Article
Gastroenterology & Hepatology
Branden D. Tarlow, W. Ray Kim, Ajitha Mannalithara, Paul Y. Kwo, C. Andrew Bonham, Allison Kwong
Summary: This study found that MELD 3.0 scores beyond 40 are associated with increasing waitlist mortality without adversely affecting posttransplant outcomes. Uncapping the MELD score for waitlist candidates may lead to greater survival benefits from liver transplantation.
Article
Endocrinology & Metabolism
Hui-Teng Cheng, Xiaoqi Xu, Paik Seong Lim, Kuan-Yu Hung
Summary: The study compared the incidence of diabetes-related end-stage renal disease globally from 2000 to 2015, finding significant geographic variation in the risk of diabetic patients reaching ESRD in different regions during the study period.
Article
Public, Environmental & Occupational Health
Rachel Wilf-Miron, Vicki Myers, Mor Saban, Ilya Novikov, Lizie Kimron, Arnona Ziv, Ofra Kalter-Leibovici
Summary: The incidence of end-stage renal disease (ESRD) is higher in Israel than the European average. Socio-economic factors and ethnicity, particularly Arab ethnicity, are associated with an increased risk of ESRD, especially due to diabetes. Allocation of health resources and culturally appropriate interventions are necessary to improve control of modifiable risk factors for chronic renal failure.
INTERNATIONAL JOURNAL OF EPIDEMIOLOGY
(2023)
Article
Urology & Nephrology
Suping Ling, Gang Xu, Francesco Zaccardi, Kamlesh Khunti, Nigel J. Brunskill
Summary: South Asians have lower mortality rates than Whites, but not significantly higher rates of ESKD. Further research is needed to better understand the reasons for these ethnic differences and their potential impact on CKD service delivery and patient outcomes.
KIDNEY INTERNATIONAL REPORTS
(2023)
Article
Medicine, General & Internal
Ming-Shian Lu, Miao-Fen Chen, Yao-Hsu Yang, Chuan-Pin Lee, Chien-Chao Lin, Yuan-Hsi Tseng, Ying-Huang Tsai
Summary: This study evaluated the impact of end-stage renal disease on the survival of lung cancer patients. The results showed that there was no significant difference in survival between lung cancer patients with and without end-stage renal disease. However, lung cancer patients with end-stage renal disease who received medical treatment had a shorter overall survival compared to those without end-stage renal disease.
ARCHIVES OF MEDICAL SCIENCE
(2023)
Article
Immunology
Laurence Bouchet-Delbos, Amandine Even, Emilie Varey, Soraya Saiagh, Sylvain Bercegeay, Cecile Braudeau, Brigitte Dreno, Gilles Blancho, Regis Josien, Maria-Cristina Cuturi, Aurelie Moreau
Summary: The study developed a GMP-compliant method for producing ATDCs and compared the phenotype and functions of ATDCs extracted from healthy volunteers and patients.
Article
Biochemistry & Molecular Biology
Ziad M. El-Zaatari, Luan D. Truong
Summary: Renal cell carcinoma (RCC) occurring in the setting of end-stage renal disease (ESRD) shows unique clinicopathological characteristics, with acquired cystic kidney disease-associated renal cell carcinoma (ACKD-RCC) and clear-cell papillary renal cell carcinoma (ccpRCC) being the most frequent types. Other types of RCC also occur in ESRD, albeit with different frequencies from the non-ESRD general population. While the histological features of RCC do not vary in the setting of ESRD vs. non-ESRD, other findings, such as multifocality and multiple tumor types, are more frequent in ESRD. Studies have generated novel and important knowledge of the etiology, epidemiology, diagnosis, treatment, immunophenotype, and molecular characteristics of ESRD-associated RCC.
Article
Surgery
Mario Spaggiari, Pierpaolo Di Cocco, Kiara Tulla, Kerim B. Kaylan, Mario A. Masrur, Chandra Hassan, Jorge A. Alvarez, Enrico Benedetti, Ivo Tzvetanov
Summary: This study compared the safety and efficacy of combining robotic sleeve gastrectomy and robotic-assisted kidney transplant to robotic kidney transplant alone in obese patients, and found that the combined surgery was more effective in reducing body weight, despite longer operation time without increased risk of complications.
