Article
Gastroenterology & Hepatology
Giuseppe Cullaro, Elizabeth C. Verna, Charles E. McCulloch, Jennifer C. Lai
Summary: This study demonstrates the feasibility and potential of objectively defined kidney dysfunction types to enhance the prognostication of waitlist mortality provided by the MELD-Na score.
Article
Medicine, General & Internal
Yi-Ping Chang, Chen-Mao Liao, Li-Hsin Wang, Hsiu-Hua Hu, Chih-Ming Lin
Summary: This study followed 1042 chronic kidney disease patients with Stage 3-5 kidney disease and found that estimated glomerular filtration rate and urine protein to creatinine ratio had strong predictive abilities for disease progression. Additionally, differences in predictive variables were observed among patients at different stages of kidney disease, suggesting the potential for tailored prevention strategies.
JOURNAL OF CLINICAL MEDICINE
(2021)
Article
Multidisciplinary Sciences
Eun Sil Koh, Kyung Do Han, Mee Kyoung Kim, Eun Sook Kim, Min-Kyung Lee, Ga Eun Nam, Oak-Kee Hong, Hyuk-Sang Kwon
Summary: This study investigated the impact of changes in MetS components on ESRD using data from the Korean National Health Insurance System. The results showed that individuals with MetS components had a higher risk of developing ESRD, especially in those with impaired renal function.
SCIENTIFIC REPORTS
(2021)
Article
Medicine, General & Internal
H. Pottel, J. Bjork, A. D. Rule, N. Ebert, B. O. Eriksen, L. Dubourg, E. Vidal-Petiot, A. Grubb, M. Hansson, E. J. Lamb, K. Littmann, C. Mariat, T. Melsom, E. Schaeffner, P. -O. Sundin, A. Akesson, A. Larsson, E. Cavalier, J. B. Bukabau, E. K. Sumaili, E. Yayo, D. Monnet, M. Flamant, U. Nyman, P. Delanaye
Summary: The study developed a cystatin C-based equation (EKFC eGFRcys) to estimate glomerular filtration rate (GFR). This equation had similar accuracy to a creatinine-based equation (EKFC eGFRcr) and outperformed other commonly used equations. Furthermore, taking the arithmetic mean of EKFC eGFRcr and EKFC eGFRcys further improved the accuracy of GFR estimation.
NEW ENGLAND JOURNAL OF MEDICINE
(2023)
Article
Surgery
Andreas Selberherr, Marta Mari, Markus Klinger, Christopher Burghuber, Wolf Eilenberg, Bernd Gollackner, Christoph Neumayer, Christoph Domenig
Summary: This study evaluated the outcomes of renal function in patients undergoing juxtarenal abdominal aortic aneurysm repair, focusing on the division of the left renal vein and the presence of a communicating lumbar vein. The results showed that ligation of the left renal vein did not significantly affect renal function. However, patients with a communicating lumbar vein had better long-term renal function.
WORLD JOURNAL OF SURGERY
(2022)
Article
Multidisciplinary Sciences
Luanfeng Lin, Xiaoling Chen, Junnian Chen, Xiaobin Pan, Pincang Xia, Hailong Lin, Houwei Du
Summary: By using ROC curve analysis and a COX proportional hazards regression model, it was found that COVID-19 patients with higher levels of sCys C are more likely to develop severe illness.
SCIENTIFIC REPORTS
(2021)
Review
Medicine, General & Internal
Vera H. Koch
Summary: Obesity is a chronic disease with a rapidly increasing global prevalence of overweight and obesity. It can affect kidney function, leading to more deaths worldwide than underweight. Creatinine may not be the ideal marker for GFR measurement in obese individuals.
