies. Kwashiorkor has significant impacts on children's health, immunity, and gut functions. Pigs are a valuable model for studying the pathophysiology and immunology of kwashiorkor.
FRONTIERS IN IMMUNOLOGY
(2022)
Article
Biochemistry & Molecular Biology
Darrell H. G. Crawford, Diana G. F. Ross, Lesley-Anne Jaskowski, Leslie J. Burke, Laurence J. Britton, Nick Musgrave, David Briskey, Gautam Rishi, Kim R. Bridle, Nathan Subramaniam
Summary: Results from experiments on Hfe(-/-) mice indicate that reducing iron intake can alleviate the development of steatosis caused by a high-calorie diet, suggesting that modulation of iron balance could be a potential approach for treating NAFLD.
BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE
(2021)
Article
Endocrinology & Metabolism
Xiao Yang, Jiali Zhou, Huige Shao, Bi Huang, Xincong Kang, Ruiyu Wu, Fangzhou Bian, Minghai Hu, Dongbo Liu
Summary: This study demonstrated the clinical efficacy of CMNT in achieving diabetes remission for at least 1 year.
JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM
(2023)
Article
Multidisciplinary Sciences
Hajira Dambha-Miller, Hilda O. Hounkpatin, Beth Stuart, Andrew Farmer, Simon Griffin
Summary: Biochemical remission of type 2 diabetes can be achieved through dietary changes, physical activity, and weight loss. This study identified distinct diabetes remission trajectories in a large population-based cohort over a seven-year follow-up period and examined the associations between these trajectories and diabetes complications. The results showed that individuals in remission for longer periods of time had a lower risk of complications, and even shorter periods of remission were beneficial in reducing the risk of cardiovascular events and mortality.
Article
Nutrition & Dietetics
Rena Kawano, Fuyuko Takahashi, Yoshitaka Hashimoto, Takuro Okamura, Akane Miki, Ayumi Kaji, Ryosuke Sakai, Noriyuki Kitagawa, Takufumi Senmaru, Saori Majima, Hiroshi Okada, Naoko Nakanishi, Emi Ushigome, Masahide Hamaguchi, Masahiro Yamazaki, Michiaki Fukui
Summary: Insufficient energy intake is associated with muscle mass loss in older people with type 2 diabetes. It is recommended for older patients to consume enough energy to maintain muscle mass.
CLINICAL NUTRITION
(2021)
Review
Nutrition & Dietetics
Valeria Calcaterra, Hellas Cena, Francesca Sottotetti, Chiara Hruby, Nagaia Madini, Noemi Zelaschi, Gianvincenzo Zuccotti
Summary: Polycystic ovary syndrome (PCOS) is the most common endocrine disorder in women of reproductive age and is mainly driven by hyperandrogenism, hyperinsulinism, and insulin resistance. Lifestyle and dietary interventions, particularly the quality and quantity of carbohydrates consumed, play a crucial role in the management of PCOS, and the ketogenic diet (KD) has shown promise in improving insulin resistance and carbohydrate metabolism. Further studies are needed to determine the specific effects of the very low-calorie ketogenic diet (LCKD) in adolescents with PCOS and excessive body weight. Rating: 8/10
Review
Endocrinology & Metabolism
Vincenzo Garofalo, Federica Barbagallo, Rossella Cannarella, Aldo Eugenio Calogero, Sandro La Vignera, Rosita Angela Condorelli
Summary: This systematic review found no significant effect of different types of ketogenic diet on bone health, including bone mass density, bone formation, and overall bone turnover. Only in female subjects after a 10% weight loss, an increase in bone resorption and a decrease in new bone synthesis were observed, without increasing the risk of osteoporosis. Additionally, ketogenic diet was associated with weight loss, increased vitamin D levels, and reduced parathyroid hormone levels.