AMERICAN JOURNAL OF TRANSPLANTATION
(2021)
Review
Medicine, General & Internal
Didier Ducloux, Mathieu Legendre, Jamal Bamoulid, Philippe Saas, Cecile Courivaud, Thomas Crepin
Summary: ESRD patients exhibit clinical features of premature ageing such as frailty, cardiovascular disease, and muscle wasting, with immune system aging and chronic inflammation also being key factors. Preventing or reversing immune senescence/inflammation is a major goal to improve clinical outcomes for ESRD patients.
FRONTIERS IN MEDICINE
(2021)
Article
Medicine, General & Internal
Christian Sohns, Henrik Fox, Nassir F. Marrouche, Harry J. G. M. Crijns, Angelika Costard-Jaeckle, Leonard Bergau, Gerhard Hindricks, Nikolaos Dagres, Samuel Sossalla, Rene Schramm, Thomas Fink, Mustapha El Hamriti, Maximilian Moersdorf, Vanessa Sciacca, Frank Konietschke, Volker Rudolph, Jan Gummert, Jan G. P. Tijssen, Philipp Sommer, CASTLE HTx Investigators
Summary: Among patients with atrial fibrillation and end-stage heart failure, catheter ablation combined with guideline-directed medical therapy was associated with a lower likelihood of a composite of death from any cause, implantation of a left ventricular assist device, or urgent heart transplantation compared to medical therapy alone.
NEW ENGLAND JOURNAL OF MEDICINE
(2023)
Article
Medicine, General & Internal
Kevin H. Nguyen, Eunhae G. Oh, David J. Meyers, Daeho Kim, Rajnish Mehrotra, Amal N. Trivedi
Summary: The study examines the changes in Medicare Advantage enrollment among Medicare beneficiaries with end-stage renal disease (ESRD) after the enactment of the 21st Century Cures Act. The results show substantial increases in MA enrollment, particularly among Black, Hispanic, and dual-eligible individuals.
JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION
(2023)
Article
Cell Biology
Zaipul I. Md Dom, Eiichiro Satake, Jan Skupien, Bozena Krolewski, Kristina O'Neil, Jill A. Willency, Simon T. Dillon, Jonathan M. Wilson, Hiroki Kobayashi, Katsuhito Ihara, Towia A. Libermann, Marlon Pragnell, Kevin L. Duffin, Andrzej S. Krolewski
Summary: This study identified three elevated plasma proteins associated with protection against progressive renal decline and progression to endstage renal disease in individuals with diabetes. These protective proteins may serve as biomarkers for stratifying diabetic individuals by their risk of developing ESRD, and could be explored as potential therapeutics to delay or prevent ESRD onset.
SCIENCE TRANSLATIONAL MEDICINE
(2021)
Review
Pharmacology & Pharmacy
Yinghui Wang, Lu Gao
Summary: Chronic kidney disease and cardiac insufficiency often co-exist, especially in uremic patients on hemodialysis. Impaired renal function is often indicative of poor prognosis in patients with cardiac insufficiency. Inflammation plays a significant role in the development of cardiovascular complications in patients with chronic kidney disease and is indicative of prognosis.
FRONTIERS IN PHARMACOLOGY
(2022)
Article
Clinical Neurology
Chang Min Heo, Won Ho Lee, Bong Soo Park, Yoo Jin Lee, Sihyung Park, Yang Wook Kim, Dong Ah Lee, Byeong Cheol Yoo, Kang Min Park
Summary: This study compares glymphatic dysfunction between patients with end-stage renal disease (ESRD) and healthy controls, and reveals the presence of glymphatic dysfunction in patients with ESRD as demonstrated by the DTI-ALPS index. Additionally, a significant positive correlation is found between the DTI-ALPS index and serum parathyroid hormone levels in ESRD patients.
FRONTIERS IN NEUROLOGY
(2022)
Article
Urology & Nephrology
Rayka Malek, Ahmadreza Baghestani, Farin Rashid-Farokhi, Shadi Shafaghi, Farzanehsadat Minoo, Foolad Eghbali, Navin Chandra, Masoud Shafaghi, Kaveh Bonyadi, Fatemeh Sadat Hosseini-Baharanchi
Summary: This study aimed to evaluate the influence of demographic and laboratory parameters on the survival of patients with End-Stage Renal Disease (ESRD) in a hemodialysis center in Iran. The results showed that male gender, hypercalcemia, and hypoparathyroidism were associated with worse outcomes. Correcting these laboratory parameters may improve patients' survival in the hemodialysis population.