FRONTIERS IN MEDICINE
(2021)
Article
Pharmacology & Pharmacy
Hyun Gi Yun, Andrew J. F. Smith, Kenneth C. C. DeBacker, Manjunath P. P. Pai
Summary: The study aimed to explore the precision in dosing with different equations for estimating glomerular filtration rate (eGFR) by using a model drug (vancomycin) dependent on kidney function clearance. The findings suggest that the nonrace-based serum cystatin C (S-cys) eGFR model outperformed other clearance models and improved the probability of target attainment. When S-cys data is not available, the new 2021 CKD-EPI eGFR(cr) equation without race factor performs equally well as the conventional approach. This study highlights the importance of removing race as a factor for kidney function dose adjustment.
BRITISH JOURNAL OF CLINICAL PHARMACOLOGY
(2023)
Article
Transplantation
Edouard L. Fu, Josef Coresh, Morgan E. Grams, Catherine M. Clase, Carl-Gustaf Elinder, Julie Paik, Chava Ramspek, Lesley A. Inker, Andrew S. Levey, Friedo W. Dekker, Juan J. Carrero
Summary: Implementing the 2021 CKD-EPI equation in predominantly White European populations would slightly increase eGFR and reclassify a significant proportion of CKD patients to a higher eGFR category. eGFR by both equations strongly predicted outcomes.
NEPHROLOGY DIALYSIS TRANSPLANTATION
(2023)
Article
Endocrinology & Metabolism
Liangjing Lv, Xiangjun Chen, Jinbo Hu, Jinshan Wu, Wenjin Luo, Yan Shen, Rui Lan, Xue Li, Yue Wang, Ting Luo, Shumin Yang, Qifu Li, Zhihong Wang
Summary: The study evaluated the performance of a predictive model (KFRE) for end-stage renal disease (ESRD) in diabetes and found that the r-LM equation performs better than the CKD-EPI and MDRD equations. The r-LM equation showed improved differentiation in predicting ESRD, especially for diabetic patients with macroalbuminuria and poor glycemic control.
FRONTIERS IN ENDOCRINOLOGY
(2022)
Article
Transplantation
Pierre Delanaye, Emmanuelle Vidal-Petiot, Jonas Bjork, Natalie Ebert, Bjorn O. Eriksen, Laurence Dubourg, Anders Grubb, Magnus Hansson, Karin Littmann, Christophe Mariat, Toralf Melsom, Elke Schaeffner, Per-Ola Sundin, Arend Bokenkamp, Ulla B. Berg, Kajsa Asling-Monemi, Anna Akesson, Anders Larsson, Etienne Cavalier, R. Neil Dalton, Marie Courbebaisse, Lionel Couzi, Francois Gaillard, Cyril Garrouste, Lola Jacquemont, Nassim Kamar, Christophe Legendre, Lionel Rostaing, Thomas Stehle, Jean-Philippe Haymann, Luciano da Silva Selistre, Jorge P. Strogoff-de-Matos, Justine B. Bukabau, Ernest K. Sumaili, Eric Yayo, Dagui Monnet, Ulf Nyman, Hans Pottel, Martin Flamant
Summary: This study compared and validated the performance of the new Chronic Kidney Disease Epidemiology Collaboration equation (CKD-EPIAS) with the European Kidney Function Consortium (EKFC) and Lund-Malmo Revised (LMREV) equations in European and African cohorts. The results showed that the EKFC equation had the best performance in both European and African populations, while CKD-EPIAS had suboptimal performance.
NEPHROLOGY DIALYSIS TRANSPLANTATION
(2023)
Article
Urology & Nephrology
Nori J. L. Smeets, Joanna IntHout, Maurice J. P. van der Burgh, George J. Schwartz, Michiel F. Schreuder, Saskia N. de Wildt
Summary: This study establishes reference values for GFR in healthy, term-born neonates through an analysis of individual participant data (IPD). The study also optimizes the estimation of GFR using creatinine levels. The findings reveal a biphasic increase in GFR in neonates, with the largest increase occurring between days 1 and 5 after birth.
JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY
(2022)
Article
Endocrinology & Metabolism
Li Chen, Zhangxiang Zhu, Shandong Ye, Mao Zheng
Summary: The study suggests that the serum uric acid to serum creatinine ratio (SUA/SCr) can be used as an indicator of diabetic kidney disease (DKD) in patients with type 2 diabetes mellitus (T2DM) and may be helpful for identifying normoalbuminuric DKD.
DIABETES METABOLIC SYNDROME AND OBESITY-TARGETS AND THERAPY
(2022)
Article
Environmental Sciences
Nan Zhao, Xinxin Fang, Shiwen Zhang, Yuting Zhu, Lei Ding, Caihong Xu
Summary: This study found that male serum total short-chain CP and medium-chain CP concentrations were associated with kidney function, specifically with elevated risk of glomerular hyperfiltration (GH), while no such associations were observed in females.
ENVIRONMENT INTERNATIONAL
(2021)
Article
Engineering, Environmental
Miao Liu, Lei Zhao, Linlin Liu, Wenting Guo, Huihua Yang, Shuang Chen, Jie Yu, Meng Li, Qin Fang, Xuefeng Lai, Liangle Yang, Rui Zhu, Xiaomin Zhang
Summary: This panel study found a significant association between certain phthalate metabolites and reduced eGFR in children, with age and weight status possibly modifying these relationships. Additionally, multiple cytokines related to eGFR were increased in the presence of phthalate metabolites, with CCL27 and CXCL1 potentially mediating the association between MEP and eGFR.
JOURNAL OF HAZARDOUS MATERIALS
(2022)
Letter
Transplantation
Rianne W. de Jong, Kitty J. Jager, Tom H. F. Broens, Vianda S. Stel
NEPHROLOGY DIALYSIS TRANSPLANTATION
(2022)
Editorial Material
Transplantation
Kitty J. Jager, Anders Asberg, Frederic Collart, Cecile Couchoud, Marie Evans, Patrik Finne, Ileana Peride, Ivan Rychlik, Ziad A. Massy
NEPHROLOGY DIALYSIS TRANSPLANTATION
(2022)
Article
Urology & Nephrology
Ondrej Derner, Anneke Kramer, Zdenka Hruskova, Mustafa Arici, Frederic Collart, Patrik Finne, Laura Fuentes Sanchez, Jerome Harambat, Marc H. Hemmelder, Kristine Hommel, Julia Kerschbaum, Johan De Meester, Runolfur Palsson, Marten Segelmark, Rannveig Skrunes, Jamie P. Traynor, Oscar Zurriaga, Ziad A. Massy, Kitty J. Jager, Vianda S. Stel, Vladimir Tesar
Summary: The incidence and prevalence of kidney replacement therapy (KRT) for kidney failure due to systemic lupus erythematosus (SLE) remained stable during the study period. The survival of SLE patients receiving KRT was similar to those with other diseases, but was worse after kidney transplant. Infections were a common cause of death in SLE patients receiving KRT.
AMERICAN JOURNAL OF KIDNEY DISEASES
(2022)
Article
Oncology
Marta Hernandez-Garcia, Ana Molina-Barcelo, Mercedes Vanaclocha-Espi, Oscar Zurriaga, Beatriz Perez-Gomez, Nuria Aragones, Pilar Amiano, Jone M. Altzibar, Gemma Castano-Vinyals, Maria Sala, Maria Ederra, Vicente Martin, Ines Gomez-Acebo, Carmen Vidal, Adonina Tardon, Rafael Marcos-Gragera, Marina Pollan, Manolis Kogevinas, Dolores Salas
Summary: There are differences in breast cancer-risk factor associations according to detection method and tumor phenotype among Spanish women aged 50-69. Reproductive risk factors are associated with screen-detected BC, as are HR+ tumors. Differences in BC-risk factor associations may be related to prevailing phenotypes among categories.
