Article
Endocrinology & Metabolism
L. Wang, K. Chen, L. Duan, X. Ke, F. Gong, H. Pan, H. Yang, H. Zhu, W. Xia
Summary: This study evaluated bone microarchitecture parameters using high-resolution peripheral quantitative computed tomography (HR-pQCT) in prolactinoma patients and compared them with healthy controls. The results showed that many bone microarchitecture parameters were impaired in prolactinoma patients, and this impairment was more prominent in patients with higher prolactin levels.
OSTEOPOROSIS INTERNATIONAL
(2022)
Article
Medicine, General & Internal
Po-Cheng Chen, Shu-Wei Chang, Chih-Yu Hsieh, Jian-Chiun Liou, Jia-Feng Chang, Ting-Ming Wang
Summary: This study explored the association between adiponectin levels and bone fracture risks in maintenance hemodialysis patients. Results showed that higher adiponectin levels were incrementally associated with an increased risk of bone fracture. In high-risk populations with hyperphosphatemia, elevated adiponectin levels could prompt clinicians to urgently correct mineral dysregulation and conduct further bone density surveys.
Article
Orthopedics
Camille P. Figueiredo, Mariana O. Perez, Lucas Peixoto Sales, Ana Cristina Medeiros, Valeria F. Caparbo, Rosa M. R. Pereira
Summary: This study found that BMD of MCP head was independently associated with the volume of bone erosion, suggesting it can be used to analyze and monitor bone destruction, as well as to evaluate treatment response in RA patients.
BMC MUSCULOSKELETAL DISORDERS
(2021)
Review
Biochemistry & Molecular Biology
Susana Coimbra, Susana Rocha, Maria Joao Valente, Cristina Catarino, Elsa Bronze-da-Rocha, Luis Belo, Alice Santos-Silva
Summary: Chronic kidney disease is often accompanied by multiple comorbidities and poor clinical outcomes. Malnutrition-inflammation-atherosclerosis syndrome is common in severe stages of CKD, and adiponectin and leptin may be associated with the risk of cardiovascular disease events.
Article
Biochemistry & Molecular Biology
Hsi-Hsien Chen, Ya-Li Huang, Mei-Chieh Chen, Chih-Yin Wu, Ying-Chin Lin, Horng-Sheng Shiue, Sheng-Lun Hsu, Yu-Mei Hsueh
Summary: This study investigated the association between ADIPOQ polymorphism and CKD, and found that ADIPOQ rs182052 and rs1501299 risk genotypes may significantly modify the association between diabetes and CKD.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Endocrinology & Metabolism
Xiaolin Ni, Yiming Feng, Wenmin Guan, Yue Chi, Xiang Li, Yiyi Gong, Nan Zhao, Qianqian Pang, Wei Yu, Huanwen Wu, Li Huo, Yong Liu, Jin Jin, Xi Zhou, Wei Lv, Lian Zhou, Yu Xia, Wei Liu, Ruizhi Jiajue, Ou Wang, Mei Li, Xiaoping Xing, Seiji Fukumoto, Yan Jiang, Weibo Xia
Summary: Tumor-induced osteomalacia (TIO) is a rare paraneoplastic syndrome caused by excessive production of fibroblast growth factor 23 (FGF23) by a tumor. This study evaluated the bone microarchitecture in TIO patients using high-resolution peripheral quantitative computed tomography (HR-pQCT) and trabecular bone score (TBS) and found that TIO patients had impaired bone microstructure in the peripheral skeleton. HR-pQCT parameters and TBS showed promising advantages for assessing bone impairment in TIO patients.
