Review
Biochemistry & Molecular Biology
Daiki Hayashi, Yasuhito Shirai
Summary: The drastic increase in the number of patients with diabetes and its complications is a global issue. Diabetic nephropathy, the leading cause of chronic kidney disease, significantly affects patients' quality of life and medical expenses. The activation of DGK to inhibit PKC activation shows potential therapeutic effect in ameliorating diabetic nephropathy.
Article
Chemistry, Medicinal
Trong Kha Pham, To Hoai T. Nguyen, Hyeong Rok Yun, Elena A. Vasileva, Natalia P. Mishchenko, Sergey A. Fedoreyev, Valentin A. Stonik, Thu Thi Vu, Huy Quang Nguyen, Sung Woo Cho, Hyoung Kyu Kim, Jin Han
Summary: Echinochrome A (EchA), a natural bioproduct from sea urchins, has antioxidant, anti-inflammatory, and antimicrobial effects. This study investigated its effects on diabetic nephropathy (DN) using mouse models. The results showed that EchA improved glucose tolerance, reduced biomarkers of kidney damage, decreased oxidative stress, and ameliorated renal fibrosis. Mechanistically, EchA inhibited specific signaling pathways involved in oxidative stress and fibrosis, while enhancing mitochondrial function and antioxidant activity. These findings suggest that EchA may be a therapeutic option for DN.
Article
Pharmacology & Pharmacy
Yan Yang, Haiming Xiao, Zeyuan Lin, Rui Chen, Shanshan Li, Chuting Li, Xiaohong Sun, Ziqing Hei, Wenyan Gong, Heqing Huang
Summary: CKIP-1 plays a nephroprotective role in diabetic nephropathy by regulating inflammation and its down-regulation exacerbates renal inflammatory fibrosis. Src kinase interacts with CKIP-1 and promotes its ubiquitination and protein degradation.
BIOCHEMICAL PHARMACOLOGY
(2022)
Article
Nutrition & Dietetics
Rajiv Rana, Jayakumar Manoharan, Anubhuti Gupta, Dheerendra Gupta, Ahmed Elwakiel, Hamzah Khawaja, Sameen Fatima, Silke Zimmermann, Kunal Singh, Saira Ambreen, Ihsan Gadi, Ronald Biemann, Shihai Jiang, Khurrum Shahzad, Shrey Kohli, Berend Isermann
Summary: Diabetic kidney disease (DKD) is a growing pandemic associated with obesity and diabetes mellitus. DKD is now the leading cause of end-stage renal disease and is linked to increased risk of cardiovascular morbidity and mortality. This study demonstrates that the cytoprotective coagulation protease activated protein C (aPC) reduces mitochondrial ROS generation in tubular cells and mitigates renal sterile inflammation in DKD, supporting the potential therapeutic use of aPC in DKD treatment.
Review
Endocrinology & Metabolism
Deng Pan, Lin Xu, Ming Guo
Summary: Protein kinase C (PKC) plays a crucial role in the development of diabetic microvascular complications by becoming activated under high-glucose conditions, leading to the accumulation of redox stress. This activation affects various types of cells in the microvasculature, resulting in changes in blood flow, microvascular permeability, extracellular matrix accumulation, basement thickening, and angiogenesis.
FRONTIERS IN ENDOCRINOLOGY
(2022)
Article
Biochemistry & Molecular Biology
Liding Zhao, Ya Li, Tian Xu, Qingbo Lv, Xukun Bi, Xianglan Liu, Guosheng Fu, Yunzeng Zou, Junbo Ge, Zhaoyang Chen, Wenbin Zhang
Summary: This study found that diabetes mellitus plays a significant role in aggravating chronic inflammation and promoting atherosclerosis, in conjunction with hyperlipidemia. The mechanism of action may involve the induction of immune maturation of dendritic cells, likely through the RAGE-TLR4-PKC β(1) signaling pathway.
MOLECULAR MEDICINE
(2022)
Article
Medicine, Research & Experimental
Tingli Sun, Jizhang Liu, Changying Xie, Jun Yang, Lijie Zhao, Jingbo Yang
Summary: This study found that metformin could reduce kidney damage caused by diabetic nephropathy (DN) by activating the AMPK-mTOR-autophagy axis, resulting in decreased oxidative damage, fibrosis, and inflammatory response. This suggests that metformin may be considered as a potential target in the treatment of DN.