CANCER CAUSES & CONTROL
(2022)
Article
Public, Environmental & Occupational Health
Mika Gissler, Melanie Durox, Lucy Smith, Beatrice Blondel, Lisa Broeders, Ashna Hindori-Mohangoo, Karen Kearns, Rumyana Kolarova, Marzia Loghi, Urelija Rodin, Katarzyna Szamotulska, Petr Velebil, Guy Weber, Oscar Zurriaga, Jennifer Zeitlin
Summary: Routine stillbirth data in European countries are not comparable and should not be used for benchmarking or surveillance without careful verification. Recommendations for improvement include using gestational age as a cut-off, excluding late terminations of pregnancy, and linking multiple sources to improve the quality of national databases.
EUROPEAN JOURNAL OF PUBLIC HEALTH
(2022)
Letter
Urology & Nephrology
Lucas Jacobs, Arnaud Devresse, Thomas Baudoux, Frederic Collart
JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY
(2022)
Article
Transplantation
Rianne W. de Jong, Edwin J. Boezeman, Nicholas C. Chesnaye, Frederike J. Bemelman, Ziad A. Massy, Kitty J. Jager, Vianda S. Stel, Angela G. E. M. de Boer
Summary: Low employment rates and impaired work ability were prevalent among European patients receiving kidney replacement therapy. Employment was associated with demographic, disease-related, work-related, and macro-economic factors.
NEPHROLOGY DIALYSIS TRANSPLANTATION
(2022)
Article
Urology & Nephrology
Rianne Boenink, Megan E. Astley, Jilske A. Huijben, Vianda S. Stel, Julia Kerschbaum, Mai Ots-Rosenberg, Anders A. Asberg, Frantisek Lopot, Eliezer Golan, Pablo Castro de la Nuez, Marta Rodriguez Camblor, Sara Trujillo-Aleman, Juan Carlos Ruiz San Millan, Pablo Ucio Mingo, Juan Manuel Diaz, M. Encarnacion Bouzas-Caamano, Marta Artamendi, Manuel Aparicio Madre, Carmen Santiuste de Pablos, Maria Fernanda Slon Roblero, Oscar Zurriaga, Maria E. Stendahl, Samira Bell, Alma Idrizi, Kyriakos Ioannou, Alicja Debska-Slizien, Ana A. Galvao, Johan M. De Meester, Halima Resic, Kristine Hommel, Danilo Radunovic, Runolfur Palsson, Mathilde Lassalle, Patrik Finne, Maria De los Angeles-Garcia Bazaga, Nikola Gjorgjievski, Nurhan Seyahi, Marjolein Bonthuis, Alberto Ortiz, Kitty J. Jager, Anneke Kramer
Summary: This study collected data on renal replacement therapy (RRT) for end-stage renal disease from European and Mediterranean countries. It analyzed the incidence and prevalence of RRT, kidney transplantation activity, and survival probabilities. The study also compared different age categories and found significant differences.
CLINICAL KIDNEY JOURNAL
(2022)
Article
Transplantation
Jilske A. Huijben, Anneke Kramer, Julia Kerschbaum, Johan de Meester, Frederic Collart, Olga Lucia Rodriguez Arevalo, Jaakko Helve, Mathilde Lassalle, Runolfur Palsson, Marc ten Dam, Anna Casula, Shona Methven, Alberto Ortiz, Pietro Manuel Ferraro, Marten Segelmark, Pablo Ucio Mingo, Mustafa Arici, Anna Varberg Reisaeter, Maria Stendahl, Vianda S. Stel, Kitty J. Jager
Summary: This study describes the trends in incidence, prevalence, and survival of patients on kidney replacement therapy (KRT) for end-stage kidney disease (ESKD) in Europe from 2008 to 2017. The incidence of KRT remained stable initially but increased slightly in recent years, primarily driven by an increase in older male patients. Diabetes mellitus was found to be a leading cause of kidney failure. The prevalence of KRT increased over the study period, and patient survival on KRT improved.