Article
Urology & Nephrology
Federica Genovese, Daniel Guldager Kring Rasmussen, Morten A. Karsdal, Mark Jesky, Charles Ferro, Anthony Fenton, Paul Cockwell
Summary: This study found that dynamic products of COL3 formation and degradation were independently associated with CKD progression and mortality, providing the opportunity to link pathological processes with targeted treatments against fibrosis.
CLINICAL KIDNEY JOURNAL
(2021)
Article
Dentistry, Oral Surgery & Medicine
Praveen Sharma, Anthony Fenton, Irundika H. K. Dias, Brenda Heaton, Caroline L. R. Brown, Amneet Sidhu, Mutahir Rahman, Helen R. Griffiths, Paul Cockwell, Charles J. Ferro, Iain L. Chapple, Thomas Dietrich
Summary: The study found a causal relationship between periodontal inflammation and renal function, mediated by systemic oxidative stress. Periodontal inflammation represents an occult source of oxidative stress in patients with CKD, and periodontal therapy may potentially improve outcomes in CKD by reducing systemic inflammatory/oxidative stress burden.
JOURNAL OF CLINICAL PERIODONTOLOGY
(2021)
Article
Transplantation
Luke Pickup, Charalampos Loutradis, Jonathan P. Law, Julia J. Arnold, Indranil Dasgupta, Pantelis Sarafidis, Jonathan N. Townend, Paul Cockwell, Charles J. Ferro
Summary: This study evaluated the incidence of acute kidney injury using pre-admission and admission creatinine levels and found that even minor increases in creatinine levels were associated with increased mortality. This can help clinicians identify patients at higher risk for adverse outcomes.
NEPHROLOGY DIALYSIS TRANSPLANTATION
(2022)
Article
Urology & Nephrology
Chava L. Ramspek, Marie Evans, Christoph Wanner, Christiane Drechsler, Nicholas C. Chesnaye, Maciej Szymczak, Magdalena Krajewska, Claudia Torino, Gaetana Porto, Samantha Hayward, Fergus Caskey, Friedo W. Dekker, Kitty J. Jager, Merel van Diepen
Summary: The study validates existing kidney failure risk prediction models in patients with advanced CKD, finding that some models perform well in the short term but overestimate risk in longer-term predictions due to competing risks. The Grams model, which accounts for competing risks, is suitable for longer-term predictions.
JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY
(2021)
Editorial Material
Urology & Nephrology
Anna Francis, Colin Baigent, T. Alp Ikizler, Paul Cockwell, Vivekanand Jha
KIDNEY INTERNATIONAL
(2021)
Review
Urology & Nephrology
Frank Bridoux, Paul Cockwell, Ilya Glezerman, Victoria Gutgarts, Jonathan J. Hogan, Kenar D. Jhaveri, Florent Joly, Samih H. Nasr, Deirdre Sawinski, Nelson Leung
Summary: Patients with haematological cancer are at a higher risk of kidney injury, either as a direct result of the malignancy or due to treatment-related effects. It is common for cancer patients, especially those with haematological malignancies, to experience acute kidney injury (AKI) which can be caused by the underlying blood disorder.
NATURE REVIEWS NEPHROLOGY
(2021)
Article
Endocrinology & Metabolism
Charalampos Loutradis, Luke Pickup, Jonathan P. Law, Indranil Dasgupta, Jonathan N. Townend, Paul Cockwell, Adnan Sharif, Pantelis Sarafidis, Charles J. Ferro
Summary: Men are at higher risk of AKI and AKI-related mortality, independent of existing risk factors for AKI. However, the association between male sex and AKI-related mortality is not independent from existing comorbidities.
BIOLOGY OF SEX DIFFERENCES
(2021)
Article
Urology & Nephrology
Harjeet K. Bhachu, Paul Cockwell, Anuradhaa Subramanian, Nicola J. Adderley, Krishna Gokhale, Anthony Fenton, Derek Kyte, Krishnarajah Nirantharakumar, Melanie Calvert
Summary: The study found that using a risk-based referral approach can lead to a significant reallocation of patients between primary care and specialist nephrology care, ensuring that those at higher risk of progression are identified and treated more promptly.