JOURNAL OF BONE AND MINERAL RESEARCH
(2022)
Article
Endocrinology & Metabolism
Ali Ghasem-Zadeh, Minh Bui, Ego Seeman, Steven K. Boyd, Sandra Iuliano, Rizwan Jaipurwala, Peter F. Mount, Nigel D. Toussaint, Cherie Chiang
Summary: Patients with chronic kidney disease (CKD) may experience reduced estimated failure load due to deterioration in bone microarchitecture, regardless of their femoral neck (FN) bone mineral density (BMD) status. This suggests that bone fragility could be present in CKD patients despite osteopenia or normal BMD, highlighting the importance of measuring microarchitecture in assessing fracture risk and targeting therapy effectively.
Article
Rheumatology
Axel P. Villani, Stephanie Boutroy, Celine Coutisson, Marie-Christine Carlier, Lois Barets, Hubert Marotte, Bertrand Richert, Roland D. Chapurlat, Denis Jullien, Cyrille B. Confavreux
Summary: This study found that onycholysis may be associated with early bone erosions of the DIP joint, which can impact the development of PsA. In the ONY group, there were significantly more bone erosions compared to the PSO group.
Article
Engineering, Biomedical
Nikolas K. Knowles, Danielle E. Whittier, Bryce A. Besler, Steven K. Boyd
Summary: Injury to the ACL increases the risk of osteoarthritis, with clinical QCT-FEMs shown to accurately replicate HR-pQCT FEM changes in bone quality.
ANNALS OF BIOMEDICAL ENGINEERING
(2021)
Article
Endocrinology & Metabolism
Qian Li, Zhen Zhao, Bo Wu, Qianqian Pang, Lijia Cui, Li Zhang, Yan Jiang, Ou Wang, Mei Li, Xiaoping Xing, Yingying Hu, Wei Yu, Xunwu Meng, Ruizhi Jiajue, Weibo Xia
Summary: Camurati-Engelmann disease is a rare skeletal dysplasia caused by mutations in the TGFB1 gene. This study conducted a retrospective review of CED patients in Beijing, China and characterized various clinical features, bone microstructure, and strength using HR-pQCT. The study revealed typical manifestations of CED and showed alterations in bone density, microstructure, and strength in CED patients.
JOURNAL OF BONE AND MINERAL RESEARCH
(2022)
Article
Endocrinology & Metabolism
Xiaolin Ni, Wenmin Guan, Qianqian Pang, Chenxi Jin, Yiyi Gong, Wei Liu, Ou Wang, Mei Li, Xiaoping Xing, Wei Yu, Yan Jiang, Weibo Xia
Summary: X-linked hypophosphatemia (XLH) patients have abnormal lumbar spine bone mass, but compromised microarchitecture and bone strength in the peripheral bone.
Article
Endocrinology & Metabolism
Joao Victor Salgado, Miguel Angelo Goes, Natalino Salgado Filho
Summary: The global nephrology community acknowledges the increasing burden of kidney disease and emphasizes on early diagnosis, understanding of disease progression, and development of new therapeutic interventions. FGF21 is considered a key regulator of lipid, glucose, and energy metabolism, as well as stress responses. While promising results have been shown with FGF21 analogs in metabolic disease, its exact role in kidney function remains poorly understood.
METABOLISM-CLINICAL AND EXPERIMENTAL
(2021)
Article
Endocrinology & Metabolism
M. S. A. M. Bevers, A. M. Daniels, B. van Rietbergen, P. P. M. M. Geusens, S. M. J. van Kuijk, S. Sassen, S. Kaarsemaker, P. F. W. Hannemann, M. Poeze, H. M. J. Janzing, J. P. van den Bergh, C. E. Wyers
Summary: By utilizing high-resolution peripheral quantitative computed tomography, this study examined changes in bone density, microstructure, and strength during the healing of conservatively-treated scaphoid fractures. The findings indicated a substantial decrease in bone density, trabecular thickness, and failure load during the initial 6 weeks of healing, followed by stabilization or increase in these parameters. However, at 26 weeks, these parameters had not returned to baseline levels.