FRONTIERS IN ENDOCRINOLOGY
(2023)
Article
Multidisciplinary Sciences
Mary Priyanka Udumula, Harshit Singh, Faraz Rashid, Laila Poisson, Nivedita Tiwari, Irina Dimitrova, Miriana Hijaz, Radhika Gogoi, Margaret Swenor, Adnan Munkarah, Shailendra Giri, Ramandeep Rattan
Summary: In a study on mice with epithelial ovarian cancer (EOC), it was found that 16-hour intermittent fasting (IF) can inhibit tumor growth and enhance anti-tumor immune response. IF alters anti-cancer immunity by increasing CD4(+) and CD8(+) cells, Th1 and cytotoxic responses.
Article
Food Science & Technology
Qian Liu, Jie Fang, Wenqi Huang, Sining Liu, Xueting Zhang, Guiping Gong, Linjuan Huang, Xiaoliang Lin, Zhongfu Wang
Summary: This study investigated the effects of konjac glucomannan with different molecular weights on high-fat and high-fructose diet-induced obese mice. The results showed that konjac glucomannan with higher molecular weight reduced body weight and improved insulin resistance. It also inhibited lipid accumulation in the liver by regulating gene expression. Furthermore, konjac glucomannan at different molecular weights caused changes in gut microbial diversity. These findings provide a scientific basis for the development and utilization of konjac resources.
FOOD RESEARCH INTERNATIONAL
(2023)
Article
Cell Biology
Hui Liu, Chen Bai, Fuyang Xian, Shaoyang Liu, Chaojun Long, Li Hu, Tiegang Liu, Xiaohong Gu
Summary: This study found that a high-calorie diet and LPS atomization synergistically aggravated lung inflammation injury in juvenile rats. The high-calorie diet disrupted the balance of Th17/Treg cells and changed the composition and abundance of the gut microbiome. These findings provide a new perspective on the pathogenesis of lung inflammation injury and suggest a potential microbiota-targeting therapy for inflammatory lung diseases.
JOURNAL OF LEUKOCYTE BIOLOGY
(2022)
Article
Endocrinology & Metabolism
Laila Silamikele, Ivars Silamikelis, Monta Ustinova, Zane Kalnina, Ilze Elbere, Ramona Petrovska, Ineta Kalnina, Janis Klovins
Summary: The study aimed to investigate the effect of metformin on gut microbiome in a high-fat diet-induced type 2 diabetes mouse model, utilizing shotgun metagenomic sequencing for the first time in mice study. The results showed significant alterations in gut microbiome diversity, composition, and functional implications, with sex-specific differences observed in response to metformin treatment. These findings suggest the importance of including both sexes in future studies focusing on metformin effects on gut microbiome.
FRONTIERS IN ENDOCRINOLOGY
(2021)
Article
Biochemistry & Molecular Biology
Xiaojing Wei, Chuanfei Wei, Yutian Tan, Ximing Dong, Zhao Yang, Jianqun Yan, Xiao Luo
Summary: This study aimed to determine the regulation of NAD+-related enzymes in the liver and their relationships with glucose and lipid metabolism. It was found that both high-fat diet feeding and calorie restriction increased hepatic NAD+ levels and the expression of related genes. In addition, high-fat diet feeding and calorie restriction had different effects on hepatic lipogenesis and gluconeogenesis. These findings highlight the importance of hepatic NAD+ metabolism in maintaining metabolic flexibility.
JOURNAL OF NUTRITIONAL BIOCHEMISTRY
(2023)
Article
Physiology
Evan M. Zeitler, J. Charles Jennette, Jennifer E. Flythe, Ronald J. Falk, John S. Poulton
Summary: This study on zebrafish shows that a high-calorie diet, regardless of fat content, can lead to kidney pathology, but these changes can be reversed after 4 weeks of calorie restriction.
