Article
Medicine, Research & Experimental
Hongyan Mo, Qian Ren, Dongyan Song, Bo Xu, Dong Zhou, Xue Hong, Fan Fan Hou, Lili Zhou, Youhua Liu
Summary: This study found that CXCR4 and beta-catenin colocalized in glomerular podocytes and that the assembly of CXCR4/beta-arrestin-1/Src signalosome led to beta-catenin activation, promoting podocyte dysfunction and proteinuria.
Article
Orthopedics
Rahul G. Alenchery, Raquel E. Ajalik, Kyle Jerreld, Firaol Midekksa, Sylvia Zhong, Bashar Alkatib, Hani A. Awad
Summary: This study found that transforming growth factor-beta (TGF-beta 1) induces plasminogen activator inhibitor 1 (PAI-1) to inhibit phosphatase and tensin homolog (PTEN), suggesting that PAI-1-induced adhesions involve phosphoinositide 3-kinase/protein kinase B/mammalian target of rapamycin (mTOR) signaling. PAI-1 deletion blunted TGF-beta 1-induced myofibroblast activation in murine flexor tenocytes and increased the gene expression of Mmp-2 to confer protective effects against fibrosis. While TGF-beta 1 significantly reduced phosphorylation of PTEN in WT cells, PAI-1 deletion rescued the activation of PTEN.
JOURNAL OF ORTHOPAEDIC RESEARCH
(2023)
Review
Cell Biology
Craig E. Higgins, Jiaqi Tang, Stephen P. Higgins, Cody C. Gifford, Badar M. Mian, David M. Jones, Wenzheng Zhang, Angelica Costello, David J. Conti, Rohan Samarakoon, Paul J. Higgins
Summary: Tubulointerstitial fibrosis is a common feature in chronic renal disorders, driven by persistent TGF-beta 1 signaling. The transcriptional co-regulator p53 plays a key role in the fibrotic response induced by TGF-beta 1.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2021)
Article
Biochemistry & Molecular Biology
Xuejing Zhu, Dan Gao, Vittorio Albertazzi, Jianyong Zhong, Li-Jun Ma, Liping Du, Yu Shyr, Valentina Kon, Hai-Chun Yang, Agnes B. Fogo
Summary: The study found that long-term treatment with high-dose angiotensin receptor blocker (ARB) and nonspecific antihypertensive therapy can ameliorate the progression of glomerulosclerosis. Among them, ARB treatment showed superior preservation of podocyte integrity, decreased proteinuria and aldosterone levels, and higher survival rate in uremic rats compared to other treatment methods.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Urology & Nephrology
R. Chimenz, V. Chirico, P. Basile, A. Carcione, G. Conti, P. Monardo, A. Lacquaniti
Summary: ALP patients with normal renal function exhibited higher levels of serum and urinary HMGB1 and TGF-beta1 compared to healthy subjects. HMGB1 and TGF-beta1 were correlated with each other and with markers of renal function and damage. Urinary biomarkers did not correlate with eGFR, while sHMGB1 and sTGF-beta1 were negatively related to filtration rate.
JOURNAL OF NEPHROLOGY
(2021)
Article
Urology & Nephrology
An S. De Vriese, Jack F. Wetzels, Richard J. Glassock, Sanjeev Sethi, Fernando C. Fervenza
Summary: Focal segmental glomerulosclerosis is a histopathological lesion with heterogeneous causes, including circulating permeability factors, genetic mutations, and unknown processes. Proper stratification of FSGS patients is crucial for treatment decisions and clinical management.
NATURE REVIEWS NEPHROLOGY
(2021)
Article
Veterinary Sciences
Mayra de Lima e Silva, Gyl Eanes Barros Silva, Sofia Borin-Crivellenti, Alef Winter Oliveira Alvarenga, Marcela Aldrovani, Larissa Ayane do Nascimento Braz, Caroline Aoki, Aureo Evangelista Santana, Caio Santos Pennacchi, Leandro Zuccolotto Crivellenti
Summary: This study aimed to analyze the glomerular and tubular alterations in dogs with terminal distemper. Results showed that dogs with distemper exhibited anemia, hypergammaglobulinemia, and proteinuria. Glomerular and tubular lesions were confirmed in the majority of these dogs.