NEPHROLOGY DIALYSIS TRANSPLANTATION
(2023)
Article
Multidisciplinary Sciences
Stine Kjaer Urhoj, Joachim Tan, Joan K. Morris, Joanne Given, Gianni Astolfi, Silvia Baldacci, Ingeborg Barisic, Joanna Brigden, Clara Cavero-Carbonell, Hannah Evans, Mika Gissler, Anna Heino, Sue Jordan, Renee Lutke, Ljubica Odak, Aurora Puccini, Michele Santoro, Ieuan Scanlon, Hermien E. K. de Walle, Diana Wellesley, Oscar Zurriaga, Maria Loane, Ester Garne
Summary: Children with congenital anomalies have a higher risk of hospitalization and longer length of stay. However, the outlook improves after the first year. It is important to provide support and assistance to the parents of children with congenital anomalies, informing them about the necessary care and the impact on family life and siblings.
Article
Health Care Sciences & Services
Lucia Paramo-Rodriguez, Clara Cavero-Carbonell, Sandra Guardiola-Vilarroig, Aurora Lopez-Maside, M. Eugenia Gonzalez Sanjuan, Oscar Zurriaga
Summary: This study used a qualitative approach to investigate the impact of diagnosis delay in rare diseases and explore the psychosocial needs of patients. The findings indicated that individuals with rare diseases exhibited high resilience and coping capacity, emphasizing the importance of professional psychosocial support during the diagnostic process.
Article
Obstetrics & Gynecology
Melissa Amyx, Marianne Philibert, Alex Farr, Serena Donati, Alexander K. Smarason, Vlad Tica, Petr Velebil, Sophie Alexander, Melanie Durox, Maria Fernandez Elorriaga, Guenther Heller, Theopisti Kyprianou, Ewa Mierzejewska, Ivan Verdenik, Irisa Zile-Velika, Jennifer Zeitlin
Summary: The study assessed changes in caesarean section (CS) rates in Europe from 2015 to 2019, and used the Robson Ten Group Classification System (TGCS) to evaluate the contribution of different obstetric populations to overall CS rates and trends. The findings showed that CS rates and trends varied among the 28 European countries. The TGCS analysis revealed that labour induction increased in most countries, while multiple pregnancies decreased. Countries with decreasing CS rates tended to see decreases across all TGCS groups, whereas countries with increasing rates tended to see increases in most groups. In countries with the greatest increase in CS rates, the absolute contribution of certain TGCS groups to the overall CS rate tended to increase.
BJOG-AN INTERNATIONAL JOURNAL OF OBSTETRICS AND GYNAECOLOGY
(2023)
Article
Transplantation
Francesco Gaetano Casino, Maria Fernanda Slon Roblero, Silvia Gonzalez-Sanchidrian, Sandra Gallego Dominguez, Ignacio Lorenzo Ferris, Valerie A. Luyckx, Vassilios Liakopoulos, Sandip Mitra, Javier Deira Lorenzo, Carlo Basile
Summary: The aim of this study was to obtain a new formula for stdKt/V that defines the minimum required values of eKt/V and TF to achieve the targeted stdKtV in home haemodialysis. The results showed that the formula is reliable and can support clinicians in prescribing the dialysis dose and treatment frequency for patients undergoing HHD.
NEPHROLOGY DIALYSIS TRANSPLANTATION
(2023)
Article
Genetics & Heredity
Monica Mazzucato, Laura Visona Dalla Pozza, Paola Facchin, Celine Angin, Francis Agius, Clara Cavero-Carbonell, Virginia Corrochano, Katerina Hanusova, Kurt Kirch, Deborah Lambert, Caterina Lucano, Sylvie Maiella, Monica Panzaru, Cristina Rusu, Stefanie Weber, Oscar Zurriaga, Miroslav Zvolsky, Ana Rath
Summary: The study tested the use of a specific rare disease (RD) codification system in five European countries/regions and found that the ORPHAcodes were a versatile resource for coding RD. They were able to provide ease of use and comparability across different databases. The ORPHAcodes described disease entities more precisely than the corresponding ICD-10 codes in the majority of cases.
ORPHANET JOURNAL OF RARE DISEASES
(2023)