EXPERIMENTAL AND THERAPEUTIC MEDICINE
(2021)
Editorial Material
Hematology
Jan A. Burger
Summary: The study reveals that MARCKS protein is differentially expressed in patients with chronic lymphocytic leukemia based on the mutation status of IGHV, and its expression and phosphorylation are linked to CLL cell migration through key signaling pathways. The findings were also confirmed in samples from patients treated with the BTK inhibitor acalabrutinib.
Article
Food Science & Technology
Ping Tang, Xinzhou Yang, Huijian Chen, Ting Zhang, Hui Tang, Kejian Pang
Summary: This study demonstrates the antidiabetic activity of ethyl acetate extract of Morus nigra L. twigs (MNT-EA) and its potential mechanisms through the activation of AMPK/PKC/GLUT4 signaling pathway, which enhances glucose uptake and improves diabetic symptoms.
JOURNAL OF FUNCTIONAL FOODS
(2022)
Article
Pharmacology & Pharmacy
Hao Xie, Xing-Yi Shen, Na Zhao, Peng Ye, Zhen Ge, Zuo-Ying Hu
Summary: In diabetic mice, ivabradine alleviates cardiac fibrosis and diastolic dysfunction by suppressing CF proliferation and activation, regulating the phosphorylation of JNK and p38 MAPK, and enhancing matrix metalloproteinase 2 expression.
FRONTIERS IN PHARMACOLOGY
(2021)
Article
Biochemistry & Molecular Biology
Paras Sehgal, Samatha Mathew, Ambily Sivadas, Arjun Ray, Jyoti Tanwar, Sushma Vishwakarma, Gyan Ranjan, K. Shamsudheen, Rahul C. Bhoyar, Abhishek Pateria, Elvin Leonard, Mukesh Lalwani, Archana Vats, Rajeev R. Pappuru, Mudit Tyagi, Saumya Jakati, Shantanu Sengupta, B. K. Binukumar, Subhabrata Chakrabarti, Inderjeet Kaur, Rajender K. Motiani, Vinod Scaria, Sridhar Sivasubbu
Summary: The study identified a novel vascular endothelial-associated lncRNA named VEAL2, which regulates endothelial permeability and function through interaction with PRKCB2, and is implicated in diabetic retinopathy.
Article
Endocrinology & Metabolism
Siddharth Sunilkumar, Esma I. Yerlikaya, Allyson L. Toro, William P. Miller, Han Chen, Kebin Hu, Scot R. Kimball, Michael D. Dennis
Summary: Chronic hyperglycemia promotes the expression of REDD1 in the kidney, leading to oxidative stress and renal injury. Deletion of REDD1 reduces reactive oxygen species and prevents podocyte loss, indicating its role in diabetes-induced renal complications.
Article
Biochemical Research Methods
Haixiang Zhang, Yinan Zheng, Lifang Hou, Cheng Zheng, Lei Liu
Summary: In this study, a novel method is introduced to identify potential mediators in high-dimensional Cox regression, with successful control of false discovery rate through data dimension reduction and multiple-testing procedure. Application to DNA methylation markers in lung cancer patients reveals two potential mediating epigenetic markers.
Article
Immunology
Qianqian Ma, Xiaozhi Hu, Fangyu Liu, Zhonglian Cao, Lei Han, Kaicheng Zhou, Yu Bai, Yuting Zhang, Yanyang Nan, Qianying Lv, Jia Rao, Tao Wu, Xue Yang, Haidong He, Dianwen Ju, Hong Xu
Summary: The antagonism of ANGPTL3 can alleviate proteinuria symptoms in diabetic nephropathy (DN), but cannot impede other pathological processes. IL-22 is considered important in suppressing inflammatory responses and regulating glucolipid metabolism. A new bifunctional fusion protein, anti-ANGPTL3/IL22, showed favorable stability and demonstrated potential in reducing podocyte injury, improving inflammatory response, and enhancing renal tissue recovery.
FRONTIERS IN IMMUNOLOGY
(2022)
Article
Biotechnology & Applied Microbiology
Yilan Shen, Yuqing Xu, Pei Shen, Peiling Shen, Qi Bian, Lei Han, Zhonglian Cao, Jiajun Fan, Xian Zeng, Yuting Zhang, Zhiyong Guo, Dianwen Ju, Xiaobin Mei
Summary: The fusion protein of anti-IL17A/IL22 demonstrated beneficial effects in diabetic nephropathy, with potential therapeutic value in slowing down disease progression.
APPLIED MICROBIOLOGY AND BIOTECHNOLOGY
(2023)