FRONTIERS IN VETERINARY SCIENCE
(2022)
Article
Immunology
Jingjing Zhang, Jinxin Qiu, Wenyong Zhou, Jianping Cao, Xuefei Hu, Wenli Mi, Bing Su, Bin He, Ju Qiu, Lei Shen
Summary: This study identifies neuropilin-1 (Nrp1) as a tissue-specific marker of lung-resident ILC2s, which enhances their function and type 2 immune response by upregulating IL-33 receptor ST2 expression. Inhibition of Nrp1 suppresses IL-5 and IL-13 production by ILC2s and protects mice from the development of pulmonary fibrosis.
Article
Biochemistry & Molecular Biology
Cody C. Gifford, Fei Lian, Jiaqi Tang, Angelica Costello, Roel Goldschmeding, Rohan Samarakoon, Paul J. Higgins
Summary: PAI-1 plays a crucial role in tubular dysfunction, leading to fibrosis and cell death through multiple signaling pathways, and is closely associated with klotho, p53, and the TGF-beta RI/SMAD3 axis.
Review
Immunology
Marc Xipell, Adriana Garcia-Herrera, Gema M. Lledo, Elena Guillen, Miquel Blasco, Gerard Espinosa, Ricard Cervera, Luis F. Quintana, Marina De Cos
Summary: Chronic kidney disease (CKD) is a growing global cause of morbidity and mortality. Immune mediated disorders and the dysregulation of extracellular matrix synthesis and degradation play crucial roles in the development of CKD and renal fibrosis. Pathways involved in renal fibrosis and CKD are closely related to each other, and their understanding and translation into clinical practice are still necessary. The future holds promise for more personalized assistance for CKD and renal fibrosis with the rapid development of technology and the availability of new drugs in nephrology.
AUTOIMMUNITY REVIEWS
(2022)
Article
Cardiac & Cardiovascular Systems
Christian Baumeier, Felicitas Escher, Ganna Aleshcheva, Heiko Pietsch, Heinz-Peter Schultheiss
Summary: The study showed that elevated levels of PAI-1 in high-grade DCMi patients are associated with reduced cardiac fibrosis, decreased TGF-beta levels, and fewer myofibroblasts. Additionally, high-grade DCMi patients exhibited a higher proportion of M2 macrophages compared to M1 macrophages, suggesting a role of PAI-1 in macrophage polarization in inflammatory cardiomyopathies.
BASIC RESEARCH IN CARDIOLOGY
(2021)
Article
Biochemistry & Molecular Biology
Jinyuan Hu, Yuanyuan Liu, Zheng Pan, Xuekuan Huang, Jianwei Wang, Wenfu Cao, Zhiwei Chen
Summary: This study investigated the effect of eupatilin on hepatic fibrosis using in vitro and in vivo experiments. The results showed that eupatilin significantly inhibited the activation of hepatic stellate cells and reduced the levels of fibrotic markers. Eupatilin also suppressed cell proliferation and decreased PAI-1 expression. Additionally, it was found that eupatilin downregulated beta-catenin and alleviated hepatic fibrosis in CCl4-treated mice.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Hematology
Takashi Yahata, Abd Aziz Ibrahim, Ken-ichi Hirano, Yukari Muguruma, Kazuhito Naka, Katsuto Hozumi, Douglas E. Vaughan, Toshio Miyata, Kiyoshi Ando
Summary: Selective blockade of PAI-1 enhances susceptibility of CML-LSC to TKI, facilitating eradication of CML-LSC and sustained remission. Combined therapy of imatinib and PAI-1 inhibitor prevents recurrence of CML-like disease in transplanted recipients, indicating elimination of CML-LSC as a novel therapeutic tactic for CML patients.
Article
Medicine, General & Internal
April Nettesheim, Myoung Sup Shim, Angela Dixon, Urmimala Raychaudhuri, Haiyan Gong, Paloma B. Liton
Summary: The deposition of extracellular matrix (ECM) in the trabecular meshwork (TM) is a hallmark of glaucoma. Previous research has identified the enzyme cathepsin B (CTSB) as playing a role in regulating ECM remodeling and outflow physiology in TM cells, suggesting it as a potential therapeutic target for attenuating fibrosis and ECM deposition in the glaucomatous outflow pathway.
JOURNAL OF CLINICAL MEDICINE
(2021)
Article
Physiology
Masahiro Okabe, Kazuyoshi Yamamoto, Yoichi Miyazaki, Masaru Motojima, Masato Ohtsuka, Ira Pastan, Takashi Yokoo, Taiji Matsusaka
Summary: The study revealed that damaged podocytes in a mosaic mouse model can lead to secondary injury in other podocytes, and treatment with angiotensin II receptor blocker significantly ameliorated the secondary podocyte injury. Understanding the molecular mechanism of secondary podocyte injury is crucial for treating progressive kidney diseases, and this model serves as a powerful tool for studying indirect podocyte damage.
