Journal
NEPHROLOGY DIALYSIS TRANSPLANTATION
Volume 25, Issue 1, Pages 310-313Publisher
OXFORD UNIV PRESS
DOI: 10.1093/ndt/gfp527
Keywords
ABO-incompatible kidney transplantation; acute antibody-mediated rejection; antigen-specific immunoadsorption
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ABO-incompatible kidney transplantation is possible after pre-treatment with rituximab, intravenous immunoglobulin and basiliximab combined with tacrolimus, mycophenolate mofetil and prednisolone. We report on the first patient treated with this protocol who developed acute antibody-mediated rejection (Banff grade II with IgG deposits) caused by ABO antibodies (anti-B). Anti-rejection treatment with anti-B-specific immunoadsorption, intravenous immunoglobulin and methylprednisolone efficiently cleared deposited IgG from the kidney allograft and re-established normal kidney function. We suggest that ABO-incompatible kidney transplantation complicated by acute antibody-mediated rejection, caused by ABO antibodies, may successfully be treated with this regime.
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