Article
Endocrinology & Metabolism
Fjola Johannesdottir, Melissa S. Putman, Sherri-Ann M. Burnett-Bowie, Joel S. Finkelstein, Elaine W. Yu, Mary L. Bouxsein
Summary: The study found that postmenopausal Black women have similar rates of bone loss compared to White women, with lower weight women experiencing greater declines in bone density and microstructure at the radius. Women who lost weight during the follow-up period had higher rates of bone loss, particularly at the tibia, while higher baseline total body fat mass was protective against bone loss.
JOURNAL OF BONE AND MINERAL RESEARCH
(2022)
Article
Endocrinology & Metabolism
M. Revel, F. Bermond, F. Duboeuf, D. Mitton, H. Follet
Summary: Although HR-pQCT allows for assessment of bone microstructure and strength to evaluate fracture risk, it does not show clear improvement in accuracy compared to DXA measurements. Changes in loading conditions do not enhance the prediction of radius fracture risk based on ex vivo experiments, as demonstrated by similar ROC curves and accuracies with different loading conditions.
Article
Urology & Nephrology
Elodie Chalencon, Laetitia Koppe, Madeleine Lauverjat, Didier Barnoud, Denis Fouque, Cecile Chambrier
Summary: This study evaluated renal function in patients with intestinal failure undergoing long-term home parenteral nutrition, finding that commonly used eGFR equations significantly overestimated the actual GFR and had low accuracy. Monitoring kidney function over time remains crucial in this population, despite the inaccuracy of eGFR equations.
CLINICAL KIDNEY JOURNAL
(2021)
Article
Transplantation
Sandra Wagner, Thomas Merkling, Marie Metzger, Lise Bankir, Maurice Laville, Luc Frimat, Christian Combe, Christian Jacquelinet, Denis Fouque, Ziad A. Massy, Benedicte Stengel
Summary: In patients with CKD, the relationship between plain water intake and progression to kidney failure appears to be U-shaped. Both low and high intake may not be beneficial in CKD.
NEPHROLOGY DIALYSIS TRANSPLANTATION
(2022)
Review
Transplantation
Pedro H. Imenez Silva, Robert Unwin, Ewout J. Hoorn, Alberto Ortiz, Francesco Trepiccione, Rikke Nielsen, Vesna Pesic, Gaye Hafez, Denis Fouque, Ziad A. Massy, Chris De Zeeuw, Giovambattista Capasso, Carsten A. Wagner
Summary: Metabolic acidosis, a common consequence of chronic kidney disease (CKD), is associated with cognitive dysfunction in CKD patients, potentially contributing to cognitive impairment. In addition to acidosis, CKD may also lead to impaired motor function and loss of muscle strength.
NEPHROLOGY DIALYSIS TRANSPLANTATION
(2022)
Article
Transplantation
Emilie Bres, Cecile Pagan, Anais Bouchara, Myriam Pastural, Samuel Granjon, Maurice Laville, Denis Fouque, Christophe O. Soulage, Laetitia Koppe
Summary: This study found that serum 3-MH levels were associated with clinical outcomes in MHD patients, with high levels indicating better lean tissue mass and nutritional status, while low levels were a predictor of cardiovascular events in this population.
NEPHROLOGY DIALYSIS TRANSPLANTATION
(2022)
Editorial Material
Transplantation
Denis Fouque
NEPHROLOGY DIALYSIS TRANSPLANTATION
(2022)
Review
Nutrition & Dietetics
David E. St-Jules, Denis Fouque
Summary: Diet therapy for hyperkalemia in chronic kidney disease (CKD) is undergoing a shift from low-potassium diet to high-potassium, plant-rich diet. While reported dietary potassium intake is not associated with plasma potassium concentrations, kinetic studies indicate that CKD patients have impaired potassium tolerance. Observational studies may not detect the acute effects of dietary potassium on plasma potassium levels. To reconcile these findings, an etiology-based approach combining elements of low-potassium and plant-rich diets, along with meal planning, is proposed to manage hyperkalemia.