AMERICAN JOURNAL OF PHYSIOLOGY-RENAL PHYSIOLOGY
(2021)
Article
Surgery
Francesco Pesce, Emma D. Stea, Chiara Divella, Matteo Accetturo, Paola Laghetti, Pasquale Gallo, Michele Rossini, Francesca Cianciotta, Lucia Crispino, Antonio Granata, Michele Battaglia, Giuseppe Lucarelli, Santiago R. de Cordoba, Giovanni Stallone, Loreto Gesualdo, Giuseppe Castellano
Summary: IgA nephropathy is a common cause of chronic kidney disease and renal impairment. Deletion of Complement factor H-related genes 1 and 3 has been associated with a decreased risk of developing IgAN. Patients with two copies of CFHR1-3 had a worse outcome, increased senescence marker expression, and tubulointerstitial fibrosis, suggesting a role of FHR1 in Complement activation and tubular senescence.
AMERICAN JOURNAL OF TRANSPLANTATION
(2021)
Review
Medicine, General & Internal
Francesco Pesce, Emma D. Stea, Michele Rossini, Marco Fiorentino, Fausta Piancone, Barbara Infante, Giovanni Stallone, Giuseppe Castellano, Loreto Gesualdo
Summary: Acute kidney injury (AKI) is increasingly recognized as a global emergency, often due to sepsis, major surgery, and nephrotoxic drugs. Glomerulonephritis is responsible for about 10% of AKI episodes in adults, necessitating prompt and accurate diagnosis and effective management to improve short- and long-term outcomes.
FRONTIERS IN MEDICINE
(2021)
Article
Cell Biology
Chiara Divella, Alessandra Stasi, Rossana Franzin, Michele Rossini, Paola Pontrelli, Fabio Sallustio, Giuseppe Stefano Netti, Elena Ranieri, Luca Lacitignola, Francesco Staffieri, Alberto Maria Crovace, Giuseppe Lucarelli, Pasquale Ditonno, Michele Battaglia, Mohamed R. Daha, Peter van der Pol, Cees van Kooten, Giuseppe Grandaliano, Loreto Gesualdo, Giovanni Stallone, Giuseppe Castellano
Summary: Pentraxin family member PTX3 plays a crucial role in I/R injury and may be a potential therapeutic target for preventing complement-induced renal I/R injury.
Article
Biochemistry & Molecular Biology
Paola Pontrelli, Francesca Conserva, Rossella Menghini, Michele Rossini, Alessandra Stasi, Chiara Divella, Viviana Casagrande, Claudia Cinefra, Mariagrazia Barozzino, Simona Simone, Francesco Pesce, Giuseppe Castellano, Giovanni Stallone, Anna Gallone, Francesco Giorgino, Massimo Federici, Loreto Gesualdo
Summary: The combined treatment of K63-Ub inhibitor NSC697923 and ACE inhibitor ramipril significantly reduces fibrosis progression and proteinuria in diabetic nephropathy. It restores expression of urinary miR-27b-3p, showing potential as a novel treatment strategy for DN.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Urology & Nephrology
Francesco Pesce, Federica Albanese, Davide Mallardi, Michele Rossini, Giuseppe Pasculli, Paola Suavo-Bulzis, Antonio Granata, Antonio Brunetti, Giacomo Donato Cascarano, Vitoantonio Bevilacqua, Loreto Gesualdo
Summary: This study proposes a computer-aided diagnosis system that can accurately discriminate between sclerotic and non-sclerotic glomeruli based on histological images. Two different artificial neural network classifiers were tested, and both showed high accuracy in distinguishing between the two types. The method based on feature extraction and classification provides additional information about the discriminating features.
JOURNAL OF NEPHROLOGY
(2022)
Review
Immunology
Francesco Paolo Schena, Michele Rossini, Daniela Isabel Abbrescia, Gianluigi Zaza
Summary: Kidney biopsy is crucial for diagnosing IgA nephropathy, with transcriptomic studies and urinary biomarkers providing insights for monitoring and personalized treatment of patients.
SEMINARS IN IMMUNOPATHOLOGY
(2021)
Article
Urology & Nephrology
Francesco P. Schena, Giovanni Tripepi, Michele Rossini, Daniela Abbrescia, Carlo Manno
Summary: This study aims to stratify patients with IgAN based on the type of renal lesions and laboratory findings, and provide personalized therapy to slow the decline of renal function and delay end-stage kidney disease.