KIDNEY INTERNATIONAL REPORTS
(2021)
Review
Medicine, General & Internal
Harjeet Kaur Bhachu, Anthony Fenton, Paul Cockwell, Olalekan Aiyegbusi, Derek Kyte, Melanie Calvert
Summary: This systematic review evaluated the impact of the Kidney Failure Risk Equation (KFRE) in clinical practice. Five studies were included in the analysis, showing conflicting evidence on the impact of KFRE on patient referrals and wait times. Further studies are needed to assess the impact of KFRE on clinical care.
Article
Peripheral Vascular Disease
Kulli Kuningas, Stephanie Stringer, Paul Cockwell, Aurangzaib Khawaja, Nicholas Inston
Summary: This study assessed the use of KFRE as an indicator for timing vascular access creation in pre-dialysis patients. The study found that the predictive models were relatively poor in determining the initiation of dialysis, resulting in a high rate of unnecessary fistula formation and non-use of fistulas.
JOURNAL OF VASCULAR ACCESS
(2022)
Article
Medicine, General & Internal
Derek Kyte, Nicola Anderson, Jon Bishop, Andrew Bissell, Elizabeth Brettell, Melanie Calvert, Marie Chadburn, Paul Cockwell, Mary Dutton, Helen Eddington, Elliot Forster, Gabby Hadley, Natalie J. Ives, Louise J. Jackson, Sonia O'Brien, Gary Price, Keeley Sharpe, Stephanie Stringer, Rav Verdi, Judi Waters, Adrian Wilcockson
Summary: This study aimed to assess the feasibility and acceptability of online electronic patient-reported outcome measures (ePROMs) in patients with chronic kidney disease (CKD). The results showed that this approach is feasible and patients are willing to participate, and the intervention was considered acceptable. However, measures to improve longer-term engagement are needed.
Article
Urology & Nephrology
Chava L. Ramspek, Rosemarijn Boekee, Marie Evans, Olof Heimburger, Charlotte M. Snead, Fergus J. Caskey, Claudia Torino, Gaetana Porto, Maciej Szymczak, Magdalena Krajewska, Christiane Drechsler, Christoph Wanner, Nicholas C. Chesnaye, Kitty J. Jager, Friedo W. Dekker, Maarten G. J. Snoeijs, Joris Rotmans, Merel van Diepen
Summary: This study validated the predictive performance of the CKD G4thorn risk calculator in patients with kidney disease and assessed its clinical impact in guiding vascular access placement. The results showed accurate predictions and using the model to guide referral for vascular access placement can reduce unnecessary surgeries.
KIDNEY INTERNATIONAL REPORTS
(2022)
Article
Medical Informatics
Z. Yonel, K. Kuningas, P. Sharma, M. Dutton, Z. Jalal, P. Cockwel, J. Webber, P. Narendran, T. Dietrich, I. L. C. Chapple
Summary: The POCT devices demonstrated acceptable concordance with laboratory-based assays, and patients reported lower levels of discomfort compared to traditional means of blood collection.
BMC MEDICAL INFORMATICS AND DECISION MAKING
(2022)
Article
Multidisciplinary Sciences
Luke E. Barry, Grainne E. Crealey, Paul Cockwell, Stephen J. Elliman, Matthew D. Griffin, Alexander P. Maxwell, Timothy O'Brien, Norberto Perico, Ciaran O'Neill
Summary: This study simulated the cost-effectiveness of Mesenchymal Stromal Cell therapy compared to other treatments in patients with Diabetic Kidney Disease. The results showed that Mesenchymal Stromal Cell therapy was more cost-effective compared to other treatments. However, sodium/glucose co-transporter 2 inhibitors had the highest cost-effectiveness among all the treatments.
Article
Respiratory System
Elizabeth Sapey, Suzy Gallier, Chris Mainey, Peter Nightingale, David McNulty, Hannah Crothers, Felicity Evison, Katharine Reeves, Domenico Pagano, Alastair K. Denniston, Krishnarajah Nirantharakumar, Peter Diggle, Simon Ball
BMJ OPEN RESPIRATORY RESEARCH
(2020)