AMERICAN JOURNAL OF PHYSIOLOGY-RENAL PHYSIOLOGY
(2022)
Article
Cell Biology
Martin Maldonado, Jianying Chen, Yang Lujun, Huiqin Duan, Mazhar Ali Raja, Ting Qu, Tianhua Huang, Jiang Gu, Ying Zhong
Summary: The interaction between a high-calorie diet (HCD) and calorie restriction (CR) influences metabolic and physiological characteristics of skeletal muscles in mice. Dietary interventions alter genetic activation patterns and boost the expression of regulatory factors, impacting mitochondrial biogenesis and metabolic fiber transition. This suggests that a balance between HCD and CR may bring potential benefits for skeletal muscle function and energy metabolism by triggering key anti-aging mechanisms.
Review
Nutrition & Dietetics
Angela D. Clontz
Summary: English summary: Glioblastoma Multiforme is an aggressive brain cancer with limited treatment options. Researchers have explored the use of the ketogenic diet as a potential therapy due to the inability of gliomas to utilize ketones. This review examines the current research on the effectiveness and manageability of the ketogenic diet in glioblastoma patients, revealing limitations and the need for further reproducible studies in human subjects.
FRONTIERS IN NUTRITION
(2023)
Article
Endocrinology & Metabolism
Tomohito Gohda, Yuji Nishizaki, Maki Murakoshi, Shuko Nojiri, Naotake Yanagisawa, Terumi Shibata, Mami Yamashita, Kanako Tanaka, Yoshinori Yamashita, Yusuke Suzuki, Nozomu Kamei
DIABETES RESEARCH AND CLINICAL PRACTICE
(2018)
Article
Multidisciplinary Sciences
Nozomu Kamei, Mami Yamashita, Yuji Nishizaki, Naotake Yanagisawa, Shuko Nojiri, Kanako Tanaka, Yoshinori Yamashita, Terumi Shibata, Maki Murakoshi, Yusuke Suzuki, Tomohito Gohda
SCIENTIFIC REPORTS
(2018)
Article
Multidisciplinary Sciences
Keiko Takahashi, Seiji Ueda, Takashi Kobayashi, Akira Nishiyama, Yoshihide Fujisawa, Takeshi Sugaya, Satomi Shiota, Kazuhisa Takahashi, Tomohito Gohda, Satoshi Horikoshi, Yusuke Suzuki
SCIENTIFIC REPORTS
(2018)
Article
Endocrinology & Metabolism
Tomohito Gohda, Nozomu Kamei, Takeo Koshida, Mitsunobu Kubota, Kanako Tanaka, Yoshinori Yamashita, Eri Adachi, Saki Ichikawa, Maki Murakoshi, Seiji Ueda, Yusuke Suzuki
JOURNAL OF DIABETES INVESTIGATION
(2020)
Review
Biochemistry & Molecular Biology
Maki Murakoshi, Tomohito Gohda, Yusuke Suzuki
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2020)
Article
Biochemistry & Molecular Biology
Saki Ichikawa, Tomohito Gohda, Maki Murakoshi, Li Zi, Eri Adachi, Takeo Koshida, Yusuke Suzuki
Article
Endocrinology & Metabolism
Tomohito Gohda, Nozomu Kamei, Mitsunobu Kubota, Kanako Tanaka, Yoshinori Yamashita, Hiroko Sakuma, Chiaki Kishida, Eri Adachi, Takeo Koshida, Maki Murakoshi, Shinji Hagiwara, Kazuhiko Funabiki, Seiji Ueda, Yusuke Suzuki
Summary: Increased concentrations of serum TNFRs are positively associated with ACR and negatively associated with eGFR in patients with type 2 diabetes. The study shows that serum TNFRs are more strongly correlated with kidney measures, while urinary TNFRs are primarily associated with ACR.
JOURNAL OF DIABETES INVESTIGATION
(2021)
Article
Biochemistry & Molecular Biology
Zi Li, Maki Murakoshi, Saki Ichikawa, Takeo Koshida, Eri Adachi, Chigure Suzuki, Seiji Ueda, Tomohito Gohda, Yusuke Suzuki
Article
Multidisciplinary Sciences
Tomohito Gohda, Maki Murakoshi, Yusuke Suzuki, Makoto Hiki, Toshio Naito, Kazuhisa Takahashi, Yoko Tabe
Summary: This study aimed to investigate the relationship between TNF-related biomarkers and mortality or disease severity in COVID-19 patients. The results showed that TNFR2 levels were associated with mortality in COVID-19 patients and may be helpful in predicting disease severity.