CLINICAL KIDNEY JOURNAL
(2022)
Article
Urology & Nephrology
Gianfranca Cabiddu, Elisa Longhitano, Emanuela Cataldo, Nicola Lepori, Antoine Chatrenet, Massimo Torreggiani, Rossella Attini, Bianca Masturzo, Michele Rossini, Elisabetta Versino, Gabriella Moroni, Antonello Pani, Loreto Gesualdo, Domenico Santoro, Giorgina Barbara Piccoli
Summary: This study examined the prevalence of preeclampsia (PE) in patients who underwent kidney biopsy after delivery and found a biphasic relationship between PE and chronic kidney disease (CKD).
KIDNEY INTERNATIONAL REPORTS
(2022)
Article
Transplantation
Simeone Andrulli, Michele Rossini, Giuseppe Gigliotti, Gaetano La Manna, Sandro Feriozzi, Filippo Aucella, Antonio Granata, Elisabetta Moggia, Domenico Santoro, Lucio Manenti, Barbara Infante, Angelo Ferrantelli, Rosario Cianci, Mario Giordano, Domenico Giannese, Giuseppe Seminara, Marina Di Luca, Mario Bonomini, Leonardo Spatola, Francesca Bruno, Olga Baraldi, David Micarelli, Matteo Piemontese, Giulio Distefano, Francesca Mattozzi, Paola De Giovanni, Davide Penna, Maurizio Garozzo, Luigi Vernaglione, Cataldo Abaterusso, Fulvia Zanchelli, Rachele Brugnano, Enrica Gintoli, Laura Sottini, Marco Quaglia, Gioacchino Li Cavoli, Marco De Fabritiis, Maria Maddalena Conte, Massimo Manes, Yuri Battaglia, Francesco Fontana, Loreto Gesualdo
Summary: This multicentre prospective study provides evidence that percutaneous native kidney biopsies carry a 5% risk of major post-biopsy complications. Predictors of increased risk include higher plasma creatinine levels, liver disease, and a higher number of needle passes.
NEPHROLOGY DIALYSIS TRANSPLANTATION
(2023)
Correction
Urology & Nephrology
Francesco P. Schena, Giovanni Tripepi, Michele Rossini, Daniela Abbrescia, Carlo Manno
CLINICAL KIDNEY JOURNAL
(2022)
Meeting Abstract
Transplantation
Giulia Fonto, Simona Simone, Francesco Pesce, Virginia Pronzo, Annalisa Casanova, Pasquale Gallo, Michele Rossini, Annalisa Schirinzi, Paola Pontrelli, Francesca Conserva, Silvio Tafuri, Francesca Di Serio, Loreto Gesualdo
NEPHROLOGY DIALYSIS TRANSPLANTATION
(2022)
Meeting Abstract
Transplantation
Filippo Giordano, Alessandra Pesino, Cosma Cortese, Flavia Esposito, Nicla Campobasso, Nicola Grandolfo, Michele Rossini, Adele Mitrotti, Loreto Gesualdo
NEPHROLOGY DIALYSIS TRANSPLANTATION
(2022)
Article
Medical Informatics
Giacomo Donato Cascarano, Francesco Saverio Debitonto, Ruggero Lemma, Antonio Brunetti, Domenico Buongiorno, Irio De Feudis, Andrea Guerriero, Umberto Venere, Silvia Matino, Maria Teresa Rocchetti, Michele Rossini, Francesco Pesce, Loreto Gesualdo, Vitoantonio Bevilacqua
Summary: A novel CAD system module based on image processing techniques and machine learning was designed and tested to classify the condition affecting renal glomeruli between sclerotic and non-sclerotic. Results confirm the consistency and reliability of the proposed workflow for discriminating two classes of glomeruli in clinical practice.
BMC MEDICAL INFORMATICS AND DECISION MAKING
(2021)
Meeting Abstract
Surgery
Fausta Piancone, Simona Simone, Pasquale Gallo, Michele Rossini, Virginia Pronzo, Michele Russo, Giuseppe Torre, Matteo Matera, Marcella Margiotta, Donata Mininni, Franco Citterio, Giuseppe Grandaliano, Salvatore Grasso, Michele Battaglia, Loreto Gesualdo
TRANSPLANT INTERNATIONAL
(2021)
Meeting Abstract
Surgery
Virginia Pronzo, Simona Simone, Michele Rossini, Giovanni Battista Pertosa, Carlo Manno, Loreto Gesualdo
TRANSPLANT INTERNATIONAL
(2021)