Letter
Urology & Nephrology
Titus Andrian, Etienne Novel-Catin, Claire Triffault-Fillit, Maud Rabeyrin, Christophe Barba, Laetitia Koppe, Denis Fouque
CLINICAL KIDNEY JOURNAL
(2022)
Article
Biochemistry & Molecular Biology
Ariane Zaloszyc, Philippe Choquet, Amira Sayeh, Maria Bartosova, Betti Schaefer, Ulrike Huegel, Gaelle Aubertin-Kirch, Christopher Healy, Francois Severac, Sebastien Rizzo, Georges Boivin, Franz Schaefer, Michel Fischbach, Justine Bacchetta, Seiamak Bahram, Claus Peter Schmitt
Summary: Chronic kidney disease often leads to bone disorders and cardiovascular mortality, and the G alpha(q/11)/PKC pathway in osteoblasts plays an important role in CKD-MBD.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Urology & Nephrology
Moustapha Faye, Karine Legrand, Lisa Le Gall, Karen Leffondre, Abdou Y. Omorou, Natalia Alencar de Pinho, Christian Combe, Denis Fouque, Christian Jacquelinet, Maurice Laville, Sophie Liabeuf, Ziad A. Massy, Elodie Speyer, Roberto Pecoits Filho, Benedicte Stengel, Luc Frimat, Carole Ayav
Summary: This study focuses on the significant worsening of symptoms in about one third of the participants, while the majority reported low symptom severity throughout the study.
CLINICAL JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY
(2022)
Editorial Material
Transplantation
Rajiv Agarwal, Denis Fouque
NEPHROLOGY DIALYSIS TRANSPLANTATION
(2023)
Editorial Material
Transplantation
Pierre Gabai, Denis Fouque
NEPHROLOGY DIALYSIS TRANSPLANTATION
(2023)
Article
Transplantation
Maelys Granal, Denis Fouque, Micher Ducher, Jean-Pierre Fauvel
Summary: This study used artificial intelligence to define the relationship between kalemia, dietary potassium intake, and renal function in chronic kidney disease (CKD) patients. The results showed that strict dietary potassium control is not necessary to regulate kalemia in CKD1-4 patients.
NEPHROLOGY DIALYSIS TRANSPLANTATION
(2023)
Article
Transplantation
Nu Thuy Dung Tran, Margaux Balezeaux, Maelys Granal, Denis Fouque, Michel Ducher, Jean-Pierre Fauvel
Summary: This study aimed to develop a clinical prediction tool for predicting the 2-year all-cause mortality in patients with stage 4-5 CKD. The prediction tools developed using Bayesian network and logistic regression showed the best performances. The optimized prediction tool, using seven variables, demonstrated satisfactory internal performance.
NEPHROLOGY DIALYSIS TRANSPLANTATION
(2023)
Review
Nutrition & Dietetics
Kamyar Kalantar-Zadeh, Vincenzo Bellizzi, Giorgina B. Piccoli, Yunying Shi, Soo Kun Lim, Sumira Riaz, Rocio Urbina Arronte, Wai Pooi Lau, Denis Fouque
Summary: An expert advisory board discussed the prevention and treatment of CKD, with a focus on dietary options. The timing of dialysis start is influenced by patients' clinical status and patient-clinician interactions. Therapies that preserve kidney function, such as adjusting lifestyle and diet, can prolong the dialysis-free period and improve CKD management.
JOURNAL OF RENAL NUTRITION
(2023)
Letter
Nutrition & Dietetics
David E. St-Jules, Denis Fouque
Summary: Diet therapy for hyperkalemia in people with chronic kidney disease has changed due to weak or no correlation between reported potassium intake and plasma potassium levels. The risk of postprandial hyperkalemia from high-potassium plant foods remains a debated topic. Although additional research is needed, some argue that the available research supports that high-potassium plant foods are not a risk for postprandial hyperkalemia. This editorial critiques the analyses offered and advocates for a cautious approach to care.