Review
Biochemistry & Molecular Biology
Tomohito Gohda, Maki Murakoshi
Summary: Diabetic kidney disease (DKD) is a major cause of chronic kidney disease (CKD) and end-stage kidney disease. Early diagnosis, treatment, and risk factor management are important for preventing DKD progression. While current biomarkers for DKD diagnosis and prognosis are limited, measuring TNFRs in serum can help predict CKD prognosis. Cardiorenal risk factor management and certain medications are effective in slowing DKD progression, but there is still a high residual risk. Emerging therapies like SGLT2 inhibitors show promise for preventing DKD progression in patients with type 2 diabetes.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Medicine, General & Internal
Maki Murakoshi, Takumi Iwasawa, Takeo Koshida, Yusuke Suzuki, Tomohito Gohda, Kazunori Kato
Summary: A novel ELISA method targeting EphA2 was validated and used to measure circulating EphA2 levels in hypertensive patients with kidney function decline, showing a potential application as a clinical biomarker for CKD presence.
Article
Biochemistry & Molecular Biology
Takeo Koshida, Tomohito Gohda, Takuya Sugimoto, Takashi Asahara, Rin Asao, Isao Ohsawa, Hiromichi Gotoh, Maki Murakoshi, Yusuke Suzuki, Yuichiro Yamashiro
Summary: The composition of the gut microbiome differs between patients with chronic kidney disease (CKD) undergoing hemodialysis (HD) and those with normal renal function (NRF). This difference is associated with altered levels of stool organic acids, systemic inflammation, and accumulation of uremic toxins (UTs). Furthermore, the levels of UTs, inflammatory markers, and stool organic acids differ significantly between patients with NRF and those undergoing HD.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Urology & Nephrology
Maki Murakoshi, Takashi Kobayashi, Masao Kihara, Seiji Ueda, Yusuke Suzuki, Tomohito Gohda
Summary: This study aimed to identify the clinical characteristics of patients with chronic kidney disease (CKD) who showed decreased proteinuria in response to dapagliflozin treatment. The results showed that the changes in urinary protein-to-creatinine ratio were positively associated with the initial decline rate in estimated glomerular filtration rate (eGFR) after 1 month of treatment.
Article
Medicine, Research & Experimental
Daisuke Sato, Tomohito Gohda, Masao Kihara, Yasuhiko Kanaguchi, Takashi Kobayashi, Satoshi Mano, Yu Sasaki, Nao Nohara, Maki Murakoshi, Junichiro Nakata, Hitoshi Suzuki, Seiji Ueda, Satoshi Horikoshi, Yusuke Suzuki
ACTA MEDICA OKAYAMA
(2018)
Article
Urology & Nephrology
Miho Shimizu, Kengo Furuichi, Tadashi Toyama, Tomoaki Funamoto, Shinji Kitajima, Akinori Hara, Daisuke Ogawa, Daisuke Koya, Kenzo Ikeda, Yoshitaka Koshino, Yukie Kurokawa, Hideharu Abe, Kiyoshi Mori, Masaaki Nakayama, Yoshio Konishi, Ken-ichi Samejima, Masaru Matsui, Hiroyuki Yamauchi, Tomohito Gohda, Kei Fukami, Daisuke Nagata, Hidenori Yamazaki, Yukio Yuzawa, Yoshiki Suzuki, Shouichi Fujimoto, Shoichi Maruyama, Sawako Kato, Takero Naito, Kenichi Yoshimura, Hitoshi Yokoyama, Takashi Wada
CLINICAL AND EXPERIMENTAL NEPHROLOGY